PT665886E - Rearranjo de complexos de ciclina e suas utilizacoes - Google Patents
Rearranjo de complexos de ciclina e suas utilizacoesInfo
- Publication number
- PT665886E PT665886E PT93924946T PT93924946T PT665886E PT 665886 E PT665886 E PT 665886E PT 93924946 T PT93924946 T PT 93924946T PT 93924946 T PT93924946 T PT 93924946T PT 665886 E PT665886 E PT 665886E
- Authority
- PT
- Portugal
- Prior art keywords
- rearrangement
- complexes
- pertains
- cycline
- cell
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4738—Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4739—Cyclin; Prad 1
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Plant Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US96330892A | 1992-10-16 | 1992-10-16 | |
US99199792A | 1992-12-17 | 1992-12-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT665886E true PT665886E (pt) | 2003-10-31 |
Family
ID=27130450
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT93924946T PT665886E (pt) | 1992-10-16 | 1993-10-18 | Rearranjo de complexos de ciclina e suas utilizacoes |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0665886B1 (pt) |
JP (1) | JP3485186B2 (pt) |
KR (1) | KR100331363B1 (pt) |
AT (1) | ATE242806T1 (pt) |
AU (1) | AU687764B2 (pt) |
CA (1) | CA2146965C (pt) |
DE (1) | DE69333043T2 (pt) |
DK (1) | DK0665886T3 (pt) |
ES (1) | ES2201064T3 (pt) |
PT (1) | PT665886E (pt) |
WO (1) | WO1994009135A1 (pt) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5889169A (en) * | 1991-05-16 | 1999-03-30 | Cold Spring Harbor Laboratory | Cell cycle regulatory protein p16 gene |
US7550561B1 (en) | 1991-05-16 | 2009-06-23 | Cold Spring Harbor Laboratory | p16INK4 polypeptides |
US6372249B1 (en) | 1991-12-16 | 2002-04-16 | Baylor College Of Medicine | Senscent cell-derived inhibitors of DNA synthesis |
US5596079A (en) * | 1991-12-16 | 1997-01-21 | Smith; James R. | Mimetics of senescent cell derived inhibitors of DNA synthesis |
US6211334B1 (en) * | 1992-10-16 | 2001-04-03 | Cold Spring Harbor | Cell-cycle regulatory proteins, and uses related thereto |
US5962316A (en) | 1992-10-16 | 1999-10-05 | Cold Spring Harbor Laboratory | Cell-cycle regulatory proteins, and uses related thereto |
US6331390B1 (en) | 1992-12-17 | 2001-12-18 | Cold Spring Harbor Laboratory | Cell-cycle regulatory proteins, and uses related thereto |
US6043030A (en) * | 1992-12-17 | 2000-03-28 | Cold Spring Harbor Laboratory | Cell-cycle regulatory proteins, and uses related thereto |
AU692794B2 (en) * | 1993-08-30 | 1998-06-18 | Baylor College Of Medicine | Senescent cell-derived inhibitors of DNA synthesis |
US7691632B2 (en) | 1993-11-18 | 2010-04-06 | Cold Spring Harbor Laboratory | Kit for detecting the level of cyclin-dependent kinase inhibitor P16 gene expression |
CN1128049A (zh) * | 1994-03-18 | 1996-07-31 | 犹他大学研究基金会 | 多肿瘤抑制因子基因种系突变及检测该基因癌肿倾向性的方法 |
US5989815A (en) * | 1994-03-18 | 1999-11-23 | University Of Utah Research Foundation | Methods for detecting predisposition to cancer at the MTS gene |
JPH08510651A (ja) * | 1994-03-18 | 1996-11-12 | ミリアド・ジェネティックス・インコーポレイテッド | Mts遺伝子、それにおける変異、およびmts遺伝子配列を用いる癌の診断方法 |
US6689561B1 (en) * | 1994-04-14 | 2004-02-10 | The Regents Of The University Of California | Tumor suppressor gene and methods for detection of cancer, monitoring of tumor progression and cancer treatment |
ES2233943T3 (es) * | 1994-05-24 | 2005-06-16 | Baylor College Of Medicine | Mimeticos de inhibidores de la sintesis de dna derivados de celulas senescentes. |
EP0775206A1 (en) * | 1994-07-22 | 1997-05-28 | Novartis AG | Dual hybrid system |
GB9422175D0 (en) | 1994-11-03 | 1994-12-21 | Univ Dundee | Indentification of the p21 waf1-pcna interaction site and therapeutic applications thereof |
US5843756A (en) * | 1995-06-07 | 1998-12-01 | Myriad Genetics, Inc. | Mouse MTSI gene |
GB9509557D0 (en) | 1995-05-11 | 1995-07-05 | Univ Dundee | PCNA binding substance |
US7163925B1 (en) | 1995-07-17 | 2007-01-16 | Board Of Regents, The University Of Texas System | p16 expression constructs and their application in cancer therapy |
CA2227193A1 (en) | 1995-07-17 | 1997-02-06 | Xiaomei Jin | P16 expression constructs and their application in cancer therapy |
US5981702A (en) * | 1995-09-21 | 1999-11-09 | Cold Spring Harbor Laboratory | Cyclin/CDK associated proteins, and uses related thereto |
GB9519275D0 (en) * | 1995-09-21 | 1995-11-22 | Univ Dundee | Substances and their therapeutic use |
US7087582B1 (en) | 1995-09-26 | 2006-08-08 | Regents Of The University Of Michigan | Combination for site-specifically transforming cells in vivo comprising a double-balloon catheter and nucleic acid comprising a gene encoding P21 |
US5863904A (en) | 1995-09-26 | 1999-01-26 | The University Of Michigan | Methods for treating cancers and restenosis with P21 |
DE69634044T2 (de) * | 1995-10-05 | 2005-12-08 | Sumitomo Electric Industries, Ltd. | Menschliches Cyclin I und das dafür codierende Gen |
US5672508A (en) * | 1996-01-23 | 1997-09-30 | Mitotix, Inc. | Inhibitors of cell-cycle progression, and uses related thereto |
ATE333465T1 (de) | 1996-05-08 | 2006-08-15 | Cyclacel Ltd | Methoden und mittel zur hemmung der cdk4- aktivität |
AU741632B2 (en) * | 1998-02-18 | 2001-12-06 | Theryte Limited | Treating cancer |
US6489305B1 (en) | 1998-05-08 | 2002-12-03 | Canji, Inc. | Methods and compositions for the treatment of ocular diseases |
DE19829473C2 (de) | 1998-07-01 | 2000-08-10 | Magnus Von Knebel Doeberitz Ch | Verfahren zur frühen Diagnose von Carcinomen |
KR20000019888A (ko) * | 1998-09-16 | 2000-04-15 | 성재갑 | 곤충세포를 이용한 cdk4/hc△p16 복합체의 제조방법 및이로부터 cdk4 단백질의 정제방법 |
KR20000038917A (ko) * | 1998-12-10 | 2000-07-05 | 성재갑 | 곤충세포를 이용한 cdk6/p16 복합체의 제조방법 |
JP4842139B2 (ja) | 2003-11-24 | 2011-12-21 | カンジ,インコーポレイテッド | 皮膚瘢痕の縮小 |
WO2006021803A2 (en) | 2004-08-27 | 2006-03-02 | Cyclacel Limited | Purine and pyrimidine cdk inhibitors and their use for the treatment of autoimmune diseases |
-
1993
- 1993-10-18 DE DE69333043T patent/DE69333043T2/de not_active Expired - Lifetime
- 1993-10-18 PT PT93924946T patent/PT665886E/pt unknown
- 1993-10-18 WO PCT/US1993/009945 patent/WO1994009135A1/en active IP Right Grant
- 1993-10-18 DK DK93924946T patent/DK0665886T3/da active
- 1993-10-18 ES ES93924946T patent/ES2201064T3/es not_active Expired - Lifetime
- 1993-10-18 JP JP51032894A patent/JP3485186B2/ja not_active Expired - Lifetime
- 1993-10-18 AT AT93924946T patent/ATE242806T1/de not_active IP Right Cessation
- 1993-10-18 EP EP93924946A patent/EP0665886B1/en not_active Expired - Lifetime
- 1993-10-18 AU AU54440/94A patent/AU687764B2/en not_active Expired
- 1993-10-18 CA CA002146965A patent/CA2146965C/en not_active Expired - Lifetime
- 1993-10-18 KR KR1019950701512A patent/KR100331363B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69333043T2 (de) | 2004-05-06 |
EP0665886A1 (en) | 1995-08-09 |
WO1994009135A1 (en) | 1994-04-28 |
EP0665886B1 (en) | 2003-06-11 |
KR950704483A (ko) | 1995-11-20 |
DK0665886T3 (da) | 2003-10-06 |
JP3485186B2 (ja) | 2004-01-13 |
AU687764B2 (en) | 1998-03-05 |
JPH08502649A (ja) | 1996-03-26 |
DE69333043D1 (de) | 2003-07-17 |
KR100331363B1 (ko) | 2002-12-05 |
ES2201064T3 (es) | 2004-03-16 |
CA2146965C (en) | 2003-07-29 |
ATE242806T1 (de) | 2003-06-15 |
CA2146965A1 (en) | 1994-04-28 |
AU5444094A (en) | 1994-05-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PT665886E (pt) | Rearranjo de complexos de ciclina e suas utilizacoes | |
BRPI9912227A (pt) | método para diagnóstico precoce in vitro de carcinomas e de seus estágios iniciais e kit para realização do método. | |
AU9058091A (en) | Preparation of nucleic acid samples | |
EP1102988B8 (de) | Verfahren zur bestimmung der immunabwehraktivität des blutes sowie testkit hierfür | |
NO954441L (no) | Tricyklopolyazamakrocyklofosfonsyrer, komplekser og derivater derav for anvendelse som kontrastmidler | |
SE9301270D0 (sv) | Biosensor | |
EP0247730A3 (en) | Antibodies, their preparation and use and products containing them | |
DE59109048D1 (de) | Inhibitoren zur antikoagulierenden Vorbehandung von Blutproben | |
EP0353985A3 (en) | Nucleic acid probe for detection of neisseria gonorrhoea | |
DE59914830D1 (de) | Verfahren und testbesteck zur beurteilung der oxid messung ihrer antiradikalen aktivität | |
DE69029398T2 (de) | Hemmung von padgem-vermittelter zellbindung | |
DE69229681D1 (de) | Ein protein, das spezifische dna-strukturen erkennt, und seine verwendungen | |
ATE318930T1 (de) | Nukleinsäuresonden zur detektion von candida- spezies | |
Barnett et al. | Antinuclear factors in synovia: Possible participants in the rheumatoid inclusion body | |
ES8501630A1 (es) | Un metodo para detectar o vigilar el estado de una condicion patologica humana que implica proteina de tejido conjuntivo. | |
DE69032329D1 (de) | Für c.difficile spezifische oligonukleotide | |
DE3852227D1 (de) | Immunologisches Nachweisverfahren für Herbizide. | |
ATE71149T1 (de) | Monoklonale antikoerper. | |
BR9305035A (pt) | Agentes de curtimento e sua aplicaçáo | |
Sirianni et al. | Sister chromatid exchange induced by promutagens/carcinogens in Chinese hamster cells cultured in diffusion chambers in mice | |
ES2009364A6 (es) | Procedimiento de preparacion de derivados de ginkgolidas. | |
NO881111D0 (no) | Fremgangsmaate til isolering av basalmembranproteiner fra menneskelige og dyriske vev. | |
ES429967A1 (es) | Procedimiento de obtencion de un preparado antigeno. | |
TR199902757T2 (xx) | Grup O HIV-1 vir�slerine ba�l� enfeksiyonlar�n tespiti i�in biyolojik testlerde kullan�labilen sentetik peptitler. | |
Feigin et al. | Modes of action and identities of protein constituents in sea urchintoxin. |