RO82508A - Procedeu pentru prepararea unor derivati de 3-(1-piperidinilalchil)-4procedeu pentru prepararea unor derivati de 3-(1-piperidinilalchil)-4h-pirido-(1,2,-a)-pirimidin-4-ona - Google Patents

Procedeu pentru prepararea unor derivati de 3-(1-piperidinilalchil)-4procedeu pentru prepararea unor derivati de 3-(1-piperidinilalchil)-4h-pirido-(1,2,-a)-pirimidin-4-ona

Info

Publication number
RO82508A
RO82508A RO81103848A RO10384881A RO82508A RO 82508 A RO82508 A RO 82508A RO 81103848 A RO81103848 A RO 81103848A RO 10384881 A RO10384881 A RO 10384881A RO 82508 A RO82508 A RO 82508A
Authority
RO
Romania
Prior art keywords
pyperidinylalkyl
derivatives
pyrido
pyrimidin
preparing
Prior art date
Application number
RO81103848A
Other languages
English (en)
French (fr)
Romanian (ro)
Other versions
RO82508B (ro
Inventor
Ludo E J Kennis
Josephus C Nertens
Original Assignee
Janssen Pharmaceutica Nv,Be
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv,Be filed Critical Janssen Pharmaceutica Nv,Be
Publication of RO82508B publication Critical patent/RO82508B/ro
Publication of RO82508A publication Critical patent/RO82508A/ro

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
RO81103848A 1980-03-28 1981-03-28 Procedeu pentru prepararea unor derivati de 3-(1-piperidinilalchil)-4procedeu pentru prepararea unor derivati de 3-(1-piperidinilalchil)-4h-pirido-(1,2,-a)-pirimidin-4-ona RO82508A (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13484580A 1980-03-28 1980-03-28
US06/191,632 US4342870A (en) 1980-03-28 1980-09-29 Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives

Publications (2)

Publication Number Publication Date
RO82508B RO82508B (ro) 1983-08-30
RO82508A true RO82508A (ro) 1983-09-26

Family

ID=26832744

Family Applications (1)

Application Number Title Priority Date Filing Date
RO81103848A RO82508A (ro) 1980-03-28 1981-03-28 Procedeu pentru prepararea unor derivati de 3-(1-piperidinilalchil)-4procedeu pentru prepararea unor derivati de 3-(1-piperidinilalchil)-4h-pirido-(1,2,-a)-pirimidin-4-ona

Country Status (22)

Country Link
US (1) US4342870A (en:Method)
EP (1) EP0037265B1 (en:Method)
AU (1) AU537700B2 (en:Method)
BG (1) BG36199A3 (en:Method)
CA (1) CA1163994A (en:Method)
CS (1) CS256366B2 (en:Method)
DE (1) DE3168433D1 (en:Method)
DK (1) DK159390C (en:Method)
ES (1) ES8300763A1 (en:Method)
FI (1) FI71737C (en:Method)
GR (1) GR72488B (en:Method)
HU (1) HU187329B (en:Method)
IE (1) IE51319B1 (en:Method)
IL (1) IL62494A (en:Method)
MA (1) MA19107A1 (en:Method)
NO (1) NO156752C (en:Method)
NZ (1) NZ196522A (en:Method)
PH (1) PH16530A (en:Method)
PT (1) PT72740B (en:Method)
RO (1) RO82508A (en:Method)
SU (1) SU1068037A3 (en:Method)
YU (1) YU43010B (en:Method)

Families Citing this family (42)

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US4443451A (en) 1981-07-15 1984-04-17 Janssen Pharmaceutica N.V. Bicyclic pyrimidin-5-one derivatives
US4548938A (en) * 1981-07-15 1985-10-22 Janssen Pharmaceutica N.V. 5-H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one compounds
US4355037A (en) * 1981-11-12 1982-10-19 Hoechst-Roussel Pharmaceuticals 3-(4-Piperidyl)-1,2-benzisoxales
US4485107A (en) * 1982-11-01 1984-11-27 Janssen Pharmaceutica N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
US4581171A (en) * 1983-07-27 1986-04-08 Janssen Pharmaceutica, N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders
US4695569A (en) * 1983-11-30 1987-09-22 Janssen Pharmaceutica N.V. Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines
US4888426A (en) * 1983-11-30 1989-12-19 Janssen Pharmaceutica N.V. 1-(5-methyl-furan-2-ylmethyl)-N-(4-piperidinyl)imidazo [4,5-6]pyridine-2-amine
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
US4548939A (en) * 1984-10-01 1985-10-22 Janssen Pharmaceutica N. V. 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
ATE146077T1 (de) * 1986-09-22 1996-12-15 Janssen Pharmaceutica Nv Serotonin-antagonisten zur behandlung von wunden
IL90879A0 (en) * 1988-09-02 1990-02-09 Janssen Pharmaceutica Nv 3-piperidinyl-indazole derivatives,their preparation and antihypertensive compositions containing them
CA2000786C (en) * 1988-11-07 1999-01-26 Cornelus G. M. Janssen 3-piperidinyl-1,2-benzisoxazoles
HU207310B (en) * 1988-12-02 1993-03-29 Pfizer Process for producing aryl-piperidine derivatives
AU5660190A (en) * 1989-03-23 1990-10-22 Mallinckrodt, Inc. Radioactive iodine- or bromine labelled piperidine compound as well as method of preparing same and composition comprising said compound
DE4138756A1 (de) * 1991-11-26 1993-05-27 Troponwerke Gmbh & Co Kg Kombination mit neuroprotektiver wirkung
US5266571A (en) * 1992-01-09 1993-11-30 Amer Moh Samir Treatment of hemorrhoids with 5-HT2 antagonists
CA2129995C (en) * 1992-02-13 2000-04-11 Albert A. Carr Piperidinyl thiacyclic derivatives
WO1994001437A1 (en) 1992-07-13 1994-01-20 Janssen Pharmaceutica N.V. Novel 4-(3-benzofuranyl)piperidinyl and 4-(3-benzothienyl)piperidinyl derivatives and pharmaceutical compositions containing them
CZ293764B6 (cs) * 1993-11-19 2004-07-14 Janssen Pharmaceutica N. V. Farmaceutický prostředek s dostatečným a dlouhodobým uvolňováním léčiva, biodegradovatelné a biokompatibilní mikročástice, způsob jejich výroby a použití
ES2085234B1 (es) * 1994-02-24 1997-01-16 Vita Invest Sa Agente activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
TW421649B (en) * 1995-01-31 2001-02-11 Janssen Pharmaceutica Nv 4-(1H-indol-1yl)-1-piperidinyl derivatives
US5753664A (en) * 1995-03-16 1998-05-19 Takeda Chemical Industries, Ltd. Heterocyclic compounds, their production and use
AU2003288017A1 (en) * 2002-11-13 2004-06-03 Synthon B.V. Process for making risperidone and intermediates therefor
WO2004094415A1 (en) * 2003-04-22 2004-11-04 Synthon B.V. Risperidone monohydrochloride
EP2252608A4 (en) 2008-02-29 2012-10-03 Vm Discovery Inc METHOD FOR TREATING PAIN SYNDROME AND OTHER SUFFERING
PH12018501711B1 (en) 2012-02-10 2023-05-05 Hoffmann La Roche Compounds for treating spinal muscular atrophy
WO2013130689A1 (en) 2012-03-01 2013-09-06 Ptc Therapeutics, Inc. Compounds for treating spinal muscular atrophy
EA028382B1 (ru) 2012-03-23 2017-11-30 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Соединения для лечения спинальной мышечной атрофии
WO2014143915A1 (en) * 2013-03-15 2014-09-18 Vm Therapeutics Llc Novel crystalline forms
US10195202B2 (en) 2013-12-19 2019-02-05 Ptc Therapeutics, Inc. Methods for modulating the amount of RNA transcripts
EP3310169B1 (en) 2015-05-30 2023-05-17 PTC Therapeutics, Inc. Methods for modulating rna splicing
CN108697709A (zh) 2015-12-10 2018-10-23 Ptc医疗公司 用于治疗亨廷顿病的方法
US11702646B2 (en) 2016-11-28 2023-07-18 Ptc Therapeutics, Inc. Methods for modulating RNA splicing
CN111065626B (zh) 2017-06-05 2024-09-27 Ptc医疗公司 用于治疗亨廷顿氏舞蹈病的化合物
EP3638318A4 (en) 2017-06-14 2021-03-17 PTC Therapeutics, Inc. RNA SPLICE MODIFICATION PROCESSES
CA3067592A1 (en) 2017-06-28 2019-01-03 Ptc Therapeutics, Inc. Methods for treating huntington's disease
MX2019015578A (es) 2017-06-28 2020-07-28 Ptc Therapeutics Inc Metodos para tratar la enfermedad de huntington.
SG11202009212WA (en) 2018-03-27 2020-10-29 Ptc Therapeutics Inc Compounds for treating huntington's disease
EP3814360B8 (en) 2018-06-27 2024-11-06 PTC Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
LT3814357T (lt) 2018-06-27 2024-06-25 Ptc Therapeutics, Inc. Heterocikliniai ir heteroarilų junginiai, skirti hantingtono ligos gydymui
CN112805280B (zh) 2018-06-27 2024-12-06 Ptc医疗公司 用于治疗亨廷顿氏病的杂芳基化合物

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US3412094A (en) * 1967-06-21 1968-11-19 Searle & Co 5-alkyl-2-amino-4-azido-6-phenylpyrimidines and congeners
US3960863A (en) * 1974-06-25 1976-06-01 Sankyo Company Limited Pyrido[1,2-a]pyrimidinone derivatives
JPS5146497A (en) * 1974-10-19 1976-04-20 Masato Aiura Hobuban
JPS525795A (en) * 1975-06-28 1977-01-17 Sankyo Co Ltd Preparation of tetrahydro pyridopyrimidinone derivatives
HU173438B (hu) * 1975-11-27 1979-05-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom

Also Published As

Publication number Publication date
DK159390B (da) 1990-10-08
MA19107A1 (fr) 1981-10-01
DK159390C (da) 1991-03-04
EP0037265B1 (en) 1985-01-23
RO82508B (ro) 1983-08-30
NO156752B (no) 1987-08-10
NO156752C (no) 1987-11-18
NO811058L (no) 1981-09-29
AU537700B2 (en) 1984-07-05
FI71737B (fi) 1986-10-31
ES500814A0 (es) 1982-11-01
EP0037265A1 (en) 1981-10-07
IL62494A0 (en) 1981-05-20
YU81081A (en) 1983-12-31
AU6842981A (en) 1981-10-01
CA1163994A (en) 1984-03-20
PT72740A (en) 1981-04-01
DK138281A (da) 1981-09-29
IE51319B1 (en) 1986-12-10
PH16530A (en) 1983-11-10
FI810956L (fi) 1981-09-29
NZ196522A (en) 1985-10-11
CS256366B2 (en) 1988-04-15
HU187329B (en) 1985-12-28
ES8300763A1 (es) 1982-11-01
IL62494A (en) 1984-08-31
GR72488B (en:Method) 1983-11-14
FI71737C (fi) 1987-02-09
DE3168433D1 (de) 1985-03-07
IE810706L (en) 1981-09-28
US4342870A (en) 1982-08-03
BG36199A3 (en) 1984-09-14
PT72740B (en) 1982-11-16
SU1068037A3 (ru) 1984-01-15
YU43010B (en) 1989-02-28

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