PT1691824E - Proteínas pertencentes à família bcl-2 e seus fragmentos e sua utilização em doentes de cancro - Google Patents
Proteínas pertencentes à família bcl-2 e seus fragmentos e sua utilização em doentes de cancro Download PDFInfo
- Publication number
- PT1691824E PT1691824E PT04797460T PT04797460T PT1691824E PT 1691824 E PT1691824 E PT 1691824E PT 04797460 T PT04797460 T PT 04797460T PT 04797460 T PT04797460 T PT 04797460T PT 1691824 E PT1691824 E PT 1691824E
- Authority
- PT
- Portugal
- Prior art keywords
- fragments
- bcl
- family
- cancer patients
- proteins belonging
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 102000004169 proteins and genes Human genes 0.000 title abstract 4
- 102000051485 Bcl-2 family Human genes 0.000 title abstract 2
- 108700038897 Bcl-2 family Proteins 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 239000012634 fragment Substances 0.000 title abstract 2
- 102000007079 Peptide Fragments Human genes 0.000 abstract 2
- 108010033276 Peptide Fragments Proteins 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 108091008874 T cell receptors Proteins 0.000 abstract 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4747—Apoptosis related proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Mycology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52311903P | 2003-11-19 | 2003-11-19 | |
| DKPA200301716 | 2003-11-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1691824E true PT1691824E (pt) | 2009-05-28 |
Family
ID=39149116
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT04797460T PT1691824E (pt) | 2003-11-19 | 2004-11-18 | Proteínas pertencentes à família bcl-2 e seus fragmentos e sua utilização em doentes de cancro |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7842294B2 (enExample) |
| EP (2) | EP1691824B1 (enExample) |
| JP (2) | JP4926714B2 (enExample) |
| KR (2) | KR101284237B1 (enExample) |
| CN (1) | CN1921878B (enExample) |
| AT (1) | ATE424842T1 (enExample) |
| AU (1) | AU2004290866B2 (enExample) |
| CA (1) | CA2546794C (enExample) |
| DE (1) | DE602004019965D1 (enExample) |
| DK (2) | DK2087904T3 (enExample) |
| ES (2) | ES2436429T3 (enExample) |
| MX (1) | MXPA06005738A (enExample) |
| PL (2) | PL2087904T3 (enExample) |
| PT (1) | PT1691824E (enExample) |
| RU (1) | RU2367468C2 (enExample) |
| WO (1) | WO2005049073A2 (enExample) |
| ZA (1) | ZA200604866B (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7892559B2 (en) * | 2002-01-30 | 2011-02-22 | Survac Aps | Survivin-derived peptides and use thereof |
| ES2661082T3 (es) * | 2003-01-30 | 2018-03-27 | Survac Aps | Péptidos derivados de survivina y uso de los mismos |
| US7612162B2 (en) | 2004-09-21 | 2009-11-03 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Peptide analogs capable of enhancing stimulation of a glioma-specific CTL response |
| CN101438437A (zh) * | 2004-10-19 | 2009-05-20 | 麻省理工学院 | 用于自组装、柔软和轻的锂电池组的病毒支架 |
| AU2011203535B2 (en) * | 2005-02-04 | 2012-10-11 | Survac Aps | Survivin peptide vaccine |
| EP1853305B1 (en) * | 2005-02-04 | 2014-08-20 | Survac ApS | Survivin peptide vaccine |
| AU2006347606B2 (en) * | 2005-09-09 | 2012-10-11 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods and compositions for inhibiting cell death or enhancing cell proliferation |
| EP2155782A2 (en) | 2007-03-26 | 2010-02-24 | Dako Denmark A/S | Mhc peptide complexes and uses thereof in infectious diseases |
| EP3620465B1 (en) * | 2007-07-03 | 2025-02-19 | Dako Denmark A/S | Improved methods for generation, labeling and use of mhc multimers |
| US10611818B2 (en) | 2007-09-27 | 2020-04-07 | Agilent Technologies, Inc. | MHC multimers in tuberculosis diagnostics, vaccine and therapeutics |
| DK2254592T3 (da) | 2008-02-28 | 2019-09-09 | Dako Denmark As | MHC-multimerer til Borrelia-diagnostik og sygdom |
| EP2254592B1 (en) * | 2008-02-28 | 2019-06-05 | Dako Denmark A/S | Mhc multimers in borrelia diagnostics and disease |
| AU2009246876B2 (en) | 2008-05-16 | 2015-04-02 | Htyr Acquisition Llc | Antibodies and processes for preparing the same |
| CA2730369A1 (en) * | 2008-07-16 | 2010-01-21 | Burnham Institute For Medical Research | Compositions and methods for modulating nod-like receptor activity and uses thereof |
| WO2010009735A2 (en) | 2008-07-23 | 2010-01-28 | Dako Denmark A/S | Combinatorial analysis and repair |
| CA2735522C (en) | 2008-08-28 | 2017-04-18 | Taiga Biotechnologies, Inc. | Modulators of myc, methods of using the same, and methods of identifying agents that modulate myc |
| GB0817244D0 (en) | 2008-09-20 | 2008-10-29 | Univ Cardiff | Use of a protein kinase inhibitor to detect immune cells, such as T cells |
| WO2010037397A1 (en) * | 2008-10-01 | 2010-04-08 | Dako Denmark A/S | Mhc multimers in cmv immune monitoring |
| WO2010037395A2 (en) * | 2008-10-01 | 2010-04-08 | Dako Denmark A/S | Mhc multimers in cancer vaccines and immune monitoring |
| US10369204B2 (en) | 2008-10-02 | 2019-08-06 | Dako Denmark A/S | Molecular vaccines for infectious disease |
| US11992518B2 (en) | 2008-10-02 | 2024-05-28 | Agilent Technologies, Inc. | Molecular vaccines for infectious disease |
| AU2009305617B2 (en) | 2008-10-17 | 2014-01-23 | University Of Miami | Tumor vaccine |
| EP3444333A1 (en) * | 2009-10-22 | 2019-02-20 | Thomas Jefferson University | Cell-based anti-cancer compositions and methods of making and using the same |
| CN102884190B (zh) | 2010-03-11 | 2016-03-23 | 肿瘤疗法科学股份有限公司 | Hjurp肽及包含它们的疫苗 |
| EP2608799B1 (en) * | 2010-08-24 | 2018-12-12 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Interleukin-13 receptor alpha 2 peptide-based brain cancer vaccines |
| SI3536334T1 (sl) | 2012-05-16 | 2021-11-30 | Stemline Therapeutics Inc. | Cepiva proti raku, ki ciljajo na rakave matične celice |
| SG10201700459XA (en) * | 2012-07-20 | 2017-02-27 | Taiga Biotechnologies Inc | Enhanced reconstitution and autoreconstitution of the hematopoietic compartment |
| US20160017011A1 (en) * | 2013-02-26 | 2016-01-21 | Rongfu Wang | Phf20 and jmjd3 compositions and methods of use in cancer immunotherapy |
| CA2902423C (en) * | 2013-03-01 | 2021-06-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of producing enriched populations of tumor-reactive t cells from tumor |
| US9704181B2 (en) * | 2014-05-06 | 2017-07-11 | International Business Machines Corporation | Real-time social group based bidding system |
| CN113786476A (zh) | 2016-12-02 | 2021-12-14 | 泰加生物工艺学公司 | 纳米颗粒调配物 |
| TWI796314B (zh) * | 2017-01-27 | 2023-03-21 | 德商英麥提克生物技術股份有限公司 | 用於卵巢癌和其他癌症免疫治療的新型肽和肽組合物 |
| EA201991444A1 (ru) | 2017-01-27 | 2019-12-30 | Имматикс Байотекнолоджиз Гмбх | Новые пептиды и комбинации пептидов для применения в иммунотерапии рака яичника и других видов рака |
| CR20210128A (es) | 2017-01-27 | 2021-04-26 | Immatics Biotechnologies Gmbh | Nuevos péptidos y nuevas combinaciones de péptidos para el uso en la inmunoterapia contra el cáncer de ovario y otros tipos de cancer (divisional exp. 2019-388) |
| US11666644B2 (en) | 2018-09-04 | 2023-06-06 | Treos Bio Limited | Peptide vaccines |
| EP3898666A2 (en) | 2018-12-17 | 2021-10-27 | Immudex ApS | Panel comprising borrelia mhc multimers |
| WO2020210231A1 (en) | 2019-04-08 | 2020-10-15 | Taiga Biotechnologies, Inc. | Compositions and methods for the cry opreservation of immune cells |
| EP3969041A4 (en) | 2019-05-14 | 2023-05-10 | Taiga Biotechnologies, Inc. | COMPOSITIONS AND METHODS FOR TREATMENT OF T-CELL DEPLETION |
| CN113355432A (zh) * | 2021-05-12 | 2021-09-07 | 甘肃农业大学 | Bmf作为细胞凋亡标志物的应用 |
| WO2022245249A1 (ru) * | 2021-05-17 | 2022-11-24 | федеральное государственное автономное образовательное учреждение высшего образования Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет) | Пептидные соединения для индукции апоптоза в опухолевой клетке |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5554372A (en) | 1986-09-22 | 1996-09-10 | Emory University | Methods and vaccines comprising surface-active copolymers |
| US5342774A (en) | 1991-05-23 | 1994-08-30 | Ludwig Institute For Cancer Research | Nucleotide sequence encoding the tumor rejection antigen precursor, MAGE-1 |
| ATE280180T1 (de) | 1992-08-31 | 2004-11-15 | Ludwig Inst Cancer Res | Vom mage-3-gen abgeleitetes und von hla-a1 präsentiertes, isoliertes nonapeptid und dessen anwendungen |
| US5470955A (en) | 1993-02-02 | 1995-11-28 | Dartmouth College | Antibodies which specifically bind mcl-1 polypeptide |
| US5646008A (en) * | 1993-06-22 | 1997-07-08 | The Regent Of The University Of Michigan | Vertebrate apoptosis gene: compositions and methods |
| US5700638A (en) * | 1993-08-26 | 1997-12-23 | Washington University | Cell death regulator |
| GB9320597D0 (en) | 1993-10-06 | 1993-11-24 | Proteus Molecular Design | Improvements in and realting to vaccines |
| US6096313A (en) | 1996-02-09 | 2000-08-01 | Ludwig Institute For Cancer Research | Compositions containing immunogenic molecules and granulocyte-macrophage colony stimulating factor, as an adjuvant |
| US5789201A (en) * | 1996-02-23 | 1998-08-04 | Cocensys, Inc. | Genes coding for bcl-y a bcl-2 homologue |
| US6245523B1 (en) | 1996-11-20 | 2001-06-12 | Yale University | Survivin, a protein that inhibits cellular apoptosis, and its modulation |
| WO1998058541A1 (en) * | 1997-06-24 | 1998-12-30 | Dana-Farber Cancer Institute, Inc. | Modulation of apoptosis |
| WO2001036594A1 (en) * | 1999-11-16 | 2001-05-25 | Dartmouth College | Mcl-1 GENE REGULATORY ELEMENTS AND A PRO-APOPTOTIC Mcl-1 VARIANT |
| AU2578401A (en) * | 1999-12-14 | 2001-06-25 | Burnham Institute, The | Bcl-g polypeptides, encoding nucleic acids and methods of use |
| WO2002005835A2 (en) * | 2000-07-17 | 2002-01-24 | Washington University | Modulation of apoptosis |
| AU2002257647A1 (en) | 2001-03-09 | 2002-09-24 | Callistogen Ag | Induction of anti-tumor cytotoxic t-lymphocytes in humans using peptide epitopes found by computer based algorithms for vaccination |
| US7892559B2 (en) * | 2002-01-30 | 2011-02-22 | Survac Aps | Survivin-derived peptides and use thereof |
| AU2004228106B2 (en) | 2003-04-11 | 2010-05-13 | Survac Aps | Therapeutic cancer vaccine |
-
2004
- 2004-11-18 EP EP04797460A patent/EP1691824B1/en not_active Expired - Lifetime
- 2004-11-18 AT AT04797460T patent/ATE424842T1/de active
- 2004-11-18 US US10/580,016 patent/US7842294B2/en active Active
- 2004-11-18 EP EP09154734.9A patent/EP2087904B1/en not_active Expired - Lifetime
- 2004-11-18 AU AU2004290866A patent/AU2004290866B2/en not_active Expired
- 2004-11-18 ES ES09154734.9T patent/ES2436429T3/es not_active Expired - Lifetime
- 2004-11-18 PL PL09154734T patent/PL2087904T3/pl unknown
- 2004-11-18 RU RU2006121466/15A patent/RU2367468C2/ru active
- 2004-11-18 CN CN2004800407050A patent/CN1921878B/zh not_active Expired - Lifetime
- 2004-11-18 MX MXPA06005738A patent/MXPA06005738A/es active IP Right Grant
- 2004-11-18 ZA ZA200604866A patent/ZA200604866B/en unknown
- 2004-11-18 PL PL04797460T patent/PL1691824T3/pl unknown
- 2004-11-18 PT PT04797460T patent/PT1691824E/pt unknown
- 2004-11-18 DK DK09154734.9T patent/DK2087904T3/da active
- 2004-11-18 CA CA2546794A patent/CA2546794C/en not_active Expired - Lifetime
- 2004-11-18 ES ES04797460T patent/ES2323588T3/es not_active Expired - Lifetime
- 2004-11-18 DE DE602004019965T patent/DE602004019965D1/de not_active Expired - Lifetime
- 2004-11-18 KR KR1020127016885A patent/KR101284237B1/ko not_active Expired - Lifetime
- 2004-11-18 WO PCT/DK2004/000799 patent/WO2005049073A2/en not_active Ceased
- 2004-11-18 KR KR1020067012186A patent/KR101216655B1/ko not_active Expired - Lifetime
- 2004-11-18 DK DK04797460T patent/DK1691824T3/da active
- 2004-11-18 JP JP2006540170A patent/JP4926714B2/ja not_active Expired - Lifetime
-
2011
- 2011-09-12 JP JP2011198605A patent/JP5502823B2/ja not_active Expired - Lifetime
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