PT792458E - Metodos para auxilio no diagnostico da doenca de alzheimer por medicao do peptido amiloide-beta (x-41) e de tau - Google Patents
Metodos para auxilio no diagnostico da doenca de alzheimer por medicao do peptido amiloide-beta (x-41) e de tauInfo
- Publication number
- PT792458E PT792458E PT95939892T PT95939892T PT792458E PT 792458 E PT792458 E PT 792458E PT 95939892 T PT95939892 T PT 95939892T PT 95939892 T PT95939892 T PT 95939892T PT 792458 E PT792458 E PT 792458E
- Authority
- PT
- Portugal
- Prior art keywords
- alzheimer
- diagnosis
- disease
- amyloid
- tau
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title abstract 3
- 238000003745 diagnosis Methods 0.000 title abstract 2
- 102000013455 Amyloid beta-Peptides Human genes 0.000 title 1
- 108010090849 Amyloid beta-Peptides Proteins 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 238000012544 monitoring process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/339,141 US6114133A (en) | 1994-11-14 | 1994-11-14 | Methods for aiding in the diagnosis of Alzheimer's disease by measuring amyloid-β peptide (x-≧41) |
US41900895A | 1995-04-07 | 1995-04-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT792458E true PT792458E (pt) | 2005-02-28 |
Family
ID=26991508
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT95939892T PT792458E (pt) | 1994-11-14 | 1995-11-13 | Metodos para auxilio no diagnostico da doenca de alzheimer por medicao do peptido amiloide-beta (x-41) e de tau |
Country Status (11)
Country | Link |
---|---|
US (4) | US7427392B1 (pt) |
EP (2) | EP1491889A3 (pt) |
JP (2) | JP3634375B2 (pt) |
AT (1) | ATE278957T1 (pt) |
AU (1) | AU705907B2 (pt) |
CA (1) | CA2205359C (pt) |
DE (1) | DE69533623T2 (pt) |
DK (1) | DK0792458T3 (pt) |
ES (1) | ES2230551T3 (pt) |
PT (1) | PT792458E (pt) |
WO (1) | WO1996015452A1 (pt) |
Families Citing this family (44)
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US6610493B1 (en) | 1993-06-17 | 2003-08-26 | Brigham And Women's Hospital | Screening compounds for the ability to alter the production of amyloid-β peptide |
US7427392B1 (en) * | 1994-11-14 | 2008-09-23 | Elan Pharmaceuticals, Inc. | Methods for aiding in the diagnosis of alzheimer's disease by measuring amyloid-β peptide (x-≧41) and tau |
BR9913112A (pt) * | 1998-09-08 | 2001-05-08 | Innogenetics Nv | Tau como um marcador para dano inicial de cns |
AU2001268005A1 (en) * | 2000-07-07 | 2002-01-21 | Lars Lannfelt | Prevention and treatment of alzheimer's disease |
US20070128191A1 (en) * | 2001-12-26 | 2007-06-07 | Universidad De Zaragoza | Polyclonal antibodies, preparation method thereof and use of same |
US8360992B2 (en) | 2002-04-19 | 2013-01-29 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
ES2246177B1 (es) * | 2003-05-08 | 2007-03-01 | Universidad De Zaragoza. | Uso de anticuerpos para el tratamiento de enfermedades amiloideas. |
SE0401601D0 (sv) | 2004-06-21 | 2004-06-21 | Bioarctic Neuroscience Ab | Protofibril specific antibodies and uses thereof |
WO2006053251A2 (en) * | 2004-11-12 | 2006-05-18 | Pfizer, Inc. | Method of measuring amyloid-beta peptides |
WO2007044094A1 (en) * | 2005-10-11 | 2007-04-19 | Blanchette Rockefeller Neurosciences Institute | Alzheimer's disease-specific alterations of the erk1/erk2 phosphorylation ratio as alzheimer's disease-specific molecular biomarkers (adsmb) |
AU2007227813B2 (en) | 2006-03-23 | 2012-09-27 | Bioarctic Neuroscience Ab | Improved protofibril selective antibodies and the use thereof |
ES2610474T3 (es) | 2007-01-11 | 2017-04-27 | Michael Bacher | Diagnóstico y tratamiento de la enfermedad de Alzheimer y otras enfermedades neurodegenerativas causantes de demencia |
EP1944314A1 (en) * | 2007-01-11 | 2008-07-16 | Philipps-Universität Marburg | Diagnosis of Alzheimer's disease and other neurodementing disorders |
EP2578692B1 (en) | 2007-04-05 | 2016-06-08 | The J. David Gladstone Institutes | Agents that reduce neuronal overexcitation |
EP2009445A1 (en) * | 2007-06-29 | 2008-12-31 | Institut Pasteur | Use of a camelid single-domain antibody for detecting an oligomeric form of an amyloid beta peptide and its applications |
EP2020602A1 (en) * | 2007-08-02 | 2009-02-04 | Araclon Biotech | High sensitivty immunoassays and kits for the determination of peptides and proteins of biological interest |
CA2753586A1 (en) * | 2009-02-24 | 2010-09-02 | Winton G. Gibbons | Detection of complexes of tau and amyloid |
CN102428101B (zh) * | 2009-03-18 | 2016-03-02 | Ac免疫有限公司 | 用于治疗用途的方法 |
UA107571C2 (xx) * | 2009-04-03 | 2015-01-26 | Фармацевтична композиція | |
EP2258398A1 (en) | 2009-05-26 | 2010-12-08 | Araclón Biotech, S. L. | Albumin-amyloid peptide conjugates and uses thereof |
WO2012142301A2 (en) | 2011-04-12 | 2012-10-18 | Quanterix Corporation | Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury |
PL2579042T3 (pl) * | 2011-10-04 | 2014-12-31 | Affiris Ag | Sposób wykrywania przeciwciał swoistych wobec Aß w próbce biologicznej |
DE102011057021A1 (de) | 2011-12-23 | 2013-06-27 | Forschungszentrum Jülich GmbH | Verfahren zur selektiven Quantifizierung von A-Beta-Aggregaten |
US20150031054A1 (en) | 2012-01-27 | 2015-01-29 | Panasonic Healthcare Co., Ltd. | Method and system for diagnosing alzheimer's disease |
JP6293731B2 (ja) | 2012-04-05 | 2018-03-14 | エーシー イミューン エス.エー. | ヒト化タウ抗体 |
PL2885010T3 (pl) | 2012-08-16 | 2020-11-16 | Ipierian, Inc. | Metody leczenia tauopatii |
US8980270B2 (en) | 2013-01-18 | 2015-03-17 | Ipierian, Inc. | Methods of treating a tauopathy |
ES2495266B8 (es) | 2013-02-13 | 2015-11-12 | Consejo Superior De Investigaciones Científicas (Csic) | Uso de igf-1 como reactivo de diagnóstico y/o pronóstico precoz de la enfermedad de alzheimer |
SG10201707855YA (en) * | 2013-03-13 | 2017-10-30 | Prothena Biosciences Ltd | Tau immunotherapy |
WO2014150877A2 (en) | 2013-03-15 | 2014-09-25 | Ac Immune S.A. | Anti-tau antibodies and methods of use |
KR20140128230A (ko) * | 2013-04-26 | 2014-11-05 | 한국과학기술연구원 | 혈액 중 단백질 응집체의 용해를 통한 단백질의 비정상적인 응집 또는 미스폴딩과 관련된 질환 또는 질병을 진단하는 진단키트 |
WO2015020523A1 (en) | 2013-08-07 | 2015-02-12 | Stichting Vu-Vumc | Biomarkers for early diagnosis of alzheimer's disease |
CN105939722A (zh) | 2014-02-14 | 2016-09-14 | 伊皮埃里安股份有限公司 | Tau肽,抗Tau抗体,及其使用方法 |
KR101890978B1 (ko) | 2014-06-17 | 2018-08-24 | 서울대학교산학협력단 | 알츠하이머 질환 모델용 형질전환 돼지 및 이의 용도 |
JO3537B1 (ar) | 2014-07-10 | 2020-07-05 | Bioarctic Neuroscience Ab | أجسام مضادة لييفية أولية لاميلويد بيتا الببتيد ab المحسنة |
EA201892412A1 (ru) * | 2016-05-02 | 2019-05-31 | Протена Биосайенсис Лимитед | Антитела, распознающие тау |
EP3452508A1 (en) | 2016-05-02 | 2019-03-13 | Prothena Biosciences Limited | Antibodies recognizing tau |
EP3452507B1 (en) | 2016-05-02 | 2022-10-19 | Prothena Biosciences Limited | Tau immunotherapy |
SG11201910066QA (en) | 2017-05-02 | 2019-11-28 | Prothena Biosciences Ltd | Antibodies recognizing tau |
KR20200077543A (ko) | 2017-10-25 | 2020-06-30 | 얀센 파마슈티칼즈, 인코포레이티드 | 인산화 타우 펩티드의 조성물 및 이의 용도 |
EP3881229A1 (fr) | 2018-11-14 | 2021-09-22 | Qynapse | Procede de determination d'un modele de prediction, procede de prediction de l'evolution d'un k-uplet de marqueurs mk et dispositif associe |
WO2020163730A2 (en) | 2019-02-08 | 2020-08-13 | Ac Immune S.A. | Method of safe administration of phosphorylated tau peptide vaccine |
WO2020180819A1 (en) | 2019-03-03 | 2020-09-10 | Prothena Biosciences Limited | Antibodies recognizing tau |
EP3965817A4 (en) | 2019-04-24 | 2023-11-22 | Janssen Pharmaceuticals, Inc. | HETEROLOGUE ADMINISTRATION OF TAU VACCINES |
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US4271140A (en) | 1978-01-23 | 1981-06-02 | Baxter Travenol Laboratories, Inc. | Method and composition for double receptor, specific binding assays |
US4474892A (en) | 1983-02-16 | 1984-10-02 | Board Of Trustees Of The Leland Stanford Junior University | Two-site immunoassays using monoclonal antibodies of different classes or subclasses and test kits for performing same |
US4666829A (en) | 1985-05-15 | 1987-05-19 | University Of California | Polypeptide marker for Alzheimer's disease and its use for diagnosis |
JPS6267297A (ja) | 1985-09-18 | 1987-03-26 | Hitachi Ltd | ポンプの軸受潤滑装置 |
ATE169673T1 (de) | 1986-11-17 | 1998-08-15 | Scios Inc | Rekombiniertes alzheimer amyloid-protein |
US5220013A (en) * | 1986-11-17 | 1993-06-15 | Scios Nova Inc. | DNA sequence useful for the detection of Alzheimer's disease |
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US5547841A (en) * | 1987-10-08 | 1996-08-20 | The Mclean Hospital Corporation | In vitro method for screening for drugs that inhibit production or degradation of human A4-amyloid |
US5262332A (en) * | 1989-04-05 | 1993-11-16 | Brigham And Women's Hospital | Diagnostic method for Alzheimer's disease: examination of non-neural tissue |
AU5525090A (en) | 1989-04-14 | 1990-11-16 | Research Foundation For Mental Hygiene, Inc. | Monoclonal antibody to amyloid peptide |
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AU7121191A (en) | 1990-02-26 | 1991-10-10 | Albert Einstein College Of Medicine Of Yeshiva University | Diagnostic assay for alzheimer's disease |
US5213962A (en) * | 1990-04-24 | 1993-05-25 | The Regents Of The University Of California | Purification, detection and methods of use of protease Nexin-2 |
DE69133372T2 (de) * | 1990-06-15 | 2005-02-24 | Scios Inc., Sunnyvale | Transgenes, nicht-menschliches säugetier das die amyloidbildende pathologie der alzheimerschen krankheit zeigt |
JPH04252955A (ja) | 1991-01-29 | 1992-09-08 | Asahi Chem Ind Co Ltd | 蛋白質の測定方法、試薬及びキット |
JPH04252956A (ja) | 1991-01-29 | 1992-09-08 | Asahi Chem Ind Co Ltd | タンパク質の測定方法、試薬及びキット |
JPH04252954A (ja) | 1991-01-29 | 1992-09-08 | Asahi Chem Ind Co Ltd | タンパクの測定方法、試薬及びキット |
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US5604102A (en) * | 1992-04-15 | 1997-02-18 | Athena Neurosciences, Inc. | Methods of screening for β-amyloid peptide production inhibitors |
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US5766846A (en) | 1992-07-10 | 1998-06-16 | Athena Neurosciences | Methods of screening for compounds which inhibit soluble β-amyloid peptide production |
US6610493B1 (en) | 1993-06-17 | 2003-08-26 | Brigham And Women's Hospital | Screening compounds for the ability to alter the production of amyloid-β peptide |
ATE474224T1 (de) | 1992-10-26 | 2010-07-15 | Elan Pharm Inc | Verfahren zur identifizierung von hemmstoffverbindungen der freisetzung von beta- amyloidpeptid (bap) |
WO1994017197A1 (en) | 1993-01-25 | 1994-08-04 | Takeda Chemical Industries, Ltd. | ANTIBODY AGAINST β-AMYLOID OR DERIVATIVE THEREOF AND USE THEREOF |
US6114133A (en) | 1994-11-14 | 2000-09-05 | Elan Pharmaceuticals, Inc. | Methods for aiding in the diagnosis of Alzheimer's disease by measuring amyloid-β peptide (x-≧41) |
US7427392B1 (en) | 1994-11-14 | 2008-09-23 | Elan Pharmaceuticals, Inc. | Methods for aiding in the diagnosis of alzheimer's disease by measuring amyloid-β peptide (x-≧41) and tau |
US5786180A (en) | 1995-02-14 | 1998-07-28 | Bayer Corporation | Monoclonal antibody 369.2B specific for β A4 peptide |
US20030086938A1 (en) | 2000-02-21 | 2003-05-08 | Jensen Martin Roland | Novel methods for down-regulation of amyloid |
US20050227941A1 (en) * | 2001-12-17 | 2005-10-13 | Karen Duff | Sequestration of ass in the periphery in the absence of immunomodulating agent as a therapeutic approach for the treatment or prevention of beta-amyloid related diseases |
US7380724B2 (en) | 2002-07-01 | 2008-06-03 | Sony Ericsson Mobile Communications Ab | Entering text into an electronic communication device |
CN100379696C (zh) | 2002-10-29 | 2008-04-09 | Hoya株式会社 | 化学强化玻璃、信息记录介质用基板及信息记录介质 |
JP4252954B2 (ja) | 2004-12-02 | 2009-04-08 | インターナショナル・ビジネス・マシーンズ・コーポレーション | 情報処理装置、情報処理装置のパワーマネージメント方法、およびそのためのプログラム |
-
1995
- 1995-06-06 US US08/466,554 patent/US7427392B1/en not_active Expired - Fee Related
- 1995-11-13 AT AT95939892T patent/ATE278957T1/de active
- 1995-11-13 AU AU41544/96A patent/AU705907B2/en not_active Ceased
- 1995-11-13 PT PT95939892T patent/PT792458E/pt unknown
- 1995-11-13 CA CA002205359A patent/CA2205359C/en not_active Expired - Lifetime
- 1995-11-13 EP EP04077711A patent/EP1491889A3/en not_active Withdrawn
- 1995-11-13 WO PCT/US1995/014659 patent/WO1996015452A1/en active IP Right Grant
- 1995-11-13 DK DK95939892T patent/DK0792458T3/da active
- 1995-11-13 EP EP95939892A patent/EP0792458B1/en not_active Revoked
- 1995-11-13 DE DE69533623T patent/DE69533623T2/de not_active Expired - Lifetime
- 1995-11-13 JP JP51622096A patent/JP3634375B2/ja not_active Expired - Lifetime
- 1995-11-13 ES ES95939892T patent/ES2230551T3/es not_active Expired - Lifetime
-
2003
- 2003-11-20 JP JP2003391483A patent/JP2004077499A/ja not_active Withdrawn
-
2004
- 2004-06-25 US US10/877,688 patent/US20040253643A1/en not_active Abandoned
- 2004-06-28 US US10/879,958 patent/US7811769B2/en not_active Expired - Fee Related
- 2004-10-12 US US10/964,484 patent/US7700309B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69533623T2 (de) | 2006-03-02 |
EP1491889A2 (en) | 2004-12-29 |
US7700309B2 (en) | 2010-04-20 |
EP1491889A3 (en) | 2005-04-06 |
ATE278957T1 (de) | 2004-10-15 |
ES2230551T3 (es) | 2005-05-01 |
DE69533623D1 (de) | 2004-11-11 |
EP0792458A1 (en) | 1997-09-03 |
CA2205359A1 (en) | 1996-05-23 |
US20040253643A1 (en) | 2004-12-16 |
US7427392B1 (en) | 2008-09-23 |
JPH10509797A (ja) | 1998-09-22 |
US20050069968A1 (en) | 2005-03-31 |
EP0792458A4 (en) | 1999-04-07 |
AU705907B2 (en) | 1999-06-03 |
AU4154496A (en) | 1996-06-06 |
JP3634375B2 (ja) | 2005-03-30 |
EP0792458B1 (en) | 2004-10-06 |
JP2004077499A (ja) | 2004-03-11 |
DK0792458T3 (da) | 2005-01-31 |
US7811769B2 (en) | 2010-10-12 |
US20040265920A1 (en) | 2004-12-30 |
CA2205359C (en) | 2006-07-04 |
WO1996015452A1 (en) | 1996-05-23 |
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