LT3384049T - Genetinių variacijų susiejimo su klinikiniais rezultatais būdai pacientams, sergantiems amžine geltonosios dėmės degeneracija, gydytiems anti-vegf - Google Patents

Genetinių variacijų susiejimo su klinikiniais rezultatais būdai pacientams, sergantiems amžine geltonosios dėmės degeneracija, gydytiems anti-vegf

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Publication number
LT3384049T
LT3384049T LTEPPCT/US2016/064403T LT16064403T LT3384049T LT 3384049 T LT3384049 T LT 3384049T LT 16064403 T LT16064403 T LT 16064403T LT 3384049 T LT3384049 T LT 3384049T
Authority
LT
Lithuania
Prior art keywords
vegf
age
methods
macular degeneration
patients suffering
Prior art date
Application number
LTEPPCT/US2016/064403T
Other languages
English (en)
Inventor
Lorah Perlee
Sara HAMON
Charles Paulding
Original Assignee
Regeneron Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57758695&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT3384049(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharmaceuticals, Inc. filed Critical Regeneron Pharmaceuticals, Inc.
Publication of LT3384049T publication Critical patent/LT3384049T/lt

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/70ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/40ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
LTEPPCT/US2016/064403T 2015-12-03 2016-12-01 Genetinių variacijų susiejimo su klinikiniais rezultatais būdai pacientams, sergantiems amžine geltonosios dėmės degeneracija, gydytiems anti-vegf LT3384049T (lt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562262589P 2015-12-03 2015-12-03
US201662291274P 2016-02-04 2016-02-04
PCT/US2016/064403 WO2017096031A1 (en) 2015-12-03 2016-12-01 Methods of associating genetic variants with a clinical outcome in patients suffering from age-related macular degeneration treated with anti-vegf

Publications (1)

Publication Number Publication Date
LT3384049T true LT3384049T (lt) 2023-09-11

Family

ID=57758695

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEPPCT/US2016/064403T LT3384049T (lt) 2015-12-03 2016-12-01 Genetinių variacijų susiejimo su klinikiniais rezultatais būdai pacientams, sergantiems amžine geltonosios dėmės degeneracija, gydytiems anti-vegf

Country Status (21)

Country Link
US (2) US11769597B2 (lt)
EP (2) EP3384049B1 (lt)
JP (4) JP6855480B2 (lt)
KR (4) KR102183910B1 (lt)
CN (2) CN108474039B (lt)
AU (4) AU2016364817B2 (lt)
CA (3) CA3137326C (lt)
DK (1) DK3384049T3 (lt)
ES (1) ES2956007T3 (lt)
FI (1) FI3384049T3 (lt)
HR (1) HRP20231379T1 (lt)
HU (1) HUE063335T2 (lt)
IL (3) IL302424A (lt)
LT (1) LT3384049T (lt)
MX (3) MX2018006740A (lt)
NZ (1) NZ744025A (lt)
PL (1) PL3384049T3 (lt)
PT (1) PT3384049T (lt)
RS (1) RS64725B1 (lt)
SI (1) SI3384049T1 (lt)
WO (1) WO2017096031A1 (lt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
BR112018013407A2 (pt) 2015-12-30 2018-12-18 Kodiak Sciences Inc anticorpos e conjugados dos mesmos
GB201805642D0 (en) * 2018-04-05 2018-05-23 Macusoft Ltd Determining a clinical outcome for a subject suffering from a macular degenerative disease
CN109632924B (zh) * 2018-12-17 2022-02-08 上海市第一人民医院 人黄斑新生血管性疾病的血浆脂质标记物及其应用
EP4041312A4 (en) 2019-10-10 2023-12-20 Kodiak Sciences Inc. METHOD FOR TREATING AN EYE DISORDER
KR102625384B1 (ko) 2020-09-28 2024-01-16 (주) 플라즈닉스 플라즈마 토치 및 이를 이용하여 대상기체를 처리하는 방법

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03504499A (ja) 1988-05-27 1991-10-03 セントカー・インコーポレーテツド 抗体試薬のための配合物
DE4243524A1 (de) 1992-12-22 1994-06-23 Hoechst Ag Gemische isomerer Nonanole und Decanole, ihre Herstellung, aus ihnen erhältliche Phthalsäureester und deren Verwendung als Weichmacher
WO1997004801A1 (en) 1995-07-27 1997-02-13 Genentech, Inc. Stabile isotonic lyophilized protein formulation
US5770700A (en) 1996-01-25 1998-06-23 Genetics Institute, Inc. Liquid factor IX formulations
DE19622283A1 (de) 1996-05-23 1997-11-27 Schering Ag Verfahren zur terminalen Sterilisierung von befüllten Spritzen
US6884879B1 (en) 1997-04-07 2005-04-26 Genentech, Inc. Anti-VEGF antibodies
JP3957765B2 (ja) 1997-04-07 2007-08-15 ジェネンテク・インコーポレイテッド 抗vegf抗体
US6171586B1 (en) 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
US6436897B2 (en) 1998-06-01 2002-08-20 Celtrix Pharmaceuticals, Inc. Pharmaceutical formulations for IGF/IGFBP
DE19849922A1 (de) 1998-10-29 2000-05-04 Degussa Verfahren zur Behandlung von Basen und organische Säuren enthaltenden wäßrigen Lösungen
DE19849924A1 (de) 1998-10-29 2000-05-04 Degussa Verfahren zur Abtrennung organischer Säuren aus wäßrigen Lösungen
US6455743B1 (en) 1998-11-27 2002-09-24 Mitsubishi Chemical Corporation Process for producing alcohols
DE19914259A1 (de) 1999-03-29 2000-10-05 Basf Ag Verfahren zur destillativen Auftrennung eines flüssigen Rohaldehydgemisches
US6342221B1 (en) 1999-04-28 2002-01-29 Board Of Regents, The University Of Texas System Antibody conjugate compositions for selectively inhibiting VEGF
US7396664B2 (en) 1999-06-08 2008-07-08 Regeneron Pharmaceuticals, Inc. VEGF-binding fusion proteins and nucleic acids encoding the same
US7087411B2 (en) 1999-06-08 2006-08-08 Regeneron Pharmaceuticals, Inc. Fusion protein capable of binding VEGF
CA2376379C (en) 1999-06-08 2007-08-07 Regeneron Pharmaceuticals, Inc. Modified chimeric polypeptides with improved pharmacokinetic properties
US7303746B2 (en) 1999-06-08 2007-12-04 Regeneron Pharmaceuticals, Inc. Methods of treating eye disorders with modified chimeric polypeptides
US7070959B1 (en) 1999-06-08 2006-07-04 Regeneron Pharmaceuticals, Inc. Modified chimeric polypeptides with improved pharmacokinetic properties
US7306799B2 (en) 1999-06-08 2007-12-11 Regeneron Pharmaceuticals, Inc. Use of VEGF inhibitors for treatment of eye disorders
DE19933348B4 (de) 1999-07-16 2005-11-17 Oxeno Olefinchemie Gmbh Verfahren zur Reduzierung oxidischer Hydrierkontakte
US6777429B1 (en) 1999-07-23 2004-08-17 Novartis Ag Ophthalmic composition
DE19957522A1 (de) 1999-11-30 2001-05-31 Oxeno Olefinchemie Gmbh Verfahren zur katalytischen Durchführung von Aldolkondensationen mittels Mehrphasenreaktion
DE10103706A1 (de) 2001-01-26 2002-08-14 Aventis Behring Gmbh Verwendung eines Hydrogenperoxid-Plasma-Sterilisationsverfahrens für die schonende Sterilisation temperaturempfindlicher Produkte
CN1259049C (zh) 2001-07-06 2006-06-14 苏坎波公司 包含白介素-2抑制剂和抗菌剂的局部给药组合物
MXPA04000747A (es) 2001-07-25 2004-07-08 Protein Desing Labs Inc Formulacion farmaceutica liofilizada estable de anticuerpos igg.
CA2466034C (en) 2001-11-08 2012-12-18 Protein Design Labs, Inc. Stable aqueous pharmaceutical formulations of daclizumab antibodies
RS35404A (en) 2001-11-09 2006-10-27 Eyetech Pharmaceuticals Methods for treating ocular neovascular diseases
JP4141156B2 (ja) 2002-03-15 2008-08-27 日本ベクトン・ディッキンソン株式会社 プランジャ後退制限機構付きプレフィルドシリンジ
JP4869064B2 (ja) 2003-04-04 2012-02-01 ジェネンテック, インコーポレイテッド 高濃度抗体及びタンパク質製剤
EP1626989A2 (en) 2003-05-28 2006-02-22 Regeneron Pharmaceuticals, Inc. Method of treating corneal transplant rejection by using vegf antagonists
WO2004110490A2 (en) 2003-06-06 2004-12-23 Regeneron Pharmaceuticals, Inc. Use of vegf inhibitors for tumor regression
CA2534197A1 (en) 2003-08-06 2005-02-24 Thomas Jefferson University Use of a vegf antagonist in combination with radiation therapy
JP4807802B2 (ja) 2004-07-30 2011-11-02 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Vegf媒介性活性をブロックすることによるi型糖尿病を処置する方法
ES2390676T3 (es) 2004-10-21 2012-11-15 Genentech, Inc. Método para el tratamiento de enfermedades neovasculares intraoculares
CN101142321B (zh) * 2004-11-18 2012-06-06 耶鲁大学 治疗眼病的方法和组合物
AU2006214658A1 (en) 2005-02-02 2006-08-24 Regeneron Pharmaceuticals, Inc. Method of treating eye injury with local administration of a VEGF inhibitor
PL1861116T3 (pl) 2005-03-25 2016-02-29 Regeneron Pharma Formulacje antagonistów VEGF
CN101237880B (zh) 2005-08-12 2011-09-21 瑞泽恩制药公司 通过vegf拮抗剂的皮下给药治疗疾病
JP2009508593A (ja) 2005-09-16 2009-03-05 (オーエスアイ)アイテツク・インコーポレーテツド 眼科用シリンジ
US8168584B2 (en) 2005-10-08 2012-05-01 Potentia Pharmaceuticals, Inc. Methods of treating age-related macular degeneration by compstatin and analogs thereof
ATE406926T1 (de) 2006-02-14 2008-09-15 Gerresheimer Buende Gmbh Verfahren zum herstellen von vorfüllbaren spritzen
EP2944306B1 (en) 2006-06-16 2021-01-27 Regeneron Pharmaceuticals, Inc. Vegf antagonist formulations suitable for intravitreal administration
CA2666709A1 (en) 2006-11-10 2008-05-29 Genentech, Inc. Method for treating age-related macular degeneration
CA2670935A1 (en) 2006-11-30 2008-06-05 Basf Se Process for the hydroformylation of olefins
WO2008077155A1 (en) 2006-12-21 2008-06-26 Genentech, Inc. Sterilization of objects containing biological molecules
BRPI0812461A2 (pt) 2007-06-08 2017-06-13 Biogen Idec Inc método de prever a resposta de um indivíduo a uma terapia, método de tratamento de um distúrbio imunológico, composição e kit
WO2009030976A1 (en) 2007-09-03 2009-03-12 Becton Dickinson France Medical device and smooth coating therefor
AU2009323307B2 (en) 2008-12-03 2015-02-19 Denki Kagaku Kogyo Kabushiki Kaisha Syringe
WO2010065671A2 (en) * 2008-12-04 2010-06-10 Curna, Inc. Treatment of vascular endothelial growth factor (vegf) related diseases by inhibition of natural antisense transcript to vegf
DE102009001594A1 (de) 2009-03-17 2010-09-30 Evonik Oxeno Gmbh Verfahren zur Herstellung von alpha, beta-ungesättigten C10-Aldehyden
WO2010107283A2 (ko) 2009-03-19 2010-09-23 주식회사 엘지화학 고순도 2-에틸헥산올 생산을 위한 분리벽형 증류탑 및 이를 이용한 분별증류방법
AR078060A1 (es) 2009-07-14 2011-10-12 Novartis Ag Descontaminacion de superficie de contenedores previamente llenados en empaque secundario
DE102009045139A1 (de) 2009-09-30 2011-03-31 Evonik Oxeno Gmbh Herstellung von alpha,beta-ungesättigten Aldehyden mittels einer Reaktionsmischpumpe
DE102009045718A1 (de) 2009-10-15 2011-04-21 Evonik Oxeno Gmbh Verfahren zur Herstellung von Decanolen durch Hydrierung von Decenalen
RU2577726C2 (ru) 2009-10-21 2016-03-20 Дженентек, Инк. Генетические полиморфизмы при возрастной дегенерации желтого пятна
WO2011115695A1 (en) 2010-03-15 2011-09-22 Exxonmobil Chemical Patents Inc. Processes for the production of alcohols
FR2966044B1 (fr) 2010-10-18 2012-11-02 Sanofi Pasteur Procede de conditionnement d'un vaccin contenant un adjuvant d'aluminium
KR20180023015A (ko) 2011-01-13 2018-03-06 리제너론 파아마슈티컬스, 인크. 혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도
CA2830407C (en) * 2011-03-15 2021-08-31 University Of Utah Research Foundation Methods of diagnosing and treating vascular associated maculopathy and symptoms thereof
BR112014017320A2 (pt) * 2012-01-13 2018-05-29 Genentech Inc método para determinar se um paciente é propenso a responder ao tratamento com um antagonista de vegf, método para otimizar a eficácia terapêutica de um antagonista de vegf, método para selecionar uma terapia, método para identificar um biomarcador e método para diagnosticar um distúrbio angiogênico
JOP20200175A1 (ar) 2012-07-03 2017-06-16 Novartis Ag حقنة
KR20140042402A (ko) 2012-09-28 2014-04-07 주식회사 엘지화학 올레핀으로부터 알코올의 제조장치 및 제조방법
JP5721150B2 (ja) * 2013-03-14 2015-05-20 学校法人 埼玉医科大学 加齢黄斑変性症の発症リスクの予測方法
CN105189426B (zh) 2013-05-03 2020-09-18 沙特基础工业公司 用于同时生产含氧醇和增塑剂的集成方法
WO2015006734A1 (en) 2013-07-12 2015-01-15 Ophthotech Corporation Methods for treating or preventing ophthalmological conditions
JP6382816B2 (ja) 2013-07-24 2018-08-29 田辺三菱製薬株式会社 眼科疾患治療剤
DE102014201756A1 (de) 2014-01-31 2015-08-06 Evonik Degussa Gmbh Reinigung chlorverschmutzter Organophosphorverbindungen
DE102014209536A1 (de) 2014-05-20 2015-11-26 Evonik Degussa Gmbh Herstellung qualitativ hochwertiger Oxo-Alkohole aus unsteten Rohstoffquellen
PT3037400T (pt) 2014-12-23 2018-10-23 Evonik Degussa Gmbh Hidrogenação livre de cromo de misturas de hidroformilação
EP3059005B1 (de) 2015-02-18 2018-10-24 Evonik Degussa GmbH Abtrennung eines homogenkatalysators aus einem reaktionsgemisch mit hilfe organophiler nanofiltration unter besonderer berücksichtigung eines membran-leistungsindikators
SG10201601501QA (en) 2015-03-05 2016-10-28 Evonik Degussa Gmbh Preparation of 2,2`-biaryls in the presence of molybdenum(v) chloride
CN104894261B (zh) * 2015-06-02 2020-02-14 北京医院 一种预测雷珠单抗治疗年龄相关性黄斑变性疗效的试剂盒
KR102602992B1 (ko) 2015-11-09 2023-11-17 에보니크 옥세노 게엠베하 운트 코. 카게 2-프로필헵탄올의 경제적 제조
ES2701843T3 (es) 2015-11-19 2019-02-26 Evonik Degussa Gmbh Influencia de la viscosidad de mezclas de ésteres basadas en n-buteno mediante empleo selectivo de eteno en la obtención de productos previos de ésteres
PL3246303T3 (pl) 2016-05-19 2020-06-01 Evonik Operations Gmbh Wytwarzanie n-pentanalu z mieszanin surowców ubogich w buten
US10245578B2 (en) 2016-11-09 2019-04-02 Evonik Degussa Gmbh Chromium- and nickel-free hydrogenation of hydroformylation mixtures
SI3351526T1 (sl) 2017-01-20 2021-02-26 Evonik Operations Gmbh Diizopentiltereftalat
JP7339248B2 (ja) 2017-11-30 2023-09-05 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 血管形成眼障害を処置するためのvegfアンタゴニストの使用

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PL3384049T3 (pl) 2024-01-22
CN114712497B (zh) 2024-03-22
IL295808B1 (en) 2023-06-01
KR20180081616A (ko) 2018-07-16
NZ744025A (en) 2020-02-28
EP4276199A3 (en) 2024-04-10
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