UA26988C2 - Спосіб седативhого впливу hа пацієhта і траhсдермальhа терапевтичhа система - Google Patents

Спосіб седативhого впливу hа пацієhта і траhсдермальhа терапевтичhа система

Info

Publication number
UA26988C2
UA26988C2 UA93004242A UA93004242A UA26988C2 UA 26988 C2 UA26988 C2 UA 26988C2 UA 93004242 A UA93004242 A UA 93004242A UA 93004242 A UA93004242 A UA 93004242A UA 26988 C2 UA26988 C2 UA 26988C2
Authority
UA
Ukraine
Prior art keywords
sedating
patient
therapeutic system
transdermal therapeutic
dexmedetomidine
Prior art date
Application number
UA93004242A
Other languages
English (en)
Russian (ru)
Inventor
Кеннет Дж Коллі
Кеннет Дж Колли
Дональд Р ВІЛЬСОH
Гарі У Клірі
Гари У Клири
Рісто ЛАММІHСТАУСЛА
Харрі ЛАЛОHЕЖ
Original Assignee
Сігнус, Інк
Сигнус, Инк
Оріон Корпорейшн
Орион Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сігнус, Інк, Сигнус, Инк, Оріон Корпорейшн, Орион Корпорейшн filed Critical Сігнус, Інк
Publication of UA26988C2 publication Critical patent/UA26988C2/uk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Спосіб седативної дії на пацієнта заснований на введенні дексмедетомідину. дексмедетомідин вводиться трансдермально через ділянку шкіри площею 2,0 – 90 см2 із швидкістю 0,1 – 200 мкг/год. винахід стосується застосування дексмедетомідину для заспокійливих, гіпотензивних, болезаспокійливих і транквілізуючих цілей, до способу і пристрою для введення ліків через шкіру.
UA93004242A 1989-08-18 1990-08-14 Спосіб седативhого впливу hа пацієhта і траhсдермальhа терапевтичhа система UA26988C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/395,717 US5124157A (en) 1989-08-18 1989-08-18 Method and device for administering dexmedetomidine transdermally
PCT/US1990/004575 WO1991002505A1 (en) 1989-08-18 1990-08-14 Method and device for administering dexmedetomidine transdermally

Publications (1)

Publication Number Publication Date
UA26988C2 true UA26988C2 (uk) 2000-02-28

Family

ID=23564195

Family Applications (1)

Application Number Title Priority Date Filing Date
UA93004242A UA26988C2 (uk) 1989-08-18 1990-08-14 Спосіб седативhого впливу hа пацієhта і траhсдермальhа терапевтичhа система

Country Status (25)

Country Link
US (1) US5124157A (uk)
EP (1) EP0413487B1 (uk)
JP (1) JP3043064B2 (uk)
CN (1) CN1035922C (uk)
AT (1) ATE122899T1 (uk)
AU (1) AU639015B2 (uk)
BG (1) BG95935A (uk)
CA (1) CA2064687C (uk)
DD (1) DD297066A5 (uk)
DE (1) DE69019628T2 (uk)
DK (1) DK0413487T3 (uk)
ES (1) ES2072397T3 (uk)
FI (1) FI100857B (uk)
HU (1) HUT64223A (uk)
IE (1) IE67127B1 (uk)
LT (1) LT3753B (uk)
LV (1) LV10685B (uk)
NO (1) NO300408B1 (uk)
NZ (1) NZ234749A (uk)
PL (1) PL165023B1 (uk)
PT (1) PT95002B (uk)
RU (1) RU2098083C1 (uk)
UA (1) UA26988C2 (uk)
WO (1) WO1991002505A1 (uk)
ZA (1) ZA906539B (uk)

Families Citing this family (59)

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US5217718A (en) * 1989-08-18 1993-06-08 Cygnus Therapeutic Systems Method and device for administering dexmedetomidine transdermally
GB2256135B (en) * 1991-05-31 1995-01-18 Orion Yhtymae Oy Transdermal administration of 4-substituted imidazoles
GB9111732D0 (en) * 1991-05-31 1991-07-24 Orion Yhtymae Oy The use of certain salts of medetomidine and its optically active enantiomers to regulate the rate of transdermal administration of the drugs
AU2782592A (en) * 1991-10-15 1993-05-21 Cygnus Therapeutic Systems Thermal enhancement of transdermal drug administration
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US5591767A (en) * 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
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US5536263A (en) * 1994-03-30 1996-07-16 Lectec Corporation Non-occulusive adhesive patch for applying medication to the skin
US5635203A (en) * 1994-09-29 1997-06-03 Alza Corporation Transdermal device having decreased delamination
US5807570A (en) * 1995-09-29 1998-09-15 Cygnus, Inc. Transdermal administration of ropinirole and analogs thereof
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US5730721A (en) * 1996-01-25 1998-03-24 Vesture Corporation Medical applicator and method
GB9614098D0 (en) 1996-07-05 1996-09-04 Orion Yhtymae Oy Transdermal delivery of levosimendan
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US6716867B1 (en) 1998-04-01 2004-04-06 Orion Corporation Use of dexmedetomidine for ICU sedation
AR015744A1 (es) * 1998-04-01 2001-05-16 Orion Corp Uso de dexmedetomidina para sedacion en terapia intensiva
DE19925338A1 (de) * 1999-06-02 2000-12-07 Lohmann Therapie Syst Lts Substratabschnitte mit erhöhter Lagerstabilität während ihrer Lagerung in Beutelverpackung, sowie Verfahren zu ihrer Herstellung
CA2388979C (en) 1999-10-29 2010-09-14 Orion Corporation Treatment or prevention of hypotension and shock with use of an imidazole derivative
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IL152574A (en) 2002-10-31 2009-09-22 Transpharma Medical Ltd A system for passing through the skin of dry items or dried medicines
DK1426049T3 (da) * 2002-12-02 2005-08-22 Sanol Arznei Schwarz Gmbh Iontophoretisk tilförsel af rotigotin til behandling af Parkinsons sygdom
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DE102006054733A1 (de) * 2006-11-21 2008-05-29 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches Systems mit hoher Wirkstoffausnutzungsrate und Dosiergenauigkeit
US20090291127A1 (en) * 2008-05-21 2009-11-26 Jianye Wen Transdermal anti-dementia active agent formulations and methods for using the same
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CN106511273A (zh) * 2009-05-15 2017-03-22 瑞克欧制药有限公司 舌下右美托咪定组合物及其使用方法
CA2786598A1 (en) * 2010-01-08 2011-07-14 Recro Pharma, Inc. Topical transdermal dexmedetomidine compositions and methods of use thereof
US20130096170A1 (en) 2011-10-14 2013-04-18 Hospira, Inc. Methods of treating pediatric patients using dexmedetomidine
WO2013090278A2 (en) 2011-12-11 2013-06-20 Recro Pharma, Inc. Intranasal dexmedetomidine compositions and methods of use thereof
US8242158B1 (en) 2012-01-04 2012-08-14 Hospira, Inc. Dexmedetomidine premix formulation
WO2013173317A1 (en) * 2012-05-14 2013-11-21 Prospire, Llc TREATMENT OF OBSTRUCTIVE SLEEP APNEA WITH α2-ADRENERGIC RECEPTOR AGONISTS
ES2847936T3 (es) * 2013-10-07 2021-08-04 Teikoku Pharma Usa Inc Métodos y composiciones para el suministro transdérmico de una cantidad no sedante de dexmedetomidina
KR101881791B1 (ko) * 2013-10-07 2018-07-25 테이코쿠 팔마 유에스에이, 인코포레이티드 비진정성 덱스메데토미딘 경피 조성물을 사용하여 금단 증후군을 치료하기 위한 방법 및 조성물
JP6188934B2 (ja) * 2013-10-07 2017-08-30 テイコク ファーマ ユーエスエー インコーポレーテッド デクスメデトミジン経皮組成物を含む疼痛管理用方法及び組成物
KR101827980B1 (ko) * 2013-10-07 2018-02-13 테이코쿠 팔마 유에스에이, 인코포레이티드 덱스메데토미딘 경피 전달 장치 및 이의 사용 방법
KR101831290B1 (ko) * 2013-10-07 2018-02-22 테이코쿠 팔마 유에스에이, 인코포레이티드 덱스메데토미딘 경피 조성물을 사용하여 주의력 결핍 과잉행동 장애, 불안 및 불면증을 치료하기 위한 방법 및 조성물
JP6469587B2 (ja) * 2013-12-18 2019-02-13 丸石製薬株式会社 含水型貼付剤
US9717796B1 (en) 2016-04-20 2017-08-01 Slypharma, Llc Heat sterilizeable, premixed, ready to use dexmedetomidine solution packaged in a flexible plastic container
CN109862885A (zh) * 2016-10-18 2019-06-07 Lts勒曼治疗系统股份公司 双层局部治疗系统
TWI764951B (zh) * 2016-10-31 2022-05-21 美商帝國製藥美國股份有限公司 用於處理疼痛之右美托咪啶經皮遞送裝置
CN110114069B (zh) * 2016-12-26 2022-03-04 久光制药株式会社 微针装置
US11160791B2 (en) 2018-11-01 2021-11-02 Medefil, Inc. Dexmedetomidine injection premix formulation in ready to use (RTU) bags
CN111346072B (zh) * 2018-12-21 2022-05-27 宜昌人福药业有限责任公司 一种透皮给药的药物组合物及其制备方法
CA3136186A1 (en) * 2019-04-24 2020-10-29 Medrx Co., Ltd. Lidocaine-containing patch
TWI772807B (zh) * 2019-05-27 2022-08-01 日商救急藥品工業股份有限公司 外用製劑

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Also Published As

Publication number Publication date
DE69019628D1 (de) 1995-06-29
HUT64223A (en) 1993-12-28
JP3043064B2 (ja) 2000-05-22
PL165023B1 (pl) 1994-11-30
EP0413487B1 (en) 1995-05-24
ES2072397T3 (es) 1995-07-16
PT95002A (pt) 1992-02-28
LTIP1773A (en) 1995-07-25
CN1035922C (zh) 1997-09-24
EP0413487A1 (en) 1991-02-20
DK0413487T3 (da) 1995-07-17
ZA906539B (en) 1991-06-26
LT3753B (en) 1996-03-25
IE902993A1 (en) 1991-02-27
NO300408B1 (no) 1997-05-26
LV10685A (lv) 1995-06-20
US5124157A (en) 1992-06-23
PL286525A1 (en) 1991-05-20
NZ234749A (en) 1992-03-26
DD297066A5 (de) 1992-01-02
AU6183490A (en) 1991-04-03
CA2064687A1 (en) 1991-02-19
ATE122899T1 (de) 1995-06-15
RU2098083C1 (ru) 1997-12-10
BG95935A (bg) 1993-12-24
JPH05503916A (ja) 1993-06-24
AU639015B2 (en) 1993-07-15
HU9200517D0 (en) 1992-05-28
LV10685B (en) 1995-12-20
DE69019628T2 (de) 1995-09-28
NO920521L (no) 1992-02-10
IE67127B1 (en) 1996-03-06
CA2064687C (en) 1998-04-21
FI100857B (fi) 1998-03-13
NO920521D0 (no) 1992-02-10
CN1049450A (zh) 1991-02-27
WO1991002505A1 (en) 1991-03-07
FI920576A0 (fi) 1992-02-11
PT95002B (pt) 1997-10-31

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