PT941094E - Processo para o fabrico de suspensoes oftalmicas contendo brinzolamida - Google Patents
Processo para o fabrico de suspensoes oftalmicas contendo brinzolamidaInfo
- Publication number
- PT941094E PT941094E PT97939835T PT97939835T PT941094E PT 941094 E PT941094 E PT 941094E PT 97939835 T PT97939835 T PT 97939835T PT 97939835 T PT97939835 T PT 97939835T PT 941094 E PT941094 E PT 941094E
- Authority
- PT
- Portugal
- Prior art keywords
- ophthalmal
- manufacture
- suspensions containing
- brinzolamide
- containing brinzolamide
- Prior art date
Links
- HCRKCZRJWPKOAR-JTQLQIEISA-N brinzolamide Chemical compound CCN[C@H]1CN(CCCOC)S(=O)(=O)C2=C1C=C(S(N)(=O)=O)S2 HCRKCZRJWPKOAR-JTQLQIEISA-N 0.000 title abstract 3
- 229960000722 brinzolamide Drugs 0.000 title abstract 3
- 239000000725 suspension Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000002876 beta blocker Substances 0.000 abstract 1
- 229940097320 beta blocking agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/77—Polymers containing oxygen of oxiranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3282096P | 1996-12-11 | 1996-12-11 | |
| US08/886,933 US6071904A (en) | 1996-12-11 | 1997-07-02 | Process for manufacturing ophthalmic suspensions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT941094E true PT941094E (pt) | 2002-05-31 |
Family
ID=26708929
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT97939835T PT941094E (pt) | 1996-12-11 | 1997-09-05 | Processo para o fabrico de suspensoes oftalmicas contendo brinzolamida |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6071904A (enExample) |
| EP (1) | EP0941094B1 (enExample) |
| JP (1) | JP3611863B2 (enExample) |
| AT (1) | ATE209917T1 (enExample) |
| CA (1) | CA2274680C (enExample) |
| DE (2) | DE69708912T2 (enExample) |
| DK (1) | DK0941094T3 (enExample) |
| ES (1) | ES2169416T3 (enExample) |
| FR (1) | FR09C0022I2 (enExample) |
| LU (1) | LU91554I2 (enExample) |
| NL (1) | NL300388I2 (enExample) |
| PT (1) | PT941094E (enExample) |
| WO (1) | WO1998025620A1 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000001365A1 (en) * | 1998-06-30 | 2000-01-13 | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) | Prolonged release ophthalmic compositions containing a fluoroquinolone |
| US7112588B2 (en) * | 2001-05-21 | 2006-09-26 | Alcon, Inc. | Use of proteasome inhibitors to treat dry eye disorders |
| MXPA03010634A (es) | 2001-05-21 | 2004-03-09 | Alcon Inc | Uso de inhibidores de proteasoma para tratar trastornos del ojo seco. |
| BR0209965A (pt) | 2001-05-21 | 2004-04-06 | Alcon Inc | Uso de inibidores de nf-kappab para tratar distúrbios do olho seco |
| JP2004531560A (ja) * | 2001-05-21 | 2004-10-14 | アルコン，インコーポレイテッド | ドライアイ障害を処置する方法 |
| US6872382B1 (en) | 2001-05-21 | 2005-03-29 | Alcon, Inc. | Use of selective PDE IV inhibitors to treat dry eye disorders |
| TWI298257B (en) | 2001-05-31 | 2008-07-01 | Allergan Inc | Hypotensive lipid and timolol compositions and methods of using same |
| US6645994B1 (en) | 2001-06-01 | 2003-11-11 | Alcon, Inc. | Method of treating dry eye disorders |
| DE60313299T2 (de) * | 2002-03-01 | 2008-01-03 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Selbstemulgierende systeme zur abgabe von taxoiden |
| ES2301964T3 (es) | 2003-01-21 | 2008-07-01 | Senju Pharmaceutical Co., Ltd. | Preparado liquido acuoso que contiene acido 2-amino-3-(4-bromobenzoil)fenilacetico. |
| DE602005026225D1 (de) * | 2004-03-12 | 2011-03-24 | Cipla Ltd | Sterilisationsprozess für Steroide |
| DK1891939T3 (da) * | 2006-07-28 | 2013-10-07 | Novagali Pharma Sa | Sammensætninger indeholdende kvaternære ammoniumforbindelser |
| WO2008035246A2 (en) | 2006-07-28 | 2008-03-27 | Novagali Pharma Sa | Compositions containing quaternary ammonium compounds |
| TWI544927B (zh) | 2008-03-17 | 2016-08-11 | 愛爾康研究有限公司 | 具有低濃度的表面活性劑以促進治療劑之生物可利用性的藥學組成物 |
| TWI489997B (zh) * | 2009-06-19 | 2015-07-01 | Alcon Res Ltd | 含有硼酸－多元醇錯合物之水性藥學組成物 |
| MX2012006401A (es) * | 2009-12-03 | 2012-07-10 | Lupin Ltd | Proceso para preparar composiciones oftalmicas farmaceuticas. |
| EP2394637A1 (en) * | 2010-05-21 | 2011-12-14 | Zaklady Farmaceutyczne Polpharma SA | Process for obtaining sterile brinzolamide suspensions |
| EP2598118B1 (en) | 2010-07-29 | 2018-09-05 | Allergan, Inc. | Preservative free bimatoprost and timolol solutions |
| US9061034B2 (en) | 2010-07-29 | 2015-06-23 | Allergan, Inc. | Preservative free bimatoprost and timolol solutions |
| WO2012053011A2 (en) | 2010-10-18 | 2012-04-26 | Usv Limited | Ophthalmic compositions comprising brinzolamide |
| US20130065888A1 (en) | 2011-08-15 | 2013-03-14 | Biserka Cetina-Cizmek | Ophthalmic formulations and processes for their preparation |
| EP2638909A1 (en) | 2012-03-15 | 2013-09-18 | Azad Pharmaceutical Ingredients AG | Process for preparing sterile Brinzolamide |
| GR1007906B (el) * | 2012-03-22 | 2013-05-30 | Φαρματεν Αβεε, | Οφθαλμικο φαρμακευτικο σκευασμα περιεχον ενα αναστολεα καρβονικης ανυδρασης και μεθοδος για την παρασκευη αυτου |
| CN104487099B (zh) | 2012-05-09 | 2017-06-20 | 艾科罗姆共同股份公司 | 无菌的活性药物成分的生产 |
| WO2013175285A1 (en) | 2012-05-21 | 2013-11-28 | Aurobindo Pharma Limited | Process for preparing ophthalmic suspension of brinzolamde |
| EP2906198B1 (en) | 2012-10-11 | 2019-04-03 | Indoco Remedies Limited | A process for manufacturing sterile brinzolamide ophthalmic suspension |
| CN104721136A (zh) * | 2013-02-21 | 2015-06-24 | 四川大学 | 一种布佐林胺眼用纳米混悬剂及其制备方法 |
| UA116273C2 (uk) * | 2013-10-17 | 2018-02-26 | Сентісс Фарма Прайвет Лімітед | Офтальмологічний фармацевтичний склад, що не містить консерванта |
| US9820991B2 (en) * | 2013-11-08 | 2017-11-21 | Sentiss Pharma Private Limited | Pharmaceutical composition comprising brinzolamide |
| US10463674B2 (en) | 2013-11-08 | 2019-11-05 | Sentiss Pharma Private Limited | Process for manufacturing sterile ophthalmic pharmaceutical suspensions |
| EA036820B1 (ru) * | 2014-01-24 | 2020-12-23 | Сентисс Фарма Прайвет Лимитед | Фармацевтическая композиция, содержащая бринзоламид |
| PL407710A1 (pl) * | 2014-03-28 | 2015-10-12 | Instytut Farmaceutyczny | Sposób wytwarzania preparatu kropli do oczu w postaci zawiesiny zawierającej brynzolamid i preparat wytworzony tym sposobem |
| JP6279395B2 (ja) * | 2014-05-01 | 2018-02-14 | 東亜薬品株式会社 | ブリンゾラミド懸濁性点眼液組成物の製造方法 |
| UA124698C2 (uk) | 2014-10-20 | 2021-11-03 | Сентіс Фарма Прайвет Лімітед | Офтальмологічний розчин |
| TWI700085B (zh) | 2015-06-22 | 2020-08-01 | 新源生物科技股份有限公司 | 酪胺酸激酶抑制劑之眼用調配物的用途 |
| CN107582519A (zh) * | 2017-06-01 | 2018-01-16 | 合肥远志医药科技开发有限公司 | 一种布林佐胺滴眼液制剂及其制备方法 |
| GR1009419B (el) | 2017-11-07 | 2018-12-14 | Φαρματεν Αβεε | Οφθαλμικο φαρμακευτικο σκευασμα που περιεχει εναν συνδυασμο βρινζολαμιδης και βριμονιδινης και μεθοδος για την παρασκευη αυτου |
| JP2021521240A (ja) | 2018-04-25 | 2021-08-26 | シルパ メディケア リミテッドＳｈｉｌｐａ Ｍｅｄｉｃａｒｅ Ｌｉｍｉｔｅｄ | ブリンゾラミドの眼科用組成物 |
| GR1009616B (el) * | 2018-07-20 | 2019-10-11 | Φαρματεν Α.Β.Ε.Ε. | Οφθαλμικο φαρμακευτικο σκευασμα που περιεχει βρινζολαμιδη και τιμολολη και μεθοδος παρασκευης αυτου |
| WO2020240451A1 (en) | 2019-05-29 | 2020-12-03 | Lupin Limited | In-situ gelling nanoemulsion of brinzolamide |
| US11850249B2 (en) | 2020-10-05 | 2023-12-26 | Somerset Therapeutics, Llc | Methods of efficiently reducing intraocular pressure |
| WO2024236599A1 (en) | 2023-05-16 | 2024-11-21 | Micro Labs Limited | Ophthalmic solution of brinzolamide |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5378703A (en) * | 1990-04-09 | 1995-01-03 | Alcon Laboratories, Inc. | Sulfonamides useful as carbonic anhydrase inhibitors |
| SK282039B6 (sk) * | 1991-04-17 | 2001-10-08 | Merck & Co., Inc. | Oftalmický prípravok na liečenie očnej hypertenzie obsahujúci kombináciu inhibítora karboanhydrázy a beta-adrenergného antagonistu |
| ATE169499T1 (de) * | 1992-02-21 | 1998-08-15 | Alcon Lab Inc | Topische antiglaukoma zusammensetzungen, enthaltend karbonhydrasehemmer und beta-blocker |
| US5362758A (en) * | 1992-09-18 | 1994-11-08 | Pfizer Inc. | Ophthalmic piroxicam solution |
| US5346702A (en) * | 1992-12-04 | 1994-09-13 | Sterling Winthrop Inc. | Use of non-ionic cloud point modifiers to minimize nanoparticle aggregation during sterilization |
| US5429824A (en) * | 1992-12-15 | 1995-07-04 | Eastman Kodak Company | Use of tyloxapole as a nanoparticle stabilizer and dispersant |
| US5576016A (en) * | 1993-05-18 | 1996-11-19 | Pharmos Corporation | Solid fat nanoemulsions as drug delivery vehicles |
| US5422116A (en) * | 1994-02-18 | 1995-06-06 | Ciba-Geigy Corporation | Liquid ophthalmic sustained release delivery system |
-
1997
- 1997-07-02 US US08/886,933 patent/US6071904A/en not_active Expired - Lifetime
- 1997-09-05 EP EP97939835A patent/EP0941094B1/en not_active Expired - Lifetime
- 1997-09-05 DE DE69708912T patent/DE69708912T2/de not_active Expired - Lifetime
- 1997-09-05 DE DE122009000016C patent/DE122009000016I1/de active Pending
- 1997-09-05 WO PCT/US1997/015727 patent/WO1998025620A1/en not_active Ceased
- 1997-09-05 CA CA002274680A patent/CA2274680C/en not_active Expired - Lifetime
- 1997-09-05 ES ES97939835T patent/ES2169416T3/es not_active Expired - Lifetime
- 1997-09-05 AT AT97939835T patent/ATE209917T1/de active
- 1997-09-05 JP JP52598698A patent/JP3611863B2/ja not_active Expired - Lifetime
- 1997-09-05 DK DK97939835T patent/DK0941094T3/da active
- 1997-09-05 PT PT97939835T patent/PT941094E/pt unknown
-
2009
- 2009-04-22 LU LU91554C patent/LU91554I2/fr unknown
- 2009-05-11 NL NL300388C patent/NL300388I2/nl unknown
- 2009-05-25 FR FR09C0022C patent/FR09C0022I2/fr active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP3611863B2 (ja) | 2005-01-19 |
| ES2169416T3 (es) | 2002-07-01 |
| FR09C0022I1 (enExample) | 2009-09-25 |
| AU718079B2 (en) | 2000-04-06 |
| NL300388I1 (nl) | 2009-07-01 |
| WO1998025620A1 (en) | 1998-06-18 |
| JP2000501749A (ja) | 2000-02-15 |
| DK0941094T3 (da) | 2002-01-07 |
| NL300388I2 (nl) | 2010-02-01 |
| ATE209917T1 (de) | 2001-12-15 |
| CA2274680A1 (en) | 1998-06-18 |
| US6071904A (en) | 2000-06-06 |
| EP0941094A1 (en) | 1999-09-15 |
| AU4183897A (en) | 1998-07-03 |
| DE69708912T2 (de) | 2002-04-11 |
| LU91554I2 (fr) | 2009-06-22 |
| FR09C0022I2 (enExample) | 2010-06-11 |
| CA2274680C (en) | 2003-11-18 |
| HK1019704A1 (en) | 2000-02-25 |
| DE69708912D1 (de) | 2002-01-17 |
| DE122009000016I1 (de) | 2009-06-25 |
| EP0941094B1 (en) | 2001-12-05 |
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