ZA200308535B - 1-Oxa-3,9-diaza-spiro[5,5]undecan-2-ones derivatives and its use as antagonist of the neurikinin receptor. - Google Patents
1-Oxa-3,9-diaza-spiro[5,5]undecan-2-ones derivatives and its use as antagonist of the neurikinin receptor. Download PDFInfo
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- ZA200308535B ZA200308535B ZA200308535A ZA200308535A ZA200308535B ZA 200308535 B ZA200308535 B ZA 200308535B ZA 200308535 A ZA200308535 A ZA 200308535A ZA 200308535 A ZA200308535 A ZA 200308535A ZA 200308535 B ZA200308535 B ZA 200308535B
- Authority
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- South Africa
- Prior art keywords
- formula
- compound
- diaza
- spiro
- oxa
- Prior art date
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- 239000005557 antagonist Substances 0.000 title description 5
- KAXASJWZSSJLPG-UHFFFAOYSA-N 1-oxa-3,9-diazaspiro[5.5]undecan-2-one Chemical class O1C(=O)NCCC11CCNCC1 KAXASJWZSSJLPG-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 106
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- 239000000203 mixture Substances 0.000 claims description 10
- -1 bromo, morpholinyl Chemical group 0.000 claims description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 9
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- 229910052736 halogen Inorganic materials 0.000 claims description 9
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- FEYUTRZPSFLEST-UHFFFAOYSA-N spiro[5.5]undecan-4-one Chemical compound C1C(=O)CCCC11CCCCC1 FEYUTRZPSFLEST-UHFFFAOYSA-N 0.000 claims description 4
- ZECJUCGRCJUNIL-UHFFFAOYSA-N 9-[3,5-bis(trifluoromethyl)benzoyl]-3-(1-methylpiperidin-4-yl)-5-phenyl-1-oxa-3,9-diazaspiro[5.5]undecan-2-one Chemical compound C1CN(C)CCC1N1C(=O)OC2(CCN(CC2)C(=O)C=2C=C(C=C(C=2)C(F)(F)F)C(F)(F)F)C(C=2C=CC=CC=2)C1 ZECJUCGRCJUNIL-UHFFFAOYSA-N 0.000 claims description 3
- KOOSRSYKRYWAAS-UHFFFAOYSA-N 9-[3,5-bis(trifluoromethyl)benzoyl]-5-(3,4-dichlorophenyl)-1-oxa-3,9-diazaspiro[5.5]undecan-2-one Chemical compound FC(F)(F)C1=CC(C(F)(F)F)=CC(C(=O)N2CCC3(CC2)C(CNC(=O)O3)C=2C=C(Cl)C(Cl)=CC=2)=C1 KOOSRSYKRYWAAS-UHFFFAOYSA-N 0.000 claims description 3
- HGXVVFLYFCJJSU-UHFFFAOYSA-N 9-[3,5-bis(trifluoromethyl)benzoyl]-5-(3,4-difluorophenyl)-1-oxa-3,9-diazaspiro[5.5]undecan-2-one Chemical compound C1=C(F)C(F)=CC=C1C1C2(CCN(CC2)C(=O)C=2C=C(C=C(C=2)C(F)(F)F)C(F)(F)F)OC(=O)NC1 HGXVVFLYFCJJSU-UHFFFAOYSA-N 0.000 claims description 3
- SEAFPVXMSCTQLM-UHFFFAOYSA-N 9-[3,5-bis(trifluoromethyl)benzoyl]-5-(3-chlorophenyl)-1-oxa-3,9-diazaspiro[5.5]undecan-2-one Chemical compound FC(F)(F)C1=CC(C(F)(F)F)=CC(C(=O)N2CCC3(CC2)C(CNC(=O)O3)C=2C=C(Cl)C=CC=2)=C1 SEAFPVXMSCTQLM-UHFFFAOYSA-N 0.000 claims description 3
- 125000000623 heterocyclic group Chemical group 0.000 claims description 3
- MIGNBVWFGCBAJP-UHFFFAOYSA-N 9-[3,5-bis(trifluoromethyl)benzoyl]-3-(3-hydroxypropyl)-5-phenyl-1-oxa-3,9-diazaspiro[5.5]undecan-2-one Chemical compound C1CN(C(=O)C=2C=C(C=C(C=2)C(F)(F)F)C(F)(F)F)CCC21OC(=O)N(CCCO)CC2C1=CC=CC=C1 MIGNBVWFGCBAJP-UHFFFAOYSA-N 0.000 claims description 2
- USKRLFGVPFHMNS-UHFFFAOYSA-N 9-[3,5-bis(trifluoromethyl)benzoyl]-3-(3-morpholin-4-ylpropyl)-5-phenyl-1-oxa-3,9-diazaspiro[5.5]undecan-2-one Chemical compound FC(F)(F)C1=CC(C(F)(F)F)=CC(C(=O)N2CCC3(CC2)C(CN(CCCN2CCOCC2)C(=O)O3)C=2C=CC=CC=2)=C1 USKRLFGVPFHMNS-UHFFFAOYSA-N 0.000 claims description 2
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- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
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- Public Health (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01111644 | 2001-05-14 |
Publications (1)
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|---|---|
| ZA200308535B true ZA200308535B (en) | 2005-01-31 |
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| ZA200308535A ZA200308535B (en) | 2001-05-14 | 2003-10-31 | 1-Oxa-3,9-diaza-spiro[5,5]undecan-2-ones derivatives and its use as antagonist of the neurikinin receptor. |
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|---|---|
| US (1) | US6599900B2 (enExample) |
| EP (1) | EP1390372B1 (enExample) |
| JP (1) | JP4056887B2 (enExample) |
| KR (1) | KR100618063B1 (enExample) |
| CN (1) | CN1264847C (enExample) |
| AR (1) | AR033631A1 (enExample) |
| AT (1) | ATE401333T1 (enExample) |
| AU (1) | AU2002342238B2 (enExample) |
| BR (1) | BR0209604A (enExample) |
| CA (1) | CA2447329C (enExample) |
| DE (1) | DE60227657D1 (enExample) |
| DK (1) | DK1390372T3 (enExample) |
| ES (1) | ES2310206T3 (enExample) |
| MX (1) | MXPA03010321A (enExample) |
| PT (1) | PT1390372E (enExample) |
| WO (1) | WO2002092604A1 (enExample) |
| ZA (1) | ZA200308535B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1716156A2 (en) * | 2004-02-10 | 2006-11-02 | F.Hoffmann-La Roche Ag | Chemokine ccr5 receptor modulators |
| CA2598762A1 (en) | 2005-02-25 | 2006-08-31 | F. Hoffmann-La Roche Ag | Tablets with improved drug substance dispersibility |
| ES2346147T3 (es) * | 2005-03-03 | 2010-10-11 | Janssen Pharmaceutica Nv | Derivados de oxa-diaza-espiro-(5.5)-undecanona sustituidos y su uso como antagonistas de las neuroquininas. |
| NZ556628A (en) | 2005-03-08 | 2009-09-25 | Janssen Pharmaceutica Nv | Diaza-spiro-[4.4]-nonane derivatives as neurokinin (NK1) antagonists |
| US7470684B2 (en) | 2007-01-03 | 2008-12-30 | Hoffmann-La Roche Inc. | Spiropiperidine derivatives as NK3 antagonists |
| US8093268B2 (en) | 2007-01-24 | 2012-01-10 | Glaxo Group Limited | Pharmaceutical compositions comprising 2-methoxy-5-(5-trifluoromethyl-tetrazol-1-yl-benzyl)-(2S-phenylpiperidin-3S-yl-) |
| BRPI0809646A2 (pt) | 2007-03-29 | 2014-09-23 | Hoffmann La Roche | Compostod antivirais heterocíclicos |
| MX375424B (es) | 2015-07-31 | 2025-03-06 | Pfizer | Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-il carbamato y derivados de 1,1,1-trifluoro-4- hidroxibutan-2-il carbamato como inhibidores de magl |
| MX2019008626A (es) | 2017-01-20 | 2019-09-19 | Pfizer | Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-ilcarbamato como inhibidores de monoacilglicerol lipasa (magl). |
| JP2020506903A (ja) | 2017-01-23 | 2020-03-05 | ファイザー・インク | Ｍａｇｌ阻害薬としての複素環式スピロ化合物 |
| WO2020048826A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Aktiengesellschaft | 5-substituted 1-oxa-3,9-diazaspiro[5.5]undecan-2-one compounds |
| WO2020048827A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Aktiengesellschaft | 1, 3, 9-triazaspiro[5.5] undecan-2-one compounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2131021B (en) * | 1982-11-24 | 1985-12-18 | Erba Farmitalia | Antipsychotic benzoxazines |
| IL111960A (en) * | 1993-12-17 | 1999-12-22 | Merck & Co Inc | Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them |
| WO1997011940A1 (en) * | 1995-09-29 | 1997-04-03 | Eli Lilly And Company | Spiro compounds as inhibitors of fibrinogen-dependent platelet aggregation |
-
2002
- 2002-05-06 DK DK02742943T patent/DK1390372T3/da active
- 2002-05-06 MX MXPA03010321A patent/MXPA03010321A/es active IP Right Grant
- 2002-05-06 DE DE60227657T patent/DE60227657D1/de not_active Expired - Lifetime
- 2002-05-06 KR KR1020037014713A patent/KR100618063B1/ko not_active Expired - Fee Related
- 2002-05-06 CA CA002447329A patent/CA2447329C/en not_active Expired - Fee Related
- 2002-05-06 PT PT02742943T patent/PT1390372E/pt unknown
- 2002-05-06 EP EP02742943A patent/EP1390372B1/en not_active Expired - Lifetime
- 2002-05-06 BR BR0209604-8A patent/BR0209604A/pt not_active IP Right Cessation
- 2002-05-06 CN CNB028094735A patent/CN1264847C/zh not_active Expired - Fee Related
- 2002-05-06 JP JP2002589488A patent/JP4056887B2/ja not_active Expired - Fee Related
- 2002-05-06 ES ES02742943T patent/ES2310206T3/es not_active Expired - Lifetime
- 2002-05-06 WO PCT/EP2002/004935 patent/WO2002092604A1/en not_active Ceased
- 2002-05-06 AT AT02742943T patent/ATE401333T1/de not_active IP Right Cessation
- 2002-05-06 AU AU2002342238A patent/AU2002342238B2/en not_active Ceased
- 2002-05-10 US US10/143,431 patent/US6599900B2/en not_active Expired - Fee Related
- 2002-05-10 AR ARP020101705A patent/AR033631A1/es unknown
-
2003
- 2003-10-31 ZA ZA200308535A patent/ZA200308535B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20030094405A (ko) | 2003-12-11 |
| US6599900B2 (en) | 2003-07-29 |
| BR0209604A (pt) | 2004-03-23 |
| CA2447329C (en) | 2009-07-28 |
| AU2002342238B2 (en) | 2007-01-25 |
| ES2310206T3 (es) | 2009-01-01 |
| EP1390372A1 (en) | 2004-02-25 |
| CN1507449A (zh) | 2004-06-23 |
| DE60227657D1 (de) | 2008-08-28 |
| CN1264847C (zh) | 2006-07-19 |
| KR100618063B1 (ko) | 2006-08-30 |
| AR033631A1 (es) | 2003-12-26 |
| DK1390372T3 (da) | 2008-09-15 |
| US20030004163A1 (en) | 2003-01-02 |
| CA2447329A1 (en) | 2002-11-21 |
| WO2002092604A1 (en) | 2002-11-21 |
| JP2004534758A (ja) | 2004-11-18 |
| PT1390372E (pt) | 2008-08-25 |
| MXPA03010321A (es) | 2004-02-17 |
| JP4056887B2 (ja) | 2008-03-05 |
| ATE401333T1 (de) | 2008-08-15 |
| EP1390372B1 (en) | 2008-07-16 |
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