PT1713473E - Combinação de anticolinérgicos e glucocorticóides para o tratamento a longo prazo de asma e copd - Google Patents
Combinação de anticolinérgicos e glucocorticóides para o tratamento a longo prazo de asma e copd Download PDFInfo
- Publication number
- PT1713473E PT1713473E PT57069791T PT05706979T PT1713473E PT 1713473 E PT1713473 E PT 1713473E PT 57069791 T PT57069791 T PT 57069791T PT 05706979 T PT05706979 T PT 05706979T PT 1713473 E PT1713473 E PT 1713473E
- Authority
- PT
- Portugal
- Prior art keywords
- use according
- day
- glucocorticoid
- copd
- glycopyrrolate
- Prior art date
Links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54195604P | 2004-02-06 | 2004-02-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1713473E true PT1713473E (pt) | 2013-05-13 |
Family
ID=34837533
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT57069791T PT1713473E (pt) | 2004-02-06 | 2005-01-24 | Combinação de anticolinérgicos e glucocorticóides para o tratamento a longo prazo de asma e copd |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20050175548A1 (https=) |
| EP (1) | EP1713473B1 (https=) |
| JP (1) | JP4819699B2 (https=) |
| CN (1) | CN100569235C (https=) |
| AU (1) | AU2005210085B2 (https=) |
| CA (1) | CA2551780C (https=) |
| DK (1) | DK1713473T3 (https=) |
| ES (1) | ES2413011T3 (https=) |
| HR (1) | HRP20130460T1 (https=) |
| NO (1) | NO336882B1 (https=) |
| NZ (1) | NZ548300A (https=) |
| PL (1) | PL1713473T3 (https=) |
| PT (1) | PT1713473E (https=) |
| RU (1) | RU2440813C2 (https=) |
| SI (1) | SI1713473T1 (https=) |
| WO (1) | WO2005074918A1 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| ES2257152B1 (es) * | 2004-05-31 | 2007-07-01 | Laboratorios Almirall S.A. | Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos. |
| GB0523653D0 (en) * | 2005-11-21 | 2005-12-28 | Novartis Ag | Organic compounds |
| GB0523654D0 (en) * | 2005-11-21 | 2005-12-28 | Novartis Ag | Organic compounds |
| GB0523655D0 (en) * | 2005-11-21 | 2005-12-28 | Novartis Ag | Organic compounds |
| GB0523656D0 (en) * | 2005-11-21 | 2005-12-28 | Novartis Ag | Organic compounds |
| NZ591969A (en) * | 2005-12-21 | 2012-05-25 | Meda Pharma Gmbh & Co Kg | Combination of anticholinergics, glucocorticoids, beta2-adrenoceptor agonists, PDE 4 inhibitor and antileukotriene for the treatment of inflammatory diseases |
| EP2100598A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
| EP2100599A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
| WO2009142589A1 (en) * | 2008-05-20 | 2009-11-26 | Astrazeneca Ab | Combination of (a) glucocorticoid receptor modulator and (b) a muscarinic antagonist |
| US8815258B2 (en) | 2009-05-29 | 2014-08-26 | Pearl Therapeutics, Inc. | Compositions, methods and systems for respiratory delivery of two or more active agents |
| MX337126B (es) | 2009-05-29 | 2016-02-12 | Pearl Therapeutics Inc | Administracion respiratoria de agentes activos. |
| UA113832C2 (xx) | 2009-12-23 | 2017-03-27 | Комбінаційна терапія для хозл | |
| EP2515853B1 (en) | 2009-12-23 | 2014-03-19 | Chiesi Farmaceutici S.p.A. | Combination therapy for COPD |
| EP2510928A1 (en) | 2011-04-15 | 2012-10-17 | Almirall, S.A. | Aclidinium for use in improving the quality of sleep in respiratory patients |
| MX356386B (es) * | 2012-08-09 | 2018-05-28 | Chase Pharmaceuticals Corp | Sales cuaternarias de piperidinio. |
| US8558008B2 (en) | 2013-02-28 | 2013-10-15 | Dermira, Inc. | Crystalline glycopyrrolate tosylate |
| EP3473615B1 (en) | 2013-02-28 | 2022-01-19 | Journey Medical Corporation | Glycopyrrolate salts |
| US9006462B2 (en) | 2013-02-28 | 2015-04-14 | Dermira, Inc. | Glycopyrrolate salts |
| KR102391332B1 (ko) | 2013-03-15 | 2022-04-26 | 펄 테라퓨틱스 인코포레이티드 | 미립자 결정질 재료를 컨디셔닝하는 방법 및 시스템 |
| EP3384898A1 (en) | 2013-12-30 | 2018-10-10 | Chiesi Farmaceutici S.p.A. | Stable pressurised aerosol solution composition of glycopyrronium bromide and formoterol combination |
| CN107847480B (zh) | 2015-03-23 | 2021-06-25 | 墨尔本大学 | 呼吸性疾病的治疗 |
| US20160310410A1 (en) | 2015-04-24 | 2016-10-27 | Glenmark Specialty S.A. | Pharmaceutical compositions comprising arformoterol and glycopyrronium |
| US10098837B2 (en) | 2016-07-28 | 2018-10-16 | Chiesi Farmaceutici S.P.A. | Combination therapy for COPD |
| MX387723B (es) | 2016-09-19 | 2025-03-18 | Mexichem Fluor Sa De Cv | Composición farmacéutica que comprende bromuro de glicopirronio, propionato de fluticasona y 1,1-difluoroetano. |
| RU2691110C2 (ru) * | 2017-11-20 | 2019-06-11 | Федеральное государственное бюджетное учреждение науки Сибирский федеральный научный центр агробиотехнологий Российской академии наук (СФНЦА РАН) | Препарат для лечения заболеваний дыхательных путей у лошадей и способ его применения |
| JP7575099B2 (ja) | 2018-11-07 | 2024-10-29 | ティアンリ バイオテック プロプライエタリ リミテッド | 呼吸器疾患の処理のための新規な化合物 |
| CN109498625B (zh) * | 2018-12-29 | 2021-04-16 | 温州医科大学附属第一医院 | 一种治疗慢性阻塞性肺疾病的药物组合物及其制备方法 |
| AU2019477296A1 (en) | 2019-12-02 | 2022-04-14 | Chiesi Farmaceutici S.P.A. | Stainles steel can for pressurised metered dose inhalers |
| CN120360953B (zh) * | 2025-06-24 | 2025-09-05 | 成都第一制药有限公司 | 一种用于copd治疗的莨菪烷类生物碱组合物及其应用 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2176252T3 (es) * | 1993-07-02 | 2002-12-01 | Altana Pharma Ag | Benzamidas sustituidas con fluoro-alcoxi y su utilizacion como agentes inhibidores de fosfodiesterasas de nucleotidos ciclicos. |
| WO1998000016A1 (en) * | 1996-07-01 | 1998-01-08 | Sepracor, Inc. | Methods and compositions for treating urinary incontinence using enantiomerically enriched (r,r)-glycopyrrolate |
| US6384038B1 (en) * | 1998-04-14 | 2002-05-07 | Sepracor Inc. | Methods and compositions using cetirizine in combination with leukotriene inhibitors or decongestants |
| WO1999062720A1 (fr) * | 1998-05-29 | 1999-12-09 | Citizen Watch Co., Ltd. | Procede permettant de soumettre une imprimante a jet d'encre a un traitement de pre-utilisation |
| CN1150890C (zh) * | 1998-08-04 | 2004-05-26 | 杰格研究股份公司 | 药用气溶胶制剂 |
| AU756852B2 (en) * | 1998-11-13 | 2003-01-23 | Jagotec Ag | Dry powder for inhalation |
| DE19921693A1 (de) * | 1999-05-12 | 2000-11-16 | Boehringer Ingelheim Pharma | Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika |
| US6086914A (en) * | 1999-03-12 | 2000-07-11 | Weinstein; Robert E. | Nonsedating formulations for allergic rhinitis which possess antihistaminic and anticholinergic activity |
| US6203779B1 (en) * | 1999-03-19 | 2001-03-20 | Charlie Ricci | Methods for treating endoleaks during endovascular repair of abdominal aortic aneurysms |
| US20040002548A1 (en) * | 1999-05-12 | 2004-01-01 | Boehringer Ingelheim Pharma Kg | Medicament compositions containing anticholinergically-effective compounds and betamimetics |
| DE19961300A1 (de) * | 1999-12-18 | 2001-06-21 | Asta Medica Ag | Vorratssystem für Arzneimittel in Pulverform und damit ausgestatteter Inhalator |
| DE10007203A1 (de) * | 2000-02-17 | 2001-08-23 | Asta Medica Ag | Neue Kombination nichtsedierender Antihistaminika mit Substanzen, die die Leukotrienwirkung beeinflussen, zur Behandlung der Rhinitis/Konjunktivitis |
| GB0008660D0 (en) | 2000-04-07 | 2000-05-31 | Arakis Ltd | The treatment of respiratory diseases |
| GB0009584D0 (en) * | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Pharmaceutical compositions |
| GB0009583D0 (en) * | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Respiratory formulations |
| DE10062712A1 (de) | 2000-12-15 | 2002-06-20 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und Corticosteroiden |
| DE10110772A1 (de) | 2001-03-07 | 2002-09-12 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und PDE-IV-Inhibitoren |
| GB0029903D0 (en) * | 2000-12-07 | 2001-01-24 | Arakis Ltd | Use of anti-muscarinic agents |
| NZ528640A (en) * | 2001-03-30 | 2004-06-25 | Jagotec Ag | Medical aerosol formulations |
| US6667344B2 (en) * | 2001-04-17 | 2003-12-23 | Dey, L.P. | Bronchodilating compositions and methods |
| WO2002096423A2 (en) | 2001-05-25 | 2002-12-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Combination of a pde4 inhibitor and tiotropium or derivate thereof for treating obstructive airways |
| BR0209992A (pt) | 2001-05-25 | 2004-04-06 | Pfizer | Inibidor de pde4 e um agente anticolinérgico em combinação para o tratamento de doenças obstrutivas das vias respiratórias |
| GB0118373D0 (en) | 2001-07-27 | 2001-09-19 | Glaxo Group Ltd | Novel therapeutic method |
| CN1422620A (zh) * | 2001-12-07 | 2003-06-11 | 中国人民解放军总装备部后勤部军事医学研究所 | 治疗氮氧化物中毒的气雾剂及其用途和制备方法 |
| US7258118B2 (en) * | 2002-01-24 | 2007-08-21 | Sofotec Gmbh & Co, Kg | Pharmaceutical powder cartridge, and inhaler equipped with same |
| EP1487411B1 (en) * | 2002-03-20 | 2019-01-02 | Civitas Therapeutics, Inc. | Inhalable sustained therapeutic formulations |
| DE10216429A1 (de) * | 2002-04-12 | 2003-10-23 | Boehringer Ingelheim Pharma | Arzneimittel enthaltend Steroide und ein neues Anticholinergikum |
| US7084153B2 (en) * | 2002-04-12 | 2006-08-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Medicaments comprising steroids and a novel anticholinergic |
| US20040038958A1 (en) * | 2002-07-11 | 2004-02-26 | Chris Rundfeldt | Topical treatment of skin diseases |
| UA82323C2 (uk) | 2002-08-09 | 2008-04-10 | Меда Фарма Гмбх & Ко. Кг | Нова комбінація глюкокортикоїду та pde-інгібітору для лікування респіраторних захворювань, алергічних захворювань, астми та хронічних обструктивних легеневих захворювань |
| WO2004023984A2 (en) * | 2002-09-13 | 2004-03-25 | Smith C Steven | Novel composition and method for treatment of upper respiratory conditions |
| WO2004084897A1 (en) | 2003-03-28 | 2004-10-07 | Altana Pharma Ag | Synergistic combination comprising roflumilast and an anticholinergic agent selected from ipratropium, oxitropium and tiotropium salts for the treatment of respiratory diseases |
| DK1610787T3 (da) * | 2003-03-28 | 2008-06-02 | Nycomed Gmbh | Synergistisk kombination der omfatter roflumilast og et antikolinergt middel der er valgt blandt tiotropiumsalte til behandling af respiratoriske sygdomme |
| JP2007530917A (ja) * | 2003-07-11 | 2007-11-01 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 改善された周波数決定 |
| RU2438660C2 (ru) * | 2004-02-06 | 2012-01-10 | Меда Фарма Гмбх Унд Ко. Кг | Комбинация и фармацевтический препарат для лечения воспалительных и обструктивных заболеваний дыхательных путей |
| WO2005082413A2 (en) | 2004-02-27 | 2005-09-09 | Altana Pharma Ag | Ciclesonide and glycopyrronium combination |
| NZ591969A (en) * | 2005-12-21 | 2012-05-25 | Meda Pharma Gmbh & Co Kg | Combination of anticholinergics, glucocorticoids, beta2-adrenoceptor agonists, PDE 4 inhibitor and antileukotriene for the treatment of inflammatory diseases |
-
2005
- 2005-01-24 EP EP05706979A patent/EP1713473B1/en not_active Expired - Lifetime
- 2005-01-24 HR HRP20130460TT patent/HRP20130460T1/hr unknown
- 2005-01-24 PT PT57069791T patent/PT1713473E/pt unknown
- 2005-01-24 DK DK05706979.1T patent/DK1713473T3/da active
- 2005-01-24 SI SI200531713T patent/SI1713473T1/sl unknown
- 2005-01-24 NZ NZ548300A patent/NZ548300A/en not_active IP Right Cessation
- 2005-01-24 PL PL05706979T patent/PL1713473T3/pl unknown
- 2005-01-24 JP JP2006551763A patent/JP4819699B2/ja not_active Expired - Fee Related
- 2005-01-24 CN CNB200580004060XA patent/CN100569235C/zh not_active Expired - Fee Related
- 2005-01-24 AU AU2005210085A patent/AU2005210085B2/en not_active Ceased
- 2005-01-24 WO PCT/EP2005/000652 patent/WO2005074918A1/en not_active Ceased
- 2005-01-24 CA CA2551780A patent/CA2551780C/en not_active Expired - Fee Related
- 2005-01-24 RU RU2006132038/15A patent/RU2440813C2/ru not_active Application Discontinuation
- 2005-01-24 ES ES05706979T patent/ES2413011T3/es not_active Expired - Lifetime
- 2005-02-07 US US11/051,468 patent/US20050175548A1/en not_active Abandoned
-
2006
- 2006-08-31 NO NO20063879A patent/NO336882B1/no not_active IP Right Cessation
-
2008
- 2008-08-11 US US12/189,598 patent/US10537550B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1713473A1 (en) | 2006-10-25 |
| RU2440813C2 (ru) | 2012-01-27 |
| DK1713473T3 (da) | 2013-06-17 |
| HRP20130460T1 (hr) | 2013-06-30 |
| US20080300226A1 (en) | 2008-12-04 |
| AU2005210085A1 (en) | 2005-08-18 |
| ES2413011T3 (es) | 2013-07-15 |
| CA2551780C (en) | 2013-02-26 |
| SI1713473T1 (sl) | 2013-06-28 |
| EP1713473B1 (en) | 2013-03-13 |
| CA2551780A1 (en) | 2005-08-18 |
| JP4819699B2 (ja) | 2011-11-24 |
| US10537550B2 (en) | 2020-01-21 |
| WO2005074918A1 (en) | 2005-08-18 |
| CN100569235C (zh) | 2009-12-16 |
| PL1713473T3 (pl) | 2013-08-30 |
| NO20063879L (no) | 2006-11-01 |
| JP2007520508A (ja) | 2007-07-26 |
| CN1913883A (zh) | 2007-02-14 |
| AU2005210085B2 (en) | 2010-06-24 |
| RU2006132038A (ru) | 2008-03-20 |
| HK1098356A1 (zh) | 2007-07-20 |
| NO336882B1 (no) | 2015-11-23 |
| US20050175548A1 (en) | 2005-08-11 |
| NZ548300A (en) | 2010-04-30 |
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