PT3384049T - Método de associação de variantes genéticas com um resultado clínico em doentes que sofrem de degeneração macular relacionada à idade tratados com anti-vegf - Google Patents

Método de associação de variantes genéticas com um resultado clínico em doentes que sofrem de degeneração macular relacionada à idade tratados com anti-vegf

Info

Publication number
PT3384049T
PT3384049T PT168233724T PT16823372T PT3384049T PT 3384049 T PT3384049 T PT 3384049T PT 168233724 T PT168233724 T PT 168233724T PT 16823372 T PT16823372 T PT 16823372T PT 3384049 T PT3384049 T PT 3384049T
Authority
PT
Portugal
Prior art keywords
vegf
age
methods
macular degeneration
patients suffering
Prior art date
Application number
PT168233724T
Other languages
English (en)
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57758695&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT3384049(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of PT3384049T publication Critical patent/PT3384049T/pt

Links

Classifications

    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/70ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/40ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
PT168233724T 2015-12-03 2016-12-01 Método de associação de variantes genéticas com um resultado clínico em doentes que sofrem de degeneração macular relacionada à idade tratados com anti-vegf PT3384049T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562262589P 2015-12-03 2015-12-03
US201662291274P 2016-02-04 2016-02-04

Publications (1)

Publication Number Publication Date
PT3384049T true PT3384049T (pt) 2023-08-18

Family

ID=57758695

Family Applications (1)

Application Number Title Priority Date Filing Date
PT168233724T PT3384049T (pt) 2015-12-03 2016-12-01 Método de associação de variantes genéticas com um resultado clínico em doentes que sofrem de degeneração macular relacionada à idade tratados com anti-vegf

Country Status (21)

Country Link
US (2) US11769597B2 (pt)
EP (2) EP3384049B1 (pt)
JP (4) JP6855480B2 (pt)
KR (4) KR102183910B1 (pt)
CN (2) CN108474039B (pt)
AU (4) AU2016364817B2 (pt)
CA (3) CA3179836A1 (pt)
DK (1) DK3384049T3 (pt)
ES (1) ES2956007T3 (pt)
FI (1) FI3384049T3 (pt)
HR (1) HRP20231379T1 (pt)
HU (1) HUE063335T2 (pt)
IL (3) IL302424A (pt)
LT (1) LT3384049T (pt)
MX (3) MX2018006740A (pt)
NZ (1) NZ744025A (pt)
PL (1) PL3384049T3 (pt)
PT (1) PT3384049T (pt)
RS (1) RS64725B1 (pt)
SI (1) SI3384049T1 (pt)
WO (1) WO2017096031A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
AU2016381964B2 (en) 2015-12-30 2024-02-15 Kodiak Sciences Inc. Antibodies and conjugates thereof
GB201805642D0 (en) * 2018-04-05 2018-05-23 Macusoft Ltd Determining a clinical outcome for a subject suffering from a macular degenerative disease
CN109632924B (zh) * 2018-12-17 2022-02-08 上海市第一人民医院 人黄斑新生血管性疾病的血浆脂质标记物及其应用
AU2020364071A1 (en) 2019-10-10 2022-05-26 Kodiak Sciences Inc. Methods of treating an eye disorder
KR102625384B1 (ko) 2020-09-28 2024-01-16 (주) 플라즈닉스 플라즈마 토치 및 이를 이용하여 대상기체를 처리하는 방법

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03504499A (ja) 1988-05-27 1991-10-03 セントカー・インコーポレーテツド 抗体試薬のための配合物
DE4243524A1 (de) 1992-12-22 1994-06-23 Hoechst Ag Gemische isomerer Nonanole und Decanole, ihre Herstellung, aus ihnen erhältliche Phthalsäureester und deren Verwendung als Weichmacher
CN1151842C (zh) 1995-07-27 2004-06-02 基因技术股份有限公司 稳定等渗的冻干蛋白制剂
US5770700A (en) 1996-01-25 1998-06-23 Genetics Institute, Inc. Liquid factor IX formulations
DE19622283A1 (de) 1996-05-23 1997-11-27 Schering Ag Verfahren zur terminalen Sterilisierung von befüllten Spritzen
US6884879B1 (en) 1997-04-07 2005-04-26 Genentech, Inc. Anti-VEGF antibodies
BRPI9809387B8 (pt) 1997-04-07 2021-05-25 Genentech Inc anticorpo humanizado anti-fator de crescimento endotelial vascular humano e composição que o compreende
US6171586B1 (en) 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
US6436897B2 (en) 1998-06-01 2002-08-20 Celtrix Pharmaceuticals, Inc. Pharmaceutical formulations for IGF/IGFBP
DE19849924A1 (de) 1998-10-29 2000-05-04 Degussa Verfahren zur Abtrennung organischer Säuren aus wäßrigen Lösungen
DE19849922A1 (de) 1998-10-29 2000-05-04 Degussa Verfahren zur Behandlung von Basen und organische Säuren enthaltenden wäßrigen Lösungen
US6455743B1 (en) 1998-11-27 2002-09-24 Mitsubishi Chemical Corporation Process for producing alcohols
DE19914259A1 (de) 1999-03-29 2000-10-05 Basf Ag Verfahren zur destillativen Auftrennung eines flüssigen Rohaldehydgemisches
ES2223705T3 (es) 1999-04-28 2005-03-01 Board Of Regents, The University Of Texas System Composiciones y metodos para el tratamiento de cancer mediante inhibi cion selectiva del vegf.
US7303746B2 (en) 1999-06-08 2007-12-04 Regeneron Pharmaceuticals, Inc. Methods of treating eye disorders with modified chimeric polypeptides
US7396664B2 (en) 1999-06-08 2008-07-08 Regeneron Pharmaceuticals, Inc. VEGF-binding fusion proteins and nucleic acids encoding the same
KR100659477B1 (ko) 1999-06-08 2006-12-20 리제네론 파라마큐티칼스 인코포레이티드 개선된 약물동태학적 성질을 가지는 변형된 키메라 폴리펩티드
US7087411B2 (en) 1999-06-08 2006-08-08 Regeneron Pharmaceuticals, Inc. Fusion protein capable of binding VEGF
US7070959B1 (en) 1999-06-08 2006-07-04 Regeneron Pharmaceuticals, Inc. Modified chimeric polypeptides with improved pharmacokinetic properties
US7306799B2 (en) 1999-06-08 2007-12-11 Regeneron Pharmaceuticals, Inc. Use of VEGF inhibitors for treatment of eye disorders
DE19933348B4 (de) 1999-07-16 2005-11-17 Oxeno Olefinchemie Gmbh Verfahren zur Reduzierung oxidischer Hydrierkontakte
US6777429B1 (en) 1999-07-23 2004-08-17 Novartis Ag Ophthalmic composition
DE19957522A1 (de) 1999-11-30 2001-05-31 Oxeno Olefinchemie Gmbh Verfahren zur katalytischen Durchführung von Aldolkondensationen mittels Mehrphasenreaktion
DE10103706A1 (de) 2001-01-26 2002-08-14 Aventis Behring Gmbh Verwendung eines Hydrogenperoxid-Plasma-Sterilisationsverfahrens für die schonende Sterilisation temperaturempfindlicher Produkte
US7033604B2 (en) 2001-07-06 2006-04-25 Sucampo Ag Composition for topical administration
EP1409018B1 (en) 2001-07-25 2010-01-06 Facet Biotech Corporation Stable lyophilized pharmaceutical formulation the igg antibody daclizumab
US20030138417A1 (en) 2001-11-08 2003-07-24 Kaisheva Elizabet A. Stable liquid pharmaceutical formulation of IgG antibodies
OA12720A (en) 2001-11-09 2006-06-27 Eyetech Pharmaceuticals Methods for treating ocular neovascular diseases.
JP4141156B2 (ja) 2002-03-15 2008-08-27 日本ベクトン・ディッキンソン株式会社 プランジャ後退制限機構付きプレフィルドシリンジ
PT1610820E (pt) 2003-04-04 2010-12-16 Novartis Ag Formulações de elevada concentração de anticorpos e proteínas
WO2004106378A2 (en) 2003-05-28 2004-12-09 Regeneron Pharmaceuticals, Inc. Method of treating corneal transplant rejection by using vegf antagonists
US7354578B2 (en) 2003-06-06 2008-04-08 Regeneron Pharmaceuticals, Inc. Method of tumor regression with VEGF inhibitors
JP2007501239A (ja) 2003-08-06 2007-01-25 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 放射線治療と組み合わせたvegfアンタゴニストの使用
US7378095B2 (en) 2004-07-30 2008-05-27 Regeneron Pharmaceuticals, Inc. Methods of treating type I diabetes by blocking VEGF-mediated activity
PL1802334T3 (pl) 2004-10-21 2013-01-31 Genentech Inc Sposób leczenia wewnątrzgałkowych chorób neowaskularnych
CA2588270A1 (en) * 2004-11-18 2006-06-15 Yale University Methods and compositions for treating ocular disorders
CA2621047A1 (en) 2005-02-02 2006-08-24 Regeneron Pharmaceuticals, Inc. Method of treating eye injury with local administration of a vegf inhibitor
HUE034109T2 (en) 2005-03-25 2018-01-29 Regeneron Pharma VEGF antagonist formulations
CA2615636A1 (en) 2005-08-12 2007-02-22 Regeneron Pharmaceuticals, Inc. Treatment of diseases by subcutaneous administration of a vegf antagonist
JP2009508593A (ja) 2005-09-16 2009-03-05 (オーエスアイ)アイテツク・インコーポレーテツド 眼科用シリンジ
US8168584B2 (en) 2005-10-08 2012-05-01 Potentia Pharmaceuticals, Inc. Methods of treating age-related macular degeneration by compstatin and analogs thereof
DE502006001489D1 (de) 2006-02-14 2008-10-16 Gerresheimer Buende Gmbh Verfahren zum Herstellen von vorfüllbaren Spritzen
US7608261B2 (en) 2006-06-16 2009-10-27 Regeneron Pharmacuticals, Inc. VEGF antagonist formulations suitable for intravitreal administration
EP2089059A2 (en) 2006-11-10 2009-08-19 Genentech, Inc. Method for treating age-related macular degeneration
MX2009005612A (es) 2006-11-30 2009-06-08 Basf Se Proceso para la hidroformilacion de olefinas.
WO2008077155A1 (en) 2006-12-21 2008-06-26 Genentech, Inc. Sterilization of objects containing biological molecules
KR20100037590A (ko) 2007-06-08 2010-04-09 바이오겐 아이덱 엠에이 인코포레이티드 항 tnf 반응 또는 무반응을 예측하기 위한 바이오마커
WO2009030976A1 (en) 2007-09-03 2009-03-12 Becton Dickinson France Medical device and smooth coating therefor
CA2745621A1 (en) 2008-12-03 2011-06-02 Denki Kagaku Kogyo Kabushiki Kaisha Syringe
WO2010065671A2 (en) * 2008-12-04 2010-06-10 Curna, Inc. Treatment of vascular endothelial growth factor (vegf) related diseases by inhibition of natural antisense transcript to vegf
DE102009001594A1 (de) 2009-03-17 2010-09-30 Evonik Oxeno Gmbh Verfahren zur Herstellung von alpha, beta-ungesättigten C10-Aldehyden
WO2010107283A2 (ko) 2009-03-19 2010-09-23 주식회사 엘지화학 고순도 2-에틸헥산올 생산을 위한 분리벽형 증류탑 및 이를 이용한 분별증류방법
AR078060A1 (es) 2009-07-14 2011-10-12 Novartis Ag Descontaminacion de superficie de contenedores previamente llenados en empaque secundario
DE102009045139A1 (de) 2009-09-30 2011-03-31 Evonik Oxeno Gmbh Herstellung von alpha,beta-ungesättigten Aldehyden mittels einer Reaktionsmischpumpe
DE102009045718A1 (de) 2009-10-15 2011-04-21 Evonik Oxeno Gmbh Verfahren zur Herstellung von Decanolen durch Hydrierung von Decenalen
SI2491134T1 (sl) 2009-10-21 2017-11-30 Genentech, Inc. Genetski polimorfizmi pri starostni degeneraciji makule
JP5746749B2 (ja) 2010-03-15 2015-07-08 エクソンモービル・ケミカル・パテンツ・インク アルコールの製造方法
FR2966044B1 (fr) 2010-10-18 2012-11-02 Sanofi Pasteur Procede de conditionnement d'un vaccin contenant un adjuvant d'aluminium
MX349901B (es) 2011-01-13 2017-08-18 Regeneron Pharma Uso de un antagonista de factor de crecimiento endotelial vascular para tratar transtornos oculares angiogenicos.
AU2012229067A1 (en) * 2011-03-15 2013-10-31 University Of Utah Research Foundation Methods of diagnosing and treating Vascular Associated Maculopathy and symptoms thereof
WO2013106765A1 (en) * 2012-01-13 2013-07-18 Genentech, Inc. Biological markers for identifying patients for treatment with vegf antagonists
JOP20200175A1 (ar) 2012-07-03 2017-06-16 Novartis Ag حقنة
KR20140042402A (ko) 2012-09-28 2014-04-07 주식회사 엘지화학 올레핀으로부터 알코올의 제조장치 및 제조방법
JP5721150B2 (ja) * 2013-03-14 2015-05-20 学校法人 埼玉医科大学 加齢黄斑変性症の発症リスクの予測方法
US9926246B2 (en) 2013-05-03 2018-03-27 Saudi Basic Industries Corporation Integrated process for simultaneous production of oxo-alcohols and plasticizers
SG10201708882TA (en) 2013-07-12 2017-12-28 Ophthotech Corp Methods for treating or preventing ophthalmological conditions
WO2015012332A1 (ja) 2013-07-24 2015-01-29 田辺三菱製薬株式会社 眼科疾患治療剤
DE102014201756A1 (de) 2014-01-31 2015-08-06 Evonik Degussa Gmbh Reinigung chlorverschmutzter Organophosphorverbindungen
DE102014209536A1 (de) 2014-05-20 2015-11-26 Evonik Degussa Gmbh Herstellung qualitativ hochwertiger Oxo-Alkohole aus unsteten Rohstoffquellen
EP3037400B1 (de) 2014-12-23 2018-08-01 Evonik Degussa GmbH Chromfreie hydrierung von hydroformylierungsgemischen
US10155200B2 (en) 2015-02-18 2018-12-18 Evonik Degussa Gmbh Separation off of a homogeneous catalyst from a reaction mixture with the help of organophilic nanofiltration
SG10201601501QA (en) 2015-03-05 2016-10-28 Evonik Degussa Gmbh Preparation of 2,2`-biaryls in the presence of molybdenum(v) chloride
CN104894261B (zh) * 2015-06-02 2020-02-14 北京医院 一种预测雷珠单抗治疗年龄相关性黄斑变性疗效的试剂盒
PL3374366T3 (pl) 2015-11-09 2020-05-18 Evonik Operations Gmbh Bis-fosforyny z jednostkami 2,4-dimetylofenylowymi i ich zastosowanie jako ligandów w hydroformylowaniu
ES2701843T3 (es) 2015-11-19 2019-02-26 Evonik Degussa Gmbh Influencia de la viscosidad de mezclas de ésteres basadas en n-buteno mediante empleo selectivo de eteno en la obtención de productos previos de ésteres
ES2765635T3 (es) 2016-05-19 2020-06-10 Evonik Operations Gmbh Producción de n-pentanal a partir de mezclas de sustancias de empleo pobres en buteno
US10245578B2 (en) 2016-11-09 2019-04-02 Evonik Degussa Gmbh Chromium- and nickel-free hydrogenation of hydroformylation mixtures
SI3351526T1 (sl) 2017-01-20 2021-02-26 Evonik Operations Gmbh Diizopentiltereftalat
RS63703B1 (sr) 2017-11-30 2022-11-30 Regeneron Pharma Upotreba antagonista vegf za lečenje angiogenih očnih poremećaja

Also Published As

Publication number Publication date
MX2023008504A (es) 2023-07-26
KR102261636B9 (ko) 2023-07-13
CN108474039A (zh) 2018-08-31
IL259672B2 (en) 2023-02-01
EP4276199A2 (en) 2023-11-15
CA3007276A1 (en) 2017-06-08
DK3384049T3 (da) 2023-10-02
AU2020203362B2 (en) 2022-07-14
JP2019503665A (ja) 2019-02-14
ES2956007T3 (es) 2023-12-11
IL302424A (en) 2023-06-01
HUE063335T2 (hu) 2024-01-28
KR20200047779A (ko) 2020-05-07
WO2017096031A1 (en) 2017-06-08
AU2020203362A1 (en) 2020-06-11
SI3384049T1 (sl) 2023-10-30
PL3384049T3 (pl) 2024-01-22
IL295808B2 (en) 2023-10-01
AU2016364817B2 (en) 2020-05-07
NZ744025A (en) 2020-02-28
IL295808B1 (en) 2023-06-01
CA3179836A1 (en) 2017-06-08
HRP20231379T1 (hr) 2024-02-16
AU2016364817A1 (en) 2018-07-19
CA3137326C (en) 2024-01-23
JP2024028658A (ja) 2024-03-04
US20240029897A1 (en) 2024-01-25
MX2023004922A (es) 2023-05-16
FI3384049T3 (fi) 2023-09-25
RS64725B1 (sr) 2023-11-30
JP7233754B2 (ja) 2023-03-07
AU2022235531A1 (en) 2022-10-13
LT3384049T (lt) 2023-09-11
KR102343004B9 (ko) 2023-07-13
KR20210157427A (ko) 2021-12-28
MX2018006740A (es) 2018-08-01
KR102183910B9 (ko) 2023-07-13
US20180276336A1 (en) 2018-09-27
JP2021091737A (ja) 2021-06-17
CA3137326A1 (en) 2017-06-08
EP3384049B1 (en) 2023-08-02
KR102261636B1 (ko) 2021-06-07
KR102343004B1 (ko) 2021-12-24
KR20180081616A (ko) 2018-07-16
IL259672B (en) 2022-10-01
IL295808A (en) 2022-10-01
CN114712497B (zh) 2024-03-22
JP2023053348A (ja) 2023-04-12
IL259672A (en) 2018-07-31
CN114712497A (zh) 2022-07-08
CN108474039B (zh) 2022-06-07
CA3007276C (en) 2021-12-28
US11769597B2 (en) 2023-09-26
EP3384049A1 (en) 2018-10-10
KR102183910B1 (ko) 2020-11-27
JP6855480B2 (ja) 2021-04-07
JP7429318B2 (ja) 2024-02-07
EP4276199A3 (en) 2024-04-10
AU2022235529A1 (en) 2022-10-13
KR20210068154A (ko) 2021-06-08

Similar Documents

Publication Publication Date Title
IL295808A (en) Methods for associating genetic variants with clinical outcome in patients suffering from age-related macular degeneration and receiving treatment against tubular endothelial growth factor
HRP20190117T1 (hr) iRNK TERAPIJA ZA LIJEČENJE BOLESTI OKA
EP3458585A4 (en) GENE THERAPY PROCEDURES FOR AGE-RELATED ILLNESSES AND SUFFERING
HK1246179A1 (zh) 治療視網膜疾病的方法
SG11201706755SA (en) Methods and compositions for treating genetic eye diseases
GB201403260D0 (en) Treatment of retinal degeneration using gene therapy
SG2014008080A (en) Methods of treatment of retinal degeneration diseases
HK1258518A1 (zh) 用於眼病的基因療法
HK1258994A1 (zh) 用於疾病治療的方法
HK1253299A1 (zh) 一種通過基因治療治療眼疾病的改進方法
IL261295A (en) Gene therapy for the treatment of retinal cone cell disease
IL261292A (en) Gene therapy for the treatment of retinal degeneration
IL259381B (en) Miravegron for the treatment of retinal diseases
PT2777699T (pt) Dietilamina-2,5-di-hidroxibenzenossulfonato para o tratamento de degeneração macular relacionada com a idade
EP2661279A4 (en) METHODS OF TREATING AGE-RELATED MACULAR DEGENERATION
GB201517565D0 (en) Treatment of genetic diseases
GB201604253D0 (en) Treatment of genetic diseases