GR3002988T3 - Ion exchange resins loaded with quinoline carboxylic acid derivatives, their preparation and use - Google Patents

Ion exchange resins loaded with quinoline carboxylic acid derivatives, their preparation and use

Info

Publication number
GR3002988T3
GR3002988T3 GR91401492T GR910401492T GR3002988T3 GR 3002988 T3 GR3002988 T3 GR 3002988T3 GR 91401492 T GR91401492 T GR 91401492T GR 910401492 T GR910401492 T GR 910401492T GR 3002988 T3 GR3002988 T3 GR 3002988T3
Authority
GR
Greece
Prior art keywords
preparation
carboxylic acid
ion exchange
acid derivatives
exchange resins
Prior art date
Application number
GR91401492T
Other languages
English (en)
Inventor
Peter Michael Dr Lange
Alfred Dr Mitschker
Arundev Haribahai Naik
Hubert Dr Rast
Martin Dr Scheer
Herbert Dr Voege
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of GR3002988T3 publication Critical patent/GR3002988T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
    • C08J5/20—Manufacture of shaped structures of ion-exchange resins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
    • C08J7/04—Coating
    • C08J7/06—Coating with compositions not containing macromolecular substances

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Manufacturing & Machinery (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Husbandry (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Materials Engineering (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Polarising Elements (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Materials For Photolithography (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GR91401492T 1987-06-13 1991-10-24 Ion exchange resins loaded with quinoline carboxylic acid derivatives, their preparation and use GR3002988T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873719764 DE3719764A1 (de) 1987-06-13 1987-06-13 Ionenaustauscherharze beladen mit chinoloncarbonsaeurederivaten, ihre herstellung und verwendung

Publications (1)

Publication Number Publication Date
GR3002988T3 true GR3002988T3 (en) 1993-01-25

Family

ID=6329624

Family Applications (1)

Application Number Title Priority Date Filing Date
GR91401492T GR3002988T3 (en) 1987-06-13 1991-10-24 Ion exchange resins loaded with quinoline carboxylic acid derivatives, their preparation and use

Country Status (27)

Country Link
US (1) US5152986A (el)
EP (1) EP0295495B1 (el)
JP (1) JP2572815B2 (el)
KR (1) KR950014238B1 (el)
CN (2) CN1054040C (el)
AR (1) AR243084A1 (el)
AT (1) ATE68694T1 (el)
AU (1) AU599239B2 (el)
BR (1) BR8802853A (el)
CA (1) CA1318078C (el)
CZ (1) CZ279867B6 (el)
DD (1) DD271061A5 (el)
DE (2) DE3719764A1 (el)
DK (1) DK170573B1 (el)
ES (1) ES2040290T3 (el)
FI (1) FI90494C (el)
GR (1) GR3002988T3 (el)
HU (1) HU199824B (el)
IE (1) IE60209B1 (el)
IL (1) IL86697A (el)
MX (1) MX168987B (el)
NZ (1) NZ224975A (el)
PL (1) PL155652B1 (el)
PT (1) PT87647B (el)
RU (1) RU1828394C (el)
SK (1) SK409688A3 (el)
ZA (1) ZA884154B (el)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8902315D0 (sv) * 1989-06-27 1989-06-27 Pharmacia Ab Anjonbytare
SE9004129D0 (sv) * 1990-12-21 1990-12-21 Pharmacia Lkb Biotech Anion exchanger
DE69224071T2 (de) * 1991-09-17 1998-05-07 Alcon Lab Inc Chinolan-antibiotika und polystyrolsulfonat enthaltende zusammensetzungen
ES2100806B1 (es) * 1994-07-27 1998-02-16 Gentec S A Procedimiento de obtencion de particulas de 1-ciclopropil-7-(4-etil-1-piperazinil)-6-fluoro-1,4-dihidro-4-oxo-3-acido quinolin carboxilico recubiertas.
DE19633480A1 (de) * 1996-08-20 1998-02-26 Bayer Ag Oral applizierbare Formulierungen von Chinolon- und Naphthyridoncarbonsäuren
US5980882A (en) * 1997-04-16 1999-11-09 Medeva Pharmaceuticals Manufacturing Drug-resin complexes stabilized by chelating agents
IN186245B (el) 1997-09-19 2001-07-14 Ranbaxy Lab Ltd
HN1999000174A (es) * 1998-10-30 1999-10-13 Bayer Ag Formulacion medicamentosa acuisa para administracion oral.
EP1200129B1 (en) * 1999-07-14 2008-10-15 Schering-Plough Ltd. Taste masking of oral quinolone liquid preparations using ion exchange resins
US6514492B1 (en) * 1999-07-14 2003-02-04 Schering-Plough Veterinary Corporation Taste masking of oral quinolone liquid preparations using ion exchange resins
US20020122824A1 (en) 2001-01-24 2002-09-05 Francisco Cabrera Solid phase dispersion of quinolone-or naphthyridonecarboxylic acids
KR100388501B1 (ko) * 2001-05-24 2003-06-25 주식회사 한국미생물연구소 엔로플록사신의 쓴맛이 개선된 사료첨가제 조성물 및 그제조방법
DE10134719A1 (de) * 2001-07-17 2003-02-06 Bayer Ag Pharmazeutische Zubereitungen enthaltend wirkstoffbeladene Ionentauscherharze
US7052712B2 (en) 2001-10-05 2006-05-30 Rubicon Scientific Llc Animal feeds including actives and methods of preparing same
US6866862B2 (en) 2001-10-05 2005-03-15 Rubicon Scientific Animal feeds including heartworm-prevention drugs
US6716448B2 (en) 2001-10-05 2004-04-06 Rubicon Scientific Llc Domesticated household pet food including maintenance amounts of ivermectin
WO2003077842A2 (en) * 2002-03-12 2003-09-25 Bristol-Myers Squibb Company Palatable oral suspension and method
DE10224086A1 (de) * 2002-05-31 2003-12-11 Bayer Ag Pharmazeutische Zubereitungen zur oralen Anwendung enthaltend wirkstoffbeladene Ionentauscherharze sowie strukturviskose Gelbildner als Verdicker
DE10328666A1 (de) * 2003-06-26 2005-01-13 Bayer Healthcare Ag Tabletten enthaltend Geschmacks-und/oder Aromastoffe
PL1666477T3 (pl) 2003-09-10 2013-11-29 Kyorin Seiyaku Kk Pochodna kwasu 7-(4-podstawionego-3-cyklopropyloaminometylo-1- pirolidynylo)chinolonokarboksylowego
DE10351448A1 (de) * 2003-11-04 2005-06-09 Bayer Healthcare Ag Geschmackstoffhaltige Arzneimittelformulierungen mit verbesserten pharmazeutischen Eigenschaften
US20070036843A1 (en) * 2005-01-28 2007-02-15 Collegium Pharmaceutical, Inc. Non-ionic non-aqueous vehicles for topical and oral administration of carrier-complexed active agents
US8222407B2 (en) 2007-05-24 2012-07-17 Kyorin Pharmaceutical Co., Ltd. Mutilin derivative having heterocyclic aromatic ring carboxylic acid structure in substituent at 14-position
JP2012139673A (ja) * 2010-12-29 2012-07-26 Dow Global Technologies Llc アニオン交換樹脂におけるニトロソアミン形成を抑制する方法
JP5599381B2 (ja) * 2010-12-29 2014-10-01 ダウ グローバル テクノロジーズ エルエルシー アニオン交換樹脂におけるニトロソアミン形成を抑制する方法
JP2012140596A (ja) * 2010-12-29 2012-07-26 Dow Global Technologies Llc ニトロソアミン形成が制御されたアニオン交換樹脂

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB857193A (en) * 1957-03-14 1960-12-29 Clinical Products Ltd Resin-drug compounds
US3051623A (en) * 1959-04-24 1962-08-28 Wallace & Tiernan Inc Codeine and 2-methyl-3-o-tolyl-4-quin-azolone analgesic composition
US3317388A (en) * 1964-11-20 1967-05-02 Wallace & Tiernan Inc Methods for treating pain
HU178455B (en) * 1979-07-17 1982-05-28 Chinoin Gyogyszer Es Vegyeszet Process for producing new 1-substituted-3-cycloalkyl-sulfonyl-pyrrolidine-2,5-dione derivatives
AU5957480A (en) * 1979-07-26 1981-01-29 American Cyanamid Company Diethyl carbamazine resinate
DE3033157A1 (de) * 1980-09-03 1982-04-01 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4369175A (en) * 1981-07-27 1983-01-18 Ciba-Geigy Corporation Process for the manufacture of prolonged action vincamine preparations, the vincamine preparations so obtained, and medicaments containing them
US4762709A (en) * 1983-09-16 1988-08-09 Pennwalt Corporation Liquid prolonged release pharmaceutical formulations containing ionic constituents
IT1175814B (it) * 1984-03-09 1987-07-15 Luso Farmaco Inst Resine solfoniche ad attivita' terapeutica,loro preparazione e composizioni farmaceutiche che le contengono
CA1236023A (en) * 1984-07-18 1988-05-03 Yegnaswami Raghunathan Controlled release pharmaceutical preparations
DE3517535A1 (de) * 1985-05-15 1986-11-20 Bayer Ag, 5090 Leverkusen 1-aryl-4-chinolon-3-carbonsaeuren
DE3608745A1 (de) * 1985-07-24 1987-01-29 Bayer Ag Bakterizide zubereitungen zur anwendung auf dem gebiet der veterinaermedizin
DE3689061T2 (de) * 1985-07-31 1994-03-10 Sumitomo Chemical Co Verwendung von Imiden als Härter für Epoxydharze und Epoxydharzzusammensetzungen, die diese Imide enthalten.
JPS6259263A (ja) * 1985-09-10 1987-03-14 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
DE3541972A1 (de) * 1985-11-28 1987-06-04 Immanuel Jeschke Transportleitung fuer gas oder fluessigkeiten
DE3542972A1 (de) * 1985-12-05 1987-06-11 Merck Patent Gmbh Pharmakadepot
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate

Also Published As

Publication number Publication date
DK170573B1 (da) 1995-10-30
PL273001A1 (en) 1989-07-24
FI882747A (fi) 1988-12-14
DK316888A (da) 1988-12-14
IL86697A0 (en) 1988-11-30
CN1081951C (zh) 2002-04-03
KR950014238B1 (ko) 1995-11-23
RU1828394C (ru) 1993-07-15
IE60209B1 (en) 1994-06-15
SK278495B6 (en) 1997-07-09
KR890000564A (ko) 1989-03-15
PT87647A (pt) 1988-07-01
NZ224975A (en) 1990-07-26
ATE68694T1 (de) 1991-11-15
IE881757L (en) 1988-12-13
CN1054040C (zh) 2000-07-05
AU1764388A (en) 1988-12-15
HU199824B (en) 1990-03-28
FI90494B (fi) 1993-11-15
SK409688A3 (en) 1997-07-09
BR8802853A (pt) 1989-01-03
AR243084A1 (es) 1993-07-30
AU599239B2 (en) 1990-07-12
CN88103473A (zh) 1988-12-28
MX168987B (es) 1993-06-16
CZ279867B6 (cs) 1995-07-12
ZA884154B (en) 1989-03-29
CA1318078C (en) 1993-05-18
PL155652B1 (en) 1991-12-31
JP2572815B2 (ja) 1997-01-16
CZ409688A3 (en) 1994-12-15
HUT48234A (en) 1989-05-29
IL86697A (en) 1992-07-15
EP0295495A1 (de) 1988-12-21
CN1108968A (zh) 1995-09-27
DK316888D0 (da) 1988-06-10
FI90494C (fi) 1994-02-25
ES2040290T3 (es) 1995-04-01
DE3719764A1 (de) 1988-12-22
DE3865748D1 (de) 1991-11-28
DD271061A5 (de) 1989-08-23
PT87647B (pt) 1992-09-30
US5152986A (en) 1992-10-06
JPS644625A (en) 1989-01-09
FI882747A0 (fi) 1988-06-09
EP0295495B1 (de) 1991-10-23

Similar Documents

Publication Publication Date Title
AR243084A1 (es) Procedimiento para obtener resinas intercambiadoras de iones cargadas con derivados del acido quinoloncarboxilico.
EP0237955A3 (en) Quinolonecarboxylic acid derivatives and their preparation
ZA857273B (en) Isoxazolecarboxylic acid derivatives,their preparation and their use
NZ217232A (en) Propionic acid derivatives with three coatings, in dosage form
SG71386G (en) Quinoline carboxylic acid derivatives and their preparation
IL78155A0 (en) Pyrimidinylbenzoic acid derivatives,their manufacture and their use as herbicides
AU7078587A (en) Quinoline-3-carboxylic acid derivatives, their preparation and use
IL75369A0 (en) 7-amino-1-cyclopropyl-6,8-dihalogeno-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids,their preparation and antibacterial agents containing them
IL60885A0 (en) Clavulanic acid salts, their preparation and their use
IL80843A0 (en) Pyridyloxy-,pyrimidyloxy-and-thio-benzoic acid derivatives,their preparation and their use as herbicides
IL80522A0 (en) Nicotinic acid derivatives,their preparation and their use as herbicides
AU587811B2 (en) Quinoline and naphthyridine carboxylic acid antibacterial agents
DE3567873D1 (en) Phosphoric acid vinyl benzyl esters, their preparation and use
IL76394A0 (en) 7-(pyridinyl)-1-alkyl-1,1,4-dihydro-4-oxoquinolinecarboxylic acid derivatives and salts thereof,their preparation and their antibacterial use
AU588915B2 (en) Quinolonecarboxylic acid derivatives and their preparation
EP0284726A3 (en) Aromatic polyester based on phenoxyterephthalic acid, process for its preparation and its use
GR3002821T3 (en) Carboxylic acid derivatives
AU577712B2 (en) Quinolonecarboxylic acid derivatives
GB8612030D0 (en) Preparing l-malic acid
IL82219A0 (en) 3-amino-2-cyano-acrylic acid esters,their preparation and their use as herbicides
IL79103A0 (en) Benzoyltriazolylacetic and-thioacetic acid derivatives,their preparation and their use as biocides
IL75311A0 (en) Substituted phenoxyphenylpropionic acid derivatives,their preparation and their use as herbicides
AU3470689A (en) 2-phenylthiobenzylamine derivatives and acid addition salts thereof
IL88072A0 (en) Nicotinic acid derivatives,their preparation and their use as fungicides
IL86894A0 (en) Nicotinic acid derivatives,their preparation and their use as fungicides