PT90363A - Metodo para o tratamento de doencas auto-imunes em mamiferos utilizando como agentes imunosupressores acidos 4-quinolinocarboxilicos e seus derivados - Google Patents

Metodo para o tratamento de doencas auto-imunes em mamiferos utilizando como agentes imunosupressores acidos 4-quinolinocarboxilicos e seus derivados

Info

Publication number
PT90363A
PT90363A PT90363A PT9036389A PT90363A PT 90363 A PT90363 A PT 90363A PT 90363 A PT90363 A PT 90363A PT 9036389 A PT9036389 A PT 9036389A PT 90363 A PT90363 A PT 90363A
Authority
PT
Portugal
Prior art keywords
derivatives
treatment
acid
quinolinocarboxyl
mammals
Prior art date
Application number
PT90363A
Other languages
English (en)
Other versions
PT90363B (pt
Inventor
Neil Richard Ackerman
Bruce Donald Jaffee
Scott Edward Loveless
Russell Howard Neubauer
Original Assignee
Du Pont Merck Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma
Publication of PT90363A publication Critical patent/PT90363A/pt
Publication of PT90363B publication Critical patent/PT90363B/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
PT90363A 1988-04-26 1989-04-24 Metodo para o tratamento de doencas auto-imunes em mamiferos utilizando como agentes imunosupressores acidos 4-quinolinocarboxilicos e seus derivados PT90363B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/186,243 US4968701A (en) 1988-04-26 1988-04-26 4-Quinoline carboxylic acid derivatives useful as immunosuppressive agents

Publications (2)

Publication Number Publication Date
PT90363A true PT90363A (pt) 1989-11-10
PT90363B PT90363B (pt) 1994-08-31

Family

ID=22684181

Family Applications (1)

Application Number Title Priority Date Filing Date
PT90363A PT90363B (pt) 1988-04-26 1989-04-24 Metodo para o tratamento de doencas auto-imunes em mamiferos utilizando como agentes imunosupressores acidos 4-quinolinocarboxilicos e seus derivados

Country Status (13)

Country Link
US (1) US4968701A (pt)
EP (1) EP0339485B1 (pt)
JP (1) JP2650757B2 (pt)
KR (1) KR0134376B1 (pt)
AT (1) ATE87480T1 (pt)
CA (1) CA1333155C (pt)
DE (1) DE68905642T2 (pt)
DK (1) DK170414B1 (pt)
IE (1) IE64760B1 (pt)
IL (1) IL90055A (pt)
MY (1) MY106038A (pt)
PT (1) PT90363B (pt)
ZA (1) ZA893087B (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5102883A (en) * 1989-10-31 1992-04-07 Du Pont Merck Pharmaceutical Company Pyrimidine biosynthesis inhibitors useful as immunosuppressive agents
US5204329A (en) * 1990-06-11 1993-04-20 Du Pont Merck Pharmaceutical Company Treatment of organ transplantation rejection
US5135934A (en) * 1990-07-06 1992-08-04 Du Pont Merck Pharmaceutical Company 3-phenyl-5,6-dihydrobenz(c) acridine-7-carboxylic acids and related compounds as immunosuppressive agents
US6004979A (en) * 1991-02-07 1999-12-21 Hoechst Marion Roussel Nitrogenous bicycles
MX9200299A (es) * 1991-02-07 1992-12-01 Roussel Uclaf Nuevos derivados biciclicos nitrogenados, su procedimiento de preparacion los nuevos compuestos intermedios obtenidos su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen.
US6077823A (en) * 1991-03-11 2000-06-20 Creative Biomolecules, Inc. Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
US6194376B1 (en) 1991-03-11 2001-02-27 Creative Biomolecules, Inc. Method for modulating inflammatory response comprising administering morphogen
US5409886A (en) * 1993-02-18 1995-04-25 Mitsui Toatsu Chemicals, Incorporated 3-pyrroline-2-one derivatives and herbicidal compositions containing same
US5428040A (en) * 1993-08-31 1995-06-27 The Du Pont Merck Pharmaceutical Company Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents
US5578609A (en) * 1994-03-25 1996-11-26 The Dupont Merck Pharmaceutical Company 2-carbocyclic and 2-heterocyclic quinoline-4-carboxylic acids and salts thereof useful as immunosuppressive agents
WO1996033717A1 (en) * 1995-04-28 1996-10-31 Takeda Chemical Industries, Ltd. Therapeutic composition for arthritis
WO1997042953A1 (en) * 1996-05-10 1997-11-20 Novartis Ag Use of brequinar and derivatives in chronic rejection of allografts and xenotransplantation
ATE216366T1 (de) * 1996-08-16 2002-05-15 Pfizer 2-aminobenzazepin-derivate und ihre verwendung für die behandlung von immunosuppression
US6103905A (en) * 1997-06-19 2000-08-15 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
AU757059B2 (en) 1997-06-19 2003-01-30 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
US6376670B1 (en) 1997-06-19 2002-04-23 Sepracor Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
US6207679B1 (en) 1997-06-19 2001-03-27 Sepracor, Inc. Antimicrobial agents uses and compositions related thereto
AU2108099A (en) * 1998-01-30 1999-08-16 Procept, Inc. Immunosuppressive agents
ES2336808T3 (es) 2004-09-27 2010-04-16 Novozymes A/S Granulos de enzima.
KR20160079123A (ko) 2013-11-22 2016-07-05 젠자임 코포레이션 신경변성 질병을 치료하기 위한 신규한 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR6592M (pt) * 1967-10-31 1968-12-30
GB1334705A (en) * 1970-06-19 1973-10-24 Ici Ltd Pharmaceutical compositions containing kynurenic acid derivatives
CH578533A5 (pt) * 1972-03-10 1976-08-13 Ciba Geigy Ag
US4407803A (en) * 1981-08-17 1983-10-04 Abbott Laboratories Antiinflammatory 1-(quinolinyl)-2-pyrazoline derivatives
US4680299A (en) * 1984-04-30 1987-07-14 E.I. Du Pont De Nemours And Company 2-phenyl-4-quinolinecarboxylic acids and pharmaceutical compositions thereof
US4625034A (en) * 1985-02-04 1986-11-25 Usv Pharmaceutical Corp. 1,2-Dihydro; 1,2,3,4-tetrahydro; 5,8 dihydro; and 5,6,7,8-tetrahydroquinoline derivatives
US4847381A (en) * 1987-08-31 1989-07-11 American Cyanamid Company 2-Phenyl-4-quinoline carboxylic acids

Also Published As

Publication number Publication date
AU628045B2 (en) 1992-09-10
IE64760B1 (en) 1995-09-06
CA1333155C (en) 1994-11-22
US4968701A (en) 1990-11-06
IL90055A0 (en) 1989-12-15
DE68905642T2 (de) 1993-08-12
PT90363B (pt) 1994-08-31
DK170414B1 (da) 1995-08-28
EP0339485B1 (en) 1993-03-31
ZA893087B (en) 1990-12-28
AU3332189A (en) 1989-11-02
EP0339485A1 (en) 1989-11-02
JP2650757B2 (ja) 1997-09-03
DE68905642D1 (de) 1993-05-06
JPH01313428A (ja) 1989-12-18
IE891328L (en) 1989-10-26
DK200289A (da) 1989-10-27
KR900016137A (ko) 1990-11-12
DK200289D0 (da) 1989-04-25
MY106038A (en) 1994-03-31
KR0134376B1 (ko) 1998-04-21
IL90055A (en) 1993-05-13
ATE87480T1 (de) 1993-04-15

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19940202

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19990831