PT4218797T - Formulações de adamts13 líquidas e liofilizadas estabilizadas - Google Patents

Formulações de adamts13 líquidas e liofilizadas estabilizadas

Info

Publication number
PT4218797T
PT4218797T PT231727595T PT23172759T PT4218797T PT 4218797 T PT4218797 T PT 4218797T PT 231727595 T PT231727595 T PT 231727595T PT 23172759 T PT23172759 T PT 23172759T PT 4218797 T PT4218797 T PT 4218797T
Authority
PT
Portugal
Prior art keywords
stabilized liquid
adamts13 formulations
lyophilized adamts13
lyophilized
formulations
Prior art date
Application number
PT231727595T
Other languages
English (en)
Portuguese (pt)
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of PT4218797T publication Critical patent/PT4218797T/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886Metalloendopeptidases (3.4.24), e.g. collagenase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24Metalloendopeptidases (3.4.24)
    • C12Y304/24087ADAMTS13 endopeptidase (3.4.24.87)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Peptides Or Proteins (AREA)
PT231727595T 2009-09-21 2010-09-21 Formulações de adamts13 líquidas e liofilizadas estabilizadas PT4218797T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24435309P 2009-09-21 2009-09-21

Publications (1)

Publication Number Publication Date
PT4218797T true PT4218797T (pt) 2024-12-09

Family

ID=43598388

Family Applications (2)

Application Number Title Priority Date Filing Date
PT202112280T PT3834841T (pt) 2009-09-21 2010-09-21 Formulações de adamts13 líquidas e liofilizadas estabilizadas
PT231727595T PT4218797T (pt) 2009-09-21 2010-09-21 Formulações de adamts13 líquidas e liofilizadas estabilizadas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT202112280T PT3834841T (pt) 2009-09-21 2010-09-21 Formulações de adamts13 líquidas e liofilizadas estabilizadas

Country Status (21)

Country Link
US (9) US8623352B2 (OSRAM)
EP (5) EP4218797B9 (OSRAM)
JP (2) JP5819303B2 (OSRAM)
KR (6) KR20220139456A (OSRAM)
CN (2) CN102573792B (OSRAM)
AU (1) AU2010295299B2 (OSRAM)
BR (1) BR112012006283B1 (OSRAM)
CA (1) CA2774556A1 (OSRAM)
DK (4) DK4218797T5 (OSRAM)
EA (1) EA024267B1 (OSRAM)
ES (4) ES2579906T3 (OSRAM)
FI (2) FI4218797T3 (OSRAM)
FR (1) FR24C1049I2 (OSRAM)
HR (1) HRP20160295T1 (OSRAM)
HU (1) HUE028688T2 (OSRAM)
IN (1) IN2012DN02645A (OSRAM)
MX (3) MX362382B (OSRAM)
NZ (1) NZ598839A (OSRAM)
PL (4) PL4218797T3 (OSRAM)
PT (2) PT3834841T (OSRAM)
WO (1) WO2011035335A2 (OSRAM)

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* Cited by examiner, † Cited by third party
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EP2358895B1 (en) 2008-12-05 2018-05-30 Baxalta GmbH Methods of measuring adamts13-mediated in vivo cleavage of von willebrand factor and uses thereof
PL4218797T3 (pl) * 2009-09-21 2025-02-10 Takeda Pharmaceutical Company Limited Stabilizowane płynne i liofilizowane preparaty adamts13
CN104334196B (zh) * 2012-02-16 2018-04-10 Atyr 医药公司 用于治疗自身免疫疾病和炎性疾病的组氨酰‑tRNA合成酶
CN103566362B (zh) * 2012-07-21 2015-07-29 复旦大学 重组adamts13在制备脑出血药物中的用途
US10441531B2 (en) * 2012-11-09 2019-10-15 Bloodworks Protein stabilizing factors
AU2013203062C1 (en) * 2013-03-15 2018-06-28 Takeda Pharmaceutical Company Limited Subcutaneous administration of adamts13
AU2014233436B2 (en) 2013-03-15 2019-12-05 Atyr Pharma, Inc. Histidyl-tRNA synthetase-Fc conjugates
MX377774B (es) * 2014-06-26 2025-03-11 Amgen Inc Formulaciones de proteinas.
GB201510870D0 (en) * 2015-05-26 2015-08-05 Baxalta Inc And Katholieke Universiteit Leuven And Baxalta Gmbh Treatment of infarction
EP3988938B1 (en) 2016-01-08 2024-06-12 Kyoto University Medicine comprising adamts13 as main ingredient
CN116159130B (zh) 2016-08-04 2025-09-09 武田药品工业株式会社 使用adamts13治疗、改善和/或预防镰状细胞病、急性肺损伤和/或急性呼吸窘迫综合征中的血管阻塞危象
WO2018128689A1 (en) 2016-11-04 2018-07-12 Baxalta Incorporated Adeno-associated virus formulations
JP7679175B2 (ja) 2017-04-20 2025-05-19 エータイアー ファーマ, インコーポレイテッド 肺の炎症を治療するための組成物および方法
UA125971C2 (uk) * 2017-07-25 2022-07-20 Джянгсу Хенгруй Медісін Ко., Лтд. Фармацевтична композиція, яка містить протеїновий комплекс il-15, та її застосування
US20210163990A1 (en) * 2018-07-11 2021-06-03 Baxalta Incorporated Aav compositions
WO2021067668A1 (en) 2019-10-04 2021-04-08 The Children's Medical Center Corporation Adamts13 treatment to enhance graft survival
US20230203469A1 (en) 2020-04-02 2023-06-29 Takeda Pharmaceutical Company Limited Adamts13 variant, compositions, and uses thereof
WO2021234458A1 (en) 2020-05-22 2021-11-25 Takeda Pharmaceutical Company Limited Adamts13 compositions and methods for treating and diagnosing complications of coronavirus disease
EP4196147A4 (en) * 2020-08-13 2024-08-21 Hadasit Medical Research Services and Development Ltd. DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN TYPE 1 MOTIF, MUTANTS OF ELEMENT 13 (ADAMTS-13), COMPOSITIONS AND THERAPEUTIC METHODS THEREFOR
JP2025509154A (ja) 2022-03-08 2025-04-11 エクアシールド メディカル リミテッド ロボット医薬品調製システムにおける流体移送ステーション
WO2024151093A1 (ko) * 2023-01-11 2024-07-18 주식회사 녹십자 혈전성 질환의 예방 또는 치료를 위한 신규한 액상 제형물

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AU2004258113B2 (en) * 2003-07-07 2009-11-05 University Of North Carolina At Chapel Hill Method and system for detection of von Willebrand factor (vWF) multimers
GB0404693D0 (en) * 2004-03-02 2004-04-07 Univ London Pharmaceutical preparations for the treatment of ocular surface and other disorders
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CA2606351C (en) 2005-06-17 2016-12-13 Baxter International Inc. Adamts13-comprising compositions having thrombolytic activity
JP4880997B2 (ja) * 2005-12-28 2012-02-22 アルフレッサファーマ株式会社 Adamts13の安定化方法
KR101423344B1 (ko) 2006-01-04 2014-07-30 백스터 인터내셔널 인코포레이티드 올리고펩티드-무함유 세포 배양 배지를 이용하여 단백질을 발현시키는 방법
PL4218797T3 (pl) * 2009-09-21 2025-02-10 Takeda Pharmaceutical Company Limited Stabilizowane płynne i liofilizowane preparaty adamts13
US8823352B2 (en) 2011-07-11 2014-09-02 Linear Technology Corporation Switching power supply having separate AC and DC current sensing paths

Also Published As

Publication number Publication date
NZ598839A (en) 2014-03-28
DK3167897T3 (da) 2021-04-19
US20160375111A1 (en) 2016-12-29
US20140178357A1 (en) 2014-06-26
EA024267B1 (ru) 2016-09-30
ES2865250T3 (es) 2021-10-15
US20180207245A1 (en) 2018-07-26
EP2480198A2 (en) 2012-08-01
US20110229455A1 (en) 2011-09-22
EP3167897A1 (en) 2017-05-17
CN104224705B (zh) 2018-02-02
EP4467160A2 (en) 2024-11-27
EP4467160A3 (en) 2025-01-15
EP4218797B1 (en) 2024-09-11
KR20210054598A (ko) 2021-05-13
US20230130866A1 (en) 2023-04-27
US8623352B2 (en) 2014-01-07
US9572778B2 (en) 2017-02-21
WO2011035335A3 (en) 2011-12-01
US10758599B2 (en) 2020-09-01
KR20190137954A (ko) 2019-12-11
KR101891646B1 (ko) 2018-08-27
US20200376098A1 (en) 2020-12-03
US20250099559A1 (en) 2025-03-27
PL3834841T3 (pl) 2023-07-24
EP4218797A1 (en) 2023-08-02
US9937244B2 (en) 2018-04-10
PL2480198T3 (pl) 2016-09-30
KR20250008986A (ko) 2025-01-16
BR112012006283B1 (pt) 2022-03-15
CN104224705A (zh) 2014-12-24
MX362382B (es) 2019-01-14
IN2012DN02645A (OSRAM) 2015-09-11
BR112012006283A2 (pt) 2016-05-31
DK4218797T5 (da) 2025-07-21
FI4218797T3 (fi) 2024-12-07
AU2010295299A1 (en) 2012-04-12
PL4218797T3 (pl) 2025-02-10
EA201200519A1 (ru) 2012-09-28
EP3834841B1 (en) 2023-05-17
JP5819303B2 (ja) 2015-11-24
ES2948612T3 (es) 2023-09-14
KR20220139456A (ko) 2022-10-14
PT3834841T (pt) 2023-06-19
KR20180095738A (ko) 2018-08-27
ES3001509T3 (en) 2025-03-05
HRP20160295T1 (hr) 2016-05-20
PL3167897T3 (pl) 2021-09-27
ES2579906T3 (es) 2016-08-17
US10238720B2 (en) 2019-03-26
FI3834841T3 (fi) 2023-06-05
MX2019000547A (es) 2020-11-12
JP2013505270A (ja) 2013-02-14
WO2011035335A2 (en) 2011-03-24
US20170112906A1 (en) 2017-04-27
MX339205B (es) 2016-05-16
CN102573792B (zh) 2014-10-15
EP3167897B1 (en) 2021-01-27
EP2480198B1 (en) 2016-03-09
MX2012003414A (es) 2012-06-19
EP2480198B9 (en) 2016-11-23
CA2774556A1 (en) 2011-03-24
DK2480198T3 (en) 2016-03-29
HK1173968A1 (zh) 2013-05-31
EP3834841A1 (en) 2021-06-16
US9351935B2 (en) 2016-05-31
EP4218797B9 (en) 2025-03-05
US11564979B2 (en) 2023-01-31
HUE028688T2 (en) 2017-01-30
DK3834841T3 (da) 2023-06-06
US20190247475A1 (en) 2019-08-15
FR24C1049I2 (fr) 2025-12-12
JP2015063556A (ja) 2015-04-09
FR24C1049I1 (fr) 2025-01-17
KR20120099646A (ko) 2012-09-11
CN102573792A (zh) 2012-07-11
US12178861B2 (en) 2024-12-31
DK4218797T3 (da) 2024-12-09
AU2010295299B2 (en) 2015-12-24

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