LT4230B - Novel cell systems having specific interaction of peptide binding pairs - Google Patents

Novel cell systems having specific interaction of peptide binding pairs Download PDF

Info

Publication number
LT4230B
LT4230B LT97-004A LT97004A LT4230B LT 4230 B LT4230 B LT 4230B LT 97004 A LT97004 A LT 97004A LT 4230 B LT4230 B LT 4230B
Authority
LT
Lithuania
Prior art keywords
peptide
host cell
cell
protein
binding
Prior art date
Application number
LT97-004A
Other languages
English (en)
Lithuanian (lt)
Other versions
LT97004A (en
Inventor
Kathleen H Young
Bradley A Ozenberger
Original Assignee
American Cyanamid Company A Ma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Company A Ma filed Critical American Cyanamid Company A Ma
Publication of LT97004A publication Critical patent/LT97004A/xx
Publication of LT4230B publication Critical patent/LT4230B/lt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72Receptors; Cell surface antigens; Cell surface determinants for hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/61Growth hormone [GH], i.e. somatotropin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Mobile Radio Communication Systems (AREA)
LT97-004A 1994-06-14 1997-01-13 Novel cell systems having specific interaction of peptide binding pairs LT4230B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/259,609 US5989808A (en) 1994-06-14 1994-06-14 Identification of compounds affecting specific interaction of peptide binding pairs

Publications (2)

Publication Number Publication Date
LT97004A LT97004A (en) 1997-07-25
LT4230B true LT4230B (en) 1997-10-27

Family

ID=22985626

Family Applications (1)

Application Number Title Priority Date Filing Date
LT97-004A LT4230B (en) 1994-06-14 1997-01-13 Novel cell systems having specific interaction of peptide binding pairs

Country Status (18)

Country Link
US (3) US5989808A (pt)
EP (1) EP0765389B1 (pt)
AT (1) ATE245189T1 (pt)
AU (1) AU706173B2 (pt)
CA (1) CA2195083A1 (pt)
DE (1) DE69531302T2 (pt)
DK (1) DK0765389T3 (pt)
ES (1) ES2202366T3 (pt)
GE (1) GEP20022619B (pt)
IL (1) IL114118A0 (pt)
LT (1) LT4230B (pt)
LV (1) LV11906B (pt)
NZ (1) NZ287372A (pt)
PT (1) PT765389E (pt)
RU (1) RU2208646C2 (pt)
SI (1) SI9520073B (pt)
WO (1) WO1995034646A1 (pt)
ZA (1) ZA954892B (pt)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7226761B2 (en) * 1992-11-05 2007-06-05 Danisco Sweeteners Oy Manufacture of five-carbon sugars and sugar alcohols
US6891021B2 (en) 1993-02-12 2005-05-10 Board Of Trustees Of The Leland Stanford Junior University Regulated apoptosis
US6972193B1 (en) * 1993-02-12 2005-12-06 Board Of Trustees Of Leland Stanford Junior University Regulated transcription of targeted genes and other biological events
US6770446B1 (en) * 1994-06-14 2004-08-03 Wyeth Cell systems having specific interaction of peptide binding pairs
US5610015A (en) * 1995-03-23 1997-03-11 Wisconsin Alumni Research Foundation System to detect protein-RNA interactions
AU716893B2 (en) * 1995-04-11 2000-03-09 General Hospital Corporation, The Reverse two-hybrid systems
US5837844A (en) * 1995-06-07 1998-11-17 Biogen, Inc. CAIP-like gene family
US6423824B1 (en) 1995-06-07 2002-07-23 Biogen, Inc. CAIP-like gene family
US6171800B1 (en) 1995-06-07 2001-01-09 Biogen, Inc. Method of making and binding CAIP polypeptides
CA2252886C (en) * 1996-04-26 2008-02-12 Massachusetts Institute Of Technology Three-hybrid screening assay
EP1241265A3 (en) * 1996-04-26 2004-02-18 Massachusetts Institute Of Technology Screening assay for small ligands
US6696251B1 (en) 1996-05-31 2004-02-24 Board Of Trustees Of The University Of Illinois Yeast cell surface display of proteins and uses thereof
WO1997049808A1 (en) * 1996-06-27 1997-12-31 Biogen, Inc. The caip-like gene family
FR2761697B1 (fr) * 1997-04-03 1999-05-28 Inst Nat Sante Rech Med Methodes de detection d'interactions entre plusieurs proteines
DE19715683C2 (de) * 1997-04-15 1999-11-11 Max Planck Gesellschaft Neue Reportervektoren für One-Hybrid und Two-Hybrid Systeme
US7005295B1 (en) 1997-04-16 2006-02-28 Wyeth β-amyloid peptide-binding proteins and polynucleotides encoding the same
US6787319B2 (en) 1997-04-16 2004-09-07 American Home Products Corp. β-amyloid peptide-binding proteins and polynucleotides encoding the same
EP0977846B1 (en) 1997-04-25 2002-06-19 Wyeth Neuronal mort1 isoforms
US6479653B1 (en) 1997-08-26 2002-11-12 Ariad Gene Therapeutics, Inc. Compositions and method for regulation of transcription
JP4296608B2 (ja) * 1997-08-27 2009-07-15 田辺三菱製薬株式会社 Pparのアゴニスト及びアンタゴニストのスクリーニング方法
EP1029076A4 (en) * 1997-10-15 2002-03-06 Diversa Inc SCREENING FOR NEW CONNECTIONS THAT REGULATE BIOLOGICAL INTERACTIONS
EP1149920A1 (en) * 1997-10-15 2001-10-31 Diversa, Inc. Screening for novel compounds which regulate biological interactions
US6261842B1 (en) 1997-10-23 2001-07-17 Wisconsin Alumni Research Foundation Microorganism genomics, compositions and methods related thereto
CA2309763A1 (en) * 1997-11-14 1999-05-27 Roche Diagnostics Corporation Variable region fusion peptides that form effector complexes in the presence of antigen
AU735887B2 (en) 1998-01-09 2001-07-19 Phylogica Limited Peptide detection method
EP0974649A1 (en) 1998-06-22 2000-01-26 Universität Zürich Screening system
US7166475B2 (en) 1999-02-26 2007-01-23 Cyclacel Ltd. Compositions and methods for monitoring the modification state of a pair of polypeptides
GB9907687D0 (en) * 1999-04-01 1999-05-26 Kudos Pharm Ltd Assays methods and means
CA2370615A1 (en) 1999-04-21 2000-10-26 American Home Products Corporation Methods for identifying modulators of n-type ion channel inactivation
CA2407382A1 (en) * 2000-04-24 2001-11-01 Wyeth Novel cell systems having specific interaction of peptide binding pairs
US20040219525A1 (en) 2000-08-25 2004-11-04 Heiko Haertel Plant polynucleotides encoding novel prenyl proteases
WO2002046400A2 (en) * 2000-12-08 2002-06-13 The Board Of Trustees Of The University Of Illinois Mutated class ii major histocompatibility proteins
NZ562736A (en) 2002-08-21 2009-07-31 Revivicor Inc Porcine animals lacking any expression of functional alpha 1,3 galactosyltransferase
US9453251B2 (en) 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
WO2004050683A2 (en) 2002-12-02 2004-06-17 Abgenix, Inc. Antibodies directed to tumor necrosis factor and uses thereof
US20070298414A1 (en) * 2003-11-17 2007-12-27 Doyle Donald F Engineering Enzymes Through Genetic Selection
EP1544307A1 (en) * 2003-12-18 2005-06-22 AXXAM S.r.l. LAC9 chimeric receptor and uses thereof
AU2005269527B2 (en) 2004-07-26 2011-12-01 Pfenex Inc. Process for improved protein expression by strain engineering
CA2909775A1 (en) 2005-08-09 2007-03-29 Revivicor, Inc. Transgenic ungulates expressing ctla4-ig and uses thereof
WO2007092487A2 (en) * 2006-02-07 2007-08-16 Wyeth Materials and methods for identifying agents that modulate norrin. norrin mimetics, and agents identified thereby
US9580719B2 (en) 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
CA2685326A1 (en) 2007-04-27 2008-11-06 Dow Global Technologies Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
CN101131363B (zh) * 2007-09-30 2010-12-01 南京大学 一种基于酵母三杂交的小分子化合物检测方法
WO2016154452A2 (en) 2015-03-24 2016-09-29 Osiris Therapeutics, Inc. Compositions comprising meniscal tissues and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5283173A (en) * 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
US5322801A (en) * 1990-04-19 1994-06-21 The General Hospital Corporation Protein partner screening assays and uses thereof
EP1362913B1 (en) * 1992-10-30 2006-01-25 The General Hospital Corporation Interaction trap system for isolating proteins
US5512473A (en) * 1993-01-29 1996-04-30 Brent; Roger Max-interacting proteins and related molecules and methods
US5582995A (en) * 1993-06-11 1996-12-10 The General Hospital Corporation Methods of screening for compounds which inhibit the direct binding of Ras to Raf
JPH09504111A (ja) * 1993-12-30 1997-04-22 ザ ソールク インスチチュート フォア バイオロジカル スタディズ Gal4−受容体構築体の新規な使用
JP3468523B2 (ja) * 1994-01-21 2003-11-17 イコス コーポレイション ガゼインキナーゼ▲i▼と相互作用するタンパク質に関連する方法および物質
US5525490A (en) * 1994-03-29 1996-06-11 Onyx Pharmaceuticals, Inc. Reverse two-hybrid method
US5691147A (en) * 1994-06-02 1997-11-25 Mitotix, Inc. CDK4 binding assay

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CUNNINGHAM, B. C. ET AL.: "Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule", SCIENCE, 1991, pages 821 - 825, XP000261650, DOI: doi:10.1126/science.1948064
LI JJ, HERSKOWITZ I.: "Isolation of ORC6, a component of the yeast origin recognition complex by a one-hybrid system", SCIENCE., 1993
S DAVIS ET AL.: "LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor", SCIENCE, 1993, pages 1805 - 1808
STATEN NR ET AL.: "Ligandspecific dimerization of the extracellular domain of the bovine growth hormone receptor.", J. BIOL. CHEM., 1993, pages 18 - 467

Also Published As

Publication number Publication date
IL114118A0 (en) 1995-10-31
DE69531302T2 (de) 2004-04-22
WO1995034646A1 (en) 1995-12-21
DK0765389T3 (da) 2003-10-27
US6251602B1 (en) 2001-06-26
ES2202366T3 (es) 2004-04-01
GEP20022619B (en) 2002-01-25
LV11906A (lv) 1997-12-20
ATE245189T1 (de) 2003-08-15
LT97004A (en) 1997-07-25
US6284519B1 (en) 2001-09-04
DE69531302D1 (de) 2003-08-21
AU2606695A (en) 1996-01-05
AU706173B2 (en) 1999-06-10
NZ287372A (en) 1997-11-24
US5989808A (en) 1999-11-23
RU2208646C2 (ru) 2003-07-20
PT765389E (pt) 2003-11-28
ZA954892B (en) 1996-01-30
CA2195083A1 (en) 1995-12-21
EP0765389B1 (en) 2003-07-16
SI9520073B (sl) 2004-06-30
EP0765389A1 (en) 1997-04-02
SI9520073A (sl) 1998-02-28
LV11906B (en) 1998-06-20

Similar Documents

Publication Publication Date Title
LT4230B (en) Novel cell systems having specific interaction of peptide binding pairs
Young Yeast two-hybrid: so many interactions,(in) so little time…
EP0371820B1 (en) Novel receptors: their identification, characterization, preparation and use
Starr et al. Intracellular receptors use a common mechanism to interpret signaling information at response elements.
Miesfeld The Structure and Function of Steroid Receptor Protein
US7122305B2 (en) Methods and compositions for identifying receptor effectors
EP0907886A1 (en) Retinoid x receptors and components of the basal transcription machinery
US7319009B2 (en) Methods and compositions for identifying receptor effectors
JP2004000282A (ja) 酵母におけるgタンパク質結合受容体の発現
Ozenberger et al. Functional interaction of ligands and receptors of the hematopoietic superfamily in yeast.
Ponticelli et al. The glutamine-rich activation domains of human Sp1 do not stimulate transcription in Saccharomyces cerevisiae
EP0752477A2 (en) Expression vectors that produce steroid receptors, steroid receptor chimera, screening assays for steroid receptors and clinical assays using synthesized receptors and receptor vectors
US6673540B1 (en) Cell systems having specific interaction of peptide binding pairs
EP1283870A1 (en) Novel cell systems having specific interaction of peptide binding pairs
Yamaguchi et al. Functional analysis of aryl hydrocarbon receptor nuclear translocator interactions with aryl hydrocarbon receptor in the yeast two-hybrid system
US7037656B2 (en) Methods and compositions for identifying ligands for nuclear receptors
US20030009022A1 (en) Methods and compositions for identifying receptor effectors
AU2003260308B2 (en) Method for identifying substances
Ozenberger et al. Investigation of Ligand/Receptor Interactions and the Formation of Tertiary Complexes
WO2003070975A2 (en) An estrogen receptor alpha construct for use in a yeast 2-hybrid assay
PAUSCH et al. HETEROLOGOUS G PROTEIN-COUPLED RECEPTORS EXPRESSED IN SACCHAROMYCES CEREVISIAE: METHODS FOR GENETIC ANALYSIS AND
WO2001061350A1 (en) Methods and compositions for identifying ligands for nuclear receptors
Starr et al. Intracellular receptors use a common mechanism to interpret

Legal Events

Date Code Title Description
PD9A Change of patent owner

Owner name: WYETH HOLDINGS CORPORATION, US

Effective date: 20031031

MM9A Lapsed patents

Effective date: 20110531