PT86436B - Processo para a preparacao de composicoes farmaceuticas de calcitonina humana - Google Patents
Processo para a preparacao de composicoes farmaceuticas de calcitonina humana Download PDFInfo
- Publication number
- PT86436B PT86436B PT86436A PT8643687A PT86436B PT 86436 B PT86436 B PT 86436B PT 86436 A PT86436 A PT 86436A PT 8643687 A PT8643687 A PT 8643687A PT 86436 B PT86436 B PT 86436B
- Authority
- PT
- Portugal
- Prior art keywords
- human calcitonin
- calcitonin
- preparation
- methyl cellulose
- solution
- Prior art date
Links
- 101000741445 Homo sapiens Calcitonin Proteins 0.000 title claims abstract description 29
- 229940045644 human calcitonin Drugs 0.000 title claims abstract description 28
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 24
- 238000000034 method Methods 0.000 title claims abstract description 10
- 238000002360 preparation method Methods 0.000 title claims description 13
- 230000008961 swelling Effects 0.000 claims abstract description 15
- 239000008135 aqueous vehicle Substances 0.000 claims abstract description 11
- 229920000642 polymer Polymers 0.000 claims description 20
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 12
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 12
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 12
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 12
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- 238000006116 polymerization reaction Methods 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 abstract description 13
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- 208000027720 dry mucous membrane Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- VSHJAJRPRRNBEK-LMVCGNDWSA-N eel calcitonin Chemical compound C([C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CS)[C@@H](C)O)C(C)C)CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C1=CN=CN1 VSHJAJRPRRNBEK-LMVCGNDWSA-N 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- SFNALCNOMXIBKG-UHFFFAOYSA-N ethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCO SFNALCNOMXIBKG-UHFFFAOYSA-N 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 150000003840 hydrochlorides Chemical class 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 125000001165 hydrophobic group Chemical group 0.000 description 1
- 229920013819 hydroxyethyl ethylcellulose Polymers 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000000644 isotonic solution Substances 0.000 description 1
- CAHGCLMLTWQZNJ-RGEKOYMOSA-N lanosterol Chemical compound C([C@]12C)C[C@@H](O)C(C)(C)[C@H]1CCC1=C2CC[C@]2(C)[C@H]([C@H](CCC=C(C)C)C)CC[C@@]21C CAHGCLMLTWQZNJ-RGEKOYMOSA-N 0.000 description 1
- 229940058690 lanosterol Drugs 0.000 description 1
- 239000008297 liquid dosage form Substances 0.000 description 1
- 239000008176 lyophilized powder Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
- 229940037525 nasal preparations Drugs 0.000 description 1
- 229940100656 nasal solution Drugs 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000000199 parathyroid hormone Substances 0.000 description 1
- 229940021222 peritoneal dialysis isotonic solution Drugs 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229940068918 polyethylene glycol 400 Drugs 0.000 description 1
- 229920000151 polyglycol Polymers 0.000 description 1
- 239000010695 polyglycol Substances 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Otolaryngology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH520086 | 1986-12-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT86436A PT86436A (en) | 1988-01-01 |
| PT86436B true PT86436B (pt) | 1990-11-20 |
Family
ID=4289609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT86436A PT86436B (pt) | 1986-12-23 | 1987-12-22 | Processo para a preparacao de composicoes farmaceuticas de calcitonina humana |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0277462B1 (enExample) |
| JP (1) | JPS63166832A (enExample) |
| AT (1) | ATE75404T1 (enExample) |
| AU (1) | AU608268B2 (enExample) |
| CA (1) | CA1322330C (enExample) |
| DE (1) | DE3778682D1 (enExample) |
| DK (1) | DK166714B1 (enExample) |
| ES (1) | ES2032303T3 (enExample) |
| GR (1) | GR3004585T3 (enExample) |
| IL (1) | IL84861A (enExample) |
| MY (1) | MY102411A (enExample) |
| NZ (1) | NZ223005A (enExample) |
| PH (1) | PH24802A (enExample) |
| PT (1) | PT86436B (enExample) |
| ZA (1) | ZA879593B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5026825A (en) * | 1988-09-08 | 1991-06-25 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Intranasal calcitonin formulations |
| AU638128B2 (en) * | 1990-04-10 | 1993-06-17 | University Of Melbourne, The | Calcitonin gene related peptide for the treatment of undescended testicles |
| JPH05506223A (ja) * | 1990-04-10 | 1993-09-16 | ザ ユニバーシティー オブ メルボルン | 下降睾丸の処理のためのカルシトニン遺伝子関連ペプチド |
| JP3179538B2 (ja) * | 1990-12-11 | 2001-06-25 | ノバルティス アクチエンゲゼルシャフト | 安定なヒトカルシトニンの水性溶液 |
| GB9108634D0 (en) * | 1991-04-23 | 1991-06-12 | Ciba Geigy | Pharmaceutical compositions |
| EP0803255A4 (en) * | 1994-06-03 | 1999-06-30 | Tsumura & Co | MEDICINAL COMPOSITION |
| DE69901936T2 (de) * | 1998-01-30 | 2002-11-28 | Novartis Consumer Health S.A., Nyon | Nasale lösungen |
| TWI243687B (en) | 1998-04-21 | 2005-11-21 | Teijin Ltd | Pharmaceutical composition for application to mucosa |
| AR026073A1 (es) | 1999-10-20 | 2002-12-26 | Nycomed Gmbh | Composicion farmaceutica acuosa que contiene ciclesonida |
| JP2002154989A (ja) * | 2000-11-14 | 2002-05-28 | Lion Corp | 眼科用組成物、及び生体粘膜への薬物の滞留性向上組成物 |
| GB2423711B (en) * | 2005-10-24 | 2007-02-14 | Fortune Apex Dev Ltd | Method for preparing a pharmaceutical composition with enhanced mucoadhesion |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1098444A (en) * | 1975-05-26 | 1981-03-31 | Leo Geller | Peptide preparations with prolonged action |
| IL70489A0 (en) * | 1982-12-29 | 1984-03-30 | Armour Pharma | Pharmaceutical compositions containing calcitonin |
| GB8514090D0 (en) * | 1985-06-04 | 1985-07-10 | Sandoz Ltd | Organic compounds |
| CH657858A5 (de) * | 1983-06-27 | 1986-09-30 | Ciba Geigy Ag | Substanz aus der gruppe der calcitonine. |
| JPS61267528A (ja) * | 1984-11-26 | 1986-11-27 | Yamanouchi Pharmaceut Co Ltd | 吸収促進剤を含有するカルシトニン経鼻剤 |
| DE3500268A1 (de) * | 1985-01-05 | 1986-07-10 | Hoechst Ag, 6230 Frankfurt | Praeparate mit verzoegerter wirkung, verfahren zu deren herstellung sowie entsprechende mittel zur human- bzw. veterinaermedizinischen anwendung |
| JPS61194034A (ja) * | 1985-02-25 | 1986-08-28 | Teijin Ltd | 経鼻投与用粉末状組成物 |
-
1987
- 1987-12-03 MY MYPI87003149A patent/MY102411A/en unknown
- 1987-12-17 IL IL84861A patent/IL84861A/xx unknown
- 1987-12-18 ES ES198787810769T patent/ES2032303T3/es not_active Expired - Lifetime
- 1987-12-18 DE DE8787810769T patent/DE3778682D1/de not_active Expired - Lifetime
- 1987-12-18 EP EP87810769A patent/EP0277462B1/de not_active Expired - Lifetime
- 1987-12-18 AT AT87810769T patent/ATE75404T1/de not_active IP Right Cessation
- 1987-12-21 CA CA000554944A patent/CA1322330C/en not_active Expired - Fee Related
- 1987-12-21 NZ NZ223005A patent/NZ223005A/xx unknown
- 1987-12-22 AU AU82955/87A patent/AU608268B2/en not_active Ceased
- 1987-12-22 PT PT86436A patent/PT86436B/pt not_active IP Right Cessation
- 1987-12-22 ZA ZA879593A patent/ZA879593B/xx unknown
- 1987-12-22 JP JP62323061A patent/JPS63166832A/ja active Pending
- 1987-12-22 PH PH36277A patent/PH24802A/en unknown
- 1987-12-22 DK DK676987A patent/DK166714B1/da not_active IP Right Cessation
-
1992
- 1992-05-13 GR GR920400684T patent/GR3004585T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ223005A (en) | 1990-07-26 |
| GR3004585T3 (enExample) | 1993-04-28 |
| ES2032303T3 (es) | 1993-02-01 |
| ZA879593B (en) | 1988-06-22 |
| JPS63166832A (ja) | 1988-07-11 |
| CA1322330C (en) | 1993-09-21 |
| PT86436A (en) | 1988-01-01 |
| EP0277462B1 (de) | 1992-04-29 |
| ATE75404T1 (de) | 1992-05-15 |
| DK676987D0 (da) | 1987-12-22 |
| AU8295587A (en) | 1988-06-23 |
| MY102411A (en) | 1992-06-17 |
| DE3778682D1 (de) | 1992-06-04 |
| IL84861A (en) | 1992-09-06 |
| AU608268B2 (en) | 1991-03-28 |
| DK166714B1 (da) | 1993-07-05 |
| DK676987A (da) | 1988-06-24 |
| PH24802A (en) | 1990-10-30 |
| EP0277462A1 (de) | 1988-08-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19941031 |