PT87647A - Process for the preparation of interchanging ions resins carried with quinolonocarboxylic acids derivatives and of veterinaries compounds for the treatment of mastitis which contain them - Google Patents

Process for the preparation of interchanging ions resins carried with quinolonocarboxylic acids derivatives and of veterinaries compounds for the treatment of mastitis which contain them

Info

Publication number
PT87647A
PT87647A PT87647A PT8764788A PT87647A PT 87647 A PT87647 A PT 87647A PT 87647 A PT87647 A PT 87647A PT 8764788 A PT8764788 A PT 8764788A PT 87647 A PT87647 A PT 87647A
Authority
PT
Portugal
Prior art keywords
quinolonocarboxylic
veterinaries
mastitis
interchanging
ions
Prior art date
Application number
PT87647A
Other languages
English (en)
Other versions
PT87647B (pt
Inventor
Peter Michael Lange
Alfred Mitschker
Arundev Haribahai Naik
Huebert Rast
Martin Scheer
Herbert Voege
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of PT87647A publication Critical patent/PT87647A/pt
Publication of PT87647B publication Critical patent/PT87647B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
    • C08J5/20—Manufacture of shaped structures of ion-exchange resins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
    • C08J7/04—Coating
    • C08J7/06—Coating with compositions not containing macromolecular substances

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Manufacturing & Machinery (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Materials Engineering (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Polarising Elements (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Materials For Photolithography (AREA)
PT87647A 1987-06-13 1988-06-03 Processo para a preparacao de resinas permutadors de ioes carregadas com derivados de acidos quinolonocarboxilicos e de composicoes veterinarias para o tratamento de mastites, que as contem PT87647B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873719764 DE3719764A1 (de) 1987-06-13 1987-06-13 Ionenaustauscherharze beladen mit chinoloncarbonsaeurederivaten, ihre herstellung und verwendung

Publications (2)

Publication Number Publication Date
PT87647A true PT87647A (pt) 1988-07-01
PT87647B PT87647B (pt) 1992-09-30

Family

ID=6329624

Family Applications (1)

Application Number Title Priority Date Filing Date
PT87647A PT87647B (pt) 1987-06-13 1988-06-03 Processo para a preparacao de resinas permutadors de ioes carregadas com derivados de acidos quinolonocarboxilicos e de composicoes veterinarias para o tratamento de mastites, que as contem

Country Status (27)

Country Link
US (1) US5152986A (pt)
EP (1) EP0295495B1 (pt)
JP (1) JP2572815B2 (pt)
KR (1) KR950014238B1 (pt)
CN (2) CN1054040C (pt)
AR (1) AR243084A1 (pt)
AT (1) ATE68694T1 (pt)
AU (1) AU599239B2 (pt)
BR (1) BR8802853A (pt)
CA (1) CA1318078C (pt)
CZ (1) CZ279867B6 (pt)
DD (1) DD271061A5 (pt)
DE (2) DE3719764A1 (pt)
DK (1) DK170573B1 (pt)
ES (1) ES2040290T3 (pt)
FI (1) FI90494C (pt)
GR (1) GR3002988T3 (pt)
HU (1) HU199824B (pt)
IE (1) IE60209B1 (pt)
IL (1) IL86697A (pt)
MX (1) MX168987B (pt)
NZ (1) NZ224975A (pt)
PL (1) PL155652B1 (pt)
PT (1) PT87647B (pt)
RU (1) RU1828394C (pt)
SK (1) SK278495B6 (pt)
ZA (1) ZA884154B (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8902315D0 (sv) * 1989-06-27 1989-06-27 Pharmacia Ab Anjonbytare
SE9004129D0 (sv) * 1990-12-21 1990-12-21 Pharmacia Lkb Biotech Anion exchanger
DE69224071T2 (de) * 1991-09-17 1998-05-07 Alcon Lab Inc Chinolan-antibiotika und polystyrolsulfonat enthaltende zusammensetzungen
ES2100806B1 (es) * 1994-07-27 1998-02-16 Gentec S A Procedimiento de obtencion de particulas de 1-ciclopropil-7-(4-etil-1-piperazinil)-6-fluoro-1,4-dihidro-4-oxo-3-acido quinolin carboxilico recubiertas.
DE19633480A1 (de) * 1996-08-20 1998-02-26 Bayer Ag Oral applizierbare Formulierungen von Chinolon- und Naphthyridoncarbonsäuren
US5980882A (en) * 1997-04-16 1999-11-09 Medeva Pharmaceuticals Manufacturing Drug-resin complexes stabilized by chelating agents
IN186245B (pt) 1997-09-19 2001-07-14 Ranbaxy Lab Ltd
HN1999000174A (es) * 1998-10-30 1999-10-13 Bayer Ag Formulacion medicamentosa acuisa para administracion oral.
US6514492B1 (en) * 1999-07-14 2003-02-04 Schering-Plough Veterinary Corporation Taste masking of oral quinolone liquid preparations using ion exchange resins
ATE411047T1 (de) * 1999-07-14 2008-10-15 Schering Plough Ltd Maskieren des geschmacks der oralen flüssigen chinolon-zubereitungen mit ionenaustauscherharzen
US20020122824A1 (en) 2001-01-24 2002-09-05 Francisco Cabrera Solid phase dispersion of quinolone-or naphthyridonecarboxylic acids
KR100388501B1 (ko) * 2001-05-24 2003-06-25 주식회사 한국미생물연구소 엔로플록사신의 쓴맛이 개선된 사료첨가제 조성물 및 그제조방법
DE10134719A1 (de) * 2001-07-17 2003-02-06 Bayer Ag Pharmazeutische Zubereitungen enthaltend wirkstoffbeladene Ionentauscherharze
US7052712B2 (en) 2001-10-05 2006-05-30 Rubicon Scientific Llc Animal feeds including actives and methods of preparing same
US6716448B2 (en) 2001-10-05 2004-04-06 Rubicon Scientific Llc Domesticated household pet food including maintenance amounts of ivermectin
US6866862B2 (en) 2001-10-05 2005-03-15 Rubicon Scientific Animal feeds including heartworm-prevention drugs
JP4619658B2 (ja) * 2002-03-12 2011-01-26 富山化学工業株式会社 快い味の経口懸濁液および方法
DE10224086A1 (de) * 2002-05-31 2003-12-11 Bayer Ag Pharmazeutische Zubereitungen zur oralen Anwendung enthaltend wirkstoffbeladene Ionentauscherharze sowie strukturviskose Gelbildner als Verdicker
DE10328666A1 (de) * 2003-06-26 2005-01-13 Bayer Healthcare Ag Tabletten enthaltend Geschmacks-und/oder Aromastoffe
CN100410249C (zh) 2003-09-10 2008-08-13 杏林制药株式会社 7-(4-取代-3-环丙基氨基甲基-1-吡咯烷基)喹诺酮羧酸衍生物
DE10351448A1 (de) * 2003-11-04 2005-06-09 Bayer Healthcare Ag Geschmackstoffhaltige Arzneimittelformulierungen mit verbesserten pharmazeutischen Eigenschaften
US20070036843A1 (en) * 2005-01-28 2007-02-15 Collegium Pharmaceutical, Inc. Non-ionic non-aqueous vehicles for topical and oral administration of carrier-complexed active agents
CA2688008A1 (en) 2007-05-24 2008-11-27 Kyorin Pharmaceutical Co., Ltd. Mutilin derivative having heterocyclic aromatic ring carboxylic acid structure in substituent at 14-position
JP2012139673A (ja) * 2010-12-29 2012-07-26 Dow Global Technologies Llc アニオン交換樹脂におけるニトロソアミン形成を抑制する方法
JP5599381B2 (ja) * 2010-12-29 2014-10-01 ダウ グローバル テクノロジーズ エルエルシー アニオン交換樹脂におけるニトロソアミン形成を抑制する方法
JP2012140596A (ja) * 2010-12-29 2012-07-26 Dow Global Technologies Llc ニトロソアミン形成が制御されたアニオン交換樹脂

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB857193A (en) * 1957-03-14 1960-12-29 Clinical Products Ltd Resin-drug compounds
US3051623A (en) * 1959-04-24 1962-08-28 Wallace & Tiernan Inc Codeine and 2-methyl-3-o-tolyl-4-quin-azolone analgesic composition
US3317388A (en) * 1964-11-20 1967-05-02 Wallace & Tiernan Inc Methods for treating pain
HU178455B (en) * 1979-07-17 1982-05-28 Chinoin Gyogyszer Es Vegyeszet Process for producing new 1-substituted-3-cycloalkyl-sulfonyl-pyrrolidine-2,5-dione derivatives
AU5957480A (en) * 1979-07-26 1981-01-29 American Cyanamid Company Diethyl carbamazine resinate
DE3033157A1 (de) * 1980-09-03 1982-04-01 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4369175A (en) * 1981-07-27 1983-01-18 Ciba-Geigy Corporation Process for the manufacture of prolonged action vincamine preparations, the vincamine preparations so obtained, and medicaments containing them
US4762709A (en) * 1983-09-16 1988-08-09 Pennwalt Corporation Liquid prolonged release pharmaceutical formulations containing ionic constituents
IT1175814B (it) * 1984-03-09 1987-07-15 Luso Farmaco Inst Resine solfoniche ad attivita' terapeutica,loro preparazione e composizioni farmaceutiche che le contengono
CA1236023A (en) * 1984-07-18 1988-05-03 Yegnaswami Raghunathan Controlled release pharmaceutical preparations
DE3517535A1 (de) * 1985-05-15 1986-11-20 Bayer Ag, 5090 Leverkusen 1-aryl-4-chinolon-3-carbonsaeuren
DE3608745A1 (de) * 1985-07-24 1987-01-29 Bayer Ag Bakterizide zubereitungen zur anwendung auf dem gebiet der veterinaermedizin
DE3689061T2 (de) * 1985-07-31 1994-03-10 Sumitomo Chemical Co Verwendung von Imiden als Härter für Epoxydharze und Epoxydharzzusammensetzungen, die diese Imide enthalten.
JPS6259263A (ja) * 1985-09-10 1987-03-14 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
DE3541972A1 (de) * 1985-11-28 1987-06-04 Immanuel Jeschke Transportleitung fuer gas oder fluessigkeiten
DE3542972A1 (de) * 1985-12-05 1987-06-11 Merck Patent Gmbh Pharmakadepot
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate

Also Published As

Publication number Publication date
IE60209B1 (en) 1994-06-15
EP0295495B1 (de) 1991-10-23
PT87647B (pt) 1992-09-30
JPS644625A (en) 1989-01-09
CN1108968A (zh) 1995-09-27
CZ409688A3 (en) 1994-12-15
BR8802853A (pt) 1989-01-03
CN1081951C (zh) 2002-04-03
FI90494B (fi) 1993-11-15
DK170573B1 (da) 1995-10-30
CN88103473A (zh) 1988-12-28
EP0295495A1 (de) 1988-12-21
GR3002988T3 (en) 1993-01-25
ES2040290T3 (es) 1995-04-01
PL273001A1 (en) 1989-07-24
DD271061A5 (de) 1989-08-23
ZA884154B (en) 1989-03-29
AR243084A1 (es) 1993-07-30
IL86697A (en) 1992-07-15
HUT48234A (en) 1989-05-29
HU199824B (en) 1990-03-28
FI882747A (fi) 1988-12-14
RU1828394C (ru) 1993-07-15
CA1318078C (en) 1993-05-18
AU599239B2 (en) 1990-07-12
DE3719764A1 (de) 1988-12-22
CN1054040C (zh) 2000-07-05
DE3865748D1 (de) 1991-11-28
SK409688A3 (en) 1997-07-09
SK278495B6 (en) 1997-07-09
JP2572815B2 (ja) 1997-01-16
PL155652B1 (en) 1991-12-31
AU1764388A (en) 1988-12-15
KR890000564A (ko) 1989-03-15
FI882747A0 (fi) 1988-06-09
IE881757L (en) 1988-12-13
FI90494C (fi) 1994-02-25
US5152986A (en) 1992-10-06
CZ279867B6 (cs) 1995-07-12
IL86697A0 (en) 1988-11-30
KR950014238B1 (ko) 1995-11-23
MX168987B (es) 1993-06-16
NZ224975A (en) 1990-07-26
DK316888A (da) 1988-12-14
ATE68694T1 (de) 1991-11-15
DK316888D0 (da) 1988-06-10

Similar Documents

Publication Publication Date Title
PT87647A (pt) Process for the preparation of interchanging ions resins carried with quinolonocarboxylic acids derivatives and of veterinaries compounds for the treatment of mastitis which contain them
PT87754A (pt) Process for the preparation of new amino acid derivatives
FR2507183B1 (fr) Procede de preparation d'acides 6,8-difluoro-1,4-dihydro-4-oxo-quinoleine-3-carboxyliques
FI882007A (fi) Menetelmä steroidi-5- -reduktaasin inhibiittorien valmistamiseksi
MA22481A1 (fr) Procede de preparation d'acides imidazolyl - alcenoiques .
PT87153A (pt) Process for the preparation of acid ribofuranuronic derivatives
PT88423A (pt) Process for the preparation of oxadiazolyl-azabicycloheptanes for the treatment of senile dementia
MA21122A1 (fr) Procede de preparation de derives d'acides aminocarboxyliques bicycliques .
PT87642A (pt) Process for the preparation of dopamine-beta-hydroxylase inhibitors
FI902316A0 (fi) Menetelmä valmistaa terapeuttisesti vaikuttavia substituoituja dihydropyrrolitsiiniyhdisteitä
FI902653A0 (fi) Valmiste hampaiden hoitamiseksi sekä valmisteen valmistus
FI890723A (fi) Menetelmä kinoliinikarboksyylihappojohdannaisten valmistamiseksi
FR2599369B1 (fr) Procede de preparation de disilylmethanes
PT88432A (pt) Process for the preparation of 4-oxo-3-quinolinecarboxylic acids useful as antibacterial agents
FR2626883B1 (fr) Procede de preparation de n-phosphonomethyl-imino-diacetique
FI883589A0 (fi) Menetelmä tyydyttämättömien aminohappoyhdisteiden valmistamiseksi
PT87236A (pt) Process for the preparation of angiogenin inhibitors
AU1958988A (en) Process for the treatment of hides
PT88431A (pt) Process for the preparation of 4-oxo-3-quinolinecarboxylic acids useful as antibacterial agents
NO178883C (no) Fremgangsmåte for fremstilling av et farmasöytisk preparat for behandling av tonsillitt
FR2609027B1 (fr) Procede de preparation de mercaptoalcools
FR2505340B1 (fr) Procede de preparation d'anhydrides d'acides alcenyl-dicarboxyliques
FR2643902B1 (fr) Procede de preparation de n-allylmetatrifluoromethylaniline
PT86899A (pt) Process for preparing 27-halo derivatives of ll-f28249 compounds
FR2561645B1 (fr) Procede de preparation d'acides hydroxyalkylaminoacetiques

Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19920312

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20080603