PT2082239E - Análise sequencial de amostras biológicas com descoloração de sinais fluorescentes intermédios - Google Patents

Análise sequencial de amostras biológicas com descoloração de sinais fluorescentes intermédios Download PDF

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Publication number
PT2082239E
PT2082239E PT07874284T PT07874284T PT2082239E PT 2082239 E PT2082239 E PT 2082239E PT 07874284 T PT07874284 T PT 07874284T PT 07874284 T PT07874284 T PT 07874284T PT 2082239 E PT2082239 E PT 2082239E
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Prior art keywords
sample
signal
antibody
targets
signal generator
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PT07874284T
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English (en)
Portuguese (pt)
Inventor
Zhengyu Pang
Michael Christopher Montalto
Fiona Ginty
Michael J Gerdes
Anup Sood
Melinda Larsen
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Gen Electric
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Publication of PT2082239E publication Critical patent/PT2082239E/pt

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333Saccharide [e.g., DNA, etc.]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Optical Measuring Cells (AREA)
PT07874284T 2006-11-16 2007-11-15 Análise sequencial de amostras biológicas com descoloração de sinais fluorescentes intermédios PT2082239E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/560,599 US7629125B2 (en) 2006-11-16 2006-11-16 Sequential analysis of biological samples
US11/864,093 US7741046B2 (en) 2006-11-16 2007-09-28 Sequential analysis of biological samples

Publications (1)

Publication Number Publication Date
PT2082239E true PT2082239E (pt) 2011-12-22

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PT07874284T PT2082239E (pt) 2006-11-16 2007-11-15 Análise sequencial de amostras biológicas com descoloração de sinais fluorescentes intermédios
PT07874282T PT2082230E (pt) 2006-11-16 2007-11-15 Análise sequencial de amostras biológicas com descoloração de sinais fluorescentes intermédios

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PT07874282T PT2082230E (pt) 2006-11-16 2007-11-15 Análise sequencial de amostras biológicas com descoloração de sinais fluorescentes intermédios

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US (5) US7629125B2 (cg-RX-API-DMAC7.html)
EP (3) EP2383574B1 (cg-RX-API-DMAC7.html)
JP (1) JP5123314B2 (cg-RX-API-DMAC7.html)
AT (2) ATE524742T1 (cg-RX-API-DMAC7.html)
AU (1) AU2007352364B2 (cg-RX-API-DMAC7.html)
CA (1) CA2669317C (cg-RX-API-DMAC7.html)
DK (2) DK2082239T3 (cg-RX-API-DMAC7.html)
ES (3) ES2371290T3 (cg-RX-API-DMAC7.html)
PL (2) PL2082239T3 (cg-RX-API-DMAC7.html)
PT (2) PT2082239E (cg-RX-API-DMAC7.html)
WO (2) WO2008133727A2 (cg-RX-API-DMAC7.html)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8060348B2 (en) * 2006-08-07 2011-11-15 General Electric Company Systems for analyzing tissue samples
US20080032321A1 (en) * 2006-08-07 2008-02-07 General Electric Company System and methods for analyzing images of tissue samples
US8131476B2 (en) * 2006-08-07 2012-03-06 General Electric Company System and method for co-registering multi-channel images of a tissue micro array
US8305579B2 (en) * 2006-11-16 2012-11-06 Thomas Pirrie Treynor Sequential analysis of biological samples
US9201063B2 (en) 2006-11-16 2015-12-01 General Electric Company Sequential analysis of biological samples
US7629125B2 (en) 2006-11-16 2009-12-08 General Electric Company Sequential analysis of biological samples
US20100279272A1 (en) * 2008-02-13 2010-11-04 Michael Craig Burrell Multiplexed analysis methods using sers-active nanoparticles
EP2389585A2 (en) * 2009-01-22 2011-11-30 Li-Cor, Inc. Single molecule proteomics with dynamic probes
US9677125B2 (en) * 2009-10-21 2017-06-13 General Electric Company Detection of plurality of targets in biological samples
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
US8568991B2 (en) * 2011-12-23 2013-10-29 General Electric Company Photoactivated chemical bleaching of dyes
US9176032B2 (en) 2011-12-23 2015-11-03 General Electric Company Methods of analyzing an H and E stained biological sample
CA2867144C (en) * 2012-03-27 2019-07-02 Ventana Medical Systems, Inc. Signaling conjugates and methods of use
WO2013148458A1 (en) 2012-03-30 2013-10-03 Clarient Diagnostic Services, Inc. Methods for generating an image of a biological sample
RU2014137129A (ru) * 2012-03-30 2016-05-27 Клариент Дайагностик Сервисез, Инк. Иммунофлуоресцентный анализ и флуоресцентный анализ нуклеиновых кислот в одном и том же образце
US9150907B2 (en) 2012-04-27 2015-10-06 General Electric Company Microfluidic flow cell assemblies and method of use
US9606111B2 (en) 2012-04-27 2017-03-28 Bio-Rad Laboratories, Inc. Stain-free protein quantification and normalization
WO2013181418A2 (en) 2012-05-30 2013-12-05 Clarient Diagnostic Services, Inc. Multiplexed diagnosis method for classical hodgkin lymphoma
WO2013181127A1 (en) 2012-05-30 2013-12-05 Clarient Diagnostic Services, Inc. Multiplexed assay method for lung cancer classification
US20140024024A1 (en) 2012-07-17 2014-01-23 General Electric Company Methods of detecting dna, rna and protein in biological samples
US20140055853A1 (en) 2012-08-27 2014-02-27 General Electric Company Open top microfluidic device for multiplexing
WO2014058919A1 (en) * 2012-10-09 2014-04-17 University Of Utah Research Foundation Monitoring temperature with fluorescence
US20150226743A1 (en) 2012-10-28 2015-08-13 Clarient Diagnostics Services, Inc. Multiplexed method for diagnosing classical hodgkin lymphoma
US9135694B2 (en) 2012-12-04 2015-09-15 General Electric Company Systems and methods for using an immunostaining mask to selectively refine ISH analysis results
JP6335187B2 (ja) * 2012-12-11 2018-05-30 ジーイー・ヘルスケア・バイオサイエンス・コーポレイション 色素の光活性化型ケミカルブリーチング
US10677802B2 (en) 2012-12-17 2020-06-09 Ge Healthcare Bio-Sciences Corp. Chemical bleaching of dyes using radical photoinitiators
HUE034313T2 (en) 2012-12-20 2018-02-28 Hoffmann La Roche Procedures for evaluating medical measurement curves
WO2014102668A2 (en) * 2012-12-26 2014-07-03 Koninklijke Philips N.V. Assessment of cellular signaling pathway activity using linear combination(s) of target gene expressions;
US9932626B2 (en) 2013-01-15 2018-04-03 Quanterix Corporation Detection of DNA or RNA using single molecule arrays and other techniques
EP2965087B1 (en) 2013-03-06 2018-10-17 General Electric Company Methods of analyzing an h&e stained biological sample
CA2900842C (en) 2013-03-12 2020-01-21 Ventana Medical Systems, Inc. Digitally enhanced microscopy for multiplexed histology
EP2972376B1 (en) * 2013-03-15 2018-12-05 Eisai Inc. Methods for determining prognosis of colorectal cancer
CN105247069A (zh) * 2013-06-04 2016-01-13 豪夫迈·罗氏有限公司 用于fret的新化合物及与其相关的方法
US9322051B2 (en) 2013-10-07 2016-04-26 General Electric Company Probing of biological samples
US9778263B2 (en) * 2013-11-13 2017-10-03 General Electric Company Quantitative in situ characterization of biological samples
WO2015102919A2 (en) 2013-12-30 2015-07-09 Clarient Diagnostic Services, Inc. Modular image analysis system and method
US20150198580A1 (en) 2014-01-13 2015-07-16 General Electric Company Coverslip and methods for removing
ES2968004T3 (es) 2014-07-30 2024-05-06 Harvard College Construcción de bibliotecas de sondas
US10417247B2 (en) 2014-09-25 2019-09-17 Oracle International Corporation Techniques for semantic searching
US10664488B2 (en) 2014-09-25 2020-05-26 Oracle International Corporation Semantic searches in a business intelligence system
US12216673B2 (en) 2014-09-25 2025-02-04 Oracle International Corporation Techniques for semantic searching
US10516980B2 (en) 2015-10-24 2019-12-24 Oracle International Corporation Automatic redisplay of a user interface including a visualization
US9708349B2 (en) 2015-02-13 2017-07-18 General Electric Company Borates for photoactivated chemical bleaching
US10101322B2 (en) 2015-02-13 2018-10-16 General Electric Company Photoactivated chemical bleaching of dyes using borates
EP3115766A1 (en) 2015-07-10 2017-01-11 3Scan Inc. Spatial multiplexing of histological stains
US11415516B2 (en) 2015-10-28 2022-08-16 Leica Microsystems Cms Gmbh Method for reduction of autofluorescence from biological samples
EP3400313A4 (en) * 2016-01-07 2019-09-18 Creatv Microtech, Inc. MULTI-PHENOTYPIC SUBTYPIZATION OF BIOLOGICAL SAMPLES THROUGH SEQUENCING FLUORESCENCE DELETION AND RENEWING
AU2017217609B2 (en) * 2016-02-08 2023-03-09 Lunaphore Technologies Sa Methods of sample cycle multiplexing and in situ imaging
US20190292259A1 (en) 2016-05-24 2019-09-26 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of non small cell lung cancer (nsclc) that coexists with chronic obstructive pulmonary disease (copd)
WO2018094113A1 (en) * 2016-11-16 2018-05-24 University Of Washington Systems and methods for cyclic fluorescence imaging
EP3541957B1 (en) 2016-11-21 2025-06-25 Bruker Spatial Biology, Inc. A method for sequencing nucleic acids
US20180164308A1 (en) 2016-12-09 2018-06-14 Ultivue, Inc. Methods for multiplex imaging using labeled nucleic acid imaging agents
WO2018122245A1 (en) 2016-12-28 2018-07-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting the survival time of patients suffering from cms3 colorectal cancer
WO2018122249A1 (en) 2016-12-28 2018-07-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of patients suffering from a microsatellite stable colorectal cancer
WO2018202850A1 (en) 2017-05-05 2018-11-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Microtubule-targeting drugs as immune checkpoint inhibitors and methods of screening novel immune checkpoint inhibitors for the treatment of cancers and infectious diseases
US11788123B2 (en) 2017-05-26 2023-10-17 President And Fellows Of Harvard College Systems and methods for high-throughput image-based screening
US10956237B2 (en) 2017-06-02 2021-03-23 Oracle International Corporation Inter-application sharing of business intelligence data
US10917587B2 (en) 2017-06-02 2021-02-09 Oracle International Corporation Importing and presenting data
US11614857B2 (en) 2017-06-02 2023-03-28 Oracle International Corporation Importing, interpreting, and presenting data
CN110720040A (zh) * 2017-06-08 2020-01-21 卢米托股份有限公司 分析至少一种分析物的样本的方法
CN109781975B (zh) * 2017-11-14 2022-05-06 河南乾坤科技有限公司 富集循环稀有细胞的试剂及方法
EP3732611B1 (en) 2018-01-11 2024-08-21 Google LLC Method for creating histopathological ground truth masks using slide restaining
JP7525402B2 (ja) 2018-05-14 2024-07-30 ナノストリング テクノロジーズ,インコーポレイティド 化学的組成物とそれを利用する方法
EP3894583A4 (en) 2018-12-13 2022-11-09 President and Fellows of Harvard College AMPLIFICATION METHODS AND SYSTEMS FOR MERFISH AND OTHER APPLICATIONS
CN113574386A (zh) 2019-01-03 2021-10-29 国家医疗保健研究所 用于增强癌症患者的cd8+t细胞依赖性免疫应答的方法和药物组合物
EP3947737A2 (en) 2019-04-02 2022-02-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting and preventing cancer in patients having premalignant lesions
US20220160692A1 (en) 2019-04-09 2022-05-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of sk2 inhibitors in combination with immune checkpoint blockade therapy for the treatment of cancer
BR112021024374A8 (pt) 2019-06-03 2022-12-06 Inst Nat Sante Rech Med Método para modular um regime de tratamento
CA3157889A1 (en) 2019-10-17 2021-04-22 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for diagnosing nasal intestinal type adenocarcinomas
WO2021170777A1 (en) 2020-02-28 2021-09-02 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing, prognosing and managing treatment of breast cancer
CN111351946B (zh) * 2020-03-19 2023-08-18 中南大学湘雅二医院 用于红斑狼疮分型的AIM2+CD4+Trm细胞检测试剂盒及其应用
JP7741831B2 (ja) 2020-06-30 2025-09-18 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 術前補助療法及び根治手術後の固形がんを患っている患者の再発及び/又は死亡のリスクを予測するための方法
EP4172621A1 (en) 2020-06-30 2023-05-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapies
US20220062898A1 (en) 2020-08-28 2022-03-03 Leica Microsystems Cms Gmbh Microfluidic Device for Image Multiplexing
KR20240012352A (ko) 2021-03-23 2024-01-29 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) T 세포 림프종의 진단 및 치료 방법
US12014830B2 (en) * 2021-04-18 2024-06-18 Mary Hitchcock Memorial Hospital, For Itself And On Behalf Of Dartmouth-Hitchcock Clinic System and method for automation of surgical pathology processes using artificial intelligence
JP2024519860A (ja) * 2021-05-19 2024-05-21 ライカ マイクロシステムズ シーエムエス ゲゼルシャフト ミット ベシュレンクテル ハフツング 生体試料を分析する方法およびデバイス
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EP4472740A1 (en) 2022-01-31 2024-12-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Cd38 as a biomarker and biotarget in t-cell lymphomas
CA3245129A1 (en) 2022-03-17 2023-09-21 Universite Paris Cite METHODS FOR PREDICTING RESPONSE TO IMMUNOTHERAPEUTIC TREATMENT IN A CANCER PATIENT
US20250231193A1 (en) 2022-04-11 2025-07-17 Institut National de la Santé et de la Recherche Médicale Methods for the diagnosis and treatment of t-cell malignancies
WO2023198874A1 (en) 2022-04-15 2023-10-19 Institut National de la Santé et de la Recherche Médicale Methods for the diagnosis and treatment of t cell-lymphomas
WO2024003310A1 (en) 2022-06-30 2024-01-04 Institut National de la Santé et de la Recherche Médicale Methods for the diagnosis and treatment of acute lymphoblastic leukemia
JP2025526336A (ja) 2022-07-22 2025-08-13 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル T細胞悪性腫瘍におけるバイオマーカー及びバイオターゲットとしてのgarp
WO2024023283A1 (en) 2022-07-29 2024-02-01 Institut National de la Santé et de la Recherche Médicale Lrrc33 as a biomarker and biotarget in cutaneous t-cell lymphomas
EP4602372A1 (en) 2022-10-12 2025-08-20 Institut National de la Santé et de la Recherche Médicale Cd81 as a biomarker and biotarget in t-cell malignancies

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4405720A (en) * 1981-03-04 1983-09-20 The United States Of America As Represented By The Department Of Health And Human Services Silver stains for protein in gels
GB8405437D0 (en) 1984-03-01 1984-04-04 Amersham Int Plc Detecting polynucleotide sequences
JP3130513B2 (ja) * 1989-04-19 2001-01-31 イビデン株式会社 生体活性物質測定用装置
US5843640A (en) 1992-06-19 1998-12-01 Northwestern University Method of simultaneously detecting amplified nucleic acid sequences and cellular antigens in cells
WO1994009022A1 (en) 1992-10-09 1994-04-28 Oncor, Inc. Methods for the detection of chromosome structural abnormalities by in situ hybridization to fixed tissue
CA2167804A1 (en) 1993-07-20 1995-02-02 Robert H. Singer In vivo nucleic acid hybridization method
FR2711671A1 (fr) 1993-10-22 1995-05-05 Centre Nat Rech Scient Procédé de détection et de quantification d'une séquence nucléotidique dans une population cellulaire.
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
DE4421891C2 (de) 1994-06-23 1996-05-15 Helmut Prof Dr Med Feucht Verfahren zum Nachweis von komplementaktivierenden IgG-Antikörpern gegen HLA-DR-Antigene
US5571643A (en) * 1994-07-22 1996-11-05 Martin; Mark T. Spectrophotometric quantitation of images in X-ray film and electrophoresis gel bands
ES2271944T3 (es) * 1994-10-28 2007-04-16 Gen-Probe Incorporated Composiciones y metodos para la deteccion y cuantificacion simultaneas de multiples secuencias especificas de acidos nucleicos.
US5830645A (en) 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US5763152A (en) * 1995-03-31 1998-06-09 Fuji Photo Film Co., Ltd. Silver halide photographic light-sensitive material
EP0801306A1 (en) 1996-04-10 1997-10-15 Becton, Dickinson and Company Method for immunohistochemically quantitating co-localized molecules
DE19709348C2 (de) 1996-05-29 1999-07-01 Schubert Walter Dr Md Automatisches Multi-Epitop-Ligand-Kartierungsverfahren
WO1998002577A1 (en) 1996-07-15 1998-01-22 The Children's Medical Center Corporation Method to co-detect introduced genes and their products
US6735531B2 (en) * 1996-10-07 2004-05-11 Lab Vision Corporation Method and apparatus for automatic tissue staining
DE19717904A1 (de) 1997-04-23 1998-10-29 Diagnostikforschung Inst Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
US6068979A (en) * 1998-04-22 2000-05-30 Lumigen, Inc. Simplified sequential chemiluminescent detection
US6083486A (en) 1998-05-14 2000-07-04 The General Hospital Corporation Intramolecularly-quenched near infrared fluorescent probes
AU4976699A (en) 1998-07-10 2000-02-01 Chromagen, Inc. Novel fluorogenic substrates for hydrolytic enzymes
DE19835284C2 (de) 1998-08-05 2001-03-01 Tuhh Tech Gmbh Vorrichtung und Verfahren zur automatischen Fokussierung und Belichtung von Bildaufnahmesystemen
US6573043B1 (en) 1998-10-07 2003-06-03 Genentech, Inc. Tissue analysis and kits therefor
NZ511408A (en) 1998-10-09 2004-04-30 Licentia Ltd Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy
US6087112A (en) * 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
US20020044353A1 (en) * 1999-02-10 2002-04-18 Salzman David B. Spintronic optical shutter
AU3567900A (en) 1999-03-30 2000-10-16 Solexa Ltd. Polynucleotide sequencing
US6391649B1 (en) * 1999-05-04 2002-05-21 The Rockefeller University Method for the comparative quantitative analysis of proteins and other biological material by isotopic labeling and mass spectroscopy
EP1218543A2 (en) 1999-09-29 2002-07-03 Solexa Ltd. Polynucleotide sequencing
GB0002389D0 (en) 2000-02-02 2000-03-22 Solexa Ltd Molecular arrays
DE10014685B4 (de) 2000-03-24 2004-07-01 Schubert, Walter, Dr. Verfahren zur Identifizierung von zellspezifischen Zielstrukturen
AU2001259586A1 (en) 2000-05-05 2001-11-20 Agilix Corporation Highly multiplexed reporter carrier systems
IL136232A0 (en) 2000-05-18 2001-05-20 Bar Ilan University Res Author Measurements of enzymatic activity in a single, individual cell in population
US6545758B1 (en) * 2000-08-17 2003-04-08 Perry Sandstrom Microarray detector and synthesizer
US20030044353A1 (en) 2001-01-05 2003-03-06 Ralph Weissleder Activatable imaging probes
JP2002323416A (ja) 2001-02-20 2002-11-08 Hitachi Ltd 検査容器
US20050230255A1 (en) 2001-03-30 2005-10-20 Sumner Lloyd W Silver destaining method
US7219016B2 (en) 2001-04-20 2007-05-15 Yale University Systems and methods for automated analysis of cells and tissues
US20020173053A1 (en) 2001-04-27 2002-11-21 Bassam Damaj Multiple simultaneous antigen detection by immunohistochemistry
JP3899845B2 (ja) 2001-05-23 2007-03-28 日本光電工業株式会社 染色標本の脱色方法および装置
AU2002325196A1 (en) * 2001-07-09 2003-01-29 Kobenhavns Universitet Epsti1, a gene induced by epithelial-stromal interaction in human breast cancer
US20040241688A1 (en) 2001-07-19 2004-12-02 Cuneyt Bukusoglu Human tissue specific drug screening procedure
DE10143757A1 (de) 2001-09-06 2003-03-27 Werner M Methode zur Darstellung von Merkmalen in Geweben
US8323903B2 (en) 2001-10-12 2012-12-04 Life Technologies Corporation Antibody complexes and methods for immunolabeling
WO2003061711A2 (en) 2002-01-16 2003-07-31 Visen Medical, Inc. Chromophore probes for optical imaging
US6731831B2 (en) 2002-02-27 2004-05-04 Xiang Zheng Tu Optical switch array assembly for DNA probe synthesis and detection
US7166478B2 (en) * 2002-03-12 2007-01-23 Enzo Life Sciences, Inc., C/O Enzo Biochem, Inc. Labeling reagents and labeled targets, target labeling processes and other processes for using same in nucleic acid determinations and analyses
US7776195B2 (en) * 2002-05-28 2010-08-17 Autogenomics, Inc. Integrated sample processing platform
JP2004041121A (ja) * 2002-07-12 2004-02-12 Hitachi Ltd アレルギー解析方法及びシステム
US7122319B2 (en) 2002-12-18 2006-10-17 Monogram Biosciences, Inc Multiplexed immunohistochemical assays using molecular tags
WO2005017485A2 (en) 2003-05-22 2005-02-24 Agdia, Inc. Multiplex enzyme-linked immunosorbent assay for detecting multiple analytes
JP3936689B2 (ja) * 2003-09-09 2007-06-27 日本碍子株式会社 シアニン系有機色素劣化環境の検知方法
US7463778B2 (en) * 2004-01-30 2008-12-09 Hewlett-Packard Development Company, L.P Motion estimation for compressing multiple view images
JP4538628B2 (ja) 2004-03-16 2010-09-08 学校法人慶應義塾 遺伝子発現検出方法
JP4189495B2 (ja) * 2004-08-02 2008-12-03 国立大学法人群馬大学 ゲノムdnaのメチル化検出方法
CN101466847B (zh) * 2005-06-15 2014-02-19 考利达基因组股份有限公司 用于遗传和化学分析的单分子阵列
JP2007033159A (ja) * 2005-07-25 2007-02-08 Assay Corp 蛍光分子で標識された測定対象物質
WO2007055302A1 (ja) * 2005-11-10 2007-05-18 National University Corporation University Of Toyama 生体物質と生体物質結合性物質との結合性評価方法
US7741045B2 (en) * 2006-11-16 2010-06-22 General Electric Company Sequential analysis of biological samples
US7629125B2 (en) * 2006-11-16 2009-12-08 General Electric Company Sequential analysis of biological samples
US8305579B2 (en) * 2006-11-16 2012-11-06 Thomas Pirrie Treynor Sequential analysis of biological samples

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US20080118944A1 (en) 2008-05-22
ATE524742T1 (de) 2011-09-15
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