PT95002A - Metodo e dispositivo para administracao transdermica de dexmedetomidina - Google Patents

Metodo e dispositivo para administracao transdermica de dexmedetomidina

Info

Publication number
PT95002A
PT95002A PT95002A PT9500290A PT95002A PT 95002 A PT95002 A PT 95002A PT 95002 A PT95002 A PT 95002A PT 9500290 A PT9500290 A PT 9500290A PT 95002 A PT95002 A PT 95002A
Authority
PT
Portugal
Prior art keywords
dexmedetomidine
adhesive layer
therapeutic system
administration
administering
Prior art date
Application number
PT95002A
Other languages
English (en)
Other versions
PT95002B (pt
Inventor
Kenneth J Colley
Donald R Wilson
Risto Lammintausta
Harry Jalonen
Gary W Cleary
Original Assignee
Cygnus Research Corp
Orion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cygnus Research Corp, Orion Corp filed Critical Cygnus Research Corp
Publication of PT95002A publication Critical patent/PT95002A/pt
Publication of PT95002B publication Critical patent/PT95002B/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
PT95002A 1989-08-18 1990-08-14 Metodo e dispositivo para administracao transdermica de dexmedetomidina PT95002B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/395,717 US5124157A (en) 1989-08-18 1989-08-18 Method and device for administering dexmedetomidine transdermally

Publications (2)

Publication Number Publication Date
PT95002A true PT95002A (pt) 1992-02-28
PT95002B PT95002B (pt) 1997-10-31

Family

ID=23564195

Family Applications (1)

Application Number Title Priority Date Filing Date
PT95002A PT95002B (pt) 1989-08-18 1990-08-14 Metodo e dispositivo para administracao transdermica de dexmedetomidina

Country Status (24)

Country Link
US (1) US5124157A (pt)
EP (1) EP0413487B1 (pt)
JP (1) JP3043064B2 (pt)
CN (1) CN1035922C (pt)
AT (1) ATE122899T1 (pt)
AU (1) AU639015B2 (pt)
CA (1) CA2064687C (pt)
DD (1) DD297066A5 (pt)
DE (1) DE69019628T2 (pt)
DK (1) DK0413487T3 (pt)
ES (1) ES2072397T3 (pt)
FI (1) FI100857B (pt)
HU (1) HUT64223A (pt)
IE (1) IE67127B1 (pt)
LT (1) LT3753B (pt)
LV (1) LV10685B (pt)
NO (1) NO300408B1 (pt)
NZ (1) NZ234749A (pt)
PL (1) PL165023B1 (pt)
PT (1) PT95002B (pt)
RU (1) RU2098083C1 (pt)
UA (1) UA26988C2 (pt)
WO (1) WO1991002505A1 (pt)
ZA (1) ZA906539B (pt)

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GB2256135B (en) * 1991-05-31 1995-01-18 Orion Yhtymae Oy Transdermal administration of 4-substituted imidazoles
WO1993007842A1 (en) * 1991-10-15 1993-04-29 Cygnus Therapeutic Systems Thermal enhancement of transdermal drug administration
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US5536263A (en) * 1994-03-30 1996-07-16 Lectec Corporation Non-occulusive adhesive patch for applying medication to the skin
US5635203A (en) * 1994-09-29 1997-06-03 Alza Corporation Transdermal device having decreased delamination
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GB9614098D0 (en) 1996-07-05 1996-09-04 Orion Yhtymae Oy Transdermal delivery of levosimendan
DE19814084B4 (de) * 1998-03-30 2005-12-22 Lts Lohmann Therapie-Systeme Ag D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung
US6716867B1 (en) 1998-04-01 2004-04-06 Orion Corporation Use of dexmedetomidine for ICU sedation
AR015744A1 (es) * 1998-04-01 2001-05-16 Orion Corp Uso de dexmedetomidina para sedacion en terapia intensiva
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US20030026830A1 (en) * 2001-05-08 2003-02-06 Thomas Lauterback Transdermal therapeutic system for parkinson's disease inducing high plasma levels of rotigotine
DE10234673B4 (de) * 2002-07-30 2007-08-16 Schwarz Pharma Ag Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren
US8246979B2 (en) 2002-07-30 2012-08-21 Ucb Pharma Gmbh Transdermal delivery system for the administration of rotigotine
US8211462B2 (en) * 2002-07-30 2012-07-03 Ucb Pharma Gmbh Hot-melt TTS for administering rotigotine
US8246980B2 (en) * 2002-07-30 2012-08-21 Ucb Pharma Gmbh Transdermal delivery system
IL152574A (en) 2002-10-31 2009-09-22 Transpharma Medical Ltd A system for passing through the skin of dry items or dried medicines
US7662404B2 (en) 2002-10-31 2010-02-16 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized peptides and polypeptides
US8133505B2 (en) 2002-10-31 2012-03-13 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
US7383084B2 (en) 2002-10-31 2008-06-03 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
ATE295726T1 (de) * 2002-12-02 2005-06-15 Sanol Arznei Schwarz Gmbh Verabreichung von rotigotine zur behandlung der parkinson'schen krankheit durch iontophorese
DE10261696A1 (de) 2002-12-30 2004-07-15 Schwarz Pharma Ag Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base
DE102006054733A1 (de) * 2006-11-21 2008-05-29 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches Systems mit hoher Wirkstoffausnutzungsrate und Dosiergenauigkeit
US20090291127A1 (en) * 2008-05-21 2009-11-26 Jianye Wen Transdermal anti-dementia active agent formulations and methods for using the same
US7795263B2 (en) * 2008-07-08 2010-09-14 Wildlife Laboratories, Inc. Pharmaceutical combination for and method of anesthetizing and immobilizing non-domesticated mammals
JP6172938B2 (ja) * 2009-05-15 2017-08-02 レクロ・ファーマ，インコーポレーテッド デクスメデトミジンの舌下組成物およびその使用方法
NZ601195A (en) * 2010-01-08 2015-02-27 Recro Pharma Inc Topical transdermal dexmedetomidine compositions and methods of use thereof
US20130096170A1 (en) 2011-10-14 2013-04-18 Hospira, Inc. Methods of treating pediatric patients using dexmedetomidine
EP3406247A1 (en) 2011-12-11 2018-11-28 Recro Pharma, Inc. Intranasal dexmedetomidine compositions and methods of use thereof
US8242158B1 (en) 2012-01-04 2012-08-14 Hospira, Inc. Dexmedetomidine premix formulation
WO2013173317A1 (en) * 2012-05-14 2013-11-21 Prospire, Llc TREATMENT OF OBSTRUCTIVE SLEEP APNEA WITH α2-ADRENERGIC RECEPTOR AGONISTS
TWI624278B (zh) * 2013-10-07 2018-05-21 帝國製藥美國股份有限公司 使用非鎮靜性右美托咪啶經皮組成物用於治療戒斷症候群的方法及組成物
TWI645866B (zh) * 2013-10-07 2019-01-01 美商帝國製藥美國股份有限公司 右美托咪啶經皮輸送裝置及使用其之方法
TWI629061B (zh) * 2013-10-07 2018-07-11 美商帝國製藥美國股份有限公司 包含右美托嘧啶（ｄｅｘｍｅｄｅｔｏｍｉｄｉｎｅ）經皮組成物之疼痛處理用方法及組成物
RU2658463C2 (ru) 2013-10-07 2018-06-21 ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. Способы и композиции для лечения синдрома дефицита внимания и гиперактивности, тревожности и бессонницы с применением трансдермальных композиций на основе дексмедетомидина
CA2924236C (en) * 2013-10-07 2020-01-07 Teikoku Pharma Usa, Inc. Methods and compositions for transdermal delivery of a non-sedative amount of dexmedetomidine
US9974754B2 (en) 2013-12-18 2018-05-22 Maruishi Pharmaceutical Co., Ltd. Hydrous adhesive patch
US9717796B1 (en) 2016-04-20 2017-08-01 Slypharma, Llc Heat sterilizeable, premixed, ready to use dexmedetomidine solution packaged in a flexible plastic container
EP3528795A1 (de) * 2016-10-18 2019-08-28 LTS Lohmann Therapie-Systeme AG Zweischichtiges topisches therapeutisches system
CA3038354C (en) * 2016-10-31 2021-08-17 Teikoku Pharma Usa, Inc. Methods of managing pain using dexmedetomidine transdermal delivery devices
EP3560495B1 (en) * 2016-12-26 2021-07-28 Hisamitsu Pharmaceutical Co., Inc. Microneedle device
US11160791B2 (en) 2018-11-01 2021-11-02 Medefil, Inc. Dexmedetomidine injection premix formulation in ready to use (RTU) bags
CN111346072B (zh) * 2018-12-21 2022-05-27 宜昌人福药业有限责任公司 一种透皮给药的药物组合物及其制备方法
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Also Published As

Publication number Publication date
PL165023B1 (pl) 1994-11-30
LTIP1773A (en) 1995-07-25
LT3753B (en) 1996-03-25
PT95002B (pt) 1997-10-31
ZA906539B (en) 1991-06-26
EP0413487B1 (en) 1995-05-24
IE67127B1 (en) 1996-03-06
FI920576A0 (fi) 1992-02-11
DE69019628T2 (de) 1995-09-28
AU639015B2 (en) 1993-07-15
US5124157A (en) 1992-06-23
RU2098083C1 (ru) 1997-12-10
NZ234749A (en) 1992-03-26
IE902993A1 (en) 1991-02-27
CN1035922C (zh) 1997-09-24
CA2064687C (en) 1998-04-21
EP0413487A1 (en) 1991-02-20
DK0413487T3 (da) 1995-07-17
LV10685B (en) 1995-12-20
PL286525A1 (en) 1991-05-20
CA2064687A1 (en) 1991-02-19
NO300408B1 (no) 1997-05-26
LV10685A (lv) 1995-06-20
JP3043064B2 (ja) 2000-05-22
DD297066A5 (de) 1992-01-02
NO920521D0 (no) 1992-02-10
ATE122899T1 (de) 1995-06-15
FI100857B (fi) 1998-03-13
HUT64223A (en) 1993-12-28
JPH05503916A (ja) 1993-06-24
WO1991002505A1 (en) 1991-03-07
AU6183490A (en) 1991-04-03
ES2072397T3 (es) 1995-07-16
HU9200517D0 (en) 1992-05-28
CN1049450A (zh) 1991-02-27
DE69019628D1 (de) 1995-06-29
UA26988C2 (uk) 2000-02-28
NO920521L (no) 1992-02-10

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BB1A Laying open of patent application

Effective date: 19911022

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Effective date: 19960909

FG3A Patent granted, date of granting

Effective date: 19970707