PT633776E - Compostos uteis para tratar doencas alergicas e inflamatorias - Google Patents
Compostos uteis para tratar doencas alergicas e inflamatorias Download PDFInfo
- Publication number
- PT633776E PT633776E PT93907233T PT93907233T PT633776E PT 633776 E PT633776 E PT 633776E PT 93907233 T PT93907233 T PT 93907233T PT 93907233 T PT93907233 T PT 93907233T PT 633776 E PT633776 E PT 633776E
- Authority
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- Portugal
- Prior art keywords
- cyano
- methoxyphenyl
- mmol
- compounds
- formula
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 95
- 230000000172 allergic effect Effects 0.000 title description 4
- 208000027866 inflammatory disease Diseases 0.000 title description 3
- 208000010668 atopic eczema Diseases 0.000 title description 2
- 238000011282 treatment Methods 0.000 claims abstract description 17
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- 208000006673 asthma Diseases 0.000 claims description 11
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- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 3
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- 239000000126 substance Substances 0.000 claims 1
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- 238000004519 manufacturing process Methods 0.000 abstract description 5
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- 108010037584 Type 4 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 abstract 1
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- 239000000243 solution Substances 0.000 description 39
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- IVOMOUWHDPKRLL-KQYNXXCUSA-N Cyclic adenosine monophosphate Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-KQYNXXCUSA-N 0.000 description 4
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
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- A—HUMAN NECESSITIES
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
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- C—CHEMISTRY; METALLURGY
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- C07C255/00—Carboxylic acid nitriles
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- C07C255/50—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/08—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of rings other than six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
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- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/30—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reactions not involving the formation of esterified sulfo groups
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- C—CHEMISTRY; METALLURGY
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- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
- C07C319/12—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols by reactions not involving the formation of mercapto groups
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- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
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- C—CHEMISTRY; METALLURGY
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- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- External Artificial Organs (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86203092A | 1992-04-02 | 1992-04-02 | |
| US96876292A | 1992-10-30 | 1992-10-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT633776E true PT633776E (pt) | 2001-10-31 |
Family
ID=27127661
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT98204466T PT919544E (pt) | 1992-04-02 | 1993-03-05 | Compostos uteis para o tratamento de alergias e doencas unflamatorias |
| PT93907233T PT633776E (pt) | 1992-04-02 | 1993-03-05 | Compostos uteis para tratar doencas alergicas e inflamatorias |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT98204466T PT919544E (pt) | 1992-04-02 | 1993-03-05 | Compostos uteis para o tratamento de alergias e doencas unflamatorias |
Country Status (16)
| Country | Link |
|---|---|
| EP (3) | EP0919544B1 (enExample) |
| JP (1) | JP2873090B2 (enExample) |
| KR (1) | KR950700731A (enExample) |
| AT (2) | ATE200980T1 (enExample) |
| AU (2) | AU705566B2 (enExample) |
| CY (2) | CY2331B1 (enExample) |
| DE (2) | DE69330206T2 (enExample) |
| DK (2) | DK0919544T3 (enExample) |
| ES (2) | ES2197421T3 (enExample) |
| MA (1) | MA22859A1 (enExample) |
| MY (1) | MY109561A (enExample) |
| OA (1) | OA10101A (enExample) |
| PH (1) | PH31379A (enExample) |
| PT (2) | PT919544E (enExample) |
| RO (1) | RO115872B1 (enExample) |
| RU (1) | RU2136656C1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005053672A1 (ja) * | 2003-12-04 | 2005-06-16 | Santen Pharmaceutical Co., Ltd. | シロミラストまたはその塩を有効成分とする掻痒治療剤 |
| JP2005187458A (ja) * | 2003-12-04 | 2005-07-14 | Santen Pharmaceut Co Ltd | シロミラストまたはその塩を有効成分とする掻痒治療剤 |
| EP2359826B1 (en) * | 2006-07-05 | 2013-10-30 | Takeda GmbH | Combination of HMG-COA reductase inhibitor rosuvastatin with a phosphodiesterase 4 inhibitor, such as roflumilast, roflumilast-N-oxide for the treatment of inflammatory pulmonary diseases |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1793383C3 (de) * | 1968-09-10 | 1979-03-01 | Knoll Ag, 6700 Ludwigshafen | 4-Cyan-4-phenyl-aminocyclohexane und deren wasserlösliche Salze, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
| US4795757A (en) * | 1984-09-04 | 1989-01-03 | Rorer Pharmaceutical Corporation | Bisarylamines |
| DE3621581A1 (de) * | 1986-06-27 | 1988-01-07 | Merck Patent Gmbh | Polymerisierbare fluessigkristallmaterialien |
| US5096906A (en) * | 1986-12-31 | 1992-03-17 | University Of Virginia Alumni Patents Foundation | Method of inhibiting the activity of leukocyte derived cytokines |
| AU3738293A (en) * | 1992-04-02 | 1993-11-08 | Smithkline Beecham Corporation | Compounds useful for treating allergic and inflammatory diseases |
| WO1993019720A2 (en) * | 1992-04-02 | 1993-10-14 | Smithkline Beecham Corporation | Compounds |
| WO1993019751A1 (en) * | 1992-04-02 | 1993-10-14 | Smithkline Beecham Corporation | Compounds useful for treating inflammatory diseases and inhibiting production of tumor necrosis factor |
-
1993
- 1993-03-05 AT AT93907233T patent/ATE200980T1/de active
- 1993-03-05 DE DE69330206T patent/DE69330206T2/de not_active Expired - Lifetime
- 1993-03-05 AT AT98204466T patent/ATE240290T1/de active
- 1993-03-05 EP EP98204466A patent/EP0919544B1/en not_active Expired - Lifetime
- 1993-03-05 EP EP03076446A patent/EP1420011A1/en not_active Withdrawn
- 1993-03-05 ES ES98204466T patent/ES2197421T3/es not_active Expired - Lifetime
- 1993-03-05 EP EP03076447A patent/EP1380571A1/en not_active Withdrawn
- 1993-03-05 DK DK98204466T patent/DK0919544T3/da active
- 1993-03-05 DK DK93907233T patent/DK0633776T3/da active
- 1993-03-05 PT PT98204466T patent/PT919544E/pt unknown
- 1993-03-05 DE DE69332987T patent/DE69332987T2/de not_active Expired - Lifetime
- 1993-03-05 ES ES93907233T patent/ES2157923T3/es not_active Expired - Lifetime
- 1993-03-05 JP JP5517446A patent/JP2873090B2/ja not_active Expired - Lifetime
- 1993-03-05 RO RO94-01601A patent/RO115872B1/ro unknown
- 1993-03-05 RU RU94045291A patent/RU2136656C1/ru active
- 1993-03-05 PT PT93907233T patent/PT633776E/pt unknown
- 1993-03-29 PH PH45956A patent/PH31379A/en unknown
- 1993-03-31 MY MYPI93000561A patent/MY109561A/en unknown
- 1993-04-01 MA MA23150A patent/MA22859A1/fr unknown
-
1994
- 1994-09-29 OA OA60565A patent/OA10101A/en unknown
- 1994-10-04 KR KR1019940703523A patent/KR950700731A/ko active Granted
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1997
- 1997-08-08 AU AU33229/97A patent/AU705566B2/en not_active Expired
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1999
- 1999-06-24 AU AU36759/99A patent/AU724115B2/en not_active Expired
-
2002
- 2002-11-05 CY CY0200061A patent/CY2331B1/xx unknown
-
2004
- 2004-08-27 CY CY0400066A patent/CY2474B1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0919544A1 (en) | 1999-06-02 |
| DK0633776T3 (da) | 2001-08-27 |
| AU724115B2 (en) | 2000-09-14 |
| RO115872B1 (ro) | 2000-07-28 |
| DE69332987T2 (de) | 2004-05-19 |
| ES2157923T3 (es) | 2001-09-01 |
| EP1380571A1 (en) | 2004-01-14 |
| AU3322997A (en) | 1997-10-23 |
| JP2873090B2 (ja) | 1999-03-24 |
| DE69330206T2 (de) | 2002-02-14 |
| PT919544E (pt) | 2003-09-30 |
| EP1420011A1 (en) | 2004-05-19 |
| HK1022467A1 (en) | 2000-08-11 |
| PH31379A (en) | 1998-10-29 |
| ATE200980T1 (de) | 2001-05-15 |
| EP0919544B1 (en) | 2003-05-14 |
| MY109561A (en) | 1997-02-28 |
| KR100344711B1 (enExample) | 2003-05-01 |
| DE69332987D1 (de) | 2003-06-18 |
| DK0919544T3 (da) | 2003-09-15 |
| HK1012263A1 (en) | 1999-07-30 |
| ES2197421T3 (es) | 2004-01-01 |
| MA22859A1 (fr) | 1993-12-31 |
| AU705566B2 (en) | 1999-05-27 |
| KR950700731A (ko) | 1995-02-20 |
| CY2474B1 (en) | 2005-06-03 |
| DE69330206D1 (de) | 2001-06-13 |
| RU2136656C1 (ru) | 1999-09-10 |
| AU3675999A (en) | 1999-08-19 |
| CY2331B1 (en) | 2004-02-06 |
| RU94045291A (ru) | 1996-09-27 |
| JPH07508508A (ja) | 1995-09-21 |
| OA10101A (en) | 1996-12-18 |
| ATE240290T1 (de) | 2003-05-15 |
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