DE122009000016I1 - Verfahren zur herstellung von ophtalmischen suspensionen enthaltend brinzolamid - Google Patents

Verfahren zur herstellung von ophtalmischen suspensionen enthaltend brinzolamid

Info

Publication number
DE122009000016I1
DE122009000016I1 DE122009000016C DE122009000016C DE122009000016I1 DE 122009000016 I1 DE122009000016 I1 DE 122009000016I1 DE 122009000016 C DE122009000016 C DE 122009000016C DE 122009000016 C DE122009000016 C DE 122009000016C DE 122009000016 I1 DE122009000016 I1 DE 122009000016I1
Authority
DE
Germany
Prior art keywords
polyide
brinol
preparation
suspensions containing
ophthalmic suspensions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE122009000016C
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Vision LLC
Original Assignee
Alcon Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Laboratories Inc filed Critical Alcon Laboratories Inc
Publication of DE122009000016I1 publication Critical patent/DE122009000016I1/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A61K31/77—Polymers containing oxygen of oxiranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
DE122009000016C 1996-12-11 1997-09-05 Verfahren zur herstellung von ophtalmischen suspensionen enthaltend brinzolamid Pending DE122009000016I1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3282096P 1996-12-11 1996-12-11
US08/886,933 US6071904A (en) 1996-12-11 1997-07-02 Process for manufacturing ophthalmic suspensions
PCT/US1997/015727 WO1998025620A1 (en) 1996-12-11 1997-09-05 Process for manufacturing ophthalmic suspensions

Publications (1)

Publication Number Publication Date
DE122009000016I1 true DE122009000016I1 (de) 2009-06-25

Family

ID=26708929

Family Applications (2)

Application Number Title Priority Date Filing Date
DE122009000016C Pending DE122009000016I1 (de) 1996-12-11 1997-09-05 Verfahren zur herstellung von ophtalmischen suspensionen enthaltend brinzolamid
DE69708912T Expired - Lifetime DE69708912T2 (de) 1996-12-11 1997-09-05 Verfahren zur herstellung von ophtalmischen suspensionen enthaltend brinzolamid

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69708912T Expired - Lifetime DE69708912T2 (de) 1996-12-11 1997-09-05 Verfahren zur herstellung von ophtalmischen suspensionen enthaltend brinzolamid

Country Status (14)

Country Link
US (1) US6071904A (de)
EP (1) EP0941094B1 (de)
JP (1) JP3611863B2 (de)
AT (1) ATE209917T1 (de)
CA (1) CA2274680C (de)
DE (2) DE122009000016I1 (de)
DK (1) DK0941094T3 (de)
ES (1) ES2169416T3 (de)
FR (1) FR09C0022I2 (de)
HK (1) HK1019704A1 (de)
LU (1) LU91554I2 (de)
NL (1) NL300388I2 (de)
PT (1) PT941094E (de)
WO (1) WO1998025620A1 (de)

Families Citing this family (41)

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WO2000001365A1 (en) * 1998-06-30 2000-01-13 Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) Prolonged release ophthalmic compositions containing a fluoroquinolone
US20030008853A1 (en) * 2001-05-21 2003-01-09 Alcon, Inc. Method for treating dry eye disorders
EP1392355B1 (de) 2001-05-21 2007-02-14 Alcon, Inc. Verwendung von proteasom-inhibitoren zur behandlung des trockenen auges
US6872382B1 (en) 2001-05-21 2005-03-29 Alcon, Inc. Use of selective PDE IV inhibitors to treat dry eye disorders
US7112588B2 (en) * 2001-05-21 2006-09-26 Alcon, Inc. Use of proteasome inhibitors to treat dry eye disorders
MXPA03010632A (es) 2001-05-21 2004-03-09 Alcon Inc Uso de inhibidores de nf-kb para tratar trastornos de resequedad de ojos.
TWI298257B (en) 2001-05-31 2008-07-01 Allergan Inc Hypotensive lipid and timolol compositions and methods of using same
US6645994B1 (en) 2001-06-01 2003-11-11 Alcon, Inc. Method of treating dry eye disorders
ES2283756T3 (es) * 2002-03-01 2007-11-01 Novagali Pharma Sa Sistemas autoemulsionantes de administracion de farmaco para taxoides.
CN100341498C (zh) 2003-01-21 2007-10-10 千寿制药株式会社 含有2－氨基－3－(4－溴苯甲酰基)苯乙酸的水成液制剂
ATE497787T1 (de) * 2004-03-12 2011-02-15 Cipla Ltd Sterilisationsprozess für steroide
ES2428868T3 (es) * 2006-07-28 2013-11-12 Novagali Pharma S.A. Composiciones que contienen compuestos de amonio cuaternario
WO2008035246A2 (en) 2006-07-28 2008-03-27 Novagali Pharma Sa Compositions containing quaternary ammonium compounds
TWI544927B (zh) 2008-03-17 2016-08-11 愛爾康研究有限公司 具有低濃度的表面活性劑以促進治療劑之生物可利用性的藥學組成物
TWI489997B (zh) * 2009-06-19 2015-07-01 Alcon Res Ltd 含有硼酸－多元醇錯合物之水性藥學組成物
WO2011067791A2 (en) 2009-12-03 2011-06-09 Lupin Limited Process for preparing pharmaceutical ophthalmic compositions
EP2394637A1 (de) * 2010-05-21 2011-12-14 Zaklady Farmaceutyczne Polpharma SA Verfahren zum Erhalt von sterilen Brinzolamidsuspensionen
PL2598118T3 (pl) 2010-07-29 2019-01-31 Allergan, Inc. Roztwory bimatoprost i tymolol bez środków konserwujących
US9061034B2 (en) 2010-07-29 2015-06-23 Allergan, Inc. Preservative free bimatoprost and timolol solutions
WO2012053011A2 (en) 2010-10-18 2012-04-26 Usv Limited Ophthalmic compositions comprising brinzolamide
US20130065888A1 (en) 2011-08-15 2013-03-14 Biserka Cetina-Cizmek Ophthalmic formulations and processes for their preparation
EP2638909A1 (de) 2012-03-15 2013-09-18 Azad Pharmaceutical Ingredients AG Verfahren zur Herstellung steriler Brinzolamid
GR1007906B (el) * 2012-03-22 2013-05-30 Φαρματεν Αβεε, Οφθαλμικο φαρμακευτικο σκευασμα περιεχον ενα αναστολεα καρβονικης ανυδρασης και μεθοδος για την παρασκευη αυτου
KR101966830B1 (ko) * 2012-05-09 2019-04-08 아이크롬 에스피에이 무균 활성 약제 성분의 제조 방법
US20150119386A1 (en) * 2012-05-21 2015-04-30 Aurobindo Pharma Limited Process for preparing opthalmic suspension of brinzolamide
US9649319B2 (en) 2012-10-11 2017-05-16 Indoco Remedies Limited Process for manufacturing sterile brinzolamide ophthalmic suspension
CN104721136A (zh) * 2013-02-21 2015-06-24 四川大学 一种布佐林胺眼用纳米混悬剂及其制备方法
UA116273C2 (uk) * 2013-10-17 2018-02-26 Сентісс Фарма Прайвет Лімітед Офтальмологічний фармацевтичний склад, що не містить консерванта
US9820991B2 (en) * 2013-11-08 2017-11-21 Sentiss Pharma Private Limited Pharmaceutical composition comprising brinzolamide
WO2015068105A1 (en) 2013-11-08 2015-05-14 Sentiss Pharma Private Limited An improved process for manufacturing sterile ophthalmic pharmaceutical suspensions
JP6487452B2 (ja) * 2014-01-24 2019-03-20 センティス ファーマ プライベート リミテッド ブリンゾラミドを含む医薬組成物
PL407710A1 (pl) 2014-03-28 2015-10-12 Instytut Farmaceutyczny Sposób wytwarzania preparatu kropli do oczu w postaci zawiesiny zawierającej brynzolamid i preparat wytworzony tym sposobem
JP6279395B2 (ja) * 2014-05-01 2018-02-14 東亜薬品株式会社 ブリンゾラミド懸濁性点眼液組成物の製造方法
ES2954412T3 (es) 2014-10-20 2023-11-22 Sentiss Pharma Private Ltd Solución oftálmica
TWI664965B (zh) * 2015-06-22 2019-07-11 新源生物科技股份有限公司 酪胺酸激酶抑制劑之眼用調配物、其使用方法、及其製備方法
CN107582519A (zh) * 2017-06-01 2018-01-16 合肥远志医药科技开发有限公司 一种布林佐胺滴眼液制剂及其制备方法
GR1009419B (el) 2017-11-07 2018-12-14 Φαρματεν Αβεε Οφθαλμικο φαρμακευτικο σκευασμα που περιεχει εναν συνδυασμο βρινζολαμιδης και βριμονιδινης και μεθοδος για την παρασκευη αυτου
AU2019259343B2 (en) 2018-04-25 2022-02-17 Shilpa Medicare Limited Ophthalmic compositions of brinzolamide
GR1009616B (el) * 2018-07-20 2019-10-11 Φαρματεν Α.Β.Ε.Ε. Οφθαλμικο φαρμακευτικο σκευασμα που περιεχει βρινζολαμιδη και τιμολολη και μεθοδος παρασκευης αυτου
MX2021014477A (es) 2019-05-29 2022-01-06 Lupin Ltd Nanoemulsion gelificante in situ de brinzolamida.
US20220105101A1 (en) * 2020-10-05 2022-04-07 Somerset Therapeutics, Llc Efficient brinzolamide and brimonidine compositions

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378703A (en) * 1990-04-09 1995-01-03 Alcon Laboratories, Inc. Sulfonamides useful as carbonic anhydrase inhibitors
IL101537A (en) * 1991-04-17 1997-11-20 Merck & Co Inc OPHTHALMIC COMPOSITIONS COMPRISING COMBINATIONS OF A CARBONIC ANHYDRASE INHIBITOR AND A b-ADRENERGIC ANTAGONIST
ATE169499T1 (de) * 1992-02-21 1998-08-15 Alcon Lab Inc Topische antiglaukoma zusammensetzungen, enthaltend karbonhydrasehemmer und beta-blocker
US5362758A (en) * 1992-09-18 1994-11-08 Pfizer Inc. Ophthalmic piroxicam solution
US5346702A (en) * 1992-12-04 1994-09-13 Sterling Winthrop Inc. Use of non-ionic cloud point modifiers to minimize nanoparticle aggregation during sterilization
US5429824A (en) * 1992-12-15 1995-07-04 Eastman Kodak Company Use of tyloxapole as a nanoparticle stabilizer and dispersant
US5576016A (en) * 1993-05-18 1996-11-19 Pharmos Corporation Solid fat nanoemulsions as drug delivery vehicles
US5422116A (en) * 1994-02-18 1995-06-06 Ciba-Geigy Corporation Liquid ophthalmic sustained release delivery system

Also Published As

Publication number Publication date
CA2274680C (en) 2003-11-18
CA2274680A1 (en) 1998-06-18
NL300388I1 (nl) 2009-07-01
HK1019704A1 (en) 2000-02-25
EP0941094A1 (de) 1999-09-15
JP3611863B2 (ja) 2005-01-19
ES2169416T3 (es) 2002-07-01
DK0941094T3 (da) 2002-01-07
AU4183897A (en) 1998-07-03
NL300388I2 (nl) 2010-02-01
WO1998025620A1 (en) 1998-06-18
US6071904A (en) 2000-06-06
LU91554I2 (fr) 2009-06-22
PT941094E (pt) 2002-05-31
ATE209917T1 (de) 2001-12-15
FR09C0022I1 (de) 2009-09-25
DE69708912D1 (de) 2002-01-17
FR09C0022I2 (de) 2010-06-11
EP0941094B1 (de) 2001-12-05
JP2000501749A (ja) 2000-02-15
DE69708912T2 (de) 2002-04-11
AU718079B2 (en) 2000-04-06

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