KR102261636B9 - 항-vegf로 치료된 연령-관련 황반 변성을 앓고 있는 환자에서의 임상 결과와 유전적 변이체를 연관시키는 방법 - Google Patents

항-vegf로 치료된 연령-관련 황반 변성을 앓고 있는 환자에서의 임상 결과와 유전적 변이체를 연관시키는 방법

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KR102261636B9
KR102261636B9 KR1020207012363A KR20207012363A KR102261636B9 KR 102261636 B9 KR102261636 B9 KR 102261636B9 KR 1020207012363 A KR1020207012363 A KR 1020207012363A KR 20207012363 A KR20207012363 A KR 20207012363A KR 102261636 B9 KR102261636 B9 KR 102261636B9
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vegf
age
methods
macular degeneration
patients suffering
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KR1020207012363A
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English (en)
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KR102261636B1 (ko
KR20200047779A (ko
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로라 퍼리
사라 하몬
찰스 폴딩
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리제너론 파마슈티칼스 인코포레이티드
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57758695&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR102261636(B9) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 리제너론 파마슈티칼스 인코포레이티드 filed Critical 리제너론 파마슈티칼스 인코포레이티드
Priority to KR1020217016566A priority Critical patent/KR102343004B1/ko
Publication of KR20200047779A publication Critical patent/KR20200047779A/ko
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    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
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    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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    • G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/40—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
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    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
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    • C12Q2600/00—Oligonucleotides characterized by their use
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  • Theoretical Computer Science (AREA)
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KR1020207012363A 2015-12-03 2016-12-01 항-vegf로 치료된 연령-관련 황반 변성을 앓고 있는 환자에서의 임상 결과와 유전적 변이체를 연관시키는 방법 KR102261636B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020217016566A KR102343004B1 (ko) 2015-12-03 2016-12-01 항-vegf로 치료된 연령-관련 황반 변성을 앓고 있는 환자에서의 임상 결과와 유전적 변이체를 연관시키는 방법

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201562262589P 2015-12-03 2015-12-03
US62/262,589 2015-12-03
US201662291274P 2016-02-04 2016-02-04
US62/291,274 2016-02-04
KR1020187017681A KR102183910B1 (ko) 2015-12-03 2016-12-01 항-vegf로 치료된 연령-관련 황반 변성을 앓고 있는 환자에서의 임상 결과와 유전적 변이체를 연관시키는 방법
PCT/US2016/064403 WO2017096031A1 (en) 2015-12-03 2016-12-01 Methods of associating genetic variants with a clinical outcome in patients suffering from age-related macular degeneration treated with anti-vegf

Related Parent Applications (1)

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KR1020187017681A Division KR102183910B1 (ko) 2015-12-03 2016-12-01 항-vegf로 치료된 연령-관련 황반 변성을 앓고 있는 환자에서의 임상 결과와 유전적 변이체를 연관시키는 방법

Related Child Applications (1)

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KR1020217016566A Division KR102343004B1 (ko) 2015-12-03 2016-12-01 항-vegf로 치료된 연령-관련 황반 변성을 앓고 있는 환자에서의 임상 결과와 유전적 변이체를 연관시키는 방법

Publications (3)

Publication Number Publication Date
KR20200047779A KR20200047779A (ko) 2020-05-07
KR102261636B1 KR102261636B1 (ko) 2021-06-07
KR102261636B9 true KR102261636B9 (ko) 2023-07-13

Family

ID=57758695

Family Applications (4)

Application Number Title Priority Date Filing Date
KR1020217016566A KR102343004B1 (ko) 2015-12-03 2016-12-01 항-vegf로 치료된 연령-관련 황반 변성을 앓고 있는 환자에서의 임상 결과와 유전적 변이체를 연관시키는 방법
KR1020187017681A KR102183910B1 (ko) 2015-12-03 2016-12-01 항-vegf로 치료된 연령-관련 황반 변성을 앓고 있는 환자에서의 임상 결과와 유전적 변이체를 연관시키는 방법
KR1020217041649A KR20210157427A (ko) 2015-12-03 2016-12-01 항-vegf로 치료된 연령-관련 황반 변성을 앓고 있는 환자에서의 임상 결과와 유전적 변이체를 연관시키는 방법
KR1020207012363A KR102261636B1 (ko) 2015-12-03 2016-12-01 항-vegf로 치료된 연령-관련 황반 변성을 앓고 있는 환자에서의 임상 결과와 유전적 변이체를 연관시키는 방법

Family Applications Before (3)

Application Number Title Priority Date Filing Date
KR1020217016566A KR102343004B1 (ko) 2015-12-03 2016-12-01 항-vegf로 치료된 연령-관련 황반 변성을 앓고 있는 환자에서의 임상 결과와 유전적 변이체를 연관시키는 방법
KR1020187017681A KR102183910B1 (ko) 2015-12-03 2016-12-01 항-vegf로 치료된 연령-관련 황반 변성을 앓고 있는 환자에서의 임상 결과와 유전적 변이체를 연관시키는 방법
KR1020217041649A KR20210157427A (ko) 2015-12-03 2016-12-01 항-vegf로 치료된 연령-관련 황반 변성을 앓고 있는 환자에서의 임상 결과와 유전적 변이체를 연관시키는 방법

Country Status (21)

Country Link
US (2) US11769597B2 (ko)
EP (2) EP3384049B1 (ko)
JP (4) JP6855480B2 (ko)
KR (4) KR102343004B1 (ko)
CN (2) CN108474039B (ko)
AU (4) AU2016364817B2 (ko)
CA (3) CA3137326C (ko)
DK (1) DK3384049T3 (ko)
ES (1) ES2956007T3 (ko)
FI (1) FI3384049T3 (ko)
HR (1) HRP20231379T1 (ko)
HU (1) HUE063335T2 (ko)
IL (3) IL295808B2 (ko)
LT (1) LT3384049T (ko)
MX (3) MX2018006740A (ko)
NZ (1) NZ744025A (ko)
PL (1) PL3384049T3 (ko)
PT (1) PT3384049T (ko)
RS (1) RS64725B1 (ko)
SI (1) SI3384049T1 (ko)
WO (1) WO2017096031A1 (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
CN108474039B (zh) 2015-12-03 2022-06-07 雷杰纳荣制药公司 抗vegf剂在制备用于治疗新生血管性年龄相关性黄斑变性患者的药物中的用途
IL260323B1 (en) 2015-12-30 2024-09-01 Kodiak Sciences Inc Antibodies and their conjugates
US12071476B2 (en) 2018-03-02 2024-08-27 Kodiak Sciences Inc. IL-6 antibodies and fusion constructs and conjugates thereof
GB201805642D0 (en) * 2018-04-05 2018-05-23 Macusoft Ltd Determining a clinical outcome for a subject suffering from a macular degenerative disease
CN109632924B (zh) * 2018-12-17 2022-02-08 上海市第一人民医院 人黄斑新生血管性疾病的血浆脂质标记物及其应用
US11912784B2 (en) 2019-10-10 2024-02-27 Kodiak Sciences Inc. Methods of treating an eye disorder
KR102625384B1 (ko) 2020-09-28 2024-01-16 (주) 플라즈닉스 플라즈마 토치 및 이를 이용하여 대상기체를 처리하는 방법

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0417191B1 (en) 1988-05-27 1993-03-10 Centocor, Inc. Formulation for antibody reagents
DE4243524A1 (de) 1992-12-22 1994-06-23 Hoechst Ag Gemische isomerer Nonanole und Decanole, ihre Herstellung, aus ihnen erhältliche Phthalsäureester und deren Verwendung als Weichmacher
SI2275119T1 (sl) 1995-07-27 2013-12-31 Genentech, Inc. Stabilna izotonična liofilizirana proteinska formulacija
US5770700A (en) 1996-01-25 1998-06-23 Genetics Institute, Inc. Liquid factor IX formulations
DE19622283A1 (de) 1996-05-23 1997-11-27 Schering Ag Verfahren zur terminalen Sterilisierung von befüllten Spritzen
NZ500078A (en) 1997-04-07 2001-10-26 Genentech Inc Humanized anti-VEGF antibodies and their use in inhibiting VEGF-induced angiogenesis in mammals
US6884879B1 (en) 1997-04-07 2005-04-26 Genentech, Inc. Anti-VEGF antibodies
US6171586B1 (en) 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
US6436897B2 (en) 1998-06-01 2002-08-20 Celtrix Pharmaceuticals, Inc. Pharmaceutical formulations for IGF/IGFBP
DE19849922A1 (de) 1998-10-29 2000-05-04 Degussa Verfahren zur Behandlung von Basen und organische Säuren enthaltenden wäßrigen Lösungen
DE19849924A1 (de) 1998-10-29 2000-05-04 Degussa Verfahren zur Abtrennung organischer Säuren aus wäßrigen Lösungen
US6455743B1 (en) 1998-11-27 2002-09-24 Mitsubishi Chemical Corporation Process for producing alcohols
DE19914259A1 (de) 1999-03-29 2000-10-05 Basf Ag Verfahren zur destillativen Auftrennung eines flüssigen Rohaldehydgemisches
US6342221B1 (en) 1999-04-28 2002-01-29 Board Of Regents, The University Of Texas System Antibody conjugate compositions for selectively inhibiting VEGF
US7070959B1 (en) 1999-06-08 2006-07-04 Regeneron Pharmaceuticals, Inc. Modified chimeric polypeptides with improved pharmacokinetic properties
US7306799B2 (en) 1999-06-08 2007-12-11 Regeneron Pharmaceuticals, Inc. Use of VEGF inhibitors for treatment of eye disorders
US7303746B2 (en) 1999-06-08 2007-12-04 Regeneron Pharmaceuticals, Inc. Methods of treating eye disorders with modified chimeric polypeptides
US7087411B2 (en) 1999-06-08 2006-08-08 Regeneron Pharmaceuticals, Inc. Fusion protein capable of binding VEGF
US7396664B2 (en) 1999-06-08 2008-07-08 Regeneron Pharmaceuticals, Inc. VEGF-binding fusion proteins and nucleic acids encoding the same
MEP3208A (xx) 1999-06-08 2010-02-10 Regeneron Pharma Modifikovani himerni polipeptidi sa poboljšanim farmakokinetičkim osobinama
DE19933348B4 (de) 1999-07-16 2005-11-17 Oxeno Olefinchemie Gmbh Verfahren zur Reduzierung oxidischer Hydrierkontakte
US6777429B1 (en) 1999-07-23 2004-08-17 Novartis Ag Ophthalmic composition
DE19957522A1 (de) 1999-11-30 2001-05-31 Oxeno Olefinchemie Gmbh Verfahren zur katalytischen Durchführung von Aldolkondensationen mittels Mehrphasenreaktion
DE10103706A1 (de) 2001-01-26 2002-08-14 Aventis Behring Gmbh Verwendung eines Hydrogenperoxid-Plasma-Sterilisationsverfahrens für die schonende Sterilisation temperaturempfindlicher Produkte
KR20040019034A (ko) 2001-07-06 2004-03-04 수캄포 아게 인터루킨 2 억제제 및 항미생물제를 포함하는 국소 투여용조성물
US20030113316A1 (en) 2001-07-25 2003-06-19 Kaisheva Elizabet A. Stable lyophilized pharmaceutical formulation of IgG antibodies
JP5290489B2 (ja) 2001-11-08 2013-09-18 アッヴィ・バイオセラピューティクス・インコーポレイテッド Ｉｇｇ抗体の安定な液体医薬製剤
RS35404A (en) 2001-11-09 2006-10-27 Eyetech Pharmaceuticals Methods for treating ocular neovascular diseases
JP4141156B2 (ja) 2002-03-15 2008-08-27 日本ベクトン・ディッキンソン株式会社 プランジャ後退制限機構付きプレフィルドシリンジ
PT1610820E (pt) 2003-04-04 2010-12-16 Novartis Ag Formulações de elevada concentração de anticorpos e proteínas
WO2004106378A2 (en) 2003-05-28 2004-12-09 Regeneron Pharmaceuticals, Inc. Method of treating corneal transplant rejection by using vegf antagonists
JP2006527198A (ja) 2003-06-06 2006-11-30 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Ｖｅｇｆインヒビターを用いる腫瘍退縮方法
CA2534197A1 (en) 2003-08-06 2005-02-24 Thomas Jefferson University Use of a vegf antagonist in combination with radiation therapy
AU2005267741A1 (en) 2004-07-30 2006-02-09 Regeneron Pharmaceuticals, Inc. Methods of treating type I diabetes by blocking VEGF-mediated activity
EP2311433A3 (en) 2004-10-21 2011-08-10 Genentech, Inc. Method for treating intraocular neovascular diseases
ES2375490T3 (es) 2004-11-18 2012-03-01 Yale University Métodos y composiciones para diagnosticar degeneración macular relacionada con la edad.
AU2006214658A1 (en) 2005-02-02 2006-08-24 Regeneron Pharmaceuticals, Inc. Method of treating eye injury with local administration of a VEGF inhibitor
PT2586459T (pt) 2005-03-25 2017-07-25 Regeneron Pharma Formulações antagonistas de fcev
WO2007022101A2 (en) 2005-08-12 2007-02-22 Regeneron Pharmaceuticals, Inc. Treatment of diseases by subcutaneous administration of a vegf antagonist
CA2622573A1 (en) 2005-09-16 2007-03-29 (Osi) Eyetech, Inc. Ophthalmic syringe
US8168584B2 (en) 2005-10-08 2012-05-01 Potentia Pharmaceuticals, Inc. Methods of treating age-related macular degeneration by compstatin and analogs thereof
ATE406926T1 (de) 2006-02-14 2008-09-15 Gerresheimer Buende Gmbh Verfahren zum herstellen von vorfüllbaren spritzen
EP3753548A1 (en) 2006-06-16 2020-12-23 Regeneron Pharmaceuticals, Inc. Vegf antagonist formulations suitable for intravitreal administration
AU2007323925A1 (en) 2006-11-10 2008-05-29 Genentech, Inc. Method for treating age-related macular degeneration
US9266808B2 (en) 2006-11-30 2016-02-23 Basf Se Method for the hydroformylation of olefins
WO2008077155A1 (en) 2006-12-21 2008-06-26 Genentech, Inc. Sterilization of objects containing biological molecules
JP5719591B2 (ja) * 2007-06-08 2015-05-20 バイオジェン アイデック エムエー インコーポレイティドＢｉｏｇｅｎ Ｉｄｅｃ Ｉｎｃ． 抗ｔｎｆ応答性または非応答性を予測するためのバイオマーカー
WO2009030976A1 (en) 2007-09-03 2009-03-12 Becton Dickinson France Medical device and smooth coating therefor
AU2009323307B2 (en) 2008-12-03 2015-02-19 Denki Kagaku Kogyo Kabushiki Kaisha Syringe
JP5971948B2 (ja) * 2008-12-04 2016-08-17 クルナ・インコーポレーテッド Ｖｅｇｆに対する天然アンチセンス転写物の抑制による血管内皮増殖因子（ｖｅｇｆ）関連疾患の治療
DE102009001594A1 (de) 2009-03-17 2010-09-30 Evonik Oxeno Gmbh Verfahren zur Herstellung von alpha, beta-ungesättigten C10-Aldehyden
US8764946B2 (en) 2009-03-19 2014-07-01 Lg Chem, Ltd. Dividing wall distillation columns for production of high-purity 2-ethylhexanol and fractionation method using same
AR078060A1 (es) 2009-07-14 2011-10-12 Novartis Ag Descontaminacion de superficie de contenedores previamente llenados en empaque secundario
DE102009045139A1 (de) 2009-09-30 2011-03-31 Evonik Oxeno Gmbh Herstellung von alpha,beta-ungesättigten Aldehyden mittels einer Reaktionsmischpumpe
DE102009045718A1 (de) 2009-10-15 2011-04-21 Evonik Oxeno Gmbh Verfahren zur Herstellung von Decanolen durch Hydrierung von Decenalen
CA2859193C (en) 2009-10-21 2023-02-07 Genentech, Inc. Genetic polymorphisms in age-related macular degeneration
WO2011115695A1 (en) 2010-03-15 2011-09-22 Exxonmobil Chemical Patents Inc. Processes for the production of alcohols
FR2966044B1 (fr) 2010-10-18 2012-11-02 Sanofi Pasteur Procede de conditionnement d'un vaccin contenant un adjuvant d'aluminium
US8684190B2 (en) 2010-11-19 2014-04-01 Warren Abar Multi-position solar panel rack
CA2824422A1 (en) 2011-01-13 2012-07-19 Regeneron Pharmaceuticals, Inc. Use of a vegf antagonist to treat angiogenic eye disorders
RU2013145890A (ru) * 2011-03-15 2015-04-20 Юниверсити Оф Юта Рисерч Фаундейшн Способы диагностики и лечения сосудисто-ассоциированной макулопатии и ее симптомов
SG11201403927XA (en) * 2012-01-13 2014-08-28 Genentech Inc Biological markers for identifying patients for treatment with vegf antagonists
JOP20200175A1 (ar) 2012-07-03 2017-06-16 Novartis Ag حقنة
KR20140042402A (ko) 2012-09-28 2014-04-07 주식회사 엘지화학 올레핀으로부터 알코올의 제조장치 및 제조방법
JP5721150B2 (ja) * 2013-03-14 2015-05-20 学校法人 埼玉医科大学 加齢黄斑変性症の発症リスクの予測方法
CN105189426B (zh) 2013-05-03 2020-09-18 沙特基础工业公司 用于同时生产含氧醇和增塑剂的集成方法
SG11201510315TA (en) * 2013-07-12 2016-01-28 Ophthotech Corp Methods for treating or preventing ophthalmological conditions
TWI679978B (zh) 2013-07-24 2019-12-21 日商田邊三菱製藥股份有限公司 眼科疾病治療劑
DE102014201756A1 (de) 2014-01-31 2015-08-06 Evonik Degussa Gmbh Reinigung chlorverschmutzter Organophosphorverbindungen
DE102014209536A1 (de) 2014-05-20 2015-11-26 Evonik Degussa Gmbh Herstellung qualitativ hochwertiger Oxo-Alkohole aus unsteten Rohstoffquellen
PL3037400T3 (pl) 2014-12-23 2019-02-28 Evonik Degussa Gmbh Bezchromowe uwodornianie mieszanin hydroformylowania
EP3059005B1 (de) 2015-02-18 2018-10-24 Evonik Degussa GmbH Abtrennung eines homogenkatalysators aus einem reaktionsgemisch mit hilfe organophiler nanofiltration unter besonderer berücksichtigung eines membran-leistungsindikators
SG10201601501QA (en) 2015-03-05 2016-10-28 Evonik Degussa Gmbh Preparation of 2,2`-biaryls in the presence of molybdenum(v) chloride
CN104894261B (zh) * 2015-06-02 2020-02-14 北京医院 一种预测雷珠单抗治疗年龄相关性黄斑变性疗效的试剂盒
MY182378A (en) 2015-11-09 2021-01-21 Evonik Operations Gmbh Economical production of 2-propylheptanol
PL3170805T3 (pl) 2015-11-19 2019-02-28 Evonik Degussa Gmbh Wpływanie na lepkość mieszanin estrów bazujących na n-butenach poprzez celowe zastosowanie etenu podczas otrzymywania prekursorów estrów
CN108474039B (zh) 2015-12-03 2022-06-07 雷杰纳荣制药公司 抗vegf剂在制备用于治疗新生血管性年龄相关性黄斑变性患者的药物中的用途
EP3246303B8 (de) 2016-05-19 2020-01-01 Evonik Operations GmbH Herstellung von n-pentanal aus butenarmen einsatzstoffgemischen
US10245578B2 (en) 2016-11-09 2019-04-02 Evonik Degussa Gmbh Chromium- and nickel-free hydrogenation of hydroformylation mixtures
EP3351526B1 (de) 2017-01-20 2020-11-18 Evonik Operations GmbH Diisopentylterephthalat
SG11202004268PA (en) 2017-11-30 2020-06-29 Regeneron Pharma Use of a vegf antagonist to treat angiogenic eye disorders

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