GB1361164A - Tricyclic alpha-hydroxycarboxylic acid derivatives - Google Patents
Tricyclic alpha-hydroxycarboxylic acid derivativesInfo
- Publication number
- GB1361164A GB1361164A GB824773A GB824773A GB1361164A GB 1361164 A GB1361164 A GB 1361164A GB 824773 A GB824773 A GB 824773A GB 824773 A GB824773 A GB 824773A GB 1361164 A GB1361164 A GB 1361164A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- prepared
- tricyclic
- acid derivatives
- feb
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D313/12—[b,e]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
- C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrane Compounds (AREA)
Abstract
1361164 Tricyclic α-hydroxy-carboxylic acid derivatives BOEHRINGER MANNHEIM GmbH 20 Feb 1973 [25 Feb 1972] 8247/73 Heading C2C Novel compounds I in which X is a valency bond or an ethylene or oxaethylene linkage; and R 1 , R 2 and R 3 are H or alkyl, and pharmacologically acceptable salts thereof are prepared by reacting a compound II with a reactive ester, of Formula III in which R<SP>1</SP> 3 is 1-3C alkyl and Y is halo or a sulphonic ester grouping, followed where necessary by conversion of R<SP>1</SP> 3 to R 3 by conventional methods. Compounds II may be prepared by condensation of compounds IV to give compounds V followed by demethylation with hydriodic acid. O - (o - Methoxyphenoxymethyl)- benzoic acid is prepared by reaction of phthalide with the sodium salt of guaiacol. Pharmaceutical compositions comprise a compound I together with a suitable carrier and are used as anti-atherosclerosis agents.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2208893A DE2208893A1 (en) | 1972-02-25 | 1972-02-25 | TRICYCLIC ALPHA-OXY-CARBONIC ACID DERIVATIVES AND METHOD FOR MANUFACTURING THE SAME |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1361164A true GB1361164A (en) | 1974-07-24 |
Family
ID=5837044
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB824773A Expired GB1361164A (en) | 1972-02-25 | 1973-02-20 | Tricyclic alpha-hydroxycarboxylic acid derivatives |
Country Status (11)
Country | Link |
---|---|
JP (1) | JPS4892357A (en) |
AR (1) | AR194412A1 (en) |
AU (1) | AU5238973A (en) |
DD (1) | DD105203A5 (en) |
DE (1) | DE2208893A1 (en) |
FR (1) | FR2181753A1 (en) |
GB (1) | GB1361164A (en) |
HU (1) | HU164384B (en) |
NL (1) | NL7302352A (en) |
SU (1) | SU470956A3 (en) |
ZA (1) | ZA731247B (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3976686A (en) * | 1972-10-13 | 1976-08-24 | Merck & Co., Inc. | [1-Oxo-2,3-hydrocarbylene-5-indanyloxy(or thio)]alkanoic acids |
CA2142735A1 (en) * | 1993-06-18 | 1995-01-05 | Tatsuyoshi Tanaka | Fluorenone derivatives, process for preparing the same and central or peripheral nerve degeneration repair and protective agent |
AR035455A1 (en) | 2001-04-23 | 2004-05-26 | Hoffmann La Roche | TRICYCLE DERIVATIVES OF ALQUILHIDROXAMATO, PROCESSES FOR THEIR DEVELOPMENT, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THE USE OF SUCH COMPOUNDS IN THE PREPARATION OF MEDICINES |
FR2880887B1 (en) * | 2005-01-14 | 2009-01-30 | Merck Sante Soc Par Actions Si | HYDROXYPHENOL DERIVATIVES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND THERAPEUTIC APPLICATIONS |
-
1972
- 1972-02-25 DE DE2208893A patent/DE2208893A1/en active Pending
-
1973
- 1973-02-01 SU SU1878329A patent/SU470956A3/en active
- 1973-02-19 DD DD168927A patent/DD105203A5/xx unknown
- 1973-02-19 AR AR246667A patent/AR194412A1/en active
- 1973-02-20 AU AU52389/73A patent/AU5238973A/en not_active Expired
- 1973-02-20 NL NL7302352A patent/NL7302352A/xx unknown
- 1973-02-20 GB GB824773A patent/GB1361164A/en not_active Expired
- 1973-02-21 FR FR7306065A patent/FR2181753A1/fr not_active Withdrawn
- 1973-02-22 ZA ZA731247A patent/ZA731247B/en unknown
- 1973-02-23 HU HUBO1416A patent/HU164384B/hu unknown
- 1973-02-26 JP JP48023057A patent/JPS4892357A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
FR2181753A1 (en) | 1973-12-07 |
ZA731247B (en) | 1973-12-19 |
AU5238973A (en) | 1974-08-22 |
SU470956A3 (en) | 1975-05-15 |
NL7302352A (en) | 1973-08-28 |
JPS4892357A (en) | 1973-11-30 |
DE2208893A1 (en) | 1973-08-30 |
DD105203A5 (en) | 1974-04-12 |
AR194412A1 (en) | 1973-07-13 |
HU164384B (en) | 1974-02-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
CSNS | Application of which complete specification have been accepted and published, but patent is not sealed |