PT1546185E - Método para a preparação de hormona do crescimento e seus antagonistas apresentando níveis inferiores de suas impurezas isoformas - Google Patents

Método para a preparação de hormona do crescimento e seus antagonistas apresentando níveis inferiores de suas impurezas isoformas Download PDF

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Publication number
PT1546185E
PT1546185E PT03799266T PT03799266T PT1546185E PT 1546185 E PT1546185 E PT 1546185E PT 03799266 T PT03799266 T PT 03799266T PT 03799266 T PT03799266 T PT 03799266T PT 1546185 E PT1546185 E PT 1546185E
Authority
PT
Portugal
Prior art keywords
growth hormone
isoform impurities
antagonist
impurities
preparation
Prior art date
Application number
PT03799266T
Other languages
English (en)
Portuguese (pt)
Inventor
Anurag S Rathore
Stephen B Lyle
David E Steinmeyer
Scott I Allen
John Meyer
Denis M Boyle
John J Buckley
Gary V Johnson
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of PT1546185E publication Critical patent/PT1546185E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PT03799266T 2002-08-28 2003-08-26 Método para a preparação de hormona do crescimento e seus antagonistas apresentando níveis inferiores de suas impurezas isoformas PT1546185E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40655302P 2002-08-28 2002-08-28
US10/646,798 US20040048315A1 (en) 2002-08-28 2003-08-25 Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof

Publications (1)

Publication Number Publication Date
PT1546185E true PT1546185E (pt) 2009-07-14

Family

ID=31997673

Family Applications (1)

Application Number Title Priority Date Filing Date
PT03799266T PT1546185E (pt) 2002-08-28 2003-08-26 Método para a preparação de hormona do crescimento e seus antagonistas apresentando níveis inferiores de suas impurezas isoformas

Country Status (20)

Country Link
US (2) US20040048315A1 (pl)
EP (1) EP1546185B1 (pl)
JP (1) JP4312154B2 (pl)
KR (1) KR101176588B1 (pl)
AT (1) ATE428721T1 (pl)
AU (1) AU2003260045B2 (pl)
BR (1) BRPI0313829B1 (pl)
CA (1) CA2497146C (pl)
CY (1) CY1109167T1 (pl)
DE (1) DE60327228D1 (pl)
DK (1) DK1546185T3 (pl)
ES (1) ES2323586T3 (pl)
IL (1) IL167121A (pl)
MX (1) MXPA05002359A (pl)
PL (1) PL211502B1 (pl)
PT (1) PT1546185E (pl)
RU (1) RU2337920C2 (pl)
SI (1) SI1546185T1 (pl)
TW (2) TW200700553A (pl)
WO (1) WO2004031213A1 (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040048315A1 (en) 2002-08-28 2004-03-11 Pharmacia Corporation Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof
EP1833841B1 (en) 2004-12-29 2010-04-07 Novo Nordisk Health Care AG Method for preventing formation of trisulfide derivatives of polypeptides
US9005926B2 (en) 2009-10-02 2015-04-14 Biogen Idec Ma Inc. Methods of preventing and removing trisulfide bonds
DK2513135T3 (da) * 2009-12-18 2020-05-18 Csl Ltd Fremgangsmåde til oprensning af polypeptider
DK2707383T3 (en) 2011-05-13 2018-07-23 Biogen Ma Inc PROCEDURES FOR PREVENTION AND REMOVAL OF TRISULPHIDE BINDINGS
RU2014108241A (ru) 2011-08-25 2015-09-27 Ф.Хоффманн-Ля Рош Аг Способ катион- и анионобменной хроматографии
MY198629A (en) 2014-07-24 2023-09-11 Genentech Inc Methods of conjugating an agent to a thiol moiety in a protein that contains at least one trisulfide bond
MX2018013683A (es) * 2016-05-10 2019-06-17 Genentech Inc Métodos para disminuir los enlaces de trisulfuro durante la producción recombinante de polipéptidos.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5153265A (en) 1988-01-20 1992-10-06 Cetus Corporation Conjugation of polymer to colony stimulating factor-1
US5969109A (en) 1990-02-28 1999-10-19 Bona; Constantin Chimeric antibodies comprising antigen binding sites and B and T cell epitopes
DK44593D0 (da) * 1993-04-20 1993-04-20 Novo Nordisk As Fremgangsmaade til fremstilling af et polypeptid
ZA955789B (en) * 1994-07-15 1996-03-11 Novo Nordisk As A method of converting a hydrophobic derivative of a polypeptide into the native form
JP3628333B2 (ja) * 1995-09-21 2005-03-09 ジェネンテック インコーポレーテッド ヒト成長ホルモン変異体
SE9802454D0 (sv) * 1998-07-08 1998-07-08 Pharmacia & Upjohn Ab Production of peptides
AR026743A1 (es) * 1999-12-09 2003-02-26 Pharmacia Ab Produccion de peptidos
US7229789B1 (en) 2001-01-19 2007-06-12 N.V. Organon Methods and compositions for extracting proteins from cells
US20040048315A1 (en) 2002-08-28 2004-03-11 Pharmacia Corporation Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof
US7470779B2 (en) * 2002-09-20 2008-12-30 Pfizer Inc. Process for decreasing aggregate levels of pegylated protein

Also Published As

Publication number Publication date
TW200407428A (en) 2004-05-16
EP1546185A1 (en) 2005-06-29
CA2497146A1 (en) 2004-04-15
DK1546185T3 (da) 2009-06-22
JP2006517091A (ja) 2006-07-20
PL211502B1 (pl) 2012-05-31
KR101176588B1 (ko) 2012-08-23
US20040048315A1 (en) 2004-03-11
EP1546185A4 (en) 2006-09-06
TWI289603B (en) 2007-11-11
BRPI0313829B1 (pt) 2021-10-26
CA2497146C (en) 2012-05-22
US8148331B2 (en) 2012-04-03
HK1077074A1 (en) 2006-02-03
PL374917A1 (pl) 2005-11-14
BR0313829A (pt) 2005-07-26
IL167121A (en) 2010-11-30
RU2337920C2 (ru) 2008-11-10
SI1546185T1 (sl) 2009-08-31
AU2003260045A1 (en) 2004-04-23
WO2004031213A1 (en) 2004-04-15
DE60327228D1 (de) 2009-05-28
JP4312154B2 (ja) 2009-08-12
TW200700553A (en) 2007-01-01
ES2323586T3 (es) 2009-07-21
US20100021966A1 (en) 2010-01-28
RU2005109388A (ru) 2005-10-27
AU2003260045B2 (en) 2010-01-07
MXPA05002359A (es) 2005-07-15
CY1109167T1 (el) 2014-07-02
KR20050059163A (ko) 2005-06-17
ATE428721T1 (de) 2009-05-15
EP1546185B1 (en) 2009-04-15

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