ZA893087B - 4-quinoline carboxylic acid derivatives useful as immunosuppressive agents - Google Patents

4-quinoline carboxylic acid derivatives useful as immunosuppressive agents

Info

Publication number
ZA893087B
ZA893087B ZA893087A ZA893087A ZA893087B ZA 893087 B ZA893087 B ZA 893087B ZA 893087 A ZA893087 A ZA 893087A ZA 893087 A ZA893087 A ZA 893087A ZA 893087 B ZA893087 B ZA 893087B
Authority
ZA
South Africa
Prior art keywords
carboxylic acid
acid derivatives
immunosuppressive agents
derivatives useful
quinoline carboxylic
Prior art date
Application number
ZA893087A
Other languages
English (en)
Inventor
Neil Richard Ackerman
Richard Ackerman Neil
Bruce Donald Jaffee
Donald Jaffee Bruce
Scott Edward Loveless
Edward Loveless Scott
Russell Howard Neubauer
Howard Neubauer Russell
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of ZA893087B publication Critical patent/ZA893087B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transplantation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA893087A 1988-04-26 1989-04-26 4-quinoline carboxylic acid derivatives useful as immunosuppressive agents ZA893087B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/186,243 US4968701A (en) 1988-04-26 1988-04-26 4-Quinoline carboxylic acid derivatives useful as immunosuppressive agents

Publications (1)

Publication Number Publication Date
ZA893087B true ZA893087B (en) 1990-12-28

Family

ID=22684181

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA893087A ZA893087B (en) 1988-04-26 1989-04-26 4-quinoline carboxylic acid derivatives useful as immunosuppressive agents

Country Status (13)

Country Link
US (1) US4968701A (xx)
EP (1) EP0339485B1 (xx)
JP (1) JP2650757B2 (xx)
KR (1) KR0134376B1 (xx)
AT (1) ATE87480T1 (xx)
CA (1) CA1333155C (xx)
DE (1) DE68905642T2 (xx)
DK (1) DK170414B1 (xx)
IE (1) IE64760B1 (xx)
IL (1) IL90055A (xx)
MY (1) MY106038A (xx)
PT (1) PT90363B (xx)
ZA (1) ZA893087B (xx)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5102883A (en) * 1989-10-31 1992-04-07 Du Pont Merck Pharmaceutical Company Pyrimidine biosynthesis inhibitors useful as immunosuppressive agents
US5204329A (en) * 1990-06-11 1993-04-20 Du Pont Merck Pharmaceutical Company Treatment of organ transplantation rejection
US5135934A (en) * 1990-07-06 1992-08-04 Du Pont Merck Pharmaceutical Company 3-phenyl-5,6-dihydrobenz(c) acridine-7-carboxylic acids and related compounds as immunosuppressive agents
MX9200299A (es) * 1991-02-07 1992-12-01 Roussel Uclaf Nuevos derivados biciclicos nitrogenados, su procedimiento de preparacion los nuevos compuestos intermedios obtenidos su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen.
US6004979A (en) * 1991-02-07 1999-12-21 Hoechst Marion Roussel Nitrogenous bicycles
US6194376B1 (en) 1991-03-11 2001-02-27 Creative Biomolecules, Inc. Method for modulating inflammatory response comprising administering morphogen
US6077823A (en) * 1991-03-11 2000-06-20 Creative Biomolecules, Inc. Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
US5409886A (en) * 1993-02-18 1995-04-25 Mitsui Toatsu Chemicals, Incorporated 3-pyrroline-2-one derivatives and herbicidal compositions containing same
US5428040A (en) * 1993-08-31 1995-06-27 The Du Pont Merck Pharmaceutical Company Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents
US5578609A (en) * 1994-03-25 1996-11-26 The Dupont Merck Pharmaceutical Company 2-carbocyclic and 2-heterocyclic quinoline-4-carboxylic acids and salts thereof useful as immunosuppressive agents
EP0830133A1 (en) * 1995-04-28 1998-03-25 Takeda Chemical Industries, Ltd. Therapeutic composition for arthritis
WO1997042953A1 (en) * 1996-05-10 1997-11-20 Novartis Ag Use of brequinar and derivatives in chronic rejection of allografts and xenotransplantation
ES2173391T3 (es) * 1996-08-16 2002-10-16 Pfizer Derivados de 2-aminobenzazepina y su uso para el tratamiento de la inmunodepresion.
US6207679B1 (en) 1997-06-19 2001-03-27 Sepracor, Inc. Antimicrobial agents uses and compositions related thereto
US6376670B1 (en) 1997-06-19 2002-04-23 Sepracor Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
EP0991623A2 (en) 1997-06-19 2000-04-12 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
US6103905A (en) * 1997-06-19 2000-08-15 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
AU2108099A (en) * 1998-01-30 1999-08-16 Procept, Inc. Immunosuppressive agents
PL1804592T3 (pl) 2004-09-27 2010-04-30 Novozymes As Granulki z enzymem
MX2016006678A (es) 2013-11-22 2016-09-13 Genzyme Corp Nuevos metodos para tratar enfermedades neurodegenerativas.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR6592M (xx) * 1967-10-31 1968-12-30
GB1334705A (en) * 1970-06-19 1973-10-24 Ici Ltd Pharmaceutical compositions containing kynurenic acid derivatives
CH576447A5 (xx) * 1972-03-10 1976-06-15 Ciba Geigy Ag
US4407803A (en) * 1981-08-17 1983-10-04 Abbott Laboratories Antiinflammatory 1-(quinolinyl)-2-pyrazoline derivatives
US4680299A (en) * 1984-04-30 1987-07-14 E.I. Du Pont De Nemours And Company 2-phenyl-4-quinolinecarboxylic acids and pharmaceutical compositions thereof
US4625034A (en) * 1985-02-04 1986-11-25 Usv Pharmaceutical Corp. 1,2-Dihydro; 1,2,3,4-tetrahydro; 5,8 dihydro; and 5,6,7,8-tetrahydroquinoline derivatives
US4847381A (en) * 1987-08-31 1989-07-11 American Cyanamid Company 2-Phenyl-4-quinoline carboxylic acids

Also Published As

Publication number Publication date
IE891328L (en) 1989-10-26
AU3332189A (en) 1989-11-02
DE68905642D1 (de) 1993-05-06
MY106038A (en) 1994-03-31
US4968701A (en) 1990-11-06
DE68905642T2 (de) 1993-08-12
IL90055A0 (en) 1989-12-15
IE64760B1 (en) 1995-09-06
PT90363A (pt) 1989-11-10
DK170414B1 (da) 1995-08-28
DK200289D0 (da) 1989-04-25
JP2650757B2 (ja) 1997-09-03
KR0134376B1 (ko) 1998-04-21
CA1333155C (en) 1994-11-22
EP0339485B1 (en) 1993-03-31
IL90055A (en) 1993-05-13
KR900016137A (ko) 1990-11-12
EP0339485A1 (en) 1989-11-02
PT90363B (pt) 1994-08-31
ATE87480T1 (de) 1993-04-15
AU628045B2 (en) 1992-09-10
DK200289A (da) 1989-10-27
JPH01313428A (ja) 1989-12-18

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