PT2298436E - Utilização de um dispositivo de filtração de fluxo tangencial e métodos de enriquecimento de leucócitos - Google Patents

Utilização de um dispositivo de filtração de fluxo tangencial e métodos de enriquecimento de leucócitos Download PDF

Info

Publication number
PT2298436E
PT2298436E PT101826386T PT10182638T PT2298436E PT 2298436 E PT2298436 E PT 2298436E PT 101826386 T PT101826386 T PT 101826386T PT 10182638 T PT10182638 T PT 10182638T PT 2298436 E PT2298436 E PT 2298436E
Authority
PT
Portugal
Prior art keywords
methods
filtration device
flow filtration
tangential flow
leukocyte enrichment
Prior art date
Application number
PT101826386T
Other languages
English (en)
Inventor
Marnix L Bosch
Paul C Harris
Steven J Monahan
Allen Turner
Alton L Boynton
Patricia A Lodge
Original Assignee
Northwest Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Northwest Biotherapeutics Inc filed Critical Northwest Biotherapeutics Inc
Publication of PT2298436E publication Critical patent/PT2298436E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3496—Plasmapheresis; Leucopheresis; Lymphopheresis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3601—Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit
    • A61M1/3603—Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit in the same direction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
    • A61M1/3633—Blood component filters, e.g. leukocyte filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D35/00—Filtering devices having features not specifically covered by groups B01D24/00 - B01D33/00, or for applications not specifically covered by groups B01D24/00 - B01D33/00; Auxiliary devices for filtration; Filter housing constructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/147—Microfiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/16—Feed pretreatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/18—Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/22—Controlling or regulating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/38—Removing constituents from donor blood and storing or returning remainder to body, e.g. for transfusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0439—White blood cells; Leucocytes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/10—Cross-flow filtration
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • External Artificial Organs (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
PT101826386T 2002-06-19 2003-06-19 Utilização de um dispositivo de filtração de fluxo tangencial e métodos de enriquecimento de leucócitos PT2298436E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39073002P 2002-06-19 2002-06-19

Publications (1)

Publication Number Publication Date
PT2298436E true PT2298436E (pt) 2014-11-12

Family

ID=30000608

Family Applications (3)

Application Number Title Priority Date Filing Date
PT37611571T PT1517740T (pt) 2002-06-19 2003-06-19 Dispositivos de filtração de fluxo tangencial e métodos para enriquecimento de leucócitos
PT101826386T PT2298436E (pt) 2002-06-19 2003-06-19 Utilização de um dispositivo de filtração de fluxo tangencial e métodos de enriquecimento de leucócitos
PT161942115T PT3173141T (pt) 2002-06-19 2003-06-19 Dispositivos e métodos de filtração de fluxo tangencial para o enriquecimento de leucócitos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT37611571T PT1517740T (pt) 2002-06-19 2003-06-19 Dispositivos de filtração de fluxo tangencial e métodos para enriquecimento de leucócitos

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT161942115T PT3173141T (pt) 2002-06-19 2003-06-19 Dispositivos e métodos de filtração de fluxo tangencial para o enriquecimento de leucócitos

Country Status (20)

Country Link
US (2) US7695627B2 (pt)
EP (4) EP3173141B1 (pt)
JP (1) JP4567446B2 (pt)
KR (1) KR101180363B1 (pt)
CN (1) CN1713951B (pt)
AU (1) AU2003243673B2 (pt)
BR (1) BRPI0312436A2 (pt)
CA (1) CA2490245C (pt)
DK (3) DK3173141T3 (pt)
ES (3) ES2755552T3 (pt)
HK (1) HK1155683A1 (pt)
HU (2) HUE031517T2 (pt)
IL (1) IL165766A0 (pt)
MX (1) MXPA04012717A (pt)
NZ (1) NZ537188A (pt)
PL (1) PL375035A1 (pt)
PT (3) PT1517740T (pt)
RU (1) RU2328317C2 (pt)
SI (1) SI2298436T1 (pt)
WO (1) WO2004000444A1 (pt)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003080801A2 (en) * 2002-03-19 2003-10-02 Advanced Research & Technology Transfer Adipose stromal stem cells for tissue and vascular modification
PT1517740T (pt) * 2002-06-19 2017-01-31 Northwest Biotherapeutics Inc Dispositivos de filtração de fluxo tangencial e métodos para enriquecimento de leucócitos
PL209998B1 (pl) 2003-02-27 2011-11-30 Northwest Biotherapeutics Inc Sposób in vitro lub ex vivo różnicowania monocytarnych prekursorów komórek dendrytycznych w niedojrzale komórki dendrytyczne
CA2529652A1 (en) * 2003-06-21 2004-12-29 Lifeforce Group Plc Leukocyte cell banks
GB0322789D0 (en) * 2003-09-30 2003-10-29 Lifeforce Group Plc Blood pack for leukocyte banking
GB0322806D0 (en) * 2003-09-30 2003-10-29 Lifeforce Group Plc Cell bank for contingent autologous leukocyte transplantation
GB0322791D0 (en) * 2003-09-30 2003-10-29 Lifeforce Group Plc Blood co-processing for contingent autologous leukocyte transplantation
US7790039B2 (en) * 2003-11-24 2010-09-07 Northwest Biotherapeutics, Inc. Tangential flow filtration devices and methods for stem cell enrichment
US20050148064A1 (en) * 2003-12-29 2005-07-07 Intel Corporation Microfluid molecular-flow fractionator and bioreactor with integrated active/passive diffusion barrier
CN1934129B (zh) * 2004-01-21 2010-07-14 东丽株式会社 分级装置和分级方法
US7354515B2 (en) 2004-02-23 2008-04-08 Millennium Medical Technologies, Inc. Fluid concentrator
JP2005336080A (ja) * 2004-05-26 2005-12-08 Asahi Kasei Medical Co Ltd 血管新生療法用細胞の分離回収方法および分離回収システム
EP1882031B1 (en) 2005-04-08 2017-11-08 Argos Therapeutics, Inc. Dendritic cell compositions and methods
CN101336291A (zh) 2005-12-08 2008-12-31 西北生物治疗药物公司 用于诱导未成熟单核细胞的树突细胞的激活的组合物和方法
EP3827841B1 (en) 2006-10-09 2024-04-03 Neurofluidics, Inc. Cerebrospinal fluid purification system
US10632237B2 (en) 2006-10-09 2020-04-28 Minnetronix, Inc. Tangential flow filter system for the filtration of materials from biologic fluids
US10850235B2 (en) 2006-10-09 2020-12-01 Minnetronix, Inc. Method for filtering cerebrospinal fluid (CSF) including monitoring CSF flow
WO2008085991A2 (en) * 2007-01-08 2008-07-17 U.S. Genomics, Inc. Reaction chamber
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
WO2010033878A2 (en) 2008-09-19 2010-03-25 David Brown Solute concentration measurement device and related methods
KR101720808B1 (ko) * 2008-12-01 2017-03-28 제너럴 일렉트릭 캄파니 세포를 체액으로부터 분리하기 위한 시스템 및 방법
US8961787B2 (en) * 2008-12-01 2015-02-24 General Electric Company Systems and methods for processing complex biological materials
US20100210989A1 (en) * 2008-12-23 2010-08-19 Janet Lesley Macpherson Processing blood
WO2011014704A2 (en) 2009-07-30 2011-02-03 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US8512566B2 (en) * 2009-12-11 2013-08-20 General Electric Company Disposable fluid path systems and methods for processing complex biological materials
WO2011091248A1 (en) * 2010-01-22 2011-07-28 Lonza Walkersville, Inc. High yield method and apparatus for volume reduction and washing of therapeutic cells using tangential flow filtration
US20130045496A1 (en) * 2010-02-12 2013-02-21 Gijsbert Johan Jansen Automatic Fluid Sample Preparation Module, Automatic Analysis System and Method for Use Thereof
CN102260628A (zh) * 2010-05-31 2011-11-30 上海康德莱企业发展集团医疗器械有限公司 一种干细胞过滤筛选富集并快速复合装置
FR2961713B1 (fr) * 2010-06-23 2012-08-10 Millipore Corp Poche pour circuit d'une installation de traitement de liquide biologique
JP2012080821A (ja) * 2010-10-12 2012-04-26 Univ Of Tsukuba 血液中の有核細胞成分濃縮方法
WO2012071135A2 (en) * 2010-11-23 2012-05-31 Biovec Transfusion, Llc Methods for removing pathogens from a platelet preparation
US9011684B2 (en) 2011-03-07 2015-04-21 Spinesmith Holdings, Llc Fluid concentrator with removable cartridge
GB201106802D0 (en) * 2011-04-21 2011-06-01 Allergy Therapeutics Ltd Process for preparing vaccine composition
WO2012170232A1 (en) 2011-06-09 2012-12-13 Bellbrook Labs, Llc Device for washing suspended cells or particles
JP6057317B2 (ja) * 2012-04-05 2017-01-11 セイコーエプソン株式会社 分離装置
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
CN102749238B (zh) * 2012-07-04 2014-10-01 烟台卓越生物技术有限责任公司 一种血站阴性滤除白细胞的洗脱和固定方法及专用过滤器
US9695393B2 (en) 2012-08-20 2017-07-04 Terumo Bct, Inc. Concentrating components of fluid circulated through a cell growth chamber
JP5920830B2 (ja) * 2012-09-28 2016-05-18 シスメックス株式会社 試料調製装置および細胞分析装置
CN104968408B (zh) * 2013-02-05 2019-09-17 普凯尔德诊断技术有限公司 过滤装置以及使用该过滤装置的方法
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
US10159980B2 (en) 2013-08-02 2018-12-25 All Cell Recovery LLC Systems and methods for recovering blood cells, in a controlled environment, for storage
US8945376B1 (en) 2013-08-02 2015-02-03 All Cell Recovery LLC Systems, methods, and apparatus for resuspending cells in solution
US9452021B2 (en) 2013-08-02 2016-09-27 All Cell Recovery LLC Systems, methods, and apparatus for resuspending cells from surgical laundry
US9545471B2 (en) 2013-08-06 2017-01-17 Viatar LLC Extracorporeal fluidic device for collecting circulating tumor cells and method of use thereof
EP3047013B1 (en) * 2013-09-16 2021-08-18 Genzyme Corporation Methods and systems for processing a cell culture
CN113634124B (zh) 2013-12-04 2022-11-18 普凯尔德诊断技术有限公司 用于处理和分析通过切向过滤提取的颗粒的方法和装置
CN103725599B (zh) * 2014-01-14 2015-05-27 刘韬 一种流体膜过滤细胞分离装置
US9968738B2 (en) 2014-03-24 2018-05-15 Fenwal, Inc. Biological fluid filters with molded frame and methods for making such filters
US10159778B2 (en) 2014-03-24 2018-12-25 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US9796166B2 (en) 2014-03-24 2017-10-24 Fenwal, Inc. Flexible biological fluid filters
US10376627B2 (en) 2014-03-24 2019-08-13 Fenwal, Inc. Flexible biological fluid filters
US9782707B2 (en) 2014-03-24 2017-10-10 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
WO2015153618A1 (en) * 2014-03-31 2015-10-08 Haemonetics Corporation System and method for concentrating plasma
WO2016200800A1 (en) 2015-06-08 2016-12-15 Becton, Dickinson And Company Filtration cell and method for filtering a biological sample
US11147540B2 (en) 2015-07-01 2021-10-19 Minnetronix, Inc. Introducer sheath and puncture tool for the introduction and placement of a catheter in tissue
RU2749610C2 (ru) 2015-09-15 2021-06-16 Нортвест Байотерапьютикс, Инк. Способы, относящиеся к композициям активированных дендритных клеток и к иммунотерапевтическому лечению индивидуумов с прогрессирующим раком
CN108026496B (zh) * 2015-10-01 2022-07-26 思拓凡瑞典有限公司 过滤器保持装置
US20180305666A1 (en) 2015-10-19 2018-10-25 University Of Maryland, Baltimore Methods for generating engineered human primary blood dendritic cell lines
CN105641988B (zh) * 2015-12-02 2018-01-30 重庆浪尖渝力科技有限公司 生物样品混悬液自动分离设备的挂板组件
CA3006975C (en) 2015-12-04 2022-02-22 Minnetronix, Inc. Systems and methods for the conditioning of cerebrospinal fluid
AU2017227802B2 (en) * 2016-03-02 2020-11-12 Becton, Dickinson And Company Biological fluid separation device
WO2018067915A1 (en) * 2016-10-07 2018-04-12 Massachusetts Institute Of Technology Particle isolation/enrichment using continuous closed-loop micro-fluidics
EP4360567A2 (en) * 2016-10-24 2024-05-01 Yale University Aspiration device
US10697964B2 (en) 2016-11-15 2020-06-30 Massachusetts Institute Of Technology Liquid biopsy detection of leukemia using closed-loop microfluidics
CN111065904A (zh) * 2017-08-02 2020-04-24 普凯尔德诊断技术有限公司 包括通过过滤器去除废液的方法和装置的处理器过滤器布置
US11027239B2 (en) 2017-10-05 2021-06-08 Global Life Sciences Solutions Usa Llc Systems and methods for utilizing crossflow filtration for cell enrichment
JP7069809B2 (ja) * 2018-02-21 2022-05-18 富士フイルムビジネスイノベーション株式会社 静電荷像現像用トナー、静電荷像現像剤、トナーカートリッジ、プロセスカートリッジ、画像形成装置、及び画像形成方法
EP3790607B1 (en) * 2018-05-11 2023-12-27 Lupagen, Inc. Systems for closed loop, real-time modifications of patient cells
US20220106554A1 (en) * 2019-01-30 2022-04-07 Repligen Corporation Method of using track etched membranes for the filtration of biological fluids
US11148083B2 (en) * 2019-12-27 2021-10-19 Pall Corporation Method and system for recovering fluid

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4191182A (en) * 1977-09-23 1980-03-04 Hemotherapy Inc. Method and apparatus for continuous plasmaphersis
US4411792A (en) * 1981-08-10 1983-10-25 Trimedyne, Inc. Lymph filtration system
US4420398A (en) 1981-08-13 1983-12-13 American National Red Cross Filteration method for cell produced antiviral substances
US4753733A (en) * 1981-10-02 1988-06-28 E. I. Du Pont De Nemours And Company Plasmapheresis method and apparatus for overcoming membrane fouling
US4888115A (en) 1983-12-29 1989-12-19 Cuno, Incorporated Cross-flow filtration
DE3432718C1 (de) 1984-09-06 1986-05-22 Biotest Pharma GmbH, 6000 Frankfurt Verfahren zur Herstellung einer Loesung von Milch- und/oder Kolostralimmunglobulinen
DE3515650A1 (de) * 1985-05-02 1986-11-06 Biochemie GmbH, Kundl, Tirol Verfahren zur abtrennung von biotechnologisch hergestellten wertstoffen durch querstrom-mikrofiltration
GB2176715A (en) 1985-06-27 1987-01-07 Apv Int Ltd Beer filtration
US4722902A (en) * 1985-11-04 1988-02-02 Endotronics, Inc. Apparatus and method for culturing cells, removing waste and concentrating product
US5026365A (en) * 1987-04-29 1991-06-25 The University Of Massachusetts Method and apparatus for therapeutically treating immunological disorders and disease states
JPS6475015A (en) * 1987-09-18 1989-03-20 Terumo Corp Filter for separating leukocytes
US5948441A (en) 1988-03-07 1999-09-07 The Liposome Company, Inc. Method for size separation of particles
US5362406A (en) 1990-07-27 1994-11-08 Pall Corporation Leucocyte depleting filter device and method of use
US5256294A (en) * 1990-09-17 1993-10-26 Genentech, Inc. Tangential flow filtration process and apparatus
JP3270125B2 (ja) * 1992-07-09 2002-04-02 旭メディカル株式会社 白血球捕捉材
CA2074671A1 (en) * 1991-11-04 1993-05-05 Thomas Bormann Device and method for separating plasma from a biological fluid
JP3461359B2 (ja) * 1991-11-30 2003-10-27 旭メディカル株式会社 白血球除去フィルターシステムおよび白血球除去方法
US5423738A (en) 1992-03-13 1995-06-13 Robinson; Thomas C. Blood pumping and processing system
RU2056866C1 (ru) 1992-06-09 1996-03-27 Ленинградский научно-исследовательский нейрохирургический институт им.проф.А.Л.Поленова Способ лечения внутрижелудочковых и субарахноидальных кровоизлияний и устройство для его осуществления
JPH07509153A (ja) 1992-07-13 1995-10-12 ポール・コーポレーション 生物学的流体を処理するための自動化されたシステムおよび方法
CA2130893A1 (en) 1993-09-17 1995-03-18 Bayer Corporation Method and system for collecting, processing and storing blood components
NL9301653A (nl) * 1993-09-24 1995-04-18 X Flow Bv Werkwijze voor het verwijderen van troebelheid veroorzakende bestanddelen uit een vloeistof met behulp van microfiltratie.
US5695653A (en) * 1994-12-23 1997-12-09 Pall Corporation Device and method for separating components from a biological fluid
RU2113863C1 (ru) 1995-05-05 1998-06-27 Акционерное общество закрытого типа "Оптика" Способ мембранного плазмафереза по одноигольной схеме и устройство для его осуществления
WO1997000121A1 (en) * 1995-06-16 1997-01-03 The University Of Washington Tangential flow planar microfabricated fluid filter
US6121044A (en) * 1995-07-12 2000-09-19 Dendreon Corporation Potent antigen presenting cell composition
US5788963A (en) 1995-07-31 1998-08-04 Pacific Northwest Cancer Foundation Isolation and/or preservation of dendritic cells for prostate cancer immunotherapy
US6194204B1 (en) * 1996-08-02 2001-02-27 Center For Blood Research, Inc. Enrichment of dendritic cells from blood
CA2214754A1 (en) 1996-09-09 1998-03-09 Masataka Narisada Method and apparatus for treating blood
TW391881B (en) * 1996-09-25 2000-06-01 Baxter Int Method and apparatus for filtering suspensions of medical and biological fluids or the like
US6168718B1 (en) 1996-11-08 2001-01-02 Pall Corporation Method for purifying blood plasma and apparatus suitable therefor
EP0956337A4 (en) 1996-11-12 2004-12-22 Univ Akron COMPOSITIONS AND METHODS RELATING TO THE PRODUCTION, ISOLATION AND MODIFICATION OF GAS MICROBUBBLES
DE19650648A1 (de) * 1996-12-06 1998-06-10 Sartorius Gmbh Wickelmodul
ATE329012T1 (de) 1997-04-08 2006-06-15 Pall Corp Verfahren zur gewinnung von seltenen zellen aus blutprodukten
US6649158B1 (en) * 1998-10-15 2003-11-18 Canji, Inc. Methods and compositions to induce antitumor response
JP2000217908A (ja) * 1999-01-29 2000-08-08 Asahi Medical Co Ltd 血液回収装置
US6214221B1 (en) * 1999-02-22 2001-04-10 Henry B. Kopf Method and apparatus for purification of biological substances
WO2001012325A1 (en) 1999-05-28 2001-02-22 Bio/Data Corporation Method and apparatus for directly sampling a fluid for microfiltration
FR2796961B1 (fr) * 1999-07-29 2003-05-02 Chu Montpellier Procede d'obtention de cellules dentritiques, les cellules dentritiques ainsi obtenues et leurs utilisations a des fins cliniques
DE50113701D1 (de) * 2000-03-07 2008-04-17 Mat Adsorption Technologies Gm Modul mit membranelementen in cross-flow und in dead-end anordnung
US6495037B1 (en) 2000-11-08 2002-12-17 Pall Corporation Caged filter cartridge assembly and filtration systems employing the same
AU2002326463A1 (en) 2001-07-25 2003-02-17 Northwest Biotherapeutics, Inc. Methods and apparatus for enrichment and culture of monocytic dendritic cell precursors
DE60237531D1 (de) * 2001-10-11 2010-10-14 Aviva Biosciences Corp Verfahren zum trennen von seltenen zellen von fluidproben
PT1517740T (pt) * 2002-06-19 2017-01-31 Northwest Biotherapeutics Inc Dispositivos de filtração de fluxo tangencial e métodos para enriquecimento de leucócitos

Also Published As

Publication number Publication date
DK3173141T3 (da) 2019-11-25
AU2003243673B2 (en) 2010-01-21
AU2003243673A1 (en) 2004-01-06
KR101180363B1 (ko) 2012-09-10
MXPA04012717A (es) 2005-03-23
EP2298436B1 (en) 2014-08-06
HK1155683A1 (en) 2012-05-25
IL165766A0 (en) 2006-01-15
ES2523366T3 (es) 2014-11-25
BRPI0312436A2 (pt) 2016-06-28
US20050173315A1 (en) 2005-08-11
CA2490245C (en) 2021-08-03
JP4567446B2 (ja) 2010-10-20
HUE031517T2 (en) 2017-07-28
PT3173141T (pt) 2019-11-25
EP3173141B1 (en) 2019-09-04
EP3650110A1 (en) 2020-05-13
ES2611772T3 (es) 2017-05-10
SI2298436T1 (sl) 2014-12-31
EP1517740A4 (en) 2006-05-03
US20110189150A1 (en) 2011-08-04
EP2298436A1 (en) 2011-03-23
ES2755552T3 (es) 2020-04-22
KR20050024342A (ko) 2005-03-10
JP2005529746A (ja) 2005-10-06
WO2004000444A1 (en) 2003-12-31
EP1517740B1 (en) 2016-10-19
EP1517740A1 (en) 2005-03-30
EP3173141A1 (en) 2017-05-31
HUE046504T2 (hu) 2020-03-30
DK1517740T3 (en) 2019-04-15
US7695627B2 (en) 2010-04-13
PT1517740T (pt) 2017-01-31
RU2005101318A (ru) 2006-01-20
RU2328317C2 (ru) 2008-07-10
NZ537188A (en) 2006-11-30
US8518636B2 (en) 2013-08-27
DK2298436T3 (da) 2014-11-10
CN1713951A (zh) 2005-12-28
CN1713951B (zh) 2010-05-26
CA2490245A1 (en) 2003-12-31
PL375035A1 (en) 2005-11-14

Similar Documents

Publication Publication Date Title
HK1155683A1 (en) Use of a tangential flow filtration device and methods for leukocyte enrichment
IL175530A0 (en) Tangential flow filtration devices and methods for stem cell enrichment
EP1601788A4 (en) TANGENTIAL FILTRATION METHODS AND APPARATUS THEREFOR
EP1507577A4 (en) PREPARATION OF A LEUCOCYTE FILTER AND METHOD OF USING THE SAME
EP1754496A4 (en) METHOD FOR REMOVING LEUKOCYTES AND FILTERS FOR USE THEREIN
EP1582228A4 (en) METHOD FOR REMOVING LEUKOCYTES, LEUKOCYTES REMOVING FILTERS AND ITS USE
HK1096146A1 (en) Flow meter filter system and method
DE60317288D1 (de) Filtrierungsvorrichtung mit Wechselfiltereinsatz und Entleerungsvorrichtung
IL165319A0 (en) A system and methods for filtering electromagneticvisual and minimizing acoustic transmissions
AU2003206032A8 (en) Integrated membrane filter and its use for gas treatment
GB0407364D0 (en) A centrifuge and a combination including a centrifuge and a coalescing filter
AU2003211913A1 (en) Fluid cleaning filter and filter device
AU2003298795A8 (en) Filter cartridge for a standalone point of use water purification device
AU2003269464A8 (en) Optical filtering device and method
IL175066A0 (en) Filter jug with replaceable cartridge and method of monitoring and controlling the efficiency of a filter cartridge in a replaceable cartridge filter device
GB0326629D0 (en) A fluid filtration system and method of filtering fluid
EP1776991A4 (en) FILTER DEVICE AND FILTER PROCESS
SG96274A1 (en) Disk apparatus and filter for disk apparatus
GB2413098B (en) A filter assembly and method of filtration
GB0425199D0 (en) A fluid filtration system and method of filtering fluid
AU2003281173A8 (en) Device for the filtration and collection of microparticles in a gaseous environment
AU2003225065A8 (en) Shaped flow distribution in filtration cassettes
PL367425A1 (en) Expandable and disposable media filter
IL155861A0 (en) Air filtering system and a kit therefor
GB0216922D0 (en) Fluids collection holding and filtration device