PT1390372E - Derivados de 1-oxa-3, 9-diaza-espiro(5, 5) undecan-2-onas e a sua utilização a título de antagonistas do receptor de neuriquinina - Google Patents
Derivados de 1-oxa-3, 9-diaza-espiro(5, 5) undecan-2-onas e a sua utilização a título de antagonistas do receptor de neuriquinina Download PDFInfo
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- PT1390372E PT1390372E PT02742943T PT02742943T PT1390372E PT 1390372 E PT1390372 E PT 1390372E PT 02742943 T PT02742943 T PT 02742943T PT 02742943 T PT02742943 T PT 02742943T PT 1390372 E PT1390372 E PT 1390372E
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- Prior art keywords
- formula
- bis
- oxa
- phenyl
- undecan
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Otolaryngology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01111644 | 2001-05-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1390372E true PT1390372E (pt) | 2008-08-25 |
Family
ID=8177412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT02742943T PT1390372E (pt) | 2001-05-14 | 2002-05-06 | Derivados de 1-oxa-3, 9-diaza-espiro(5, 5) undecan-2-onas e a sua utilização a título de antagonistas do receptor de neuriquinina |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6599900B2 (enExample) |
| EP (1) | EP1390372B1 (enExample) |
| JP (1) | JP4056887B2 (enExample) |
| KR (1) | KR100618063B1 (enExample) |
| CN (1) | CN1264847C (enExample) |
| AR (1) | AR033631A1 (enExample) |
| AT (1) | ATE401333T1 (enExample) |
| AU (1) | AU2002342238B2 (enExample) |
| BR (1) | BR0209604A (enExample) |
| CA (1) | CA2447329C (enExample) |
| DE (1) | DE60227657D1 (enExample) |
| DK (1) | DK1390372T3 (enExample) |
| ES (1) | ES2310206T3 (enExample) |
| MX (1) | MXPA03010321A (enExample) |
| PT (1) | PT1390372E (enExample) |
| WO (1) | WO2002092604A1 (enExample) |
| ZA (1) | ZA200308535B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1716156A2 (en) * | 2004-02-10 | 2006-11-02 | F.Hoffmann-La Roche Ag | Chemokine ccr5 receptor modulators |
| CA2598762A1 (en) | 2005-02-25 | 2006-08-31 | F. Hoffmann-La Roche Ag | Tablets with improved drug substance dispersibility |
| ES2346147T3 (es) * | 2005-03-03 | 2010-10-11 | Janssen Pharmaceutica Nv | Derivados de oxa-diaza-espiro-(5.5)-undecanona sustituidos y su uso como antagonistas de las neuroquininas. |
| NZ556628A (en) | 2005-03-08 | 2009-09-25 | Janssen Pharmaceutica Nv | Diaza-spiro-[4.4]-nonane derivatives as neurokinin (NK1) antagonists |
| US7470684B2 (en) | 2007-01-03 | 2008-12-30 | Hoffmann-La Roche Inc. | Spiropiperidine derivatives as NK3 antagonists |
| US8093268B2 (en) | 2007-01-24 | 2012-01-10 | Glaxo Group Limited | Pharmaceutical compositions comprising 2-methoxy-5-(5-trifluoromethyl-tetrazol-1-yl-benzyl)-(2S-phenylpiperidin-3S-yl-) |
| BRPI0809646A2 (pt) | 2007-03-29 | 2014-09-23 | Hoffmann La Roche | Compostod antivirais heterocíclicos |
| MX375424B (es) | 2015-07-31 | 2025-03-06 | Pfizer | Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-il carbamato y derivados de 1,1,1-trifluoro-4- hidroxibutan-2-il carbamato como inhibidores de magl |
| MX2019008626A (es) | 2017-01-20 | 2019-09-19 | Pfizer | Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-ilcarbamato como inhibidores de monoacilglicerol lipasa (magl). |
| JP2020506903A (ja) | 2017-01-23 | 2020-03-05 | ファイザー・インク | Ｍａｇｌ阻害薬としての複素環式スピロ化合物 |
| WO2020048826A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Aktiengesellschaft | 5-substituted 1-oxa-3,9-diazaspiro[5.5]undecan-2-one compounds |
| WO2020048827A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Aktiengesellschaft | 1, 3, 9-triazaspiro[5.5] undecan-2-one compounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2131021B (en) * | 1982-11-24 | 1985-12-18 | Erba Farmitalia | Antipsychotic benzoxazines |
| IL111960A (en) * | 1993-12-17 | 1999-12-22 | Merck & Co Inc | Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them |
| WO1997011940A1 (en) * | 1995-09-29 | 1997-04-03 | Eli Lilly And Company | Spiro compounds as inhibitors of fibrinogen-dependent platelet aggregation |
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2002
- 2002-05-06 DK DK02742943T patent/DK1390372T3/da active
- 2002-05-06 MX MXPA03010321A patent/MXPA03010321A/es active IP Right Grant
- 2002-05-06 DE DE60227657T patent/DE60227657D1/de not_active Expired - Lifetime
- 2002-05-06 KR KR1020037014713A patent/KR100618063B1/ko not_active Expired - Fee Related
- 2002-05-06 CA CA002447329A patent/CA2447329C/en not_active Expired - Fee Related
- 2002-05-06 PT PT02742943T patent/PT1390372E/pt unknown
- 2002-05-06 EP EP02742943A patent/EP1390372B1/en not_active Expired - Lifetime
- 2002-05-06 BR BR0209604-8A patent/BR0209604A/pt not_active IP Right Cessation
- 2002-05-06 CN CNB028094735A patent/CN1264847C/zh not_active Expired - Fee Related
- 2002-05-06 JP JP2002589488A patent/JP4056887B2/ja not_active Expired - Fee Related
- 2002-05-06 ES ES02742943T patent/ES2310206T3/es not_active Expired - Lifetime
- 2002-05-06 WO PCT/EP2002/004935 patent/WO2002092604A1/en not_active Ceased
- 2002-05-06 AT AT02742943T patent/ATE401333T1/de not_active IP Right Cessation
- 2002-05-06 AU AU2002342238A patent/AU2002342238B2/en not_active Ceased
- 2002-05-10 US US10/143,431 patent/US6599900B2/en not_active Expired - Fee Related
- 2002-05-10 AR ARP020101705A patent/AR033631A1/es unknown
-
2003
- 2003-10-31 ZA ZA200308535A patent/ZA200308535B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20030094405A (ko) | 2003-12-11 |
| US6599900B2 (en) | 2003-07-29 |
| BR0209604A (pt) | 2004-03-23 |
| CA2447329C (en) | 2009-07-28 |
| AU2002342238B2 (en) | 2007-01-25 |
| ES2310206T3 (es) | 2009-01-01 |
| EP1390372A1 (en) | 2004-02-25 |
| CN1507449A (zh) | 2004-06-23 |
| DE60227657D1 (de) | 2008-08-28 |
| CN1264847C (zh) | 2006-07-19 |
| KR100618063B1 (ko) | 2006-08-30 |
| AR033631A1 (es) | 2003-12-26 |
| DK1390372T3 (da) | 2008-09-15 |
| US20030004163A1 (en) | 2003-01-02 |
| CA2447329A1 (en) | 2002-11-21 |
| WO2002092604A1 (en) | 2002-11-21 |
| JP2004534758A (ja) | 2004-11-18 |
| MXPA03010321A (es) | 2004-02-17 |
| JP4056887B2 (ja) | 2008-03-05 |
| ATE401333T1 (de) | 2008-08-15 |
| EP1390372B1 (en) | 2008-07-16 |
| ZA200308535B (en) | 2005-01-31 |
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