PT765389E - Novos sistemas celulares tendo interaccao especifica de pares de peptidicos que se ligam mutuamente - Google Patents

Novos sistemas celulares tendo interaccao especifica de pares de peptidicos que se ligam mutuamente

Info

Publication number
PT765389E
PT765389E PT95920689T PT95920689T PT765389E PT 765389 E PT765389 E PT 765389E PT 95920689 T PT95920689 T PT 95920689T PT 95920689 T PT95920689 T PT 95920689T PT 765389 E PT765389 E PT 765389E
Authority
PT
Portugal
Prior art keywords
peptide
transcriptional activation
fusion protein
protein
host cell
Prior art date
Application number
PT95920689T
Other languages
English (en)
Inventor
Kathleen H Young
Bradley A Ozenberger
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PT765389E publication Critical patent/PT765389E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Mobile Radio Communication Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT95920689T 1994-06-14 1995-05-31 Novos sistemas celulares tendo interaccao especifica de pares de peptidicos que se ligam mutuamente PT765389E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/259,609 US5989808A (en) 1994-06-14 1994-06-14 Identification of compounds affecting specific interaction of peptide binding pairs

Publications (1)

Publication Number Publication Date
PT765389E true PT765389E (pt) 2003-11-28

Family

ID=22985626

Family Applications (1)

Application Number Title Priority Date Filing Date
PT95920689T PT765389E (pt) 1994-06-14 1995-05-31 Novos sistemas celulares tendo interaccao especifica de pares de peptidicos que se ligam mutuamente

Country Status (18)

Country Link
US (3) US5989808A (pt)
EP (1) EP0765389B1 (pt)
AT (1) ATE245189T1 (pt)
AU (1) AU706173B2 (pt)
CA (1) CA2195083A1 (pt)
DE (1) DE69531302T2 (pt)
DK (1) DK0765389T3 (pt)
ES (1) ES2202366T3 (pt)
GE (1) GEP20022619B (pt)
IL (1) IL114118A0 (pt)
LT (1) LT4230B (pt)
LV (1) LV11906B (pt)
NZ (1) NZ287372A (pt)
PT (1) PT765389E (pt)
RU (1) RU2208646C2 (pt)
SI (1) SI9520073B (pt)
WO (1) WO1995034646A1 (pt)
ZA (1) ZA954892B (pt)

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US7226761B2 (en) * 1992-11-05 2007-06-05 Danisco Sweeteners Oy Manufacture of five-carbon sugars and sugar alcohols
US6972193B1 (en) * 1993-02-12 2005-12-06 Board Of Trustees Of Leland Stanford Junior University Regulated transcription of targeted genes and other biological events
US6891021B2 (en) 1993-02-12 2005-05-10 Board Of Trustees Of The Leland Stanford Junior University Regulated apoptosis
US6770446B1 (en) * 1994-06-14 2004-08-03 Wyeth Cell systems having specific interaction of peptide binding pairs
US5610015A (en) * 1995-03-23 1997-03-11 Wisconsin Alumni Research Foundation System to detect protein-RNA interactions
DE69636866D1 (en) * 1995-04-11 2007-03-15 Gen Hospital Corp Reverse "two-hybrid"-systeme
US5837844A (en) * 1995-06-07 1998-11-17 Biogen, Inc. CAIP-like gene family
US6423824B1 (en) 1995-06-07 2002-07-23 Biogen, Inc. CAIP-like gene family
US6171800B1 (en) 1995-06-07 2001-01-09 Biogen, Inc. Method of making and binding CAIP polypeptides
DE29724617U1 (de) * 1996-04-26 2002-06-13 Massachusetts Inst Technology Drei-Hybrid-Kit zur Molekülauswahl
DE69715621T2 (de) * 1996-04-26 2003-05-22 Massachusetts Inst Technology Drei hybriden screening test
US6696251B1 (en) 1996-05-31 2004-02-24 Board Of Trustees Of The University Of Illinois Yeast cell surface display of proteins and uses thereof
AU6342696A (en) * 1996-06-27 1998-01-14 Biogen, Inc. The caip-like gene family
FR2761697B1 (fr) * 1997-04-03 1999-05-28 Inst Nat Sante Rech Med Methodes de detection d'interactions entre plusieurs proteines
DE19715683C2 (de) * 1997-04-15 1999-11-11 Max Planck Gesellschaft Neue Reportervektoren für One-Hybrid und Two-Hybrid Systeme
US7005295B1 (en) 1997-04-16 2006-02-28 Wyeth β-amyloid peptide-binding proteins and polynucleotides encoding the same
US6787319B2 (en) 1997-04-16 2004-09-07 American Home Products Corp. β-amyloid peptide-binding proteins and polynucleotides encoding the same
AU6969998A (en) 1997-04-25 1998-11-24 American Home Products Corporation Neuronal mort1 isoforms
US6479653B1 (en) 1997-08-26 2002-11-12 Ariad Gene Therapeutics, Inc. Compositions and method for regulation of transcription
JP4296608B2 (ja) * 1997-08-27 2009-07-15 田辺三菱製薬株式会社 Ｐｐａｒのアゴニスト及びアンタゴニストのスクリーニング方法
EP1149920A1 (en) * 1997-10-15 2001-10-31 Diversa, Inc. Screening for novel compounds which regulate biological interactions
EP1029076A4 (en) * 1997-10-15 2002-03-06 Diversa Inc SCREENING FOR NEW CONNECTIONS THAT REGULATE BIOLOGICAL INTERACTIONS
US6261842B1 (en) 1997-10-23 2001-07-17 Wisconsin Alumni Research Foundation Microorganism genomics, compositions and methods related thereto
CA2309763A1 (en) * 1997-11-14 1999-05-27 Roche Diagnostics Corporation Variable region fusion peptides that form effector complexes in the presence of antigen
CA2317816C (en) 1998-01-09 2009-02-17 Tvw Telethon Institute For Child Health Research Peptide detection method
EP0974649A1 (en) * 1998-06-22 2000-01-26 Universität Zürich Screening system
US7166475B2 (en) 1999-02-26 2007-01-23 Cyclacel Ltd. Compositions and methods for monitoring the modification state of a pair of polypeptides
GB9907687D0 (en) * 1999-04-01 1999-05-26 Kudos Pharm Ltd Assays methods and means
JP2002541863A (ja) 1999-04-21 2002-12-10 ワイス Ｎ−型イオンチャンネル不活性化のモジュレーターを同定する方法
BR0110214A (pt) * 2000-04-24 2003-01-21 Wyeth Corp Célula de levedura e métodos de detecção da interação de um primeiro peptìdio com um segundo peptìdio de um par de ligação de peptìdios, de determinação da interação de uma amostra de teste com um primeiro ou um segundo peptìdios de um par de ligação de peptìdios e de detecção simultânea da interação de dois pares de ligação de peptìdios diferentes
CN1564869A (zh) 2000-08-25 2005-01-12 巴斯福种植科学有限公司 编码新型异戊二烯基蛋白酶的植物多核苷酸
WO2002046400A2 (en) * 2000-12-08 2002-06-13 The Board Of Trustees Of The University Of Illinois Mutated class ii major histocompatibility proteins
EP1534819B1 (en) 2002-08-21 2009-12-09 Revivicor, Inc. Porcine animals lacking any expression of functional alpha 1,3 galactosyltransferase
US9453251B2 (en) 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
US7285269B2 (en) 2002-12-02 2007-10-23 Amgen Fremont, Inc. Antibodies directed to tumor necrosis factor
WO2005049804A2 (en) * 2003-11-17 2005-06-02 Georgia Tech Research Corporation Engineering enzymes through genetic selection
EP1544307A1 (en) * 2003-12-18 2005-06-22 AXXAM S.r.l. LAC9 chimeric receptor and uses thereof
EP2412816B1 (en) 2004-07-26 2014-12-03 Pfenex Inc. Process for improved protein expression by strain engineering
EP3138403A1 (en) 2005-08-09 2017-03-08 Revivicor, Inc. Transgenic ungulates expressing ctla4-ig and uses thereof
CN101365945A (zh) * 2006-02-07 2009-02-11 惠氏公司 用于鉴别调节诺里蛋白、诺里蛋白模拟物的药剂的物质和方法以及由此鉴别出的药剂
US9580719B2 (en) 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
MX2009011523A (es) 2007-04-27 2009-11-09 Dow Global Technologies Inc Metodo para clasificar rapidamente huespedes microbianos para identificar ciertas cepas con rendimiento y/o calidad mejorados en la expresion de proteinas heterologas.
CN101131363B (zh) * 2007-09-30 2010-12-01 南京大学 一种基于酵母三杂交的小分子化合物检测方法
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US5283173A (en) * 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
US5322801A (en) * 1990-04-19 1994-06-21 The General Hospital Corporation Protein partner screening assays and uses thereof
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US5512473A (en) * 1993-01-29 1996-04-30 Brent; Roger Max-interacting proteins and related molecules and methods
US5582995A (en) * 1993-06-11 1996-12-10 The General Hospital Corporation Methods of screening for compounds which inhibit the direct binding of Ras to Raf
CA2180271A1 (en) * 1993-12-30 1995-07-06 Ronald M. Evans Novel uses for gal4-receptor constructs
ES2146749T3 (es) * 1994-01-21 2000-08-16 Icos Corp Materiales y metodos en relacion con proteinas que interaccionan con la caseina quinasa i.
US5525490A (en) * 1994-03-29 1996-06-11 Onyx Pharmaceuticals, Inc. Reverse two-hybrid method
US5691147A (en) * 1994-06-02 1997-11-25 Mitotix, Inc. CDK4 binding assay

Also Published As

Publication number Publication date
ES2202366T3 (es) 2004-04-01
DE69531302D1 (de) 2003-08-21
IL114118A0 (en) 1995-10-31
EP0765389B1 (en) 2003-07-16
LV11906B (en) 1998-06-20
RU2208646C2 (ru) 2003-07-20
LT97004A (en) 1997-07-25
SI9520073A (sl) 1998-02-28
DE69531302T2 (de) 2004-04-22
SI9520073B (sl) 2004-06-30
AU706173B2 (en) 1999-06-10
US6284519B1 (en) 2001-09-04
GEP20022619B (en) 2002-01-25
LV11906A (lv) 1997-12-20
US6251602B1 (en) 2001-06-26
NZ287372A (en) 1997-11-24
ZA954892B (en) 1996-01-30
CA2195083A1 (en) 1995-12-21
WO1995034646A1 (en) 1995-12-21
AU2606695A (en) 1996-01-05
US5989808A (en) 1999-11-23
EP0765389A1 (en) 1997-04-02
ATE245189T1 (de) 2003-08-15
LT4230B (en) 1997-10-27
DK0765389T3 (da) 2003-10-27

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