PT2298436E - Utilização de um dispositivo de filtração de fluxo tangencial e métodos de enriquecimento de leucócitos - Google Patents

Utilização de um dispositivo de filtração de fluxo tangencial e métodos de enriquecimento de leucócitos Download PDF

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Publication number
PT2298436E
PT2298436E PT101826386T PT10182638T PT2298436E PT 2298436 E PT2298436 E PT 2298436E PT 101826386 T PT101826386 T PT 101826386T PT 10182638 T PT10182638 T PT 10182638T PT 2298436 E PT2298436 E PT 2298436E
Authority
PT
Portugal
Prior art keywords
methods
filtration device
flow filtration
tangential flow
leukocyte enrichment
Prior art date
Application number
PT101826386T
Other languages
English (en)
Inventor
Marnix L Bosch
Paul C Harris
Steven J Monahan
Allen Turner
Alton L Boynton
Patricia A Lodge
Original Assignee
Northwest Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Northwest Biotherapeutics Inc filed Critical Northwest Biotherapeutics Inc
Publication of PT2298436E publication Critical patent/PT2298436E/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3496—Plasmapheresis; Leucopheresis; Lymphopheresis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3601—Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit
    • A61M1/3603—Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit in the same direction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
    • A61M1/3633—Blood component filters, e.g. leukocyte filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D35/00—Filtering devices having features not specifically covered by groups B01D24/00 - B01D33/00, or for applications not specifically covered by groups B01D24/00 - B01D33/00; Auxiliary devices for filtration; Filter housing constructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/147—Microfiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/16—Feed pretreatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/18—Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/22—Controlling or regulating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/38—Removing constituents from donor blood and storing or returning remainder to body, e.g. for transfusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0439—White blood cells; Leucocytes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/10—Cross-flow filtration
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • External Artificial Organs (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
PT101826386T 2002-06-19 2003-06-19 Utilização de um dispositivo de filtração de fluxo tangencial e métodos de enriquecimento de leucócitos PT2298436E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39073002P 2002-06-19 2002-06-19

Publications (1)

Publication Number Publication Date
PT2298436E true PT2298436E (pt) 2014-11-12

Family

ID=30000608

Family Applications (3)

Application Number Title Priority Date Filing Date
PT37611571T PT1517740T (pt) 2002-06-19 2003-06-19 Dispositivos de filtração de fluxo tangencial e métodos para enriquecimento de leucócitos
PT101826386T PT2298436E (pt) 2002-06-19 2003-06-19 Utilização de um dispositivo de filtração de fluxo tangencial e métodos de enriquecimento de leucócitos
PT161942115T PT3173141T (pt) 2002-06-19 2003-06-19 Dispositivos e métodos de filtração de fluxo tangencial para o enriquecimento de leucócitos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT37611571T PT1517740T (pt) 2002-06-19 2003-06-19 Dispositivos de filtração de fluxo tangencial e métodos para enriquecimento de leucócitos

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT161942115T PT3173141T (pt) 2002-06-19 2003-06-19 Dispositivos e métodos de filtração de fluxo tangencial para o enriquecimento de leucócitos

Country Status (20)

Country Link
US (2) US7695627B2 (pt)
EP (4) EP1517740B1 (pt)
JP (1) JP4567446B2 (pt)
KR (1) KR101180363B1 (pt)
CN (1) CN1713951B (pt)
AU (1) AU2003243673B2 (pt)
BR (1) BRPI0312436A2 (pt)
CA (1) CA2490245C (pt)
DK (3) DK1517740T3 (pt)
ES (3) ES2611772T3 (pt)
HK (1) HK1155683A1 (pt)
HU (2) HUE031517T2 (pt)
IL (1) IL165766A0 (pt)
MX (1) MXPA04012717A (pt)
NZ (1) NZ537188A (pt)
PL (1) PL375035A1 (pt)
PT (3) PT1517740T (pt)
RU (1) RU2328317C2 (pt)
SI (1) SI2298436T1 (pt)
WO (1) WO2004000444A1 (pt)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050250202A1 (en) * 2002-03-19 2005-11-10 March Keith L Adipose stromal stem cells for tissue and vascular modification
US7695627B2 (en) * 2002-06-19 2010-04-13 Northwest Biotherapeutics, Inc. Tangential flow filtration devices and methods for leukocyte enrichment
AU2004214896A1 (en) * 2003-02-27 2004-09-10 Northwest Biotherapeutics, Inc. Generation of dendritic cells from monocytic dendritic precursor cells with GM-CSF in the absence of additional cytokines
AU2004248962A1 (en) * 2003-06-21 2004-12-29 Lifeforce Group Plc Leukocyte cell banks
GB0322789D0 (en) * 2003-09-30 2003-10-29 Lifeforce Group Plc Blood pack for leukocyte banking
GB0322806D0 (en) * 2003-09-30 2003-10-29 Lifeforce Group Plc Cell bank for contingent autologous leukocyte transplantation
GB0322791D0 (en) * 2003-09-30 2003-10-29 Lifeforce Group Plc Blood co-processing for contingent autologous leukocyte transplantation
US7790039B2 (en) * 2003-11-24 2010-09-07 Northwest Biotherapeutics, Inc. Tangential flow filtration devices and methods for stem cell enrichment
US20050148064A1 (en) * 2003-12-29 2005-07-07 Intel Corporation Microfluid molecular-flow fractionator and bioreactor with integrated active/passive diffusion barrier
JP4655938B2 (ja) * 2004-01-21 2011-03-23 東レ株式会社 分画装置および分画方法
US7354515B2 (en) 2004-02-23 2008-04-08 Millennium Medical Technologies, Inc. Fluid concentrator
JP2005336080A (ja) * 2004-05-26 2005-12-08 Asahi Kasei Medical Co Ltd 血管新生療法用細胞の分離回収方法および分離回収システム
KR20150032915A (ko) 2005-04-08 2015-03-30 아르고스 쎄라퓨틱스 인코포레이티드 수지상 세포 조성물 및 방법
KR20080109717A (ko) 2005-12-08 2008-12-17 노쓰웨스트 바이오써라퓨틱스, 인크. 미성숙 단핵구성 수지상 세포의 활성화를 유도하기 위한조성물 및 방법
US10850235B2 (en) 2006-10-09 2020-12-01 Minnetronix, Inc. Method for filtering cerebrospinal fluid (CSF) including monitoring CSF flow
US10632237B2 (en) 2006-10-09 2020-04-28 Minnetronix, Inc. Tangential flow filter system for the filtration of materials from biologic fluids
EP2086573B1 (en) 2006-10-09 2020-11-25 Neurofluidics, Inc. Cerebrospinal fluid purification system
WO2008085991A2 (en) * 2007-01-08 2008-07-17 U.S. Genomics, Inc. Reaction chamber
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
US8650937B2 (en) 2008-09-19 2014-02-18 Tandem Diabetes Care, Inc. Solute concentration measurement device and related methods
US8961787B2 (en) 2008-12-01 2015-02-24 General Electric Company Systems and methods for processing complex biological materials
CN102264410B (zh) * 2008-12-01 2016-08-03 通用电气公司 用于从体液分离细胞的系统和方法
US20100210989A1 (en) * 2008-12-23 2010-08-19 Janet Lesley Macpherson Processing blood
AU2010278894B2 (en) 2009-07-30 2014-01-30 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US8512566B2 (en) * 2009-12-11 2013-08-20 General Electric Company Disposable fluid path systems and methods for processing complex biological materials
EP2525899A1 (en) * 2010-01-22 2012-11-28 Lonza Walkersville, Inc. High yield method and apparatus for volume reduction and washing of therapeutic cells using tangential flow filtration
WO2011099861A1 (en) 2010-02-12 2011-08-18 Dutch Water Technologies B.V. Automatic fluid sample preparation module, automatic analysis system and method for use thereof
CN102260628A (zh) * 2010-05-31 2011-11-30 上海康德莱企业发展集团医疗器械有限公司 一种干细胞过滤筛选富集并快速复合装置
FR2961713B1 (fr) * 2010-06-23 2012-08-10 Millipore Corp Poche pour circuit d'une installation de traitement de liquide biologique
JP2012080821A (ja) * 2010-10-12 2012-04-26 Univ Of Tsukuba 血液中の有核細胞成分濃縮方法
WO2012071135A2 (en) * 2010-11-23 2012-05-31 Biovec Transfusion, Llc Methods for removing pathogens from a platelet preparation
US9011684B2 (en) 2011-03-07 2015-04-21 Spinesmith Holdings, Llc Fluid concentrator with removable cartridge
GB201106802D0 (en) * 2011-04-21 2011-06-01 Allergy Therapeutics Ltd Process for preparing vaccine composition
WO2012170232A1 (en) 2011-06-09 2012-12-13 Bellbrook Labs, Llc Device for washing suspended cells or particles
JP6057317B2 (ja) * 2012-04-05 2017-01-11 セイコーエプソン株式会社 分離装置
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
CN102749238B (zh) * 2012-07-04 2014-10-01 烟台卓越生物技术有限责任公司 一种血站阴性滤除白细胞的洗脱和固定方法及专用过滤器
US9695393B2 (en) 2012-08-20 2017-07-04 Terumo Bct, Inc. Concentrating components of fluid circulated through a cell growth chamber
JP5920830B2 (ja) * 2012-09-28 2016-05-18 シスメックス株式会社 試料調製装置および細胞分析装置
EP2953703A4 (en) 2013-02-05 2017-02-08 Pocared Diagnostics Ltd Filter arrangement and method for using the same
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
US9452021B2 (en) 2013-08-02 2016-09-27 All Cell Recovery LLC Systems, methods, and apparatus for resuspending cells from surgical laundry
US10159980B2 (en) 2013-08-02 2018-12-25 All Cell Recovery LLC Systems and methods for recovering blood cells, in a controlled environment, for storage
US8945376B1 (en) 2013-08-02 2015-02-03 All Cell Recovery LLC Systems, methods, and apparatus for resuspending cells in solution
US9545471B2 (en) 2013-08-06 2017-01-17 Viatar LLC Extracorporeal fluidic device for collecting circulating tumor cells and method of use thereof
EP3047013B1 (en) * 2013-09-16 2021-08-18 Genzyme Corporation Methods and systems for processing a cell culture
CA2931609A1 (en) * 2013-12-04 2015-06-11 Pocared Diagnostics Ltd. Filter arrangement with slider valve and method for using the same
CN103725599B (zh) * 2014-01-14 2015-05-27 刘韬 一种流体膜过滤细胞分离装置
US10376627B2 (en) 2014-03-24 2019-08-13 Fenwal, Inc. Flexible biological fluid filters
US10159778B2 (en) 2014-03-24 2018-12-25 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US9796166B2 (en) 2014-03-24 2017-10-24 Fenwal, Inc. Flexible biological fluid filters
US9968738B2 (en) 2014-03-24 2018-05-15 Fenwal, Inc. Biological fluid filters with molded frame and methods for making such filters
US9782707B2 (en) 2014-03-24 2017-10-10 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
WO2015153618A1 (en) * 2014-03-31 2015-10-08 Haemonetics Corporation System and method for concentrating plasma
WO2016200800A1 (en) 2015-06-08 2016-12-15 Becton, Dickinson And Company Filtration cell and method for filtering a biological sample
US11147540B2 (en) 2015-07-01 2021-10-19 Minnetronix, Inc. Introducer sheath and puncture tool for the introduction and placement of a catheter in tissue
CN108291204A (zh) 2015-09-15 2018-07-17 西北生物治疗药物公司 涉及用于患有晚期癌症的受试者的经活化树突状细胞组合物和免疫治疗处理的方法
EP3356509B1 (en) * 2015-10-01 2019-07-31 GE Healthcare Bio-Sciences AB A filter holding device
WO2017070237A1 (en) 2015-10-19 2017-04-27 University Of Maryland, Baltimore Methods for generating engineered human primary blood dendritic cell lines
CN105641988B (zh) * 2015-12-02 2018-01-30 重庆浪尖渝力科技有限公司 生物样品混悬液自动分离设备的挂板组件
CN108778355B (zh) 2015-12-04 2021-04-30 米奈特朗尼克斯有限公司 用于对脑脊液进行调节的系统及方法
CN108885203B (zh) 2016-03-02 2021-02-05 贝克顿·迪金森公司 生物流体分离装置
US10697871B2 (en) 2016-10-07 2020-06-30 Massachusetts Institute Of Technology Particle isolation/enrichment using continuous closed-loop micro-fluidics
JP2019532654A (ja) * 2016-10-24 2019-11-14 イェール ユニバーシティーＹａｌｅ Ｕｎｉｖｅｒｓｉｔｙ 吸引デバイス
WO2018093475A1 (en) 2016-11-15 2018-05-24 Massachusetts Institute Of Technology Liquid biopsy detection of leukemia using closed-loop microfluidics
EP3662246A4 (en) * 2017-08-02 2021-05-26 Pocared Diagnostics Ltd. PROCESSOR FILTER ARRANGEMENT WHICH INCLUDES A PROCESS AND APPARATUS FOR REMOVING WASTE FLUID THROUGH A FILTER
US11027239B2 (en) 2017-10-05 2021-06-08 Global Life Sciences Solutions Usa Llc Systems and methods for utilizing crossflow filtration for cell enrichment
JP7069809B2 (ja) * 2018-02-21 2022-05-18 富士フイルムビジネスイノベーション株式会社 静電荷像現像用トナー、静電荷像現像剤、トナーカートリッジ、プロセスカートリッジ、画像形成装置、及び画像形成方法
EP3790607B1 (en) * 2018-05-11 2023-12-27 Lupagen, Inc. Systems for closed loop, real-time modifications of patient cells
CA3127798A1 (en) * 2019-01-30 2020-08-06 Repligen Corporation Method of using track etched membranes for the filtration of biological fluids
US11148083B2 (en) * 2019-12-27 2021-10-19 Pall Corporation Method and system for recovering fluid

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4191182A (en) * 1977-09-23 1980-03-04 Hemotherapy Inc. Method and apparatus for continuous plasmaphersis
US4411792A (en) 1981-08-10 1983-10-25 Trimedyne, Inc. Lymph filtration system
US4420398A (en) 1981-08-13 1983-12-13 American National Red Cross Filteration method for cell produced antiviral substances
US4753733A (en) 1981-10-02 1988-06-28 E. I. Du Pont De Nemours And Company Plasmapheresis method and apparatus for overcoming membrane fouling
US4888115A (en) 1983-12-29 1989-12-19 Cuno, Incorporated Cross-flow filtration
DE3432718C1 (de) 1984-09-06 1986-05-22 Biotest Pharma GmbH, 6000 Frankfurt Verfahren zur Herstellung einer Loesung von Milch- und/oder Kolostralimmunglobulinen
DE3515650A1 (de) * 1985-05-02 1986-11-06 Biochemie GmbH, Kundl, Tirol Verfahren zur abtrennung von biotechnologisch hergestellten wertstoffen durch querstrom-mikrofiltration
GB2176715A (en) 1985-06-27 1987-01-07 Apv Int Ltd Beer filtration
US4722902A (en) * 1985-11-04 1988-02-02 Endotronics, Inc. Apparatus and method for culturing cells, removing waste and concentrating product
US5026365A (en) * 1987-04-29 1991-06-25 The University Of Massachusetts Method and apparatus for therapeutically treating immunological disorders and disease states
JPS6475015A (en) * 1987-09-18 1989-03-20 Terumo Corp Filter for separating leukocytes
US5948441A (en) 1988-03-07 1999-09-07 The Liposome Company, Inc. Method for size separation of particles
US5362406A (en) 1990-07-27 1994-11-08 Pall Corporation Leucocyte depleting filter device and method of use
US5256294A (en) * 1990-09-17 1993-10-26 Genentech, Inc. Tangential flow filtration process and apparatus
JP3270125B2 (ja) * 1992-07-09 2002-04-02 旭メディカル株式会社 白血球捕捉材
CA2074671A1 (en) * 1991-11-04 1993-05-05 Thomas Bormann Device and method for separating plasma from a biological fluid
JP3461359B2 (ja) * 1991-11-30 2003-10-27 旭メディカル株式会社 白血球除去フィルターシステムおよび白血球除去方法
US5423738A (en) 1992-03-13 1995-06-13 Robinson; Thomas C. Blood pumping and processing system
RU2056866C1 (ru) 1992-06-09 1996-03-27 Ленинградский научно-исследовательский нейрохирургический институт им.проф.А.Л.Поленова Способ лечения внутрижелудочковых и субарахноидальных кровоизлияний и устройство для его осуществления
JPH07509153A (ja) 1992-07-13 1995-10-12 ポール・コーポレーション 生物学的流体を処理するための自動化されたシステムおよび方法
CA2130893A1 (en) 1993-09-17 1995-03-18 Bayer Corporation Method and system for collecting, processing and storing blood components
NL9301653A (nl) * 1993-09-24 1995-04-18 X Flow Bv Werkwijze voor het verwijderen van troebelheid veroorzakende bestanddelen uit een vloeistof met behulp van microfiltratie.
US5695653A (en) * 1994-12-23 1997-12-09 Pall Corporation Device and method for separating components from a biological fluid
RU2113863C1 (ru) 1995-05-05 1998-06-27 Акционерное общество закрытого типа "Оптика" Способ мембранного плазмафереза по одноигольной схеме и устройство для его осуществления
US5922210A (en) * 1995-06-16 1999-07-13 University Of Washington Tangential flow planar microfabricated fluid filter and method of using thereof
US6121044A (en) * 1995-07-12 2000-09-19 Dendreon Corporation Potent antigen presenting cell composition
US5788963A (en) 1995-07-31 1998-08-04 Pacific Northwest Cancer Foundation Isolation and/or preservation of dendritic cells for prostate cancer immunotherapy
US6194204B1 (en) 1996-08-02 2001-02-27 Center For Blood Research, Inc. Enrichment of dendritic cells from blood
EP0834329A1 (en) * 1996-09-09 1998-04-08 Kaneka Corporation Method and apparatus for treating blood
TW391881B (en) * 1996-09-25 2000-06-01 Baxter Int Method and apparatus for filtering suspensions of medical and biological fluids or the like
US6168718B1 (en) 1996-11-08 2001-01-02 Pall Corporation Method for purifying blood plasma and apparatus suitable therefor
AU5359198A (en) * 1996-11-12 1998-06-03 University Of Akron, The Compositions and methods relating to the production, isolation, and modification of gas vesicles
DE19650648A1 (de) * 1996-12-06 1998-06-10 Sartorius Gmbh Wickelmodul
EP0973873B1 (en) 1997-04-08 2006-06-07 Pall Corporation Method of harvesting rare cells from blood products
US6649158B1 (en) * 1998-10-15 2003-11-18 Canji, Inc. Methods and compositions to induce antitumor response
JP2000217908A (ja) 1999-01-29 2000-08-08 Asahi Medical Co Ltd 血液回収装置
US6214221B1 (en) * 1999-02-22 2001-04-10 Henry B. Kopf Method and apparatus for purification of biological substances
EP1230028B1 (en) * 1999-05-28 2008-07-16 Bio/Data Corporation Method and apparatus for directly sampling a fluid for microfiltration
FR2796961B1 (fr) * 1999-07-29 2003-05-02 Chu Montpellier Procede d'obtention de cellules dentritiques, les cellules dentritiques ainsi obtenues et leurs utilisations a des fins cliniques
EP1289630B1 (de) * 2000-03-07 2008-03-05 MAT Adsorption Technologies GmbH & Co. KG Modul mit membranelementen in cross-flow und in dead-end anordnung
US6495037B1 (en) 2000-11-08 2002-12-17 Pall Corporation Caged filter cartridge assembly and filtration systems employing the same
WO2003010292A2 (en) 2001-07-25 2003-02-06 Northwest Biotherapeutics, Inc. Methods and apparatus for enrichment and culture of monocytic dendritic cell precursors
DK1439897T3 (da) * 2001-10-11 2011-01-03 Aviva Biosciences Corp Fremgangsmåder til adskillelse af sjældne celler fra væskeprøver
US7695627B2 (en) * 2002-06-19 2010-04-13 Northwest Biotherapeutics, Inc. Tangential flow filtration devices and methods for leukocyte enrichment

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ES2611772T3 (es) 2017-05-10
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CN1713951A (zh) 2005-12-28
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CA2490245A1 (en) 2003-12-31
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US8518636B2 (en) 2013-08-27
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HUE046504T2 (hu) 2020-03-30
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