PT2109449E - Medicamento para o tratamento da endometriose - Google Patents
Medicamento para o tratamento da endometriose Download PDFInfo
- Publication number
- PT2109449E PT2109449E PT08751001T PT08751001T PT2109449E PT 2109449 E PT2109449 E PT 2109449E PT 08751001 T PT08751001 T PT 08751001T PT 08751001 T PT08751001 T PT 08751001T PT 2109449 E PT2109449 E PT 2109449E
- Authority
- PT
- Portugal
- Prior art keywords
- agonist
- dopamine
- endometriosis
- treatment
- cabergoline
- Prior art date
Links
- 201000009273 Endometriosis Diseases 0.000 title claims description 44
- 238000011282 treatment Methods 0.000 title claims description 36
- 239000003814 drug Substances 0.000 title claims description 8
- 239000003136 dopamine receptor stimulating agent Substances 0.000 claims description 56
- KORNTPPJEAJQIU-KJXAQDMKSA-N Cabaser Chemical compound C1=CC([C@H]2C[C@H](CN(CC=C)[C@@H]2C2)C(=O)N(CCCN(C)C)C(=O)NCC)=C3C2=CNC3=C1 KORNTPPJEAJQIU-KJXAQDMKSA-N 0.000 claims description 40
- 229960004596 cabergoline Drugs 0.000 claims description 39
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims description 27
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims description 26
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims description 26
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims description 20
- 239000000556 agonist Substances 0.000 claims description 12
- 230000009471 action Effects 0.000 claims description 10
- 229960003638 dopamine Drugs 0.000 claims description 10
- GDFGTRDCCWFXTG-SCTDSRPQSA-N (3r,4ar,10as)-3-(diethylsulfamoylamino)-6-hydroxy-1-propyl-3,4,4a,5,10,10a-hexahydro-2h-benzo[g]quinoline Chemical compound C1=CC=C2C[C@@H]3N(CCC)C[C@H](NS(=O)(=O)N(CC)CC)C[C@H]3CC2=C1O GDFGTRDCCWFXTG-SCTDSRPQSA-N 0.000 claims description 8
- 229960000924 quinagolide Drugs 0.000 claims description 8
- 238000001356 surgical procedure Methods 0.000 claims description 8
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- 239000000203 mixture Substances 0.000 claims description 6
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- OZVBMTJYIDMWIL-AYFBDAFISA-N bromocriptine Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=C(Br)NC3=C1 OZVBMTJYIDMWIL-AYFBDAFISA-N 0.000 claims description 5
- 239000002775 capsule Substances 0.000 claims description 4
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- BKRGVLQUQGGVSM-KBXCAEBGSA-N Revanil Chemical compound C1=CC(C=2[C@H](N(C)C[C@H](C=2)NC(=O)N(CC)CC)C2)=C3C2=CNC3=C1 BKRGVLQUQGGVSM-KBXCAEBGSA-N 0.000 claims description 2
- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 claims description 2
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- 229960003089 pramipexole Drugs 0.000 claims description 2
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- 229960001879 ropinirole Drugs 0.000 claims description 2
- UHSKFQJFRQCDBE-UHFFFAOYSA-N ropinirole Chemical compound CCCN(CCC)CCC1=CC=CC2=C1CC(=O)N2 UHSKFQJFRQCDBE-UHFFFAOYSA-N 0.000 claims description 2
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- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 description 2
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- HRLIOXLXPOHXTA-UHFFFAOYSA-N medetomidine Chemical compound C=1C=CC(C)=C(C)C=1C(C)C1=CN=C[N]1 HRLIOXLXPOHXTA-UHFFFAOYSA-N 0.000 description 2
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07250429A EP1952813A1 (en) | 2007-02-01 | 2007-02-01 | Medicament for the treatment of endometriosis |
| US94716507P | 2007-06-29 | 2007-06-29 | |
| GB0712626A GB2450533A (en) | 2007-06-29 | 2007-06-29 | Treatment and prevention of endometriosis using dopamine agonists. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2109449E true PT2109449E (pt) | 2011-11-02 |
Family
ID=39674574
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT08751001T PT2109449E (pt) | 2007-02-01 | 2008-02-01 | Medicamento para o tratamento da endometriose |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US8927568B2 (enExample) |
| EP (1) | EP2109449B1 (enExample) |
| JP (1) | JP5211073B2 (enExample) |
| AR (1) | AR065139A1 (enExample) |
| AT (1) | ATE516805T1 (enExample) |
| AU (1) | AU2008211633B2 (enExample) |
| BR (1) | BRPI0806944A2 (enExample) |
| CA (1) | CA2676910C (enExample) |
| DK (1) | DK2109449T3 (enExample) |
| IL (1) | IL200032A (enExample) |
| JO (1) | JO2730B1 (enExample) |
| MX (1) | MX2009008191A (enExample) |
| NZ (1) | NZ578569A (enExample) |
| PL (1) | PL2109449T3 (enExample) |
| PT (1) | PT2109449E (enExample) |
| RU (1) | RU2423146C2 (enExample) |
| SA (1) | SA08290041B1 (enExample) |
| SI (1) | SI2109449T1 (enExample) |
| TW (1) | TWI411436B (enExample) |
| WO (1) | WO2008093247A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010150098A2 (en) * | 2009-06-26 | 2010-12-29 | Ferring International Center Sa | Treatment of endometriosis |
| EP3017809A1 (en) | 2014-11-07 | 2016-05-11 | Ferring B.V. | Drug-device unit containing quinagolide |
| WO2017210117A1 (en) * | 2016-06-02 | 2017-12-07 | Board Of Trustees, Southern Illinois University | Treatment of endometriosis and niclosamide derivatives |
| JP6562332B2 (ja) * | 2017-05-30 | 2019-08-21 | 有限会社イムノ | 活性化ｔ細胞からのｉｌ−８産生を抑制するための組成物 |
| RU2732251C1 (ru) * | 2019-11-29 | 2020-09-14 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт акушерства, гинекологии и репродуктологии имени Д.О. Отта" | Способ лечения наружного генитального эндометриоза |
| US20240361338A1 (en) | 2021-08-31 | 2024-10-31 | Ferring B.V. | Diagnosis and treatment of ectopic endometriosis |
| WO2024153752A1 (en) | 2023-01-20 | 2024-07-25 | Ferring B.V. | Stereoselective synthesis of intermediates and synthesis of quinagolids |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0208417A3 (en) * | 1985-06-12 | 1989-09-06 | SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu | Use of 1-(8-alpha-ergolinyl)-3,3-diethyl urea derivatives in the treatment of endometritis |
| WO1993003752A1 (en) * | 1991-08-19 | 1993-03-04 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Decapeptide having dopamine stimulating activity |
| US6572879B1 (en) | 1995-06-07 | 2003-06-03 | Alza Corporation | Formulations for transdermal delivery of pergolide |
| US6127401A (en) * | 1998-06-05 | 2000-10-03 | Cephalon, Inc. | Bridged indenopyrrolocarbazoles |
| RU2273481C2 (ru) * | 2004-05-27 | 2006-04-10 | Варвара Анатольевна Волкова | Способ повышения эффективности лечения бесплодия, вызванного малыми формами внешнего генитального эндометриоза |
| WO2006117608A1 (en) * | 2005-04-29 | 2006-11-09 | Ferring International Center S.A. | Treatment or prevention of ovarian hyperstimulation syndrome (ohss) using a dopamine agonist |
| WO2010150098A2 (en) * | 2009-06-26 | 2010-12-29 | Ferring International Center Sa | Treatment of endometriosis |
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2008
- 2008-01-30 SA SA08290041A patent/SA08290041B1/ar unknown
- 2008-02-01 DK DK08751001.2T patent/DK2109449T3/da active
- 2008-02-01 MX MX2009008191A patent/MX2009008191A/es active IP Right Grant
- 2008-02-01 PT PT08751001T patent/PT2109449E/pt unknown
- 2008-02-01 NZ NZ578569A patent/NZ578569A/en not_active IP Right Cessation
- 2008-02-01 PL PL08751001T patent/PL2109449T3/pl unknown
- 2008-02-01 RU RU2009129252/15A patent/RU2423146C2/ru active
- 2008-02-01 WO PCT/IB2008/001273 patent/WO2008093247A2/en not_active Ceased
- 2008-02-01 AU AU2008211633A patent/AU2008211633B2/en not_active Ceased
- 2008-02-01 CA CA2676910A patent/CA2676910C/en active Active
- 2008-02-01 AR ARP080100431A patent/AR065139A1/es not_active Application Discontinuation
- 2008-02-01 SI SI200830385T patent/SI2109449T1/sl unknown
- 2008-02-01 EP EP08751001A patent/EP2109449B1/en active Active
- 2008-02-01 TW TW097103971A patent/TWI411436B/zh not_active IP Right Cessation
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Also Published As
| Publication number | Publication date |
|---|---|
| HK1134911A1 (en) | 2010-05-20 |
| IL200032A0 (en) | 2010-04-15 |
| SI2109449T1 (sl) | 2011-11-30 |
| WO2008093247A2 (en) | 2008-08-07 |
| RU2009129252A (ru) | 2011-03-10 |
| US20150073010A1 (en) | 2015-03-12 |
| RU2423146C2 (ru) | 2011-07-10 |
| AU2008211633B2 (en) | 2011-04-21 |
| US9023862B2 (en) | 2015-05-05 |
| SA08290041B1 (ar) | 2012-06-05 |
| IL200032A (en) | 2015-06-30 |
| EP2109449B1 (en) | 2011-07-20 |
| JP5211073B2 (ja) | 2013-06-12 |
| PL2109449T3 (pl) | 2011-12-30 |
| AR065139A1 (es) | 2009-05-20 |
| AU2008211633A1 (en) | 2008-08-07 |
| JO2730B1 (en) | 2013-09-15 |
| US8927568B2 (en) | 2015-01-06 |
| BRPI0806944A2 (pt) | 2014-05-06 |
| CA2676910A1 (en) | 2008-08-07 |
| WO2008093247A3 (en) | 2008-12-04 |
| TW200845989A (en) | 2008-12-01 |
| ATE516805T1 (de) | 2011-08-15 |
| US20100113499A1 (en) | 2010-05-06 |
| DK2109449T3 (da) | 2011-09-12 |
| EP2109449A2 (en) | 2009-10-21 |
| MX2009008191A (es) | 2009-08-12 |
| NZ578569A (en) | 2011-08-26 |
| CA2676910C (en) | 2012-01-03 |
| JP2010517992A (ja) | 2010-05-27 |
| TWI411436B (zh) | 2013-10-11 |
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