PT84654B - Processo para a preparacao de derivados de 4-h-1benzopirano-4-ona e de composicoes farmaceuticas que os contenham - Google Patents
Processo para a preparacao de derivados de 4-h-1benzopirano-4-ona e de composicoes farmaceuticas que os contenhamInfo
- Publication number
- PT84654B PT84654B PT84654A PT8465487A PT84654B PT 84654 B PT84654 B PT 84654B PT 84654 A PT84654 A PT 84654A PT 8465487 A PT8465487 A PT 8465487A PT 84654 B PT84654 B PT 84654B
- Authority
- PT
- Portugal
- Prior art keywords
- alkyl
- aryl
- cycloalkyl
- represents hydrogen
- integer
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- -1 nitro, amino Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002861 (C1-C4) alkanoyl group Chemical group 0.000 abstract 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000000043 antiallergic agent Substances 0.000 abstract 1
- 125000003435 aroyl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 150000004777 chromones Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- 229960003444 immunosuppressant agent Drugs 0.000 abstract 1
- 239000003018 immunosuppressive agent Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19863612337 DE3612337A1 (de) | 1986-04-11 | 1986-04-11 | 4h-1-benzopyran-4-on-derivate, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT84654A PT84654A (de) | 1987-05-01 |
| PT84654B true PT84654B (pt) | 1989-12-29 |
Family
ID=6298535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT84654A PT84654B (pt) | 1986-04-11 | 1987-04-10 | Processo para a preparacao de derivados de 4-h-1benzopirano-4-ona e de composicoes farmaceuticas que os contenham |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4900727A (OSRAM) |
| EP (1) | EP0241003B1 (OSRAM) |
| JP (1) | JPH0686446B2 (OSRAM) |
| KR (1) | KR950009861B1 (OSRAM) |
| AT (2) | ATE95519T1 (OSRAM) |
| AU (1) | AU602891B2 (OSRAM) |
| CA (1) | CA1332238C (OSRAM) |
| DE (2) | DE3612337A1 (OSRAM) |
| DK (1) | DK169760B1 (OSRAM) |
| ES (1) | ES2060582T3 (OSRAM) |
| IE (1) | IE62244B1 (OSRAM) |
| IL (1) | IL82149A (OSRAM) |
| IN (1) | IN164232B (OSRAM) |
| PT (1) | PT84654B (OSRAM) |
| ZA (1) | ZA872555B (OSRAM) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5284856A (en) * | 1988-10-28 | 1994-02-08 | Hoechst Aktiengesellschaft | Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives |
| DE3836676A1 (de) * | 1988-10-28 | 1990-05-03 | Hoechst Ag | Die verwendung von 4h-1-benzopyran-4-on-derivaten, neue 4h-1-benzopyran-4-on-derivate und diese enthaltende arzneimittel |
| US5278174A (en) * | 1990-06-04 | 1994-01-11 | Scios Nova, Inc. | Sigma binding site agents |
| EP0508347A1 (en) * | 1991-04-10 | 1992-10-14 | Hoechst Aktiengesellschaft | 5,7-Dihydroxy-2-methyl-8-[4-(3-hydroxy-1-(1-propyl)) piperidinyl]-4H-1-benzopyran-4-one, its preparation and its use |
| US6903084B2 (en) * | 1991-08-28 | 2005-06-07 | Sterix Limited | Steroid sulphatase inhibitors |
| GB9604709D0 (en) * | 1996-03-05 | 1996-05-01 | Imperial College | A compound |
| US6476011B1 (en) | 1991-08-28 | 2002-11-05 | Sterix Limited | Methods for introducing an estrogenic compound |
| US6011024A (en) | 1991-08-28 | 2000-01-04 | Imperial College Of Science Technology & Medicine | Steroid sulphatase inhibitors |
| CZ285937B6 (cs) * | 1992-01-16 | 1999-12-15 | Hoechst Aktiengesellschaft | Arylcykloalkylové deriváty, způsob přípravy těchto derivátů a jejich použití |
| US5733920A (en) * | 1995-10-31 | 1998-03-31 | Mitotix, Inc. | Inhibitors of cyclin dependent kinases |
| US20060241173A1 (en) * | 1996-02-16 | 2006-10-26 | Sterix Ltd. | Compound |
| US6506792B1 (en) | 1997-03-04 | 2003-01-14 | Sterix Limited | Compounds that inhibit oestrone sulphatase and/or aromatase and methods for making and using |
| US6087366A (en) * | 1996-03-07 | 2000-07-11 | The Trustees Of Columbia University In The City Of New York | Use of flavopiridol or a pharmaceutically acceptable salt thereof for inhibiting cell damage or cell death |
| US5849733A (en) * | 1996-05-10 | 1998-12-15 | Bristol-Myers Squibb Co. | 2-thio or 2-oxo flavopiridol analogs |
| US5908934A (en) * | 1996-09-26 | 1999-06-01 | Bristol-Myers Squibb Company | Process for the preparation of chiral ketone intermediates useful for the preparation of flavopiridol and analogs |
| DE19802449A1 (de) * | 1998-01-23 | 1999-07-29 | Hoechst Marion Roussel De Gmbh | Verfahren zur Herstellung von (-)cis-3-Hydroxy-1-methyl-4-(2,4,6-trimethoxypyhenyl)-piperidin |
| GB9807779D0 (en) * | 1998-04-09 | 1998-06-10 | Ciba Geigy Ag | Organic compounds |
| US6399633B1 (en) * | 1999-02-01 | 2002-06-04 | Aventis Pharmaceuticals Inc. | Use of 4-H-1-benzopryan-4-one derivatives as inhibitors of smooth muscle cell proliferation |
| DE19959546A1 (de) * | 1999-12-09 | 2001-06-21 | Rhone Poulenc Rorer Gmbh | Pharmazeutische Zubereitung zur Behandlung von Tumorerkrankungen |
| US7335650B2 (en) | 2000-01-14 | 2008-02-26 | Sterix Limited | Composition |
| PT1259507E (pt) * | 2000-01-18 | 2004-12-31 | Aventis Pharma Inc | Forma pseudopolimorfica de (-)-cis-2-(2-clorofenil)-5,7-di-hidroxi-8[4r(3s-hidroxi-1-metil)piperidinil]-4h-benzopiran-4-ona |
| ATE284400T1 (de) * | 2000-01-18 | 2004-12-15 | Aventis Pharma Inc | Ethanolsolvat von (-)-cis-2-(2-chlorphenyl)-5,7- dihydroxy-8- (4r-(3s-hydroxy-1- methyl)piperidinyl)-4h-1-benzopyran-4-on |
| US6576647B2 (en) | 2000-01-18 | 2003-06-10 | Aventis Pharmaceuticals Inc. | Pseudopolymorph of (—)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8[4R-(3S-hydroxy -1-methyl)piperidinyl]-4H-1-benzopyran-4-one |
| US6821990B2 (en) * | 2000-01-18 | 2004-11-23 | Aventis Pharma Deutschland Gmbh | Ethanol solvate of (-)-cis-2-(2-chlorophenyl)-5, 7-dihydroxy-8 [4R-(3S-hydroxy-1-M ethyl) piperidinyl]-4H-1-benzopyran-4-one |
| FR2805538B1 (fr) * | 2000-02-29 | 2006-08-04 | Hoechst Marion Roussel Inc | Nouveaux derives de flavones, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation |
| KR100423899B1 (ko) | 2000-05-10 | 2004-03-24 | 주식회사 엘지생명과학 | 세포 증식 억제제로 유용한 1,1-디옥소이소티아졸리딘을갖는 인다졸 |
| NZ536190A (en) | 2002-04-17 | 2007-08-31 | Cytokinetics Inc | Compounds for treating cellular proliferative diseases by modulating the activity of the mitotic kinesin KSP |
| US7884127B2 (en) * | 2002-07-08 | 2011-02-08 | Pirimal Life Sciences Ltd. | Inhibitors of cyclin dependent kinases and their use |
| US7271193B2 (en) * | 2002-07-08 | 2007-09-18 | Nicholas Piramal India, Ltd. | Inhibitors of cyclin-dependent kinases and their use |
| US7915301B2 (en) | 2002-07-08 | 2011-03-29 | Piramal Life Science Limited | Inhibitors of cyclin dependent kinases and their use |
| DE60326248D1 (de) * | 2002-07-17 | 2009-04-02 | Cytokinetics Inc | Verbindungen, zusammensetzungen und verfahren zur behandlung von zellulären proliferativen erkrankungen |
| WO2004024086A2 (en) * | 2002-09-13 | 2004-03-25 | Cytokinetics, Inc. | Compounds, compositions and methods |
| EP1670456A2 (en) * | 2003-10-06 | 2006-06-21 | Cytokinetics, Inc. | Compounds, compositions and methods |
| CA2546920A1 (en) * | 2003-12-09 | 2005-06-23 | Joel Moss | Methods for suppressing an immune response or treating a proliferative disorder |
| US20050171182A1 (en) * | 2003-12-11 | 2005-08-04 | Roger Briesewitz | Methods and compositions for use in the treatment of mutant receptor tyrosine kinase driven cellular proliferative diseases |
| ES2552338T3 (es) | 2005-01-21 | 2015-11-27 | Astex Therapeutics Limited | Compuestos farmacéuticos |
| US8563596B2 (en) | 2006-06-21 | 2013-10-22 | Piramal Enterprises Limited | Enantiomerically pure compounds for the treatment of proliferative disorders |
| US8883790B2 (en) | 2006-10-12 | 2014-11-11 | Astex Therapeutics Limited | Pharmaceutical combinations |
| WO2008044041A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
| TWI461194B (zh) | 2009-05-05 | 2014-11-21 | Piramal Entpr Ltd | 吡咯啶取代黃酮作為輻射致敏劑 |
| AU2010346973A1 (en) | 2010-02-26 | 2012-10-18 | Piramal Enterprises Limited | Pyrrolidine substituted flavones for the treatment of inflammatory disorders |
| ES2986590T3 (es) | 2010-06-14 | 2024-11-12 | Scripps Research Inst | Reprogramación de células hacia un nuevo destino |
| TW201300105A (zh) | 2011-05-31 | 2013-01-01 | Piramal Life Sciences Ltd | 治療頭頸鱗狀細胞癌之相乘藥物組合物 |
| US9776989B2 (en) | 2013-04-10 | 2017-10-03 | Council Of Scientific & Industrial Research | Chromone alkaloid dysoline for the treatment of cancer and inflammatory disorders |
| EP2986605B1 (en) | 2013-04-17 | 2017-11-15 | Council of Scientific and Industrial Research | Rohitukine analogs as cyclin-dependent kinase inhibitors and a process for the preparation thereof |
| AR096892A1 (es) | 2013-07-12 | 2016-02-03 | Piramal Entpr Ltd | Una combinación farmacéutica para el tratamiento del melanoma |
| CA2967595A1 (en) | 2014-11-12 | 2016-05-19 | Siamab Therapeutics, Inc. | Glycan-interacting compounds and methods of use |
| HK1251655A1 (zh) | 2015-04-20 | 2019-02-01 | Tolero Pharmaceuticals, Inc. | 通过线粒体分析预测对阿伏西地的应答 |
| TR201911032T4 (tr) * | 2015-05-18 | 2019-08-21 | Tolero Pharmaceuticals Inc | Artırılmış biyoyararlanıma sahip alvocıdıb ön ilaçları. |
| CN108289861B (zh) | 2015-08-03 | 2021-11-02 | 大日本住友制药肿瘤公司 | 用于治疗癌症的组合疗法 |
| JP7066613B2 (ja) | 2015-11-12 | 2022-05-13 | シージェン インコーポレイテッド | グリカン相互作用化合物および使用方法 |
| US11401330B2 (en) | 2016-11-17 | 2022-08-02 | Seagen Inc. | Glycan-interacting compounds and methods of use |
| WO2018094275A1 (en) | 2016-11-18 | 2018-05-24 | Tolero Pharmaceuticals, Inc. | Alvocidib prodrugs and their use as protein kinase inhibitors |
| US10132797B2 (en) | 2016-12-19 | 2018-11-20 | Tolero Pharmaceuticals, Inc. | Profiling peptides and methods for sensitivity profiling |
| CA3054939A1 (en) | 2017-03-03 | 2018-09-07 | Seattle Genetics, Inc. | Glycan-interacting compounds and methods of use |
| US11497756B2 (en) | 2017-09-12 | 2022-11-15 | Sumitomo Pharma Oncology, Inc. | Treatment regimen for cancers that are insensitive to BCL-2 inhibitors using the MCL-1 inhibitor alvocidib |
| JP2022511029A (ja) | 2018-12-04 | 2022-01-28 | スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド | がんの処置のための薬剤としての使用のためのｃｄｋ９インヒビターおよびその多形 |
| JP2022525149A (ja) | 2019-03-20 | 2022-05-11 | スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド | ベネトクラクスが失敗した急性骨髄性白血病（ａｍｌ）の処置 |
| US12304889B2 (en) * | 2019-04-18 | 2025-05-20 | Sumitomo Pharma Co., Ltd. | Method for producing cis-(-)-flocino piperidol |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1223690A (en) * | 1967-10-17 | 1971-03-03 | Fisons Pharmaceuticals Ltd | Substituted chromon-2-carboxylic acids |
| DE2731566A1 (de) * | 1977-07-13 | 1979-02-01 | Bayer Ag | Verfahren zur herstellung von neuen chromon-derivaten, sowie ihre verwendung als pflanzenschutzmittel |
| GB2101115A (en) * | 1980-10-23 | 1983-01-12 | Pfizer Ltd | Thromboxane synthetase inhibitors |
| DE3311005A1 (de) * | 1983-03-25 | 1984-09-27 | Bayer Ag, 5090 Leverkusen | Chromon- und thiochromonsubstituierte 1,4-dihydropyridinderivate, mehrere verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
| DE3329186A1 (de) * | 1983-08-12 | 1985-02-21 | Hoechst Ag, 6230 Frankfurt | Chromonalkaloid, verfahren zu seiner isolierung aus dysoxylum binectariferum, und seine verwendung als arzneimittel |
| DE3445852A1 (de) * | 1984-12-15 | 1986-06-19 | Bayer Ag, 5090 Leverkusen | Dihydropyridin-carbonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
-
1985
- 1985-10-31 IN IN300/BOM/85A patent/IN164232B/en unknown
-
1986
- 1986-04-11 DE DE19863612337 patent/DE3612337A1/de not_active Withdrawn
-
1987
- 1987-04-08 AT AT87105180T patent/ATE95519T1/de not_active IP Right Cessation
- 1987-04-08 ES ES87105180T patent/ES2060582T3/es not_active Expired - Lifetime
- 1987-04-08 DE DE87105180T patent/DE3787661D1/de not_active Expired - Lifetime
- 1987-04-08 EP EP87105180A patent/EP0241003B1/de not_active Expired - Lifetime
- 1987-04-09 IL IL8214987A patent/IL82149A/en not_active IP Right Cessation
- 1987-04-09 ZA ZA872555A patent/ZA872555B/xx unknown
- 1987-04-10 PT PT84654A patent/PT84654B/pt unknown
- 1987-04-10 DK DK185287A patent/DK169760B1/da not_active IP Right Cessation
- 1987-04-10 AU AU71397/87A patent/AU602891B2/en not_active Expired
- 1987-04-10 CA CA000534430A patent/CA1332238C/en not_active Expired - Lifetime
- 1987-04-10 KR KR87003427A patent/KR950009861B1/ko not_active Expired - Lifetime
- 1987-04-10 IE IE94187A patent/IE62244B1/en not_active IP Right Cessation
- 1987-04-10 JP JP62087252A patent/JPH0686446B2/ja not_active Expired - Lifetime
- 1987-10-08 AT AT0260587A patent/AT389875B/de active
-
1989
- 1989-01-26 US US07/302,084 patent/US4900727A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IL82149A0 (en) | 1987-10-30 |
| IE62244B1 (en) | 1995-01-11 |
| EP0241003A3 (en) | 1988-10-12 |
| HK1006021A1 (en) | 1999-02-05 |
| ZA872555B (en) | 1987-11-25 |
| DE3787661D1 (de) | 1993-11-11 |
| DK169760B1 (da) | 1995-02-20 |
| IN164232B (OSRAM) | 1989-02-04 |
| AT389875B (de) | 1990-02-12 |
| ATE95519T1 (de) | 1993-10-15 |
| KR950009861B1 (en) | 1995-08-29 |
| ATA260587A (de) | 1989-07-15 |
| ES2060582T3 (es) | 1994-12-01 |
| IL82149A (en) | 1994-01-25 |
| CA1332238C (en) | 1994-10-04 |
| PT84654A (de) | 1987-05-01 |
| DE3612337A1 (de) | 1987-10-15 |
| DK185287A (da) | 1987-10-12 |
| US4900727A (en) | 1990-02-13 |
| JPH0686446B2 (ja) | 1994-11-02 |
| IE870941L (en) | 1987-10-11 |
| KR870010045A (ko) | 1987-11-30 |
| EP0241003B1 (de) | 1993-10-06 |
| JPS62242680A (ja) | 1987-10-23 |
| EP0241003A2 (de) | 1987-10-14 |
| AU602891B2 (en) | 1990-11-01 |
| AU7139787A (en) | 1987-10-15 |
| DK185287D0 (da) | 1987-04-10 |
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