BRPI0312436A2 - dispositivo de filtragem de fluxo tangencial e métodos para enriquecimento em leucócito - Google Patents

dispositivo de filtragem de fluxo tangencial e métodos para enriquecimento em leucócito

Info

Publication number
BRPI0312436A2
BRPI0312436A2 BRPI0312436A BR0312436A BRPI0312436A2 BR PI0312436 A2 BRPI0312436 A2 BR PI0312436A2 BR PI0312436 A BRPI0312436 A BR PI0312436A BR 0312436 A BR0312436 A BR 0312436A BR PI0312436 A2 BRPI0312436 A2 BR PI0312436A2
Authority
BR
Brazil
Prior art keywords
methods
filtering device
tangential flow
flow filtering
leukocyte enrichment
Prior art date
Application number
BRPI0312436A
Other languages
English (en)
Inventor
Allen Turner
Alton L Boynton
Marnix L Bosch
Patricia Anne Lodge
Paul C Harris
Steven J Monahan
Original Assignee
Northwest Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Northwest Biotherapeutics Inc filed Critical Northwest Biotherapeutics Inc
Publication of BRPI0312436A2 publication Critical patent/BRPI0312436A2/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3496Plasmapheresis; Leucopheresis; Lymphopheresis
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14Ultrafiltration; Microfiltration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3601Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit
    • A61M1/3603Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit in the same direction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3627Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
    • A61M1/3633Blood component filters, e.g. leukocyte filters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D35/00Filtering devices having features not specifically covered by groups B01D24/00 - B01D33/00, or for applications not specifically covered by groups B01D24/00 - B01D33/00; Auxiliary devices for filtration; Filter housing constructions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14Ultrafiltration; Microfiltration
    • B01D61/147Microfiltration
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14Ultrafiltration; Microfiltration
    • B01D61/16Feed pretreatment
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14Ultrafiltration; Microfiltration
    • B01D61/18Apparatus therefor
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14Ultrafiltration; Microfiltration
    • B01D61/22Controlling or regulating
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/38Removing constituents from donor blood and storing or returning remainder to body, e.g. for transfusion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/04Liquids
    • A61M2202/0413Blood
    • A61M2202/0439White blood cells; Leucocytes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D2315/00Details relating to the membrane module operation
    • B01D2315/10Cross-flow filtration
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • External Artificial Organs (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
BRPI0312436A 2002-06-19 2003-06-19 dispositivo de filtragem de fluxo tangencial e métodos para enriquecimento em leucócito BRPI0312436A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39073002P 2002-06-19 2002-06-19
PCT/US2003/019428 WO2004000444A1 (en) 2002-06-19 2003-06-19 Tangential flow filtration devices and methods for leukocyte enrichment

Publications (1)

Publication Number Publication Date
BRPI0312436A2 true BRPI0312436A2 (pt) 2016-06-28

Family

ID=30000608

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0312436A BRPI0312436A2 (pt) 2002-06-19 2003-06-19 dispositivo de filtragem de fluxo tangencial e métodos para enriquecimento em leucócito

Country Status (20)

Country Link
US (2) US7695627B2 (pt)
EP (4) EP1517740B1 (pt)
JP (1) JP4567446B2 (pt)
KR (1) KR101180363B1 (pt)
CN (1) CN1713951B (pt)
AU (1) AU2003243673B2 (pt)
BR (1) BRPI0312436A2 (pt)
CA (1) CA2490245C (pt)
DK (3) DK2298436T3 (pt)
ES (3) ES2611772T3 (pt)
HK (1) HK1155683A1 (pt)
HU (2) HUE031517T2 (pt)
IL (1) IL165766A0 (pt)
MX (1) MXPA04012717A (pt)
NZ (1) NZ537188A (pt)
PL (1) PL375035A1 (pt)
PT (3) PT3173141T (pt)
RU (1) RU2328317C2 (pt)
SI (1) SI2298436T1 (pt)
WO (1) WO2004000444A1 (pt)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050250202A1 (en) * 2002-03-19 2005-11-10 March Keith L Adipose stromal stem cells for tissue and vascular modification
PT3173141T (pt) * 2002-06-19 2019-11-25 Northwest Biotherapeutics Inc Dispositivos e métodos de filtração de fluxo tangencial para o enriquecimento de leucócitos
EP1604016B1 (en) * 2003-02-27 2009-01-14 NorthWest Biotherapeutics, Inc. Generation of dendritic cells from monocytic dendritic precursor cells with gm-csf in the absence of additional cytokines
US20070148772A1 (en) * 2003-06-21 2007-06-28 Lifeforce Group Plc Leukocyte cell banks
GB0322791D0 (en) * 2003-09-30 2003-10-29 Lifeforce Group Plc Blood co-processing for contingent autologous leukocyte transplantation
GB0322806D0 (en) * 2003-09-30 2003-10-29 Lifeforce Group Plc Cell bank for contingent autologous leukocyte transplantation
GB0322789D0 (en) * 2003-09-30 2003-10-29 Lifeforce Group Plc Blood pack for leukocyte banking
US7790039B2 (en) * 2003-11-24 2010-09-07 Northwest Biotherapeutics, Inc. Tangential flow filtration devices and methods for stem cell enrichment
US20050148064A1 (en) * 2003-12-29 2005-07-07 Intel Corporation Microfluid molecular-flow fractionator and bioreactor with integrated active/passive diffusion barrier
KR20070001927A (ko) * 2004-01-21 2007-01-04 도레이 가부시끼가이샤 분획 장치 및 분획 방법
US7354515B2 (en) 2004-02-23 2008-04-08 Millennium Medical Technologies, Inc. Fluid concentrator
JP2005336080A (ja) * 2004-05-26 2005-12-08 Asahi Kasei Medical Co Ltd 血管新生療法用細胞の分離回収方法および分離回収システム
CN101155914B (zh) 2005-04-08 2013-03-06 阿戈斯治疗公司 树状细胞组合物和方法
CN103589684A (zh) 2005-12-08 2014-02-19 西北生物治疗药物公司 用于诱导未成熟单核细胞的树突细胞的激活的组合物和方法
US10850235B2 (en) 2006-10-09 2020-12-01 Minnetronix, Inc. Method for filtering cerebrospinal fluid (CSF) including monitoring CSF flow
US10632237B2 (en) 2006-10-09 2020-04-28 Minnetronix, Inc. Tangential flow filter system for the filtration of materials from biologic fluids
EP2086573B1 (en) 2006-10-09 2020-11-25 Neurofluidics, Inc. Cerebrospinal fluid purification system
US8999636B2 (en) * 2007-01-08 2015-04-07 Toxic Report Llc Reaction chamber
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
EP2334234A4 (en) 2008-09-19 2013-03-20 Tandem Diabetes Care Inc DEVICE FOR MEASURING THE CONCENTRATION OF A SOLVED SUBSTANCE AND CORRESPONDING METHOD
KR101720808B1 (ko) * 2008-12-01 2017-03-28 제너럴 일렉트릭 캄파니 세포를 체액으로부터 분리하기 위한 시스템 및 방법
US8961787B2 (en) 2008-12-01 2015-02-24 General Electric Company Systems and methods for processing complex biological materials
US20100210989A1 (en) * 2008-12-23 2010-08-19 Janet Lesley Macpherson Processing blood
EP2932994B1 (en) 2009-07-30 2017-11-08 Tandem Diabetes Care, Inc. New o-ring seal, and delivery mechanism and portable infusion pump system related thereto
US8512566B2 (en) 2009-12-11 2013-08-20 General Electric Company Disposable fluid path systems and methods for processing complex biological materials
CA2787656A1 (en) * 2010-01-22 2011-07-28 Lonza Walkersville, Inc. High yield method and apparatus for volume reduction and washing of therapeutic cells using tangential flow filtration
US20130045496A1 (en) * 2010-02-12 2013-02-21 Gijsbert Johan Jansen Automatic Fluid Sample Preparation Module, Automatic Analysis System and Method for Use Thereof
CN102260628A (zh) * 2010-05-31 2011-11-30 上海康德莱企业发展集团医疗器械有限公司 一种干细胞过滤筛选富集并快速复合装置
FR2961713B1 (fr) * 2010-06-23 2012-08-10 Millipore Corp Poche pour circuit d'une installation de traitement de liquide biologique
JP2012080821A (ja) * 2010-10-12 2012-04-26 Univ Of Tsukuba 血液中の有核細胞成分濃縮方法
WO2012071135A2 (en) * 2010-11-23 2012-05-31 Biovec Transfusion, Llc Methods for removing pathogens from a platelet preparation
US9011684B2 (en) 2011-03-07 2015-04-21 Spinesmith Holdings, Llc Fluid concentrator with removable cartridge
GB201106802D0 (en) 2011-04-21 2011-06-01 Allergy Therapeutics Ltd Process for preparing vaccine composition
US20140193900A1 (en) 2011-06-09 2014-07-10 Ivar Meyvantsson Device for washing suspended cells or particles
JP6057317B2 (ja) * 2012-04-05 2017-01-11 セイコーエプソン株式会社 分離装置
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
CN102749238B (zh) * 2012-07-04 2014-10-01 烟台卓越生物技术有限责任公司 一种血站阴性滤除白细胞的洗脱和固定方法及专用过滤器
CN104583386A (zh) 2012-08-20 2015-04-29 泰尔茂比司特公司 浓缩穿过细胞生长腔室循环的流体的组分
JP5920830B2 (ja) * 2012-09-28 2016-05-18 シスメックス株式会社 試料調製装置および細胞分析装置
JP6116709B2 (ja) * 2013-02-05 2017-04-19 ポカード・ディアグノスティクス・リミテッドPocared Diagnostics, Ltd. フィルタ装置及びその使用方法
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
US10159980B2 (en) 2013-08-02 2018-12-25 All Cell Recovery LLC Systems and methods for recovering blood cells, in a controlled environment, for storage
US9452021B2 (en) 2013-08-02 2016-09-27 All Cell Recovery LLC Systems, methods, and apparatus for resuspending cells from surgical laundry
US8945376B1 (en) 2013-08-02 2015-02-03 All Cell Recovery LLC Systems, methods, and apparatus for resuspending cells in solution
US9545471B2 (en) 2013-08-06 2017-01-17 Viatar LLC Extracorporeal fluidic device for collecting circulating tumor cells and method of use thereof
SG10201803601SA (en) * 2013-09-16 2018-06-28 Genzyme Corp Methods and systems for processing a cell culture
EP3077505A4 (en) * 2013-12-04 2018-01-24 Pocared Diagnostics Ltd Method and apparatus for processing and analyzing particles extracted from tangential filtering
CN103725599B (zh) * 2014-01-14 2015-05-27 刘韬 一种流体膜过滤细胞分离装置
US9968738B2 (en) 2014-03-24 2018-05-15 Fenwal, Inc. Biological fluid filters with molded frame and methods for making such filters
US10159778B2 (en) 2014-03-24 2018-12-25 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US10376627B2 (en) 2014-03-24 2019-08-13 Fenwal, Inc. Flexible biological fluid filters
US9796166B2 (en) 2014-03-24 2017-10-24 Fenwal, Inc. Flexible biological fluid filters
US9782707B2 (en) 2014-03-24 2017-10-10 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
WO2015153618A1 (en) * 2014-03-31 2015-10-08 Haemonetics Corporation System and method for concentrating plasma
US11344849B2 (en) 2015-06-08 2022-05-31 Becton, Dickinson And Company Filtration cell and method for filtering a biological sample
EP3317403A4 (en) 2015-06-30 2019-07-03 NorthWest Biotherapeutics, Inc. OPTIMALLY ACTIVATED DENDRITIC CELLS THAT INDUCE ENHANCED OR ENHANCED ANTI-TUMOR IMMUNE RESPONSE
US11147540B2 (en) 2015-07-01 2021-10-19 Minnetronix, Inc. Introducer sheath and puncture tool for the introduction and placement of a catheter in tissue
EP3350318B1 (en) 2015-09-15 2022-04-13 NorthWest Biotherapeutics, Inc. Methods relating to activated dendritic cell compositions for subjects with advanced cancers
EP3356509B1 (en) * 2015-10-01 2019-07-31 GE Healthcare Bio-Sciences AB A filter holding device
CN108289909A (zh) 2015-10-19 2018-07-17 巴尔的摩马里兰大学 用于产生工程改造的人原代血液树突细胞系的方法
CN105641988B (zh) * 2015-12-02 2018-01-30 重庆浪尖渝力科技有限公司 生物样品混悬液自动分离设备的挂板组件
ES2856599T3 (es) 2015-12-04 2021-09-27 Minnetronix Inc Sistemas de acondicionamiento de fluido cerebrospinal
EP3423827A2 (en) 2016-03-02 2019-01-09 Becton, Dickinson and Company Biological fluid separation device
WO2018067915A1 (en) * 2016-10-07 2018-04-12 Massachusetts Institute Of Technology Particle isolation/enrichment using continuous closed-loop micro-fluidics
EP3528709B1 (en) * 2016-10-24 2023-12-06 Yale University Aspiration device
WO2018093475A1 (en) 2016-11-15 2018-05-24 Massachusetts Institute Of Technology Liquid biopsy detection of leukemia using closed-loop microfluidics
CA3070832A1 (en) * 2017-08-02 2019-02-07 Pocared Diagnostics Ltd. Processor filter arrangement that includes method and apparatus to remove waste fluid through a filter
US11027239B2 (en) 2017-10-05 2021-06-08 Global Life Sciences Solutions Usa Llc Systems and methods for utilizing crossflow filtration for cell enrichment
JP7069809B2 (ja) * 2018-02-21 2022-05-18 富士フイルムビジネスイノベーション株式会社 静電荷像現像用トナー、静電荷像現像剤、トナーカートリッジ、プロセスカートリッジ、画像形成装置、及び画像形成方法
WO2019217964A1 (en) * 2018-05-11 2019-11-14 Lupagen, Inc. Systems and methods for closed loop, real-time modifications of patient cells
AU2020214316B2 (en) * 2019-01-30 2023-01-12 Repligen Corporation Method of using track etched membranes for the filtration of biological fluids
US11148083B2 (en) * 2019-12-27 2021-10-19 Pall Corporation Method and system for recovering fluid

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4191182A (en) * 1977-09-23 1980-03-04 Hemotherapy Inc. Method and apparatus for continuous plasmaphersis
US4411792A (en) * 1981-08-10 1983-10-25 Trimedyne, Inc. Lymph filtration system
US4420398A (en) 1981-08-13 1983-12-13 American National Red Cross Filteration method for cell produced antiviral substances
US4753733A (en) * 1981-10-02 1988-06-28 E. I. Du Pont De Nemours And Company Plasmapheresis method and apparatus for overcoming membrane fouling
US4888115A (en) 1983-12-29 1989-12-19 Cuno, Incorporated Cross-flow filtration
DE3432718C1 (de) 1984-09-06 1986-05-22 Biotest Pharma GmbH, 6000 Frankfurt Verfahren zur Herstellung einer Loesung von Milch- und/oder Kolostralimmunglobulinen
DE3515650A1 (de) * 1985-05-02 1986-11-06 Biochemie GmbH, Kundl, Tirol Verfahren zur abtrennung von biotechnologisch hergestellten wertstoffen durch querstrom-mikrofiltration
GB2176715A (en) 1985-06-27 1987-01-07 Apv Int Ltd Beer filtration
US4722902A (en) * 1985-11-04 1988-02-02 Endotronics, Inc. Apparatus and method for culturing cells, removing waste and concentrating product
US5026365A (en) * 1987-04-29 1991-06-25 The University Of Massachusetts Method and apparatus for therapeutically treating immunological disorders and disease states
JPS6475015A (en) * 1987-09-18 1989-03-20 Terumo Corp Filter for separating leukocytes
US5948441A (en) 1988-03-07 1999-09-07 The Liposome Company, Inc. Method for size separation of particles
US5362406A (en) * 1990-07-27 1994-11-08 Pall Corporation Leucocyte depleting filter device and method of use
US5256294A (en) * 1990-09-17 1993-10-26 Genentech, Inc. Tangential flow filtration process and apparatus
JP3270125B2 (ja) * 1992-07-09 2002-04-02 旭メディカル株式会社 白血球捕捉材
CA2074671A1 (en) * 1991-11-04 1993-05-05 Thomas Bormann Device and method for separating plasma from a biological fluid
JP3461359B2 (ja) * 1991-11-30 2003-10-27 旭メディカル株式会社 白血球除去フィルターシステムおよび白血球除去方法
US5423738A (en) 1992-03-13 1995-06-13 Robinson; Thomas C. Blood pumping and processing system
RU2056866C1 (ru) 1992-06-09 1996-03-27 Ленинградский научно-исследовательский нейрохирургический институт им.проф.А.Л.Поленова Способ лечения внутрижелудочковых и субарахноидальных кровоизлияний и устройство для его осуществления
JPH07509153A (ja) * 1992-07-13 1995-10-12 ポール・コーポレーション 生物学的流体を処理するための自動化されたシステムおよび方法
CA2130893A1 (en) * 1993-09-17 1995-03-18 Bayer Corporation Method and system for collecting, processing and storing blood components
NL9301653A (nl) * 1993-09-24 1995-04-18 X Flow Bv Werkwijze voor het verwijderen van troebelheid veroorzakende bestanddelen uit een vloeistof met behulp van microfiltratie.
US5695653A (en) * 1994-12-23 1997-12-09 Pall Corporation Device and method for separating components from a biological fluid
RU2113863C1 (ru) 1995-05-05 1998-06-27 Акционерное общество закрытого типа "Оптика" Способ мембранного плазмафереза по одноигольной схеме и устройство для его осуществления
EP0871539B1 (en) * 1995-06-16 2002-02-20 University of Washington Tangential flow planar microfabricated fluid filter
US6121044A (en) 1995-07-12 2000-09-19 Dendreon Corporation Potent antigen presenting cell composition
US5788963A (en) 1995-07-31 1998-08-04 Pacific Northwest Cancer Foundation Isolation and/or preservation of dendritic cells for prostate cancer immunotherapy
WO1998005795A1 (en) * 1996-08-02 1998-02-12 The Center For Blood Research, Inc. Enrichment of dendritic cells from blood
CA2214754A1 (en) * 1996-09-09 1998-03-09 Masataka Narisada Method and apparatus for treating blood
TW391881B (en) * 1996-09-25 2000-06-01 Baxter Int Method and apparatus for filtering suspensions of medical and biological fluids or the like
US6168718B1 (en) * 1996-11-08 2001-01-02 Pall Corporation Method for purifying blood plasma and apparatus suitable therefor
AU5359198A (en) 1996-11-12 1998-06-03 University Of Akron, The Compositions and methods relating to the production, isolation, and modification of gas vesicles
DE19650648A1 (de) * 1996-12-06 1998-06-10 Sartorius Gmbh Wickelmodul
DE69834809T2 (de) * 1997-04-08 2007-05-16 Pall Corp. Verfahren zur gewinnung von seltenen zellen aus blutprodukten
US6649158B1 (en) * 1998-10-15 2003-11-18 Canji, Inc. Methods and compositions to induce antitumor response
JP2000217908A (ja) * 1999-01-29 2000-08-08 Asahi Medical Co Ltd 血液回収装置
US6214221B1 (en) * 1999-02-22 2001-04-10 Henry B. Kopf Method and apparatus for purification of biological substances
EP1230028B1 (en) * 1999-05-28 2008-07-16 Bio/Data Corporation Method and apparatus for directly sampling a fluid for microfiltration
FR2796961B1 (fr) * 1999-07-29 2003-05-02 Chu Montpellier Procede d'obtention de cellules dentritiques, les cellules dentritiques ainsi obtenues et leurs utilisations a des fins cliniques
EP1289630B1 (de) * 2000-03-07 2008-03-05 MAT Adsorption Technologies GmbH & Co. KG Modul mit membranelementen in cross-flow und in dead-end anordnung
US6495037B1 (en) * 2000-11-08 2002-12-17 Pall Corporation Caged filter cartridge assembly and filtration systems employing the same
WO2003010292A2 (en) 2001-07-25 2003-02-06 Northwest Biotherapeutics, Inc. Methods and apparatus for enrichment and culture of monocytic dendritic cell precursors
ATE479490T1 (de) * 2001-10-11 2010-09-15 Aviva Biosciences Corp Verfahren zum trennen von seltenen zellen von fluidproben
PT3173141T (pt) * 2002-06-19 2019-11-25 Northwest Biotherapeutics Inc Dispositivos e métodos de filtração de fluxo tangencial para o enriquecimento de leucócitos

Also Published As

Publication number Publication date
EP3173141A1 (en) 2017-05-31
RU2328317C2 (ru) 2008-07-10
EP3650110A1 (en) 2020-05-13
HUE046504T2 (hu) 2020-03-30
MXPA04012717A (es) 2005-03-23
US20050173315A1 (en) 2005-08-11
ES2755552T3 (es) 2020-04-22
DK1517740T3 (en) 2019-04-15
US7695627B2 (en) 2010-04-13
EP2298436A1 (en) 2011-03-23
CA2490245C (en) 2021-08-03
NZ537188A (en) 2006-11-30
AU2003243673A1 (en) 2004-01-06
AU2003243673B2 (en) 2010-01-21
WO2004000444A1 (en) 2003-12-31
ES2523366T3 (es) 2014-11-25
DK2298436T3 (da) 2014-11-10
EP1517740B1 (en) 2016-10-19
JP2005529746A (ja) 2005-10-06
EP3173141B1 (en) 2019-09-04
US8518636B2 (en) 2013-08-27
JP4567446B2 (ja) 2010-10-20
IL165766A0 (en) 2006-01-15
SI2298436T1 (sl) 2014-12-31
HK1155683A1 (en) 2012-05-25
PT1517740T (pt) 2017-01-31
PT3173141T (pt) 2019-11-25
CA2490245A1 (en) 2003-12-31
HUE031517T2 (en) 2017-07-28
EP1517740A4 (en) 2006-05-03
DK3173141T3 (da) 2019-11-25
CN1713951B (zh) 2010-05-26
CN1713951A (zh) 2005-12-28
EP2298436B1 (en) 2014-08-06
RU2005101318A (ru) 2006-01-20
US20110189150A1 (en) 2011-08-04
ES2611772T3 (es) 2017-05-10
PL375035A1 (en) 2005-11-14
EP1517740A1 (en) 2005-03-30
KR101180363B1 (ko) 2012-09-10
PT2298436E (pt) 2014-11-12
KR20050024342A (ko) 2005-03-10

Similar Documents

Publication Publication Date Title
BRPI0312436A2 (pt) dispositivo de filtragem de fluxo tangencial e métodos para enriquecimento em leucócito
IL175530A0 (en) Tangential flow filtration devices and methods for stem cell enrichment
FI20031207A (fi) Suodatusmenetelmä ja suodatinlaite
DE602005004592D1 (de) Lithografische Vorrichtung, Beleuchtungssystem und Debrisauffangsystem
DE602004003404D1 (de) Partikelfilterregeneration
DE60300575D1 (de) Regenerationsvorrichtung für Partikelfilter
DE602004027774D1 (de) Signaltrennverfahren, Signaltrenneinrichtung,und Signaltrennprogramm
DE60320542D1 (de) Mikroporöse filtermedien, diese enthaltende filtersysteme und herstellungs- und verwendungsverfahren
EP1601788A4 (en) TANGENTIAL FILTRATION METHODS AND APPARATUS THEREFOR
DE60321401D1 (de) Demodulationseinrichtung und demodulationsverfahren
DE602004021212D1 (de) Protokolldateiübertragungsgerät und Protokolldateiübertragungsverfahren
EP1754496A4 (en) METHOD FOR REMOVING LEUKOCYTES AND FILTERS FOR USE THEREIN
HK1096146A1 (en) Flow meter filter system and method
DE602004012417D1 (de) Dekodierungsvorrichtung und dekodierungsverfahren
EP1812850A4 (en) EFFICIENT MULTI-PROCESSOR SYSTEM AND ASSOCIATED METHODS
DE602004024961D1 (de) Filter und filtermodul
DK1572317T3 (da) Filterpatron med bøjle samt fremgangsmåde
DE602004024605D1 (de) Tiefpassfilter und Feedbacksystem
DE60300253D1 (de) Dieselpartikelfiltereinrichtung
DE50303933D1 (de) Filtereinrichtung
DE50306836D1 (de) Filtereinrichtung und Filterelement
ATE533546T1 (de) Filtrationselement für flüssigkeiten und filtrationsanlage damit
FI20030546A (fi) Puhdistuslaite, puhdistustyökalu ja puhdistuslaitteen käyttötapa
DE60303620D1 (de) Dateiwiedergabevorrichtung und Dateiwiedergabeverfahren
FI20035050A0 (fi) Suodatusmenetelmä ja laitteisto

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]