PT904285E - Inibidores de adesao ciclicos - Google Patents

Inibidores de adesao ciclicos

Info

Publication number
PT904285E
PT904285E PT97917291T PT97917291T PT904285E PT 904285 E PT904285 E PT 904285E PT 97917291 T PT97917291 T PT 97917291T PT 97917291 T PT97917291 T PT 97917291T PT 904285 E PT904285 E PT 904285E
Authority
PT
Portugal
Prior art keywords
cyclical
adhesion inhibitors
inhibitors
adhesion
cyclical adhesion
Prior art date
Application number
PT97917291T
Other languages
English (en)
Inventor
Alfred Jonczyk
Kessler Prof Dr Horst
Beate Diefenbach
Simon Goodman
Marcus Koppitz
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of PT904285E publication Critical patent/PT904285E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
PT97917291T 1996-04-06 1997-04-02 Inibidores de adesao ciclicos PT904285E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19613933A DE19613933A1 (de) 1996-04-06 1996-04-06 Cyclische Adhäsionsinhibitoren

Publications (1)

Publication Number Publication Date
PT904285E true PT904285E (pt) 2003-02-28

Family

ID=7790744

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97917291T PT904285E (pt) 1996-04-06 1997-04-02 Inibidores de adesao ciclicos

Country Status (24)

Country Link
US (1) US6127335A (pt)
EP (1) EP0904285B1 (pt)
JP (1) JP4115530B2 (pt)
KR (1) KR100438378B1 (pt)
CN (1) CN1119351C (pt)
AR (1) AR006523A1 (pt)
AT (1) ATE224402T1 (pt)
AU (1) AU717496B2 (pt)
BR (1) BR9708530A (pt)
CA (1) CA2250861C (pt)
CZ (1) CZ291510B6 (pt)
DE (2) DE19613933A1 (pt)
DK (1) DK0904285T3 (pt)
ES (1) ES2183159T3 (pt)
HU (1) HUP9903631A3 (pt)
NO (1) NO984667L (pt)
PL (1) PL187924B1 (pt)
PT (1) PT904285E (pt)
RU (1) RU2184121C2 (pt)
SK (1) SK283718B6 (pt)
TW (1) TW570929B (pt)
UA (1) UA61071C2 (pt)
WO (1) WO1997038009A1 (pt)
ZA (1) ZA972843B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
AU2593600A (en) 1998-12-23 2000-07-12 G.D. Searle & Co. Method of using a cyclooxygenase-2 inhibitor and a matrix metalloproteinase inhibitor as a combination therapy in the treatment of neoplasia
US6521593B1 (en) * 1999-02-01 2003-02-18 Childrens Hospital Los Angeles Methods for inhibiting brain tumor growth
UA71608C2 (en) 1999-03-11 2004-12-15 Merck Patent Gmbh A method for producing the cyclic pentapeptide
AU3840802A (en) 2000-11-01 2002-06-03 Merck Patent Gmbh Methods and compositions for the treatment of diseases of the eye
UA75898C2 (en) * 2000-11-14 2006-06-15 Merck Patent Gmbh Method for prophylaxis and treatment of eye diseases using antagonist of integrin receptors
JP4499327B2 (ja) * 2001-12-06 2010-07-07 松崎 浩巳 拡径器具および手術器具セット
EP1487489A4 (en) * 2002-03-04 2008-10-01 Medimmune Inc METHODS FOR PREVENTING OR TREATING DISORDERS BY ADMINISTERING AN INTEGRIN AVB3 ANTAGONIST ASSOCIATED WITH HMG-COA REDUCTASE INHIBITOR OR BISPHOSPHONATE
CA2478239A1 (en) * 2002-03-04 2003-09-18 Medimmune, Inc. The prevention or treatment of cancer using integrin alphavbeta3 antagonists in combination with other agents
SI1483251T1 (sl) 2002-03-12 2010-03-31 Bristol Myers Squibb Co C cian epotilonski derivati
ITRM20020402A1 (it) * 2002-07-29 2004-01-29 Sigma Tau Ind Farmaceuti Derivati fluoro-alchil-ciclopeptidi ad attivita' anti-integrine.
ES2355139T3 (es) * 2002-08-16 2011-03-23 Janssen Pharmaceutica Nv Compuestos de piperidinilo que unen selectivamente a receptores de integrinas.
US20040224986A1 (en) 2002-08-16 2004-11-11 Bart De Corte Piperidinyl targeting compounds that selectively bind integrins
CA2514653A1 (en) * 2003-01-30 2004-08-12 Medimmune, Inc. Uses of integrin alphavbeta3 antagonists
EP2259768B1 (en) * 2008-04-08 2019-05-22 Merck Patent GmbH Compositions containing cyclic peptides and methods of use
ES2904658T3 (es) * 2017-04-17 2022-04-05 Univ Nat Tsing Hua Método para preparar un ciclopéptido
US10745444B2 (en) 2017-04-17 2020-08-18 National Tsing Hua University Cyclopeptide, pharmaceutical or cosmetic composition comprising the same and method for preparing the same
US10494403B2 (en) 2018-03-06 2019-12-03 Ciphore Biomed Technology Limited Company Cyclopeptide, pharmaceutical or cosmetic composition comprising the same and method for preparing the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1077279A (zh) * 1992-04-09 1993-10-13 北京矿冶研究总院 雷管桥丝发火电阻安全检测仪
UA43823C2 (uk) * 1992-07-06 2002-01-15 Мерк Патент Геселлшафт Міт Бесшренктер Хафтунг ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ДЛЯ ІНГІБУВАННЯ ІНТЕГРИН <font face="Symbol">a</font><sub>V</sub><font face="Symbol">b</font><sub>3</sub>-ОПОСЕРЕДКОВАНОЇ КЛІТИННОЇ АДГЕЗІЇ КЛІТИН ССАВЦІВ, СПОСІБ ЛІКУВАННЯ ТА ПРОФІЛАКТИКИ ЗАХВОРЮВАННЯ, АСОЦІЙОВАНОГО З ПОРУШЕННЯМ АДГЕЗІЇ КЛІТИН, СПОСІБ БЛОКУВАННЯ ЗВ'ЯЗУВАННЯ ФІБРИНОГЕНОМ ІНТЕГРИНУ, КОМПОЗИЦІЯ ДЛЯ ЗАГОЄННЯ РАН
DE4310643A1 (de) * 1993-04-01 1994-10-06 Merck Patent Gmbh Cyclische Adhäsionsinhibitoren
DE19534177A1 (de) * 1995-09-15 1997-03-20 Merck Patent Gmbh Cyclische Adhäsionsinhibitoren

Also Published As

Publication number Publication date
SK283718B6 (sk) 2003-12-02
ES2183159T3 (es) 2003-03-16
BR9708530A (pt) 1999-08-03
DK0904285T3 (da) 2003-01-27
DE19613933A1 (de) 1997-10-09
EP0904285B1 (de) 2002-09-18
PL187924B1 (pl) 2004-11-30
DE59708269D1 (de) 2002-10-24
CN1218478A (zh) 1999-06-02
KR20000005210A (ko) 2000-01-25
NO984667D0 (no) 1998-10-06
WO1997038009A1 (de) 1997-10-16
AU717496B2 (en) 2000-03-30
NO984667L (no) 1998-10-06
AU2568897A (en) 1997-10-29
CA2250861C (en) 2008-07-15
US6127335A (en) 2000-10-03
CZ291510B6 (cs) 2003-03-12
HUP9903631A2 (hu) 2000-03-28
JP4115530B2 (ja) 2008-07-09
CN1119351C (zh) 2003-08-27
ATE224402T1 (de) 2002-10-15
SK136498A3 (en) 1999-05-07
JP2000510102A (ja) 2000-08-08
CA2250861A1 (en) 1997-10-16
PL329154A1 (en) 1999-03-15
ZA972843B (en) 1998-02-19
RU2184121C2 (ru) 2002-06-27
HUP9903631A3 (en) 2000-04-28
EP0904285A1 (de) 1999-03-31
UA61071C2 (en) 2003-11-17
AR006523A1 (es) 1999-09-08
KR100438378B1 (ko) 2004-08-25
TW570929B (en) 2004-01-11
CZ320398A3 (cs) 1999-01-13

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