RO81371B - Procedeu de preparare a unui suport lipoid solubil destinat legarii substantelor biologic active - Google Patents

Procedeu de preparare a unui suport lipoid solubil destinat legarii substantelor biologic active

Info

Publication number
RO81371B
RO81371B RO102952A RO10295280A RO81371B RO 81371 B RO81371 B RO 81371B RO 102952 A RO102952 A RO 102952A RO 10295280 A RO10295280 A RO 10295280A RO 81371 B RO81371 B RO 81371B
Authority
RO
Romania
Prior art keywords
soluble
preparing
biollogically
bonding
active substances
Prior art date
Application number
RO102952A
Other languages
English (en)
Other versions
RO81371A (ro
Inventor
Zoltan Riedel
Laszlo Sztankov
Istvan Horvath
Original Assignee
Human Oltoanyagtermelo Es Kutato Intezet Budapesta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Human Oltoanyagtermelo Es Kutato Intezet Budapesta filed Critical Human Oltoanyagtermelo Es Kutato Intezet Budapesta
Publication of RO81371B publication Critical patent/RO81371B/ro
Publication of RO81371A publication Critical patent/RO81371A/ro

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/586—Liposomes, microcapsules or cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • External Artificial Organs (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedeu de preparare a unui suport lipoid solubil destinat legarii substantei biologic active, caracterizat prin aceea ca o solutie din 3 parti lecitina si 9 parti colesterina formînd granule lipoid solubile în alcool, se amesteca cu apa sau cu o solutie apoasa de electrolit cu un pH de 2 la 10, într-un raport volumetric de 0,1...900:100, particulele precipitate se separa si se suspenda eventual în apa sau într-o solutie apoasa de electrolit cu un pH de 2 la 10 dupa care se centrifugheaza si eventual liofilizeaza.
RO80102952A 1979-12-27 1980-12-25 Procedeu de preparare a unui suport lipoid solubil destinat legarii substantelor biologice active RO81371A (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU79HU299A HU184141B (en) 1979-12-27 1979-12-27 Adjuvant particles compositions containing said particles and biologically active substances adsorbed thereon and a process for the preparation thereof

Publications (2)

Publication Number Publication Date
RO81371B true RO81371B (ro) 1983-11-02
RO81371A RO81371A (ro) 1984-04-02

Family

ID=10997378

Family Applications (1)

Application Number Title Priority Date Filing Date
RO80102952A RO81371A (ro) 1979-12-27 1980-12-25 Procedeu de preparare a unui suport lipoid solubil destinat legarii substantelor biologice active

Country Status (21)

Country Link
US (1) US4396630A (ro)
JP (1) JPS57112334A (ro)
BE (1) BE886884A (ro)
CA (1) CA1165237A (ro)
CH (1) CH655246A5 (ro)
CS (1) CS241478B2 (ro)
DD (1) DD158738A5 (ro)
DE (1) DE3048815A1 (ro)
DK (1) DK160288C (ro)
ES (1) ES498048A0 (ro)
FR (1) FR2472386B1 (ro)
GB (1) GB2066203B (ro)
HU (1) HU184141B (ro)
IT (1) IT1150073B (ro)
NL (1) NL8007041A (ro)
PL (1) PL228755A1 (ro)
PT (1) PT72261B (ro)
RO (1) RO81371A (ro)
SE (1) SE453537B (ro)
SU (1) SU1487802A3 (ro)
YU (1) YU44413B (ro)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4598051A (en) * 1980-03-12 1986-07-01 The Regents Of The University Of California Liposome conjugates and diagnostic methods therewith
US4806466A (en) * 1981-10-29 1989-02-21 The Regents Of The University Of California Cell agglutination reagent comprising conjugates of antibody covalently bound to liposomes
FR2521565B1 (fr) * 1982-02-17 1985-07-05 Dior Sa Parfums Christian Melange pulverulent de constituants lipidiques et de constituants hydrophobes, procede pour le preparer, phases lamellaires lipidiques hydratees et procede de fabrication, compositions pharmaceutiques ou cosmetiques comportant des phases lamellaires lipidiques hydratees
DD247570A3 (de) * 1983-01-14 1987-07-15 Univ Berlin Humboldt Vesikulaeres trenn-, fuell- und traegermaterial
US4515736A (en) * 1983-05-12 1985-05-07 The Regents Of The University Of California Method for encapsulating materials into liposomes
US5059591B1 (en) * 1983-05-26 2000-04-25 Liposome Co Inc Drug preparations of reduced toxicity
US4708861A (en) * 1984-02-15 1987-11-24 The Liposome Company, Inc. Liposome-gel compositions
US5916588A (en) * 1984-04-12 1999-06-29 The Liposome Company, Inc. Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use
US6090406A (en) * 1984-04-12 2000-07-18 The Liposome Company, Inc. Potentiation of immune responses with liposomal adjuvants
GB2160312B (en) * 1984-04-13 1987-09-16 South African Inventions Adjuvant for immunisation
PT78628B (en) * 1984-05-02 1986-06-18 Liposome Co Inc Pharmaceutical composition with reduced toxicity
US4619904A (en) * 1984-10-29 1986-10-28 General Electric Company Agglutinating immunoassay using protein-coated liquid droplets
US4857319A (en) * 1985-01-11 1989-08-15 The Regents Of The University Of California Method for preserving liposomes
US5266329A (en) * 1985-10-31 1993-11-30 Kv Pharmaceutical Company Vaginal delivery system
JP2519029B2 (ja) * 1985-10-31 1996-07-31 ケ−・ブイ・ファ−マシュ−ティカル・カンパニ− 腟内送達用製剤
US4790987A (en) * 1985-11-15 1988-12-13 Research Corporation Viral glycoprotein subunit vaccine
CA1338736C (fr) * 1986-12-05 1996-11-26 Roger Baurain Microcristaux comportant une substance active presentant une affinite pour les phospholipides, et au moins un phospholipide, procede de preparation
US4748024A (en) * 1987-04-06 1988-05-31 Endocon, Inc. Flash flow fused medicinal implants
US5688519A (en) * 1987-04-06 1997-11-18 Leonard; Robert J. Flash-flow fused medicinal implants
WO1990001948A1 (en) * 1988-08-25 1990-03-08 The Liposome Company, Inc. Influenza vaccine and novel adjuvants
DE3852950T2 (de) * 1988-12-22 1995-06-14 Baxter Diagnostics Inc Lipohaptene und Verwendung trägergebundener Lipohaptene im Immuntest.
US5100662A (en) * 1989-08-23 1992-03-31 The Liposome Company, Inc. Steroidal liposomes exhibiting enhanced stability
JPH07113641B2 (ja) * 1989-11-17 1995-12-06 積水化学工業株式会社 梅毒診断試薬の製造方法
NL9000207A (ro) * 1990-01-29 1991-08-16 Duphar Int Res
AU654824B2 (en) * 1990-06-29 1994-11-24 Chiron Corporation Vaccine compositions containing liposomes
US5709879A (en) * 1990-06-29 1998-01-20 Chiron Corporation Vaccine compositions containing liposomes
IE912535A1 (en) * 1990-07-27 1992-01-29 Res Dev Foundation Liposomes that Provide Thymic Dependent Help to Weak Vaccine¹Antigens
WO1992004887A1 (en) * 1990-09-25 1992-04-02 Kyowa Hakko Kogyo Co., Ltd. Induction of cytotoxic t cell
US6048531A (en) * 1991-04-15 2000-04-11 Albany Medical College Immunogenic composites capable of stimulating production of anti-peptide antibodies, pharmaceutical compositions employing these composites and methods of selectively inducing production of anti-peptide antibodies
US5336507A (en) * 1992-12-11 1994-08-09 Sterling Winthrop Inc. Use of charged phospholipids to reduce nanoparticle aggregation
GB9320668D0 (en) 1993-10-07 1993-11-24 Secr Defence Liposomes containing particulare materials
AUPM500494A0 (en) * 1994-04-12 1994-05-05 Minister For Agriculture & Rural Affairs For The State Of New South Wales, The Composition for use in increasing mucosal immunity
NZ525552A (en) * 2000-11-09 2005-04-29 Neopharm Inc SN-38 lipid complexes with cardiolipin and methods of use for the treatment of cancers and multiple sclerosis
WO2003030864A1 (en) * 2001-05-29 2003-04-17 Neopharm, Inc. Liposomal formulation of irinotecan
EP1487413A4 (en) * 2002-03-05 2010-11-10 Transave Inc INHALATION SYSTEM FOR THE TREATMENT OF INTRACELLULAR INFECTIONS
AU2003296897A1 (en) * 2002-08-20 2004-05-04 Neopharm, Inc. Pharmaceutical formulations of camptothecine derivatives
US20060030578A1 (en) * 2002-08-20 2006-02-09 Neopharm, Inc. Pharmaceutically active lipid based formulation of irinotecan
US7718189B2 (en) * 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
KR101424980B1 (ko) * 2002-10-29 2014-08-01 인스메드 인코포레이티드 항감염제의 지속적인 방출
US7879351B2 (en) * 2002-10-29 2011-02-01 Transave, Inc. High delivery rates for lipid based drug formulations, and methods of treatment thereof
KR100651728B1 (ko) * 2004-11-10 2006-12-06 한국전자통신연구원 정착기를 갖는 전자 소자용 화합물 및 이를 포함하는 전자소자와 이들의 제조 방법
WO2006090816A1 (ja) * 2005-02-25 2006-08-31 Mie University リポソームワクチンの作製法
CA2896083A1 (en) * 2005-12-08 2007-06-14 Insmed Incorporated Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof
US20100196455A1 (en) 2007-05-04 2010-08-05 Transave, Inc. Compositions of Multicationic Drugs for Reducing Interactions with Polyanionic Biomolecules and Methods of Use Thereof
US9333214B2 (en) 2007-05-07 2016-05-10 Insmed Incorporated Method for treating pulmonary disorders with liposomal amikacin formulations
US9114081B2 (en) 2007-05-07 2015-08-25 Insmed Incorporated Methods of treating pulmonary disorders with liposomal amikacin formulations
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
US9566234B2 (en) 2012-05-21 2017-02-14 Insmed Incorporated Systems for treating pulmonary infections
EP3581186A1 (en) 2012-11-29 2019-12-18 Insmed Incorporated Stabilized vancomycin formulations
DK3142643T3 (da) 2014-05-15 2019-10-14 Insmed Inc Fremgangsmåder til behandling af ikke-tuberkuløse mykobakterielle lungeinfektioner
EP3773505A4 (en) 2018-03-30 2021-12-22 Insmed Incorporated PROCESS FOR THE CONTINUOUS MANUFACTURING OF LIPOSOMAL MEDICINAL PRODUCTS

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3265629A (en) * 1958-12-22 1966-08-09 Ncr Co Coating by phase separation
DE2249552A1 (de) * 1971-10-12 1973-05-30 Inchema S A Verfahren zur inkapsulation von insbesondere wasserloeslichen verbindungen
GB1502774A (en) * 1974-06-25 1978-03-01 Nat Res Dev Immunological preparations
JPS5126213A (ja) * 1974-08-21 1976-03-04 Tanabe Seiyaku Co Johoseibiryushiseizaino seiho
GB1564500A (en) * 1975-09-29 1980-04-10 Wellcome Found Biological preparations
GB1523965A (en) * 1976-03-19 1978-09-06 Ici Ltd Pharmaceutical compositions containing steroids
GB1575343A (en) * 1977-05-10 1980-09-17 Ici Ltd Method for preparing liposome compositions containing biologically active compounds
IT1110989B (it) * 1979-01-19 1986-01-13 Erba Farmitalia Forme farmaceutiche costitutite da liposomi e procedimenti relativi
FR2416008A1 (fr) * 1978-02-02 1979-08-31 Oreal Lyophilisats de liposomes
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
JPS55118415A (en) * 1979-02-28 1980-09-11 Pii Papahadojiyopo Dometoriosu Method of encapsulating biologically active substance in lipoid cell

Also Published As

Publication number Publication date
DK552280A (da) 1981-06-28
GB2066203A (en) 1981-07-08
SE8009068L (sv) 1981-06-28
CS241478B2 (en) 1986-03-13
DK160288C (da) 1991-08-05
SU1487802A3 (ru) 1989-06-15
ES8201316A1 (es) 1981-12-16
IT8026950A0 (it) 1980-12-24
DD158738A5 (de) 1983-02-02
PL228755A1 (ro) 1982-02-15
SE453537B (sv) 1988-02-08
YU329080A (en) 1984-04-30
HU184141B (en) 1984-07-30
ES498048A0 (es) 1981-12-16
CS924680A2 (en) 1985-07-16
JPH0314814B2 (ro) 1991-02-27
BE886884A (fr) 1981-06-29
PT72261B (en) 1981-11-05
PT72261A (en) 1981-01-01
CA1165237A (en) 1984-04-10
FR2472386A1 (ro) 1981-07-03
FR2472386B1 (ro) 1985-08-23
DE3048815A1 (de) 1981-09-10
YU44413B (en) 1990-08-31
DK160288B (da) 1991-02-25
RO81371A (ro) 1984-04-02
NL8007041A (nl) 1981-07-16
IT1150073B (it) 1986-12-10
US4396630A (en) 1983-08-02
JPS57112334A (en) 1982-07-13
GB2066203B (en) 1984-01-11
CH655246A5 (de) 1986-04-15

Similar Documents

Publication Publication Date Title
RO81371B (ro) Procedeu de preparare a unui suport lipoid solubil destinat legarii substantelor biologic active
DK307787A (da) Hydrofobe cis-platinkomplekser samt liposomer omfattende saadanne komplekser og fremgangsmaade til fremstilling af saadanne komplekser og liposomer
GB1510665A (en) Stannous imidodiphosphonate complex
IE40114L (en) Preparation of thromboplastin-containing extract.
JPS5743695A (en) Preparation of human follicle-stimulating hormone
HUP0000119A2 (hu) Eljárás fehérje készítményekben oldhatatlan kalciumsók szuszpendálására
JPS5743696A (en) Preparation of human luteinizing hormone
JPS5794293A (en) Preparation of urokinase
GB1533261A (en) Animal litter
IT1095579B (it) Procedimento per la produzione di particelle di colorante idrosolubili,resistenti all'usura,che non impolverano e che sono solubili in acqua
IT1024317B (it) Sistema elettro ottico la cancellazione degli effetti dei glo buli rossi in un campione di cellu le biologiche
Dux et al. Kinetics of proliferation, cell differentiation, and IgM secretion in the omental lymphoid organ of B10/Sn mice following intraperitoneal immunization with sheep erythrocytes
Damadian Ion exchange in Escherichia coli: potassium-binding proteins
ES8800757A1 (es) Procedimiento para preparar un reactivo para valorar por hemaglutinacion anticuerpos dirigidos contra toxinas bacterianas
BG94104A (bg) Метод и контейнер за получаване на нетоксичен разтвор
ES8800054A1 (es) Procedimiento para obtener un producto a base de un principio activo de baja hidrosolubilidad y finamente dividido, apto para ser dispensado en el agua sin formar deposito.
Shearer et al. Fractionation of lymphocytes involved in the generation of cell-mediated cytotoxicity over insolubilized conjugated histamine columns
Simon et al. Properties of a synthetic plasma membrane marker: Fluorescent-Mercury-Dextran
Hubold et al. Distribution of Eggs and Larvae of Five Clupeoid Fish Species in the Southwest Atlantic Between 25 degree S and 40 degree S.
JPS56102787A (en) Preparation of human placenta superoxide dismutase
JPS57115180A (en) Preparation of human tyroid-stimulating hormone
JPS57114524A (en) Preparation of human cellular multiplication stimulating factor
BE861767A (fr) Comprime destine au nettoyage automatique, en solution aqueuse de protheses dentaires, et procede de preparation de ce comprime
DE3466404D1 (en) Solid preparations of slightly water soluble or insoluble dyes
ATE161393T1 (de) Wasserlösliches instanttee-erzeugnis