PT80841B - Process for the preparation of compounds for site-enhanced delivery of radionuclides and of chelating agents useful therefor - Google Patents
Process for the preparation of compounds for site-enhanced delivery of radionuclides and of chelating agents useful therefor Download PDFInfo
- Publication number
- PT80841B PT80841B PT80841A PT8084185A PT80841B PT 80841 B PT80841 B PT 80841B PT 80841 A PT80841 A PT 80841A PT 8084185 A PT8084185 A PT 8084185A PT 80841 B PT80841 B PT 80841B
- Authority
- PT
- Portugal
- Prior art keywords
- group
- alkylene
- general formula
- formula
- preparation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Optics & Photonics (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63231484A | 1984-07-19 | 1984-07-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT80841A PT80841A (en) | 1985-08-01 |
| PT80841B true PT80841B (en) | 1987-06-03 |
Family
ID=24535023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT80841A PT80841B (en) | 1984-07-19 | 1985-07-19 | Process for the preparation of compounds for site-enhanced delivery of radionuclides and of chelating agents useful therefor |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0187832A1 (xx) |
| JP (1) | JPS61106556A (xx) |
| KR (1) | KR900007514B1 (xx) |
| AU (1) | AU4635885A (xx) |
| CA (1) | CA1267899A (xx) |
| DK (1) | DK124786A (xx) |
| ES (1) | ES8704900A1 (xx) |
| FI (1) | FI861118A0 (xx) |
| GR (1) | GR851792B (xx) |
| NO (1) | NO860981L (xx) |
| PT (1) | PT80841B (xx) |
| WO (1) | WO1986000898A1 (xx) |
| ZA (1) | ZA855476B (xx) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4888427A (en) * | 1987-04-07 | 1989-12-19 | University Of Florida | Amino acids containing dihydropyridine ring systems for site-specific delivery of peptides to the brain |
| US5079366A (en) * | 1987-04-07 | 1992-01-07 | University Of Florida | Quarternary pyridinium salts |
| DE3879024T2 (de) * | 1987-07-31 | 1993-10-07 | Takeda Chemical Industries Ltd | Pyridinium-Derivate, ihre Herstellung und Verwendung. |
| DE4107570A1 (de) * | 1991-03-07 | 1992-11-19 | Diagnostikforschung Inst | Chelate, deren metallkomplexe sowie ihre verwendung in diagnostik und therapie |
| JP4677863B2 (ja) * | 2005-09-05 | 2011-04-27 | 堺化学工業株式会社 | チオール系光硬化性モノマーおよび光硬化型樹脂組成物 |
| US8701166B2 (en) | 2011-12-09 | 2014-04-15 | Blackberry Limited | Secure authentication |
| US10864279B2 (en) | 2016-12-16 | 2020-12-15 | Industrial Technology Research Institute | Linker-drug and antibody-drug conjugate (ADC) employing the same |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0110955B1 (en) * | 1982-05-18 | 1995-08-23 | University Of Florida | Brain-specific drug delivery |
-
1985
- 1985-07-15 AU AU46358/85A patent/AU4635885A/en not_active Abandoned
- 1985-07-15 EP EP85903633A patent/EP0187832A1/en not_active Withdrawn
- 1985-07-15 WO PCT/US1985/001334 patent/WO1986000898A1/en not_active Application Discontinuation
- 1985-07-18 GR GR851792A patent/GR851792B/el unknown
- 1985-07-18 KR KR1019850005137A patent/KR900007514B1/ko not_active IP Right Cessation
- 1985-07-19 ZA ZA855476A patent/ZA855476B/xx unknown
- 1985-07-19 CA CA000487165A patent/CA1267899A/en not_active Expired - Lifetime
- 1985-07-19 JP JP60160040A patent/JPS61106556A/ja active Pending
- 1985-07-19 PT PT80841A patent/PT80841B/pt unknown
-
1986
- 1986-02-17 ES ES552072A patent/ES8704900A1/es not_active Expired
- 1986-03-14 NO NO860981A patent/NO860981L/no unknown
- 1986-03-18 FI FI861118A patent/FI861118A0/fi not_active Application Discontinuation
- 1986-03-18 DK DK124786A patent/DK124786A/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DK124786A (da) | 1986-05-20 |
| NO860981L (no) | 1986-05-20 |
| ES552072A0 (es) | 1987-04-16 |
| KR900007514B1 (ko) | 1990-10-11 |
| JPS61106556A (ja) | 1986-05-24 |
| KR860000871A (ko) | 1986-02-20 |
| PT80841A (en) | 1985-08-01 |
| AU4635885A (en) | 1986-02-25 |
| WO1986000898A1 (en) | 1986-02-13 |
| GR851792B (xx) | 1985-11-26 |
| DK124786D0 (da) | 1986-03-18 |
| ZA855476B (en) | 1987-03-25 |
| FI861118A (fi) | 1986-03-18 |
| ES8704900A1 (es) | 1987-04-16 |
| EP0187832A1 (en) | 1986-07-23 |
| CA1267899A (en) | 1990-04-17 |
| FI861118A0 (fi) | 1986-03-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69310733T2 (de) | Technetium-99m-markierte peptide zur bilderzeugung | |
| DE68908273T2 (de) | Metal Radionukleid-Chelatverbindungen mit verbesserter Chelatierungskinetik. | |
| EP0329737B1 (en) | Tri-aza macrocycles and metal complexes thereof | |
| US4963688A (en) | Compounds for site-enhanced delivery of radionuclides and uses thereof | |
| JPH02104588A (ja) | ５員‐又は６員‐環を有する巨大環状ポリアザ‐化合物、その製法及びこれを含有するｎｍｒ‐、ｘ線‐、放射線‐診断用及び放射能‐及び照射線‐治療用薬剤及びこの薬剤の製法 | |
| PT87216B (pt) | Processo para a preparacao de novos ligandos ciclicos azotados, de complexos metalicos formados por estes ligandos, e de composicoes de diagnostico contendo estes complexos | |
| PT1940817E (pt) | Amplificadores colinérgicos com permeabilidade à barreira hemato-encefálica melhorada para o tratamento de doenças acompanhadas de défice cognitivo | |
| PT96505B (pt) | Processo para preparacao de compostos tetra-aza macrociclicos contendo um anel de 6 elementos e de composicoes farmaceuticas que os contem | |
| JPH04505022A (ja) | 診断または治療に使用する放射性同位元素で標識した蛋白質 | |
| US4963682A (en) | Novel radiopharmaceuticals and chelating agents useful in their preparation | |
| DE69132805T2 (de) | Pro-medikamente für cck-antagonisten | |
| BR9712081B1 (pt) | derivado peptÍdico, composto, composiÇço farmacÊutica e composiÇço para ativar o sistema nervoso central. | |
| PT80841B (en) | Process for the preparation of compounds for site-enhanced delivery of radionuclides and of chelating agents useful therefor | |
| JPH06220079A (ja) | レニウム錯体 | |
| PT95629A (pt) | Processo para a preparacao de compostos de adenosina n-(6)substituida | |
| JP6087386B2 (ja) | 造影剤としてのｎ−アルコキシアミド抱合体 | |
| US20040208822A1 (en) | New quaternary ammonium compounds | |
| JPH06504273A (ja) | キレート剤 | |
| JPS61501562A (ja) | 中枢作用アミン類の脳特異性類似化合物 | |
| JPS6230762A (ja) | 新規５−オキソ−１−イミダゾリジンアセトアミド誘導体 | |
| US5136038A (en) | Radiopharmaceuticals and chelating agents useful in their preparation | |
| NO860980L (no) | Diagnostiseringsmiddel for radiografi og fremgangsmaate for dets fremstilling. | |
| US4764598A (en) | Precursors to radiopharmaceutical agents for tissue imaging | |
| US5155227A (en) | Compounds for site-enhanced delivery of radionuclides | |
| JPH05501411A (ja) | 抗ガストリン活性を持つグルタミン酸およびアスパラギン酸誘導体並びにそれらの製造法 |