PT1641743E - Processo para a produção de iohexol - Google Patents
Processo para a produção de iohexol Download PDFInfo
- Publication number
- PT1641743E PT1641743E PT04748775T PT04748775T PT1641743E PT 1641743 E PT1641743 E PT 1641743E PT 04748775 T PT04748775 T PT 04748775T PT 04748775 T PT04748775 T PT 04748775T PT 1641743 E PT1641743 E PT 1641743E
- Authority
- PT
- Portugal
- Prior art keywords
- sub
- iohexol
- manufacture
- dihydroxypropyl
- triiodoisophtalamide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/08—Preparation of carboxylic acid amides from amides by reaction at nitrogen atoms of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Glass Compositions (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO20033058A NO20033058D0 (no) | 2003-07-03 | 2003-07-03 | Prosess |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1641743E true PT1641743E (pt) | 2008-12-30 |
Family
ID=27800766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT04748775T PT1641743E (pt) | 2003-07-03 | 2004-07-01 | Processo para a produção de iohexol |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20060178533A1 (zh) |
| EP (1) | EP1641743B1 (zh) |
| JP (1) | JP4933253B2 (zh) |
| KR (1) | KR101083147B1 (zh) |
| CN (1) | CN100349858C (zh) |
| AT (1) | ATE414057T1 (zh) |
| DE (1) | DE602004017729D1 (zh) |
| ES (1) | ES2314414T3 (zh) |
| NO (1) | NO20033058D0 (zh) |
| PT (1) | PT1641743E (zh) |
| WO (1) | WO2005003080A1 (zh) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO20053676D0 (no) | 2005-07-29 | 2005-07-29 | Amersham Health As | Crystallisation Process |
| NO20053687D0 (no) * | 2005-07-29 | 2005-07-29 | Amersham Health As | Crystallisation Process. |
| NO342021B1 (no) * | 2005-07-29 | 2018-03-12 | Ge Healthcare As | Kontinuerlig krystalliseringsprosess |
| PT103391B (pt) * | 2005-11-24 | 2008-10-30 | Hovione Farmaciencia S A | Processo para fabrico de lohexol |
| CN101195587B (zh) * | 2006-12-19 | 2010-07-21 | 浙江尖峰海洲制药有限公司 | 一种碘克沙醇水解物的制备方法 |
| US20120184772A1 (en) * | 2009-09-30 | 2012-07-19 | Bailey Allan R | Alkylation of triiodo-substituted arylamides in an aqueous mixed solvent system |
| EP2504298B1 (en) * | 2009-11-26 | 2016-09-21 | iMAX Diagnostic Imaging Holding Limited | Preparation and purification of iodixanol |
| ES2680019T3 (es) * | 2010-12-21 | 2018-09-03 | Ge Healthcare As | Desalinización de una composición que comprende un agente de contraste |
| US20140065076A1 (en) * | 2012-08-30 | 2014-03-06 | Otsuka Pharmaceutical Co. Ltd. | Container with concentrated substance and method of using the same |
| CN110054569B (zh) * | 2019-05-17 | 2022-05-17 | 浙江海洲制药有限公司 | 一种制备碘海醇的方法 |
| CN110590591B (zh) * | 2019-09-25 | 2022-05-17 | 浙江海洲制药有限公司 | 一种碘克沙醇，碘海醇杂质的制备方法 |
| CN115403481A (zh) * | 2022-04-13 | 2022-11-29 | 江苏宇田医药有限公司 | 一种通过离子交换树脂纯化碘海醇的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9618056D0 (en) * | 1996-08-29 | 1996-10-09 | Nycomed Imaging As | Process |
| US5847212A (en) * | 1997-04-21 | 1998-12-08 | Abbott Laboratories | Process for the preparation of iohexol |
| GB9725010D0 (en) * | 1997-11-26 | 1998-01-28 | Nycomed Imaging As | Process |
| ITMI20010773A1 (it) * | 2001-04-11 | 2002-10-11 | Chemi Spa | Processo per la produzione di ioexolo ad elevata purezza |
-
2003
- 2003-07-03 NO NO20033058A patent/NO20033058D0/no unknown
-
2004
- 2004-07-01 JP JP2006517004A patent/JP4933253B2/ja not_active Expired - Lifetime
- 2004-07-01 WO PCT/NO2004/000199 patent/WO2005003080A1/en active Search and Examination
- 2004-07-01 EP EP04748775A patent/EP1641743B1/en not_active Expired - Lifetime
- 2004-07-01 PT PT04748775T patent/PT1641743E/pt unknown
- 2004-07-01 US US10/560,497 patent/US20060178533A1/en not_active Abandoned
- 2004-07-01 ES ES04748775T patent/ES2314414T3/es not_active Expired - Lifetime
- 2004-07-01 DE DE602004017729T patent/DE602004017729D1/de not_active Expired - Lifetime
- 2004-07-01 CN CNB2004800191766A patent/CN100349858C/zh not_active Expired - Lifetime
- 2004-07-01 KR KR1020067000051A patent/KR101083147B1/ko active IP Right Grant
- 2004-07-01 AT AT04748775T patent/ATE414057T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1641743B1 (en) | 2008-11-12 |
| WO2005003080A1 (en) | 2005-01-13 |
| CN1816519A (zh) | 2006-08-09 |
| NO20033058D0 (no) | 2003-07-03 |
| EP1641743A1 (en) | 2006-04-05 |
| KR101083147B1 (ko) | 2011-11-11 |
| ES2314414T3 (es) | 2009-03-16 |
| CN100349858C (zh) | 2007-11-21 |
| JP4933253B2 (ja) | 2012-05-16 |
| US20060178533A1 (en) | 2006-08-10 |
| DE602004017729D1 (de) | 2008-12-24 |
| ATE414057T1 (de) | 2008-11-15 |
| KR20060041207A (ko) | 2006-05-11 |
| JP2007521262A (ja) | 2007-08-02 |
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