AU2002326463A1 - Methods and apparatus for enrichment and culture of monocytic dendritic cell precursors - Google Patents

Methods and apparatus for enrichment and culture of monocytic dendritic cell precursors

Info

Publication number
AU2002326463A1
AU2002326463A1 AU2002326463A AU2002326463A AU2002326463A1 AU 2002326463 A1 AU2002326463 A1 AU 2002326463A1 AU 2002326463 A AU2002326463 A AU 2002326463A AU 2002326463 A AU2002326463 A AU 2002326463A AU 2002326463 A1 AU2002326463 A1 AU 2002326463A1
Authority
AU
Australia
Prior art keywords
enrichment
culture
methods
dendritic cell
cell precursors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002326463A
Inventor
Marnix L. Bosch
Paul C. Harris
Benjamin A. Tjoa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Northwest Biotherapeutics LLC
Original Assignee
Northwest Biotherapeutics LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Northwest Biotherapeutics LLC filed Critical Northwest Biotherapeutics LLC
Publication of AU2002326463A1 publication Critical patent/AU2002326463A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0081—Purging biological preparations of unwanted cells
    • C12N5/0087—Purging against subsets of blood cells, e.g. purging alloreactive T cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4615—Dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4622—Antigen presenting cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464493—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; Prostatic acid phosphatase [PAP]; Prostate-specific G-protein-coupled receptor [PSGR]
    • A61K39/464495—Prostate specific membrane antigen [PSMA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
AU2002326463A 2001-07-25 2002-07-25 Methods and apparatus for enrichment and culture of monocytic dendritic cell precursors Abandoned AU2002326463A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30797801P 2001-07-25 2001-07-25
US60/307,978 2001-07-25
PCT/US2002/023865 WO2003010292A2 (en) 2001-07-25 2002-07-25 Methods and apparatus for enrichment and culture of monocytic dendritic cell precursors

Publications (1)

Publication Number Publication Date
AU2002326463A1 true AU2002326463A1 (en) 2003-02-17

Family

ID=23191999

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002326463A Abandoned AU2002326463A1 (en) 2001-07-25 2002-07-25 Methods and apparatus for enrichment and culture of monocytic dendritic cell precursors

Country Status (2)

Country Link
AU (1) AU2002326463A1 (en)
WO (1) WO2003010292A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050027163A (en) * 2001-09-06 2005-03-17 노쓰웨스트 바이오써라퓨틱스, 인크. Compositions and methods for priming monocytic dendritic cells and t cells for th-1 response
PT1517740T (en) 2002-06-19 2017-01-31 Northwest Biotherapeutics Inc Tangential flow filtration devices and methods for leukocyte enrichment
MXPA05006042A (en) * 2002-12-06 2005-09-21 Northwest Biotherapeutics Inc Administration of dendritic cells partially matured in vitro for the treatment of tumors.
PL209998B1 (en) 2003-02-27 2011-11-30 Northwest Biotherapeutics Inc Generation of dendritic cells from monocytic dendritic precursor cells with gm-csf in the absence of additional cytokines
CN101336291A (en) 2005-12-08 2008-12-31 西北生物治疗药物公司 Compositions and methods for inducing the activation of immature monocytic dendritic cells
SI2913394T1 (en) * 2012-12-18 2017-01-31 Immunicum Ab Co-differentiation and activation of monocytes from allogeneic donors to provide pro-inflammatory dendritic cells
WO2017004169A1 (en) 2015-06-29 2017-01-05 Northeastern University Dendritic cell generator
BR112018005180B1 (en) 2015-09-15 2023-11-28 Northwest Biotherapeutics, Inc In vitro method for determining the immunotherapeutic potency of a composition of active and not fully mature human dendritic cells, in vitro method for selecting a patient with a solid tumor who will respond or not respond to administration of the composition of active and not fully mature human dendritic cells patient-derived and in vitro method for selecting a dendritic cell maturation agent to produce active, not fully mature human dendritic cells with increased immunotherapeutic potency
EP3371295A1 (en) 2015-11-04 2018-09-12 Northeastern University Systems for producing cellular immunotherapeutics and methods of use thereof
US10647954B1 (en) 2018-11-15 2020-05-12 Flaskworks, Llc Dendritic cell generating apparatus and method
US11566217B2 (en) 2019-08-13 2023-01-31 Flaskworks, Llc Duty cycle for cell culture systems
CN114901799A (en) 2019-10-21 2022-08-12 弗拉斯沃克斯有限责任公司 Systems and methods for cell culture

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0633929T3 (en) * 1992-04-01 2004-06-28 Univ Rockefeller Method for in vitro proliferation of dendritic cell precursors and their use to produce immunogens

Also Published As

Publication number Publication date
WO2003010292A3 (en) 2003-05-22
WO2003010292A2 (en) 2003-02-06

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase