DK172531B1 - Fremgangsmåde til fremstilling af et delta1-4-azasteroid - Google Patents

Fremgangsmåde til fremstilling af et delta1-4-azasteroid Download PDF

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Publication number
DK172531B1
DK172531B1 DK198803550A DK355088A DK172531B1 DK 172531 B1 DK172531 B1 DK 172531B1 DK 198803550 A DK198803550 A DK 198803550A DK 355088 A DK355088 A DK 355088A DK 172531 B1 DK172531 B1 DK 172531B1
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DK
Denmark
Prior art keywords
hydrogen
carbon atoms
alkyl
methyl
alk
Prior art date
Application number
DK198803550A
Other languages
Danish (da)
English (en)
Other versions
DK355088A (da
DK355088D0 (da
Inventor
Ulf H Dolling
Apurba Bhattacharya
Alan W Douglas
Edward J Grabowski
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK355088D0 publication Critical patent/DK355088D0/da
Publication of DK355088A publication Critical patent/DK355088A/da
Priority to DK199800580A priority Critical patent/DK175240B1/da
Application granted granted Critical
Publication of DK172531B1 publication Critical patent/DK172531B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DK198803550A 1987-06-29 1988-06-28 Fremgangsmåde til fremstilling af et delta1-4-azasteroid DK172531B1 (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK199800580A DK175240B1 (da) 1987-06-29 1998-04-28 Krystallinsk 17beta-(N-tert-butylcarbamoyl)-4-aza-5alfa-androst-1-en-3-on og fremgangsmåde til fremstilling deraf, farmaceutisk præparat indeholdende forbindelsen og anvendelse af forbindelsen til fremstilling af et medikament til behandling

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US6757287A 1987-06-29 1987-06-29
US6756887A 1987-06-29 1987-06-29
US6757287 1987-06-29
US6756887 1987-06-29

Publications (3)

Publication Number Publication Date
DK355088D0 DK355088D0 (da) 1988-06-28
DK355088A DK355088A (da) 1989-02-24
DK172531B1 true DK172531B1 (da) 1999-06-21

Family

ID=26748021

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198803550A DK172531B1 (da) 1987-06-29 1988-06-28 Fremgangsmåde til fremstilling af et delta1-4-azasteroid

Country Status (16)

Country Link
EP (1) EP0298652B1 (pt)
JP (1) JPH0725791B2 (pt)
KR (1) KR960015038B1 (pt)
AT (1) ATE117317T1 (pt)
AU (1) AU608860B2 (pt)
CA (1) CA1331601C (pt)
CY (1) CY1871A (pt)
DE (1) DE3852790T2 (pt)
DK (1) DK172531B1 (pt)
ES (1) ES2066786T3 (pt)
GR (1) GR3015690T3 (pt)
HK (1) HK116695A (pt)
IE (1) IE64996B1 (pt)
IL (1) IL86821A (pt)
NZ (1) NZ225100A (pt)
PT (1) PT87777B (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5049562A (en) * 1984-02-27 1991-09-17 Merck & Co., Inc. 17β-acyl-4-aza-5α-androst-1-ene-3-ones as 5α-reductase inhibitors
US5084574A (en) * 1988-04-18 1992-01-28 Merck & Co., Inc. Dehydrogenation process
US5237061A (en) * 1988-10-31 1993-08-17 Merck & Co., Inc. Methods of synthesizing benign prostatic hypertropic agents and their intermediates
US5021575A (en) * 1989-11-13 1991-06-04 Merck & Co., Inc. Method for introducing a 1,2 double bond into azasteroids
GB9002922D0 (en) * 1990-02-09 1990-04-04 Erba Carlo Spa 17 beta-substituted-4-aza-5 alpha-androstan-3-one derivatives and process for their preparation
US5187278A (en) * 1990-08-27 1993-02-16 Merck & Co., Inc. Trialkylsilyl trifluoromethanesulfonate mediated α-methylenic carbon functionalization of 4-aza-5α-androstan-3-one steroids
US5120847A (en) * 1990-08-27 1992-06-09 Merck & Co., Inc. Process for iodinating or brominating the α-methylenic carbon of a secondary amide
US5091534A (en) * 1990-08-27 1992-02-25 Merck & Co., Inc. Trialkylsilyl trifluoromethanesulfonate mediated α-methylenic carbon functionalization of 4-AZA-5α-androstan-3-one steroids
CA2135056A1 (en) * 1992-05-20 1993-11-25 Donald W. Graham New delta-17 and delta-20 olefinic and saturated 17b-substituted-4-aza-5a-andros-tan-3-ones as 5a-reductase inhibitors
EP0641211A1 (en) * 1992-05-21 1995-03-08 Endorecherche Inc. INHIBITORS OF TESTOSTERONE 5$g(a)-REDUCTASE ACTIVITY
US5468860A (en) 1992-11-19 1995-11-21 Merck & Co., Inc. New finasteride processes
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
US5541322A (en) * 1994-10-14 1996-07-30 Glaxo Wellcome Inc. Synthesis of 6-azaandrostenones
WO1997015564A1 (en) * 1995-10-26 1997-05-01 Merck & Co., Inc. 4-oxa and 4-thia steroids
CZ2003679A3 (cs) * 2000-09-07 2004-02-18 Dr. Reddy´S Laboratories Ltd. Nová polymorfní forma 17beta-(N-terc-butylkarbamoyl)-4-aza-5alfa-androst-1-en-3-on a způsob její přípravy
MXPA03002031A (es) 2000-09-07 2004-12-13 Reddys Lab Ltd Dr Forma polimorfica novedosa de 17-beta-(n-tercbutil carbamoil)-4-aza-5-alfa-androst-1-en-3-ona y proceso para preparar la misma.
JP2004508380A (ja) * 2000-09-07 2004-03-18 ドクター・レディーズ・ラボラトリーズ・リミテッド １７−β−（Ｎ−ｔｅｒ−ブチルカルバモイル）−４−アザ−５−α−アンドロスト−１−エン−３−オンの新規の多形体及びその調製方法
US6645974B2 (en) 2001-07-31 2003-11-11 Merck & Co., Inc. Androgen receptor modulators and methods for use thereof
ES2185503B1 (es) * 2001-09-29 2004-08-01 Ragactives, S.L. Procedimiento para la obtencion de 17beta-(sustituido)-3-oxoalfa1,2-4-azaesteroides e intermedios.
HU227117B1 (en) 2002-05-10 2010-07-28 Richter Gedeon Nyrt Process for dehydrogenation of aza-androstane compounds
AU2003240373B2 (en) 2002-07-16 2007-09-20 Siegfried Generics International Ag Method for introducing a 1,2 double bond into 3-oxo-4-azasteroid compounds
ES2206065B1 (es) 2002-10-31 2005-08-16 Ragactives, S.L. Procedimiento para la obtencion de la forma polimorfica i de finasterida.
KR100508019B1 (ko) 2003-07-19 2005-08-17 한미약품 주식회사 고순도 1-안드로스텐 유도체의 제조 방법
CA2531603A1 (en) * 2003-07-21 2005-01-27 Siegfried Generics International Ag Method for production of .alpha., .beta.-unsaturated amide compounds
EP2070943A1 (en) * 2007-12-14 2009-06-17 Crystal Pharma, S.A. Process for obtaining 6-Alkylidenandrost-1,4-diene-3one
DE102010024714C5 (de) 2010-06-23 2018-10-18 Bwg Bergwerk- Und Walzwerk-Maschinenbau Gmbh Verfahren zum Streckbiegerichten von Metallbändern und Streckbiegerichtanlage
KR102234106B1 (ko) * 2019-07-16 2021-04-01 한국에너지기술연구원 NOx 및 SOx 동시 제거를 위한 흡수제, 조성물 및 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54109958A (en) * 1978-02-16 1979-08-29 Patpharma Ets Steroid compound and its manufacture
AU527030B2 (en) * 1978-04-13 1983-02-10 Merck & Co., Inc. 4-aza-17-substituted-5a-androstan-3-ones
ZA802452B (en) * 1979-05-02 1981-04-29 Richardson Merrell Inc Novel steroid 5 alpha-reductase inhibitors
NZ211145A (en) * 1984-02-27 1988-10-28 Merck & Co Inc 4-aza-5-alpha-androst-1-en-3-ones and pharmaceutical compositions

Also Published As

Publication number Publication date
EP0298652B1 (en) 1995-01-18
IE881958L (en) 1988-12-29
EP0298652A2 (en) 1989-01-11
DK355088A (da) 1989-02-24
JPS6479198A (en) 1989-03-24
AU1845788A (en) 1989-01-05
JPH0725791B2 (ja) 1995-03-22
PT87777B (pt) 1992-10-30
KR960015038B1 (ko) 1996-10-24
CA1331601C (en) 1994-08-23
IL86821A0 (en) 1988-11-30
EP0298652A3 (en) 1990-03-07
GR3015690T3 (en) 1995-07-31
IE64996B1 (en) 1995-10-04
HK116695A (en) 1995-07-21
ES2066786T3 (es) 1995-03-16
ATE117317T1 (de) 1995-02-15
DK355088D0 (da) 1988-06-28
AU608860B2 (en) 1991-04-18
NZ225100A (en) 1991-09-25
PT87777A (pt) 1989-05-31
DE3852790T2 (de) 1995-08-17
CY1871A (en) 1996-04-05
DE3852790D1 (de) 1995-03-02
IL86821A (en) 1993-05-13
KR890000512A (ko) 1989-03-15

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B1 Patent granted (law 1993)
PUP Patent expired