PT87777A - Process for the dehydrogenation of azasteroid compounds - Google Patents

Process for the dehydrogenation of azasteroid compounds

Info

Publication number
PT87777A
PT87777A PT87777A PT8777788A PT87777A PT 87777 A PT87777 A PT 87777A PT 87777 A PT87777 A PT 87777A PT 8777788 A PT8777788 A PT 8777788A PT 87777 A PT87777 A PT 87777A
Authority
PT
Portugal
Prior art keywords
chem
dehydrogenation
straight
compound
formula
Prior art date
Application number
PT87777A
Other languages
English (en)
Other versions
PT87777B (pt
Inventor
Apurba Bhattacharya
Alan W Douglas
Edward J Grabowski
Ulf H Dolling
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of PT87777A publication Critical patent/PT87777A/pt
Publication of PT87777B publication Critical patent/PT87777B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Catalysts (AREA)
PT87777A 1987-06-29 1988-06-21 Processo para a desidrogenacao de compostos azasteroides PT87777B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6756887A 1987-06-29 1987-06-29
US6757287A 1987-06-29 1987-06-29

Publications (2)

Publication Number Publication Date
PT87777A true PT87777A (pt) 1989-05-31
PT87777B PT87777B (pt) 1992-10-30

Family

ID=26748021

Family Applications (1)

Application Number Title Priority Date Filing Date
PT87777A PT87777B (pt) 1987-06-29 1988-06-21 Processo para a desidrogenacao de compostos azasteroides

Country Status (16)

Country Link
EP (1) EP0298652B1 (pt)
JP (1) JPH0725791B2 (pt)
KR (1) KR960015038B1 (pt)
AT (1) ATE117317T1 (pt)
AU (1) AU608860B2 (pt)
CA (1) CA1331601C (pt)
CY (1) CY1871A (pt)
DE (1) DE3852790T2 (pt)
DK (1) DK172531B1 (pt)
ES (1) ES2066786T3 (pt)
GR (1) GR3015690T3 (pt)
HK (1) HK116695A (pt)
IE (1) IE64996B1 (pt)
IL (1) IL86821A (pt)
NZ (1) NZ225100A (pt)
PT (1) PT87777B (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5049562A (en) * 1984-02-27 1991-09-17 Merck & Co., Inc. 17β-acyl-4-aza-5α-androst-1-ene-3-ones as 5α-reductase inhibitors
US5084574A (en) * 1988-04-18 1992-01-28 Merck & Co., Inc. Dehydrogenation process
US5237061A (en) * 1988-10-31 1993-08-17 Merck & Co., Inc. Methods of synthesizing benign prostatic hypertropic agents and their intermediates
US5021575A (en) * 1989-11-13 1991-06-04 Merck & Co., Inc. Method for introducing a 1,2 double bond into azasteroids
GB9002922D0 (en) * 1990-02-09 1990-04-04 Erba Carlo Spa 17 beta-substituted-4-aza-5 alpha-androstan-3-one derivatives and process for their preparation
US5187278A (en) * 1990-08-27 1993-02-16 Merck & Co., Inc. Trialkylsilyl trifluoromethanesulfonate mediated α-methylenic carbon functionalization of 4-aza-5α-androstan-3-one steroids
US5091534A (en) * 1990-08-27 1992-02-25 Merck & Co., Inc. Trialkylsilyl trifluoromethanesulfonate mediated α-methylenic carbon functionalization of 4-AZA-5α-androstan-3-one steroids
US5120847A (en) * 1990-08-27 1992-06-09 Merck & Co., Inc. Process for iodinating or brominating the α-methylenic carbon of a secondary amide
US5510351A (en) * 1992-05-20 1996-04-23 Merck & Co., Inc. Delta-17 and delta-20 olefinic and saturated 17 beta-substituted 4-aza-5 alpha-androstan-ones as 5 alpha reductase inhibitors useful in the prevention and treatment of hyperandrogenic disorders
EP0641211A1 (en) * 1992-05-21 1995-03-08 Endorecherche Inc. INHIBITORS OF TESTOSTERONE 5$g(a)-REDUCTASE ACTIVITY
US5468860A (en) * 1992-11-19 1995-11-21 Merck & Co., Inc. New finasteride processes
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
US5541322A (en) * 1994-10-14 1996-07-30 Glaxo Wellcome Inc. Synthesis of 6-azaandrostenones
EP0858455A4 (en) * 1995-10-26 2000-04-12 Merck & Co Inc 4-OXA AND 4-THIA STEROIDS
AU2001269911B2 (en) * 2000-09-07 2006-09-21 Dr. Reddy's Laboratories Ltd. Novel polymorphic form of 17-beta-(n-ter.butyl carbamoyl)-4-aza-5-alpha-androst-1-en-3-one and a process for preparing it
AU6991101A (en) * 2000-09-07 2002-03-22 Reddys Lab Ltd Dr Novel polymorphic form of 17-beta-(n-ter.butyl carbamoyl)-4-aza-5-alpha-androst-1-en-3-one and a process for preparing it
EP1790653A3 (en) * 2000-09-07 2010-06-02 Dr. Reddy's Laboratories Ltd. Novel polymorphic form of 17-beta-(n-ter.butyl carbamoyl)-4-aza-5-alpha-androst-1-en-3-one and a process for preparing it
US6645974B2 (en) 2001-07-31 2003-11-11 Merck & Co., Inc. Androgen receptor modulators and methods for use thereof
ES2185503B1 (es) * 2001-09-29 2004-08-01 Ragactives, S.L. Procedimiento para la obtencion de 17beta-(sustituido)-3-oxoalfa1,2-4-azaesteroides e intermedios.
HU227117B1 (en) 2002-05-10 2010-07-28 Richter Gedeon Nyrt Process for dehydrogenation of aza-androstane compounds
WO2004007523A1 (de) 2002-07-16 2004-01-22 Siegfried Generics International Ag Verfahren zur einführung einer 1,2-doppelbindung bei 3-oxo-4-azasteroidverbindungen
ES2206065B1 (es) 2002-10-31 2005-08-16 Ragactives, S.L. Procedimiento para la obtencion de la forma polimorfica i de finasterida.
KR100508019B1 (ko) * 2003-07-19 2005-08-17 한미약품 주식회사 고순도 1-안드로스텐 유도체의 제조 방법
ATE399756T1 (de) * 2003-07-21 2008-07-15 Siegfried Generics Int Ag Verfahren zur herstellung von alpha, beta- ungesattigten ami dverbindungen
EP2070943A1 (en) * 2007-12-14 2009-06-17 Crystal Pharma, S.A. Process for obtaining 6-Alkylidenandrost-1,4-diene-3one
DE102010024714C5 (de) 2010-06-23 2018-10-18 Bwg Bergwerk- Und Walzwerk-Maschinenbau Gmbh Verfahren zum Streckbiegerichten von Metallbändern und Streckbiegerichtanlage
KR102234106B1 (ko) * 2019-07-16 2021-04-01 한국에너지기술연구원 NOx 및 SOx 동시 제거를 위한 흡수제, 조성물 및 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54109958A (en) * 1978-02-16 1979-08-29 Patpharma Ets Steroid compound and its manufacture
AU527030B2 (en) * 1978-04-13 1983-02-10 Merck & Co., Inc. 4-aza-17-substituted-5a-androstan-3-ones
ZA802452B (en) * 1979-05-02 1981-04-29 Richardson Merrell Inc Novel steroid 5 alpha-reductase inhibitors
NZ211145A (en) * 1984-02-27 1988-10-28 Merck & Co Inc 4-aza-5-alpha-androst-1-en-3-ones and pharmaceutical compositions

Also Published As

Publication number Publication date
JPS6479198A (en) 1989-03-24
EP0298652B1 (en) 1995-01-18
KR890000512A (ko) 1989-03-15
IE64996B1 (en) 1995-10-04
DK355088D0 (da) 1988-06-28
JPH0725791B2 (ja) 1995-03-22
HK116695A (en) 1995-07-21
DK172531B1 (da) 1999-06-21
DE3852790D1 (de) 1995-03-02
DE3852790T2 (de) 1995-08-17
IL86821A0 (en) 1988-11-30
ATE117317T1 (de) 1995-02-15
IL86821A (en) 1993-05-13
GR3015690T3 (en) 1995-07-31
EP0298652A3 (en) 1990-03-07
EP0298652A2 (en) 1989-01-11
ES2066786T3 (es) 1995-03-16
IE881958L (en) 1988-12-29
CA1331601C (en) 1994-08-23
AU1845788A (en) 1989-01-05
NZ225100A (en) 1991-09-25
DK355088A (da) 1989-02-24
CY1871A (en) 1996-04-05
PT87777B (pt) 1992-10-30
KR960015038B1 (ko) 1996-10-24
AU608860B2 (en) 1991-04-18

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19920414

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20080621