AR006523A1 - Compuestos ciclicos, inhibidores de la adhesion - Google Patents
Compuestos ciclicos, inhibidores de la adhesionInfo
- Publication number
- AR006523A1 AR006523A1 ARP970101342A ARP970101342A AR006523A1 AR 006523 A1 AR006523 A1 AR 006523A1 AR P970101342 A ARP970101342 A AR P970101342A AR P970101342 A ARP970101342 A AR P970101342A AR 006523 A1 AR006523 A1 AR 006523A1
- Authority
- AR
- Argentina
- Prior art keywords
- phe
- alkyl
- atoms
- substituted
- gly
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
El campo de aplicación es la medicina, en particular la inhibición de las integrinas. Se proponen péptidos cíclicos de fórmula (I): ciclo-(Arg-Gly-Asp-X-Y), en la que X es Cha, Nal, Phe, 2-R1-Phe, 3-R1-Phe, 4-R1-Phe, homo-Phe, Phg,T hi, Trp, Tyr o derivados de Tyr, donde el grupo OHpuede encontrarse eterificado con restos de alquilo de 1 a 18 átomos de C, pudiendo tratarse, además, de derivados de dichos aminoácidos; R1 es NH2, NO2,I, Br, Cl, F, alquilo de 1 a 18 átomosde C, Ar, Ar-O o 3H; Y es Gly, donde el N en posición alfa puede estar sustituido con R2, y/o el C en posiciónalfa puede esta sustituido con R3 y/o R4, con la condición de que Gly ha de estar sustituido al menos una vez del modo indicado; Ares feniloeventualmente sustituido una o dos veces con NH2, NO2, I, Br, Cl, F, alquilo de 1 a 6 átomos de C o 3H; R2, R3 o R4 son alquilo de 1 a 18 átomos de C,o bien R2 junto con R3 y R3 junto con R4 son una cadena de alquileno. Estoscompuestos acuan como inhibidores de las integrinas y se pueden emplear enparticular para prevenir y tratar enfermedades del sistema circulatorio, enfermedades angiogénicas, infecciones microbianas y para el tratamaiento detumores.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19613933A DE19613933A1 (de) | 1996-04-06 | 1996-04-06 | Cyclische Adhäsionsinhibitoren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR006523A1 true AR006523A1 (es) | 1999-09-08 |
Family
ID=7790744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970101342A AR006523A1 (es) | 1996-04-06 | 1997-04-04 | Compuestos ciclicos, inhibidores de la adhesion |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6127335A (es) |
| EP (1) | EP0904285B1 (es) |
| JP (1) | JP4115530B2 (es) |
| KR (1) | KR100438378B1 (es) |
| CN (1) | CN1119351C (es) |
| AR (1) | AR006523A1 (es) |
| AT (1) | ATE224402T1 (es) |
| AU (1) | AU717496B2 (es) |
| BR (1) | BR9708530A (es) |
| CA (1) | CA2250861C (es) |
| CZ (1) | CZ291510B6 (es) |
| DE (2) | DE19613933A1 (es) |
| DK (1) | DK0904285T3 (es) |
| ES (1) | ES2183159T3 (es) |
| HU (1) | HUP9903631A3 (es) |
| NO (1) | NO984667L (es) |
| PL (1) | PL187924B1 (es) |
| PT (1) | PT904285E (es) |
| RU (1) | RU2184121C2 (es) |
| SK (1) | SK283718B6 (es) |
| TW (1) | TW570929B (es) |
| UA (1) | UA61071C2 (es) |
| WO (1) | WO1997038009A1 (es) |
| ZA (1) | ZA972843B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6858598B1 (en) | 1998-12-23 | 2005-02-22 | G. D. Searle & Co. | Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| AU2593600A (en) | 1998-12-23 | 2000-07-12 | G.D. Searle & Co. | Method of using a cyclooxygenase-2 inhibitor and a matrix metalloproteinase inhibitor as a combination therapy in the treatment of neoplasia |
| US6521593B1 (en) * | 1999-02-01 | 2003-02-18 | Childrens Hospital Los Angeles | Methods for inhibiting brain tumor growth |
| UA71608C2 (en) | 1999-03-11 | 2004-12-15 | Merck Patent Gmbh | A method for producing the cyclic pentapeptide |
| AU3840802A (en) | 2000-11-01 | 2002-06-03 | Merck Patent Gmbh | Methods and compositions for the treatment of diseases of the eye |
| UA75898C2 (en) * | 2000-11-14 | 2006-06-15 | Merck Patent Gmbh | Method for prophylaxis and treatment of eye diseases using antagonist of integrin receptors |
| JP4499327B2 (ja) * | 2001-12-06 | 2010-07-07 | 松崎 浩巳 | 拡径器具および手術器具セット |
| EP1487489A4 (en) * | 2002-03-04 | 2008-10-01 | Medimmune Inc | METHODS FOR PREVENTING OR TREATING DISORDERS BY ADMINISTERING AN INTEGRIN AVB3 ANTAGONIST ASSOCIATED WITH HMG-COA REDUCTASE INHIBITOR OR BISPHOSPHONATE |
| CA2478239A1 (en) * | 2002-03-04 | 2003-09-18 | Medimmune, Inc. | The prevention or treatment of cancer using integrin alphavbeta3 antagonists in combination with other agents |
| SI1483251T1 (sl) | 2002-03-12 | 2010-03-31 | Bristol Myers Squibb Co | C cian epotilonski derivati |
| ITRM20020402A1 (it) * | 2002-07-29 | 2004-01-29 | Sigma Tau Ind Farmaceuti | Derivati fluoro-alchil-ciclopeptidi ad attivita' anti-integrine. |
| ES2355139T3 (es) * | 2002-08-16 | 2011-03-23 | Janssen Pharmaceutica Nv | Compuestos de piperidinilo que unen selectivamente a receptores de integrinas. |
| US20040224986A1 (en) | 2002-08-16 | 2004-11-11 | Bart De Corte | Piperidinyl targeting compounds that selectively bind integrins |
| CA2514653A1 (en) * | 2003-01-30 | 2004-08-12 | Medimmune, Inc. | Uses of integrin alphavbeta3 antagonists |
| EP2259768B1 (en) * | 2008-04-08 | 2019-05-22 | Merck Patent GmbH | Compositions containing cyclic peptides and methods of use |
| ES2904658T3 (es) * | 2017-04-17 | 2022-04-05 | Univ Nat Tsing Hua | Método para preparar un ciclopéptido |
| US10745444B2 (en) | 2017-04-17 | 2020-08-18 | National Tsing Hua University | Cyclopeptide, pharmaceutical or cosmetic composition comprising the same and method for preparing the same |
| US10494403B2 (en) | 2018-03-06 | 2019-12-03 | Ciphore Biomed Technology Limited Company | Cyclopeptide, pharmaceutical or cosmetic composition comprising the same and method for preparing the same |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1077279A (zh) * | 1992-04-09 | 1993-10-13 | 北京矿冶研究总院 | 雷管桥丝发火电阻安全检测仪 |
| UA43823C2 (uk) * | 1992-07-06 | 2002-01-15 | Мерк Патент Геселлшафт Міт Бесшренктер Хафтунг | ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ДЛЯ ІНГІБУВАННЯ ІНТЕГРИН <font face="Symbol">a</font><sub>V</sub><font face="Symbol">b</font><sub>3</sub>-ОПОСЕРЕДКОВАНОЇ КЛІТИННОЇ АДГЕЗІЇ КЛІТИН ССАВЦІВ, СПОСІБ ЛІКУВАННЯ ТА ПРОФІЛАКТИКИ ЗАХВОРЮВАННЯ, АСОЦІЙОВАНОГО З ПОРУШЕННЯМ АДГЕЗІЇ КЛІТИН, СПОСІБ БЛОКУВАННЯ ЗВ'ЯЗУВАННЯ ФІБРИНОГЕНОМ ІНТЕГРИНУ, КОМПОЗИЦІЯ ДЛЯ ЗАГОЄННЯ РАН |
| DE4310643A1 (de) * | 1993-04-01 | 1994-10-06 | Merck Patent Gmbh | Cyclische Adhäsionsinhibitoren |
| DE19534177A1 (de) * | 1995-09-15 | 1997-03-20 | Merck Patent Gmbh | Cyclische Adhäsionsinhibitoren |
-
1996
- 1996-04-06 DE DE19613933A patent/DE19613933A1/de not_active Withdrawn
-
1997
- 1997-02-04 UA UA98105792A patent/UA61071C2/uk unknown
- 1997-04-02 ES ES97917291T patent/ES2183159T3/es not_active Expired - Lifetime
- 1997-04-02 PL PL32915497A patent/PL187924B1/pl not_active IP Right Cessation
- 1997-04-02 DK DK97917291T patent/DK0904285T3/da active
- 1997-04-02 EP EP97917291A patent/EP0904285B1/de not_active Expired - Lifetime
- 1997-04-02 JP JP53581497A patent/JP4115530B2/ja not_active Expired - Lifetime
- 1997-04-02 DE DE59708269T patent/DE59708269D1/de not_active Expired - Lifetime
- 1997-04-02 PT PT97917291T patent/PT904285E/pt unknown
- 1997-04-02 CZ CZ19983203A patent/CZ291510B6/cs not_active IP Right Cessation
- 1997-04-02 CA CA002250861A patent/CA2250861C/en not_active Expired - Fee Related
- 1997-04-02 WO PCT/EP1997/001657 patent/WO1997038009A1/de active IP Right Grant
- 1997-04-02 KR KR10-1998-0707888A patent/KR100438378B1/ko not_active IP Right Cessation
- 1997-04-02 HU HU9903631A patent/HUP9903631A3/hu unknown
- 1997-04-02 RU RU98120600/04A patent/RU2184121C2/ru active
- 1997-04-02 CN CN97194526A patent/CN1119351C/zh not_active Expired - Lifetime
- 1997-04-02 BR BR9708530A patent/BR9708530A/pt not_active Application Discontinuation
- 1997-04-02 SK SK1364-98A patent/SK283718B6/sk unknown
- 1997-04-02 AU AU25688/97A patent/AU717496B2/en not_active Ceased
- 1997-04-02 AT AT97917291T patent/ATE224402T1/de active
- 1997-04-02 US US09/155,721 patent/US6127335A/en not_active Expired - Lifetime
- 1997-04-03 ZA ZA9702843A patent/ZA972843B/xx unknown
- 1997-04-04 AR ARP970101342A patent/AR006523A1/es not_active Application Discontinuation
- 1997-07-08 TW TW086104359A patent/TW570929B/zh active
-
1998
- 1998-10-06 NO NO984667A patent/NO984667L/no not_active Application Discontinuation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |