BR112017010319B1 - Esteroides 6-alquil-7-hidróxi-4-en-3-ona e processo para a preparação dos mesmos - Google Patents

Esteroides 6-alquil-7-hidróxi-4-en-3-ona e processo para a preparação dos mesmos Download PDF

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Publication number
BR112017010319B1
BR112017010319B1 BR112017010319-2A BR112017010319A BR112017010319B1 BR 112017010319 B1 BR112017010319 B1 BR 112017010319B1 BR 112017010319 A BR112017010319 A BR 112017010319A BR 112017010319 B1 BR112017010319 B1 BR 112017010319B1
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BR
Brazil
Prior art keywords
general formula
compound
alkyl
halo
reaction
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BR112017010319-2A
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English (en)
Portuguese (pt)
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BR112017010319A2 (pt
Inventor
Alexander Weymouth-Wilson
Zofia KOMSTA
James BOYDELL
Carl OTTER
Laura WALLIS
Rhys BATCHELOR
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NZP UK Limited
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Priority claimed from GBGB1420594.2A external-priority patent/GB201420594D0/en
Priority claimed from GBGB1420593.4A external-priority patent/GB201420593D0/en
Priority claimed from GBGB1505670.8A external-priority patent/GB201505670D0/en
Application filed by NZP UK Limited filed Critical NZP UK Limited
Publication of BR112017010319A2 publication Critical patent/BR112017010319A2/pt
Publication of BR112017010319B1 publication Critical patent/BR112017010319B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BR112017010319-2A 2014-11-19 2015-11-19 Esteroides 6-alquil-7-hidróxi-4-en-3-ona e processo para a preparação dos mesmos BR112017010319B1 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB1420594.2A GB201420594D0 (en) 2014-11-19 2014-11-19 Compounds
GB1420594.2 2014-11-19
GBGB1420593.4A GB201420593D0 (en) 2014-11-19 2014-11-19 Compounds
GB1420593.4 2014-11-19
GBGB1505670.8A GB201505670D0 (en) 2015-04-01 2015-04-01 Compounds
GB1505670.8 2015-04-01
PCT/GB2015/053516 WO2016079517A1 (en) 2014-11-19 2015-11-19 6-alkyl-7-hydroxy-4-en-3-one steroids as intermediates for the production of steroidal fxr modulators

Publications (2)

Publication Number Publication Date
BR112017010319A2 BR112017010319A2 (pt) 2017-12-26
BR112017010319B1 true BR112017010319B1 (pt) 2023-04-11

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BR112017010319-2A BR112017010319B1 (pt) 2014-11-19 2015-11-19 Esteroides 6-alquil-7-hidróxi-4-en-3-ona e processo para a preparação dos mesmos

Country Status (15)

Country Link
US (1) US10301350B2 (enExample)
EP (1) EP3221331B1 (enExample)
JP (1) JP6700274B2 (enExample)
KR (1) KR102526631B1 (enExample)
CN (1) CN107207559B (enExample)
BR (1) BR112017010319B1 (enExample)
CA (1) CA2968309A1 (enExample)
DK (1) DK3221331T3 (enExample)
EA (1) EA033427B1 (enExample)
ES (1) ES2759725T3 (enExample)
MX (1) MX375863B (enExample)
PL (1) PL3221331T3 (enExample)
PT (1) PT3221331T (enExample)
TW (1) TWI690536B (enExample)
WO (1) WO2016079517A1 (enExample)

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GB201608777D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Compounds
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WO2023288123A1 (en) * 2021-07-16 2023-01-19 Interecept Pharmaceuticals, Inc. Methods and intermediates for the preparation of 3.alpha.,7.alpha.,11.beta.-trihydroxy-6.alpha.-ethyl-5.beta.-cholan-24-oic acid
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Publication number Publication date
WO2016079517A1 (en) 2016-05-26
MX2017006563A (es) 2018-01-26
EA201790884A8 (ru) 2019-07-31
US10301350B2 (en) 2019-05-28
CN107207559B (zh) 2019-10-25
TW201632537A (zh) 2016-09-16
EA033427B1 (ru) 2019-10-31
JP2017534670A (ja) 2017-11-24
US20170327528A1 (en) 2017-11-16
PT3221331T (pt) 2019-12-23
EP3221331B1 (en) 2019-09-18
MX375863B (es) 2025-03-07
ES2759725T3 (es) 2020-05-12
DK3221331T3 (da) 2019-12-02
EP3221331A1 (en) 2017-09-27
KR20170086604A (ko) 2017-07-26
NZ731924A (en) 2020-12-18
JP6700274B2 (ja) 2020-05-27
KR102526631B1 (ko) 2023-04-27
CA2968309A1 (en) 2016-05-26
CN107207559A (zh) 2017-09-26
BR112017010319A2 (pt) 2017-12-26
TWI690536B (zh) 2020-04-11
PL3221331T3 (pl) 2020-03-31
EA201790884A1 (ru) 2017-11-30
HK1246801A1 (en) 2018-09-14

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