PT78075B - Process for preparing 3-(5-aminopentyl)-amino-1-benzazepin-2-one-1-alkanoic acids - Google Patents

Process for preparing 3-(5-aminopentyl)-amino-1-benzazepin-2-one-1-alkanoic acids

Info

Publication number
PT78075B
PT78075B PT78075A PT7807584A PT78075B PT 78075 B PT78075 B PT 78075B PT 78075 A PT78075 A PT 78075A PT 7807584 A PT7807584 A PT 7807584A PT 78075 B PT78075 B PT 78075B
Authority
PT
Portugal
Prior art keywords
benzazepin
aminopentyl
amino
preparing
alkanoic acids
Prior art date
Application number
PT78075A
Other languages
English (en)
Portuguese (pt)
Other versions
PT78075A (en
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of PT78075A publication Critical patent/PT78075A/pt
Publication of PT78075B publication Critical patent/PT78075B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
PT78075A 1983-02-10 1984-02-08 Process for preparing 3-(5-aminopentyl)-amino-1-benzazepin-2-one-1-alkanoic acids PT78075B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/465,695 US4473575A (en) 1982-07-19 1983-02-10 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids

Publications (2)

Publication Number Publication Date
PT78075A PT78075A (en) 1984-03-01
PT78075B true PT78075B (en) 1986-06-11

Family

ID=23848805

Family Applications (1)

Application Number Title Priority Date Filing Date
PT78075A PT78075B (en) 1983-02-10 1984-02-08 Process for preparing 3-(5-aminopentyl)-amino-1-benzazepin-2-one-1-alkanoic acids

Country Status (24)

Country Link
US (1) US4473575A (zh-CN)
EP (2) EP0119955B1 (zh-CN)
JP (2) JPS59172473A (zh-CN)
KR (1) KR900009023B1 (zh-CN)
AR (8) AR242564A1 (zh-CN)
AT (2) ATE50989T1 (zh-CN)
AU (1) AU574061B2 (zh-CN)
CA (2) CA1218993A (zh-CN)
CY (1) CY1674A (zh-CN)
DD (1) DD218359A5 (zh-CN)
DE (2) DE3481612D1 (zh-CN)
DK (2) DK58184A (zh-CN)
ES (10) ES8707216A1 (zh-CN)
FI (1) FI77857C (zh-CN)
GR (1) GR79809B (zh-CN)
HK (1) HK97592A (zh-CN)
HU (1) HU192394B (zh-CN)
IE (1) IE56858B1 (zh-CN)
IL (1) IL70881A (zh-CN)
NO (1) NO166232C (zh-CN)
NZ (1) NZ207091A (zh-CN)
PT (1) PT78075B (zh-CN)
SG (1) SG94992G (zh-CN)
ZA (1) ZA84958B (zh-CN)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4473575A (en) * 1982-07-19 1984-09-25 Ciba-Geigy Corporation 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
US4575503A (en) * 1983-02-10 1986-03-11 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4537885A (en) * 1983-02-10 1985-08-27 Ciba Geigy Corporation Certain benzazocinone and benzazoninone derivatives
US4600534A (en) * 1984-02-06 1986-07-15 Ciba-Geigy Corporation Process and intermediates for manufacture of 3-(5-amino-1-carboxypentylamino)-tetrahydro-1-benzazepin-2-one-1-acetic acid
EP0166357A3 (en) * 1984-06-26 1988-10-26 Merck & Co. Inc. Benzofused lactams and pharmaceutical compositions containing them
EP0166354B1 (en) * 1984-06-26 1992-08-05 Merck & Co. Inc. Benzofused lactam compounds and pharmaceutical compositions containing them
US4692522A (en) * 1985-04-01 1987-09-08 Merck & Co., Inc. Benzofused lactams useful as cholecystokinin antagonists
US4785089A (en) * 1985-06-13 1988-11-15 Ciba-Geigy Corporation Novel sulfonic acid esters and their preparation
EP0237267B1 (en) * 1986-03-11 1991-01-23 Barry Anthony Thompson Feeding livestock with polymers
AT399717B (de) * 1986-05-28 1995-07-25 Ciba Geigy Ag Verfahren zur herstellung von (2,5-dihydro-2-oxo- 5-phenyl-3-furanyl)aminen
US4918187A (en) * 1986-05-28 1990-04-17 Ciba-Geigy Corporation [2,5-Dihydro 5-phenyl-2-oxo-3-furanyl]amines
US5028704A (en) * 1986-05-28 1991-07-02 Ciba-Geigy Corporation (2,5-dihydro 5-phenyl-2-oxo-3-furanyl)amines, methods of manufacture, and use thereof in the production of angiotensin converting enzyme inhibitors
FI88723C (fi) * 1986-05-28 1993-06-28 Ciba Geigy Ag /2,5-dihydro-2-oxo-5-fenyl-3-furanyl/aminer samt deras anvaendning vid framstaellning av ACE-inhibitorer
US4962105A (en) * 1987-10-19 1990-10-09 Ciba-Geigy Corporation Potentiation of antihypertensive effect of ace inhibitors
JPH07116224B2 (ja) * 1987-12-29 1995-12-13 吉富製薬株式会社 ベンゾラクタム化合物
GB9100028D0 (en) * 1991-01-02 1991-02-20 Ici Plc Compounds
US5428031A (en) * 1991-12-03 1995-06-27 Merck & Co., Inc. Methods of treating cardiac arrhythmia
US5646276A (en) * 1992-05-13 1997-07-08 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
RU2124503C1 (ru) 1992-05-18 1999-01-10 И.Р.Сквибб энд Санз, Инк. Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция
GB9212308D0 (en) * 1992-06-10 1992-07-22 Ici Plc Therapeutic compositions
GB9311948D0 (en) * 1993-06-10 1993-07-28 Zeneca Ltd Substituted nitrogen heterocycles
ES2162907T3 (es) * 1993-11-22 2002-01-16 Merck & Co Inc 3-acilaminobenzacepinas.
US5801168A (en) * 1994-06-09 1998-09-01 Zeneca Limited Substituted nitrogen heterocycles
US5658901A (en) * 1994-08-18 1997-08-19 Merck & Co., Inc. 2,3-dihydro-1-(2,2,2,-trifluoroethyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepines
US5587375A (en) * 1995-02-17 1996-12-24 Bristol-Myers Squibb Company Azepinone compounds useful in the inhibition of ACE and NEP
US5877313A (en) 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5726171A (en) * 1995-06-07 1998-03-10 Merck & Co Inc N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo B! 1,4!diazepin-3yl)-acetamides
US5700797A (en) * 1995-06-07 1997-12-23 Merck & Co, Inc. N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides
US5635504A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
US5650408A (en) * 1995-06-07 1997-07-22 Karanewsky; Donald S. Thiazolo benzazepine containing dual action inhibitors
US5691331A (en) * 1995-06-07 1997-11-25 Merck & Co., Inc. N-(2,4-Dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3yl) -3- amides
US5631251A (en) * 1995-06-07 1997-05-20 Merck & Co., Inc. 5-cyclopropyl-1,4 benzodiazepine-2-ones
WO1996040656A1 (en) * 1995-06-07 1996-12-19 Merck & Co., Inc. Novel n-(2,4-dioxo-2,3,4,5-tetrahydro-1h-1,5-benzodiazepin-3yl)-3-amides
US6211235B1 (en) 1996-11-22 2001-04-03 Elan Pharmaceuticals, Inc. Compounds for inhibiting β-amyloid peptide release and/or its synthesis
US6191166B1 (en) * 1997-11-21 2001-02-20 Elan Pharmaceuticals, Inc. Methods and compounds for inhibiting β-amyloid peptide release and/or its synthesis
US6635632B1 (en) 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6683075B1 (en) 1996-12-23 2004-01-27 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use
JP2002241368A (ja) * 1997-02-18 2002-08-28 Shionogi & Co Ltd 新規ベンゾラクタム誘導体およびそれを含有する医薬組成物
WO1998041510A1 (fr) * 1997-03-14 1998-09-24 Shionogi & Co., Ltd. Nouveaux derives du benzolactame et compositions medicamenteuses les contenant
US6509331B1 (en) 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6774125B2 (en) * 1998-06-22 2004-08-10 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6528505B1 (en) 1998-06-22 2003-03-04 Elan Pharmaceuticals, Inc. Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6569851B1 (en) * 1998-06-22 2003-05-27 Elan Pharmaceutials, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6552013B1 (en) 1998-06-22 2003-04-22 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
EP1229913A4 (en) * 1999-11-18 2005-01-19 Antexpharma Inc SUBSTITUTED 1-BENZAZEPINE AND THEIR DERIVATIVES
US7795468B2 (en) * 2001-01-19 2010-09-14 Chevron U.S.A. Inc. Functionalized higher diamondoids
WO2003043624A1 (en) * 2001-11-16 2003-05-30 Bristol-Myers Squibb Company Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein
US20050192265A1 (en) * 2003-03-20 2005-09-01 Thompson Richard C. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
US20050203168A1 (en) * 2004-03-11 2005-09-15 The Regents Of The University Of Michigan Angiotensin converting enzyme inhibitor use for treatment and prevention of gastrointestinal disorders
US8080579B2 (en) * 2005-10-03 2011-12-20 The Regents Of The University Of Michigan Compositions and methods for treatment of inflammatory bowel disease
US7592461B2 (en) 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US20070238770A1 (en) * 2006-04-05 2007-10-11 Bristol-Myers Squibb Company Process for preparing novel crystalline forms of peliglitazar, novel stable forms produced therein and formulations
US7968577B2 (en) 2006-11-01 2011-06-28 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
JP2010508358A (ja) 2006-11-01 2010-03-18 ブリストル−マイヤーズ スクイブ カンパニー グルココルチコイド受容体、ＡＰ−１、および／またはＮＦ−κＢ活性の調節剤、並びにその使用
US20100120694A1 (en) 2008-06-04 2010-05-13 Synergy Pharmaceuticals, Inc. Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
CA3089569C (en) 2007-06-04 2023-12-05 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US7828840B2 (en) * 2007-11-15 2010-11-09 Med Institute, Inc. Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists
JP2011525537A (ja) 2008-06-24 2011-09-22 ブリストル−マイヤーズ スクイブ カンパニー グルココルチコイド受容体、ＡＰ−１、および／またはＮＦ−κＢ活性のシクロペンタチオフェン調節剤およびその使用
EP2321341B1 (en) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
JP2016514670A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
RS65632B1 (sr) 2013-06-05 2024-07-31 Bausch Health Ireland Ltd Ultra-prečišćeni agonisti guanilat-ciklaze c, postupak njihove pripreme i upotrebe
US9593113B2 (en) 2013-08-22 2017-03-14 Bristol-Myers Squibb Company Imide and acylurea derivatives as modulators of the glucocorticoid receptor

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3330823A (en) * 1964-12-16 1967-07-11 Squibb & Sons Inc N-amino-loweralkylene-benzo-lactams
US3395150A (en) * 1965-02-26 1968-07-30 Squibb & Sons Inc Benzothiazepine carboxamides and derivatives thereof
GB1305278A (zh-CN) * 1970-03-12 1973-01-31
JPS5129522B2 (zh-CN) * 1972-07-13 1976-08-26
JPS5520970B2 (zh-CN) * 1972-07-15 1980-06-06
FR2358151A1 (fr) * 1976-03-31 1978-02-10 Roussel Uclaf Nouvelles benzazepines et leurs sels, procede de preparation et application a titre de medicaments
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4377515A (en) * 1979-10-01 1983-03-22 Merck & Co., Inc. Long lasting agonists and antagonists of LH-RH
GR74635B (zh-CN) * 1980-08-18 1984-06-29 Merck & Co Inc
US4409146A (en) * 1980-10-06 1983-10-11 Merck & Co., Inc. Substituted caprolactam derivatives as antihypertensives
IN156096B (zh-CN) * 1981-03-19 1985-05-11 Usv Pharma Corp
US4415496A (en) * 1981-03-23 1983-11-15 Merck & Co., Inc. Bicyclic lactams
EP0072352B1 (de) * 1981-08-11 1986-03-05 Ciba-Geigy Ag Benzazepin-2-one, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese Verbindungen enthalten, sowie die Verbindungen zur therapeutischen Verwendung
ZA825779B (en) * 1981-08-11 1984-04-25 Ciba Geigy Ag Benzazepins-2-ones
US4410520A (en) * 1981-11-09 1983-10-18 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4473575A (en) * 1982-07-19 1984-09-25 Ciba-Geigy Corporation 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
EP0107095B1 (en) * 1982-09-30 1987-09-09 Merck & Co. Inc. 1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents

Also Published As

Publication number Publication date
NO166232C (no) 1991-06-19
CA1225397A (en) 1987-08-11
DE3480705D1 (de) 1990-01-18
ES8609262A1 (es) 1986-09-01
KR900009023B1 (ko) 1990-12-17
EP0119955A3 (en) 1986-06-11
DK58284D0 (da) 1984-02-09
PT78075A (en) 1984-03-01
AR243163A1 (es) 1993-07-30
ES8703859A1 (es) 1987-03-01
ES529594A0 (es) 1986-07-16
ES544258A0 (es) 1986-09-01
ES8702363A1 (es) 1987-01-01
AU574061B2 (en) 1988-06-30
DK58184D0 (da) 1984-02-09
IE56858B1 (en) 1992-01-01
HU192394B (en) 1987-06-29
JPH0421665B2 (zh-CN) 1992-04-13
GR79809B (zh-CN) 1984-10-31
KR840007722A (ko) 1984-12-10
JPS59172473A (ja) 1984-09-29
ES544256A0 (es) 1987-05-01
AR242564A1 (es) 1993-04-30
AR243165A1 (es) 1993-07-30
AU2443084A (en) 1984-08-16
AR243162A1 (es) 1993-07-30
NO840487L (no) 1984-08-13
ES544255A0 (es) 1986-09-01
ES544127A0 (es) 1987-01-01
ES8609261A1 (es) 1986-07-16
FI77857C (fi) 1989-05-10
ES544254A0 (es) 1987-03-01
US4473575A (en) 1984-09-25
JPS59172475A (ja) 1984-09-29
HK97592A (en) 1992-12-11
ES544257A0 (es) 1986-09-01
ES529595A0 (es) 1987-07-16
DD218359A5 (de) 1985-02-06
ES8609265A1 (es) 1986-09-01
NO166232B (no) 1991-03-11
DK58184A (da) 1984-08-11
EP0119955A2 (de) 1984-09-26
CY1674A (en) 1993-10-10
ATE50989T1 (de) 1990-03-15
EP0119955B1 (de) 1989-12-13
EP0119954B1 (de) 1990-03-14
ES8609263A1 (es) 1986-09-01
ES8707216A1 (es) 1987-07-16
DK171257B1 (da) 1996-08-12
DE3481612D1 (de) 1990-04-19
ES8705409A1 (es) 1987-05-01
ES544260A0 (es) 1986-09-01
AR242190A1 (es) 1993-03-31
FI840513A (fi) 1984-08-11
DK58284A (da) 1984-08-11
EP0119954A3 (en) 1986-06-11
IL70881A0 (en) 1984-05-31
AR242191A1 (es) 1993-03-31
IL70881A (en) 1987-10-30
SG94992G (en) 1992-12-04
NZ207091A (en) 1985-11-08
ES8700239A1 (es) 1986-10-16
FI840513A0 (fi) 1984-02-08
FI77857B (fi) 1989-01-31
AR243164A1 (es) 1993-07-30
AR243161A1 (es) 1993-07-30
EP0119954A2 (de) 1984-09-26
ES544259A0 (es) 1986-10-16
ES8609264A1 (es) 1986-09-01
ATE48598T1 (de) 1989-12-15
IE840302L (en) 1984-08-10
CA1218993A (en) 1987-03-10
ZA84958B (en) 1984-09-26
JPH0460108B2 (zh-CN) 1992-09-25

Similar Documents

Publication Publication Date Title
PT78075A (en) Process for preparing 3-(5-aminopentyl)-amino-1-benzazepin-2-one-1-alkanoic acids
PT79287A (en) Process for preparing carboxyalkenamidocephalosporins
HUT34467A (en) Process for preparing substituted indeno-pyridazinones
DE3472249D1 (en) Process for preparing di-amino-polyalkenyl-ethers
PL250044A1 (en) Process for preparing novel polypeptydes
PT78292B (en) Process for preparing benzoquinolizines
HUT34434A (en) New process for preparing aspertame
PT78734B (en) Process for preparing thiazolo-and thiazinobenzimidazoles
DE3469524D1 (en) Process for preparing 2-alkyl-4-amino-5-aminomethylpyrimidine
HU35634A (en) Process for preparing cyanohydrines
DE3360014D1 (en) Process for preparing 2-methoxyalkanoic acids
IL72092A0 (en) Process for preparing 3-substituted-3-aminonitrile
PL242191A2 (en) Process for preparing 1-aminoalkanophosphonic acids
PL244702A1 (en) Process for preparing novel n-aminosalicylophosphonic acids
DE3362454D1 (en) Process for preparing 1-hydroxy-alkane-1-phosphonic acids
DE3470316D1 (en) Process for preparing 6-fluorine-steroids
ZA843320B (en) Process for preparing aminoalkylureas
PT78789B (en) Process for preparing oxazolyl-substituted diazaheterocycles
PL246667A1 (en) Process for preparing lineatine
PT77656A (en) Process for preparing an oral product for controlling gingivits
PL242192A2 (en) Process for preparing 1-aminoalkanophosphonic acids
PL242178A2 (en) Process for preparing 1-aminoalkanophosphonic acids
PL240060A2 (en) Process for preparing alpha-amino-omega-phosphonocarboxylic acids
PL242193A2 (en) Process for preparing 1-aminoalkanophosphonic acids
DE3463656D1 (en) Process for preparing 1-dimethylaminomethyl-triazolobenzodiazepines

Legal Events

Date Code Title Description
PC3A Transfer or assignment

Free format text: 970618 NOVARTIS AG CH

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19981231