PT3221331T - Esteroides 6-alquil-7-hidroxi-4-en-3-ona como intermediários para a produção de moduladores de fxr esteroidais - Google Patents
Esteroides 6-alquil-7-hidroxi-4-en-3-ona como intermediários para a produção de moduladores de fxr esteroidaisInfo
- Publication number
- PT3221331T PT3221331T PT158009092T PT15800909T PT3221331T PT 3221331 T PT3221331 T PT 3221331T PT 158009092 T PT158009092 T PT 158009092T PT 15800909 T PT15800909 T PT 15800909T PT 3221331 T PT3221331 T PT 3221331T
- Authority
- PT
- Portugal
- Prior art keywords
- steroids
- intermediates
- hydroxy
- alkyl
- production
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title 1
- 230000003637 steroidlike Effects 0.000 title 1
- 150000003431 steroids Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1420593.4A GB201420593D0 (en) | 2014-11-19 | 2014-11-19 | Compounds |
| GBGB1420594.2A GB201420594D0 (en) | 2014-11-19 | 2014-11-19 | Compounds |
| GBGB1505670.8A GB201505670D0 (en) | 2015-04-01 | 2015-04-01 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3221331T true PT3221331T (pt) | 2019-12-23 |
Family
ID=54704019
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT158009092T PT3221331T (pt) | 2014-11-19 | 2015-11-19 | Esteroides 6-alquil-7-hidroxi-4-en-3-ona como intermediários para a produção de moduladores de fxr esteroidais |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US10301350B2 (enExample) |
| EP (1) | EP3221331B1 (enExample) |
| JP (1) | JP6700274B2 (enExample) |
| KR (1) | KR102526631B1 (enExample) |
| CN (1) | CN107207559B (enExample) |
| BR (1) | BR112017010319B1 (enExample) |
| CA (1) | CA2968309A1 (enExample) |
| DK (1) | DK3221331T3 (enExample) |
| EA (1) | EA033427B1 (enExample) |
| ES (1) | ES2759725T3 (enExample) |
| MX (1) | MX375863B (enExample) |
| PL (1) | PL3221331T3 (enExample) |
| PT (1) | PT3221331T (enExample) |
| TW (1) | TWI690536B (enExample) |
| WO (1) | WO2016079517A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6698085B2 (ja) | 2014-11-19 | 2020-05-27 | エヌゼットピー ユーケー リミテッド | ステロイドＦＸＲモジュレーター製造のための中間体としての６α−アルキル−６，７−ジオン−ステロイド |
| KR102526632B1 (ko) | 2014-11-19 | 2023-04-27 | 엔제트피 유케이 리미티드 | 스테로이드 FXR 조절인자를 제조하기 위한 중간체로서의 5β-6-알킬-7-하이드록시-3-온 스테로이드 |
| ES2748692T3 (es) | 2014-11-19 | 2020-03-17 | Nzp Uk Ltd | Esteroides 6.alfa.-alquil-3,7-diona como intermedios para la producción de moduladores FXR de esteroides |
| CZ2015504A3 (cs) * | 2015-07-16 | 2017-01-25 | Zentiva, K.S. | Krystalické formy obeticholové kyseliny |
| CA3009149A1 (en) * | 2015-12-22 | 2017-06-29 | Intercept Pharmaceuticals, Inc. | Polymorphic crystalline forms of obeticholic acid |
| GB201608776D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Methods and compounds |
| GB201608777D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Compounds |
| GB201608779D0 (en) * | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Methods and compounds |
| AU2017368069B2 (en) * | 2016-11-29 | 2021-07-08 | Enanta Pharmaceuticals, Inc. | Process for preparation of sulfonylurea bile acid derivatives |
| EP3431486A1 (en) | 2017-07-18 | 2019-01-23 | Bionice, S.L.U. | Process and intermediates for the synthesis of obeticholic acid and derivatives thereof |
| CN111138509B (zh) * | 2018-11-02 | 2022-12-06 | 东莞东阳光药物研发有限公司 | 奥贝胆酸的制备方法 |
| CN112521438B (zh) * | 2020-12-08 | 2021-11-23 | 苏利制药科技江阴有限公司 | 一种β-谷甾醇的合成工艺 |
| WO2023288123A1 (en) * | 2021-07-16 | 2023-01-19 | Interecept Pharmaceuticals, Inc. | Methods and intermediates for the preparation of 3.alpha.,7.alpha.,11.beta.-trihydroxy-6.alpha.-ethyl-5.beta.-cholan-24-oic acid |
| CN113912661B (zh) * | 2021-11-11 | 2023-04-21 | 湖南科瑞生物制药股份有限公司 | 一种7-羟基甾体化合物的合成方法 |
| GB202416085D0 (en) | 2024-10-31 | 2024-12-18 | Nzp Uk Ltd | Reduction process |
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| US2624748A (en) | 1950-09-09 | 1953-01-06 | Upjohn Co | Bisnorchola-4, 6-dien-3-one-22-al |
| US4289872A (en) | 1979-04-06 | 1981-09-15 | Allied Corporation | Macromolecular highly branched homogeneous compound based on lysine units |
| US5229490A (en) | 1987-05-06 | 1993-07-20 | The Rockefeller University | Multiple antigen peptide system |
| ATE156158T1 (de) | 1992-04-14 | 1997-08-15 | Cornell Res Foundation Inc | Makromoleküle auf basis von dendritischen polymeren und verfahren zur herstellung |
| AU6392894A (en) | 1993-02-26 | 1994-09-14 | Magainin Pharmaceuticals, Inc. | Chemical synthesis of squalamine |
| US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| DK1392714T3 (da) | 2001-03-12 | 2006-01-09 | Intercept Pharmaceuticals Inc | Steroider som agonister for FXR |
| US20090062256A1 (en) | 2001-06-01 | 2009-03-05 | Bristol-Myers Squibb Pharma Company | LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Abeta PROTEIN PRODUCTION |
| EP1446438A2 (en) | 2001-11-07 | 2004-08-18 | Nektar Therapeutics Al, Corporation | Branched polymers and their conjugates |
| EP1568706A1 (en) | 2004-02-26 | 2005-08-31 | Intercept Pharmaceuticals, Inc. | Novel steroid agonist for FXR |
| ITMI20050912A1 (it) | 2005-05-19 | 2006-11-20 | Erregierre Spa | Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici |
| JP2007210888A (ja) * | 2006-01-12 | 2007-08-23 | Mitsubishi Chemicals Corp | ステロイド化合物の製造方法 |
| CN101395170A (zh) | 2006-02-14 | 2009-03-25 | 英特塞普特药品公司 | 用于预防或治疗fxr介导的疾病或状态的作为fxr配体的胆汁酸衍生物 |
| DK2040713T3 (da) | 2006-06-27 | 2014-09-29 | Intercept Pharmaceuticals Inc | Galdesyrederivater som fxr-ligander til forebyggelsen eller behandlingen af fxr-medierede sygdomme eller tilstande |
| CA2928178C (en) | 2007-01-19 | 2019-09-10 | Intercept Pharmaceuticals, Inc. | Tgr5 modulators and methods of use thereof |
| US8796249B2 (en) | 2008-07-30 | 2014-08-05 | Intercept Pharmaceuticals, Inc. | TGR5 modulators and methods of use thereof |
| AU2009316484B2 (en) * | 2008-11-19 | 2015-04-16 | Intercept Pharmaceuticals, Inc. | TGR5 modulators and methods of use thereof |
| HUE039171T2 (hu) | 2008-11-19 | 2018-12-28 | Intercept Pharmaceuticals Inc | TGR5 modulátorok és azok alkalmazási eljárása |
| JP2013500986A (ja) | 2009-07-29 | 2013-01-10 | ザ・ユニバーシティ・オブ・シカゴ | 肝臓ｘ受容体アゴニスト |
| ES2822375T3 (es) | 2012-06-19 | 2021-04-30 | Intercept Pharmaceuticals Inc | Preparación de la forma no cristalina del ácido obeticólico |
| NZ707389A (en) | 2012-10-26 | 2018-08-31 | Intercept Pharmaceuticals Inc | Process for preparing bile acid derivatives |
| WO2014085474A1 (en) | 2012-11-28 | 2014-06-05 | Intercept Pharmaceuticals, Inc. | Treatment of pulmonary disease |
| US20140206657A1 (en) | 2013-01-18 | 2014-07-24 | City Of Hope | Bile acid analog tgr5 agonists |
| CN105377870B (zh) | 2013-05-14 | 2018-04-03 | 英特塞普特医药品公司 | 作为法尼醇x受体调节剂的胆汁酸的11‑羟基衍生物及其氨基酸共轭物 |
| CA2913108A1 (en) | 2013-05-24 | 2014-11-27 | Nestec S.A. | Pathway specific assays for predicting irritable bowel syndrome diagnosis |
| WO2015183794A1 (en) | 2014-05-27 | 2015-12-03 | City Of Hope | Tgr5 agonist complexes for treating diabetes and cancer |
| SI3626725T1 (sl) | 2014-05-29 | 2023-04-28 | Bar Pharmaceuticals S.R.L. | Derivati holana za uporabo pri zdravljenju in/ali preprečevanju bolezni, posredovanih s FXR in TGR5/GPBAR1 |
| BR112017009657A2 (pt) | 2014-11-06 | 2018-01-23 | Enanta Pharmaceuticals, Inc | análogos de ácidos biliares como agonistas de fxr/tgr5 e métodos de uso dos mesmos |
| JP6698085B2 (ja) | 2014-11-19 | 2020-05-27 | エヌゼットピー ユーケー リミテッド | ステロイドＦＸＲモジュレーター製造のための中間体としての６α−アルキル−６，７−ジオン−ステロイド |
| ES2748692T3 (es) | 2014-11-19 | 2020-03-17 | Nzp Uk Ltd | Esteroides 6.alfa.-alquil-3,7-diona como intermedios para la producción de moduladores FXR de esteroides |
| KR102526632B1 (ko) | 2014-11-19 | 2023-04-27 | 엔제트피 유케이 리미티드 | 스테로이드 FXR 조절인자를 제조하기 위한 중간체로서의 5β-6-알킬-7-하이드록시-3-온 스테로이드 |
| WO2016086134A1 (en) | 2014-11-26 | 2016-06-02 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof |
| RU2017121457A (ru) | 2014-11-26 | 2018-12-26 | Энанта Фармасьютикалс, Инк. | Аналоги желчной кислоты в качестве агонистов fxr/tgr5 и способы их применения |
| US10208081B2 (en) | 2014-11-26 | 2019-02-19 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof |
| WO2016086115A1 (en) | 2014-11-26 | 2016-06-02 | Enanta Pharmaceuticals, Inc. | Tetrazole derivatives of bile acids as fxr/tgr5 agonists and methods of use thereof |
| CN106279328A (zh) | 2015-05-20 | 2017-01-04 | 重庆药友制药有限责任公司 | 一种制备6α-烷基鹅去氧胆酸的方法 |
| TW201700447A (zh) | 2015-06-19 | 2017-01-01 | 英特賽普醫藥品公司 | Tgr5調控劑及其用法 |
| CN106397522A (zh) | 2015-07-31 | 2017-02-15 | 中国人民解放军军事医学科学院毒物药物研究所 | 3,7‑二（叔丁基二甲基硅基氧基）‑6‑烯‑5β‑胆烷‑24‑酸甲酯 |
| CN106478759A (zh) | 2015-08-31 | 2017-03-08 | 陕西合成药业股份有限公司 | 奥贝胆酸衍生物及其制备方法和用途 |
| CN106478756A (zh) | 2015-09-02 | 2017-03-08 | 中美华世通生物医药科技（武汉）有限公司 | Oca-e单晶及其制备方法和用途 |
| CN106518946A (zh) | 2015-09-10 | 2017-03-22 | 上海迪诺医药科技有限公司 | 磺酰脲衍生物、其药物组合物及应用 |
-
2015
- 2015-11-19 EA EA201790884A patent/EA033427B1/ru not_active IP Right Cessation
- 2015-11-19 WO PCT/GB2015/053516 patent/WO2016079517A1/en not_active Ceased
- 2015-11-19 TW TW104138183A patent/TWI690536B/zh not_active IP Right Cessation
- 2015-11-19 CN CN201580062904.XA patent/CN107207559B/zh active Active
- 2015-11-19 CA CA2968309A patent/CA2968309A1/en not_active Abandoned
- 2015-11-19 US US15/528,214 patent/US10301350B2/en active Active
- 2015-11-19 PL PL15800909T patent/PL3221331T3/pl unknown
- 2015-11-19 ES ES15800909T patent/ES2759725T3/es active Active
- 2015-11-19 BR BR112017010319-2A patent/BR112017010319B1/pt not_active IP Right Cessation
- 2015-11-19 JP JP2017527817A patent/JP6700274B2/ja active Active
- 2015-11-19 PT PT158009092T patent/PT3221331T/pt unknown
- 2015-11-19 KR KR1020177016855A patent/KR102526631B1/ko active Active
- 2015-11-19 EP EP15800909.2A patent/EP3221331B1/en active Active
- 2015-11-19 MX MX2017006563A patent/MX375863B/es active IP Right Grant
- 2015-11-19 DK DK15800909T patent/DK3221331T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| KR102526631B1 (ko) | 2023-04-27 |
| EP3221331B1 (en) | 2019-09-18 |
| TW201632537A (zh) | 2016-09-16 |
| BR112017010319A2 (pt) | 2017-12-26 |
| EA201790884A1 (ru) | 2017-11-30 |
| ES2759725T3 (es) | 2020-05-12 |
| PL3221331T3 (pl) | 2020-03-31 |
| MX2017006563A (es) | 2018-01-26 |
| JP2017534670A (ja) | 2017-11-24 |
| CA2968309A1 (en) | 2016-05-26 |
| US20170327528A1 (en) | 2017-11-16 |
| HK1246801A1 (en) | 2018-09-14 |
| MX375863B (es) | 2025-03-07 |
| EP3221331A1 (en) | 2017-09-27 |
| JP6700274B2 (ja) | 2020-05-27 |
| KR20170086604A (ko) | 2017-07-26 |
| DK3221331T3 (da) | 2019-12-02 |
| NZ731924A (en) | 2020-12-18 |
| CN107207559A (zh) | 2017-09-26 |
| BR112017010319B1 (pt) | 2023-04-11 |
| WO2016079517A1 (en) | 2016-05-26 |
| TWI690536B (zh) | 2020-04-11 |
| EA033427B1 (ru) | 2019-10-31 |
| CN107207559B (zh) | 2019-10-25 |
| EA201790884A8 (ru) | 2019-07-31 |
| US10301350B2 (en) | 2019-05-28 |
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