IN2012DN02645A - - Google Patents

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Publication number
IN2012DN02645A
IN2012DN02645A IN2645DEN2012A IN2012DN02645A IN 2012DN02645 A IN2012DN02645 A IN 2012DN02645A IN 2645DEN2012 A IN2645DEN2012 A IN 2645DEN2012A IN 2012DN02645 A IN2012DN02645 A IN 2012DN02645A
Authority
IN
India
Prior art keywords
adamts13
formulations
various diseases
present
conditions
Prior art date
Application number
Other languages
English (en)
Inventor
Peter Matthiessen H
L Turecek Peter
Schwarz Hans-Peter
Original Assignee
Baxter Int
Baxter Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int, Baxter Healthcare Sa filed Critical Baxter Int
Publication of IN2012DN02645A publication Critical patent/IN2012DN02645A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886Metalloendopeptidases (3.4.24), e.g. collagenase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24Metalloendopeptidases (3.4.24)
    • C12Y304/24087ADAMTS13 endopeptidase (3.4.24.87)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
IN2645DEN2012 2009-09-21 2010-09-21 IN2012DN02645A (OSRAM)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24435309P 2009-09-21 2009-09-21
PCT/US2010/049723 WO2011035335A2 (en) 2009-09-21 2010-09-21 Stabilized liquid and lyophilized adamts13 formulations

Publications (1)

Publication Number Publication Date
IN2012DN02645A true IN2012DN02645A (OSRAM) 2015-09-11

Family

ID=43598388

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2645DEN2012 IN2012DN02645A (OSRAM) 2009-09-21 2010-09-21

Country Status (21)

Country Link
US (9) US8623352B2 (OSRAM)
EP (5) EP4218797B9 (OSRAM)
JP (2) JP5819303B2 (OSRAM)
KR (6) KR20250008986A (OSRAM)
CN (2) CN104224705B (OSRAM)
AU (1) AU2010295299B2 (OSRAM)
BR (1) BR112012006283B1 (OSRAM)
CA (1) CA2774556A1 (OSRAM)
DK (4) DK2480198T3 (OSRAM)
EA (1) EA024267B1 (OSRAM)
ES (4) ES3001509T3 (OSRAM)
FI (2) FI3834841T3 (OSRAM)
FR (1) FR24C1049I2 (OSRAM)
HR (1) HRP20160295T1 (OSRAM)
HU (1) HUE028688T2 (OSRAM)
IN (1) IN2012DN02645A (OSRAM)
MX (3) MX362382B (OSRAM)
NZ (1) NZ598839A (OSRAM)
PL (4) PL2480198T3 (OSRAM)
PT (2) PT4218797T (OSRAM)
WO (1) WO2011035335A2 (OSRAM)

Families Citing this family (21)

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Publication number Priority date Publication date Assignee Title
EP3388529A1 (en) 2008-12-05 2018-10-17 Baxalta GmbH Methods of measuring adamts13-mediated in vivo cleavage of von willebrand factor and uses thereof
AU2010295299B2 (en) 2009-09-21 2015-12-24 Takeda Pharmaceutical Company Limited Stabilized liquid and lyophilized ADAMTS13 formulations
DK2814514T3 (en) * 2012-02-16 2017-12-18 Atyr Pharma Inc Histidyl tRNA synthetases for the treatment of autoimmune and inflammatory diseases
CN103566362B (zh) * 2012-07-21 2015-07-29 复旦大学 重组adamts13在制备脑出血药物中的用途
WO2014075033A2 (en) 2012-11-09 2014-05-15 Puget Sound Blood Center Protein stabilizing factors
AU2013203062C1 (en) * 2013-03-15 2018-06-28 Takeda Pharmaceutical Company Limited Subcutaneous administration of adamts13
ES2847383T3 (es) 2013-03-15 2021-08-03 Atyr Pharma Inc Conjugados de Fc-histidil-ARNt sintetasa
AU2015280480A1 (en) * 2014-06-26 2017-01-05 Amgen Inc. Protein formulations
GB201510870D0 (en) * 2015-05-26 2015-08-05 Baxalta Inc And Katholieke Universiteit Leuven And Baxalta Gmbh Treatment of infarction
ES2983978T3 (es) 2016-01-08 2024-10-28 Univ Kyoto Medicina que comprende ADAMTS13 como ingrediente principal
KR20230079461A (ko) 2016-08-04 2023-06-07 다케다 파머수티컬 컴패니 리미티드 급성 폐 손상 및/또는 급성 호흡 곤란 증후군에서 혈관폐색 위기의 치료, 개선 및/또는 예방을 위한 adamts13의 용도
ES2981519T3 (es) 2016-11-04 2024-10-09 Takeda Pharmaceuticals Co Formulaciones de virus adeno-asociados
EP3612215B1 (en) 2017-04-20 2024-08-28 aTyr Pharma, Inc. Compositions for treating lung inflammation
UA125971C2 (uk) * 2017-07-25 2022-07-20 Джянгсу Хенгруй Медісін Ко., Лтд. Фармацевтична композиція, яка містить протеїновий комплекс il-15, та її застосування
MX2020013953A (es) * 2018-07-11 2021-03-09 Takeda Pharmaceuticals Co Composiciones de virus adenoasociado (aav).
EP4037704B1 (en) 2019-10-04 2025-12-03 The Children's Medical Center Corporation Adamts13 treatment to enhance graft survival
WO2021198781A2 (en) 2020-04-02 2021-10-07 Takeda Pharmaceutical Company Limited Adamts13 variant, compositions, and uses thereof
JP2023526546A (ja) 2020-05-22 2023-06-21 武田薬品工業株式会社 コロナウイルス疾患の合併症の治療及び診断のための、adamts13組成物及び方法
US20230295597A1 (en) * 2020-08-13 2023-09-21 Hadasit Medical Research Services & Development Limited A disintegrin and metalloproteinase with a thrombospondin type i motif, member 13 (adamts-13) mutants, compositions and therapeutic methods thereof
CA3244889A1 (en) 2022-03-08 2023-09-14 Equashield Medical Ltd FLUID TRANSFER STATION IN A ROBOTIC PHARMACEUTICAL PREPARATION SYSTEM
KR20240112755A (ko) * 2023-01-11 2024-07-19 주식회사 녹십자 혈전성 질환의 예방 또는 치료를 위한 신규한 액상 제형물

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AU2010295299B2 (en) * 2009-09-21 2015-12-24 Takeda Pharmaceutical Company Limited Stabilized liquid and lyophilized ADAMTS13 formulations
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Also Published As

Publication number Publication date
ES2948612T3 (es) 2023-09-14
CN104224705B (zh) 2018-02-02
FI3834841T3 (fi) 2023-06-05
US20250099559A1 (en) 2025-03-27
US20140178357A1 (en) 2014-06-26
CN102573792A (zh) 2012-07-11
KR20180095738A (ko) 2018-08-27
DK4218797T5 (da) 2025-07-21
HUE028688T2 (en) 2017-01-30
FR24C1049I1 (fr) 2025-01-17
AU2010295299B2 (en) 2015-12-24
JP5819303B2 (ja) 2015-11-24
ES2579906T3 (es) 2016-08-17
HRP20160295T1 (hr) 2016-05-20
JP2013505270A (ja) 2013-02-14
PL3834841T3 (pl) 2023-07-24
FR24C1049I2 (fr) 2025-12-12
EP4218797A1 (en) 2023-08-02
MX362382B (es) 2019-01-14
MX2019000547A (es) 2020-11-12
EP3834841A1 (en) 2021-06-16
MX2012003414A (es) 2012-06-19
US9351935B2 (en) 2016-05-31
DK2480198T3 (en) 2016-03-29
PL4218797T3 (pl) 2025-02-10
US9572778B2 (en) 2017-02-21
WO2011035335A3 (en) 2011-12-01
KR20210054598A (ko) 2021-05-13
DK3834841T3 (da) 2023-06-06
US12178861B2 (en) 2024-12-31
PT4218797T (pt) 2024-12-09
CA2774556A1 (en) 2011-03-24
PL2480198T3 (pl) 2016-09-30
KR101891646B1 (ko) 2018-08-27
HK1173968A1 (zh) 2013-05-31
EP3167897B1 (en) 2021-01-27
EA201200519A1 (ru) 2012-09-28
EP3834841B1 (en) 2023-05-17
US20160375111A1 (en) 2016-12-29
BR112012006283B1 (pt) 2022-03-15
US10238720B2 (en) 2019-03-26
WO2011035335A2 (en) 2011-03-24
EP4218797B1 (en) 2024-09-11
EP4467160A3 (en) 2025-01-15
EP2480198A2 (en) 2012-08-01
DK3167897T3 (da) 2021-04-19
KR20250008986A (ko) 2025-01-16
EP3167897A1 (en) 2017-05-17
BR112012006283A2 (pt) 2016-05-31
CN102573792B (zh) 2014-10-15
EP2480198B9 (en) 2016-11-23
US11564979B2 (en) 2023-01-31
US10758599B2 (en) 2020-09-01
US20200376098A1 (en) 2020-12-03
PL3167897T3 (pl) 2021-09-27
KR20120099646A (ko) 2012-09-11
ES2865250T3 (es) 2021-10-15
CN104224705A (zh) 2014-12-24
EP2480198B1 (en) 2016-03-09
JP2015063556A (ja) 2015-04-09
US20180207245A1 (en) 2018-07-26
ES3001509T3 (en) 2025-03-05
KR20190137954A (ko) 2019-12-11
NZ598839A (en) 2014-03-28
DK4218797T3 (da) 2024-12-09
EA024267B1 (ru) 2016-09-30
US20190247475A1 (en) 2019-08-15
US8623352B2 (en) 2014-01-07
KR20220139456A (ko) 2022-10-14
PT3834841T (pt) 2023-06-19
US20230130866A1 (en) 2023-04-27
FI4218797T3 (fi) 2024-12-07
MX339205B (es) 2016-05-16
US20110229455A1 (en) 2011-09-22
US20170112906A1 (en) 2017-04-27
US9937244B2 (en) 2018-04-10
AU2010295299A1 (en) 2012-04-12
EP4467160A2 (en) 2024-11-27
EP4218797B9 (en) 2025-03-05

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