PT1301539E - Pragmentos de ligação a antigénios específicos para células dendríticas, composições e métodos para a sua utilização antigénicos assim reconhecidos e células assim obtidas. - Google Patents

Pragmentos de ligação a antigénios específicos para células dendríticas, composições e métodos para a sua utilização antigénicos assim reconhecidos e células assim obtidas. Download PDF

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Publication number
PT1301539E
PT1301539E PT00979855T PT00979855T PT1301539E PT 1301539 E PT1301539 E PT 1301539E PT 00979855 T PT00979855 T PT 00979855T PT 00979855 T PT00979855 T PT 00979855T PT 1301539 E PT1301539 E PT 1301539E
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Prior art keywords
bdca
cells
antigen
cell
protein
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PT00979855T
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English (en)
Portuguese (pt)
Inventor
Juergen Schmitz
Andrzej Dzionek
David William Buck
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Miltenyi Biotec Gmbh
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Application filed by Miltenyi Biotec Gmbh filed Critical Miltenyi Biotec Gmbh
Publication of PT1301539E publication Critical patent/PT1301539E/pt

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    • C—CHEMISTRY; METALLURGY
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
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    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C—CHEMISTRY; METALLURGY
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • A61K2039/515—Animal cells
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
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  • Immunology (AREA)
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  • Biomedical Technology (AREA)
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  • Biochemistry (AREA)
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  • Hematology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
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PT00979855T 1999-11-15 2000-11-15 Pragmentos de ligação a antigénios específicos para células dendríticas, composições e métodos para a sua utilização antigénicos assim reconhecidos e células assim obtidas. PT1301539E (pt)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US16555599P 1999-11-15 1999-11-15
US16707699P 1999-11-23 1999-11-23
US17900300P 2000-01-28 2000-01-28
US18077500P 2000-02-07 2000-02-07
US19682400P 2000-04-11 2000-04-11
US19720500P 2000-04-13 2000-04-13

Publications (1)

Publication Number Publication Date
PT1301539E true PT1301539E (pt) 2007-04-30

Family

ID=27558547

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Application Number Title Priority Date Filing Date
PT00979855T PT1301539E (pt) 1999-11-15 2000-11-15 Pragmentos de ligação a antigénios específicos para células dendríticas, composições e métodos para a sua utilização antigénicos assim reconhecidos e células assim obtidas.

Country Status (11)

Country Link
EP (3) EP1301539B1 (enExample)
JP (4) JP5007007B2 (enExample)
KR (1) KR100868235B1 (enExample)
CN (1) CN1454215B (enExample)
AU (1) AU785198B2 (enExample)
CA (2) CA2396428C (enExample)
DE (1) DE60033062T2 (enExample)
DK (1) DK1301539T3 (enExample)
ES (1) ES2280264T3 (enExample)
PT (1) PT1301539E (enExample)
WO (1) WO2001036487A2 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1454215B (zh) * 1999-11-15 2013-01-02 米勒腾尼生物技术有限公司 树突状细胞特异的抗原结合片段、组合物及其使用方法、被其识别的抗原及由其获得的细胞
WO2002032958A2 (en) * 2000-10-16 2002-04-25 Bayer Aktiengesellschaft Polynucleotide and polypeptide sequences of human dendritic cell immunoreceptors
US7252990B2 (en) 2001-03-12 2007-08-07 Lexicon Genetics Incorporated Human dectin proteins and polynucleotides encoding the same
EP1395826A4 (en) * 2001-05-17 2005-11-09 Miltenyi Biotec Gmbh ANTIGEN-BINDING FRAGMENTS FOR A SUB-GROUP OF DENDRITIC CELLS AND USE THEREOF
KR100522526B1 (ko) * 2002-11-28 2005-10-19 주식회사 바이넥스 면역 치료용 수지상 세포의 제조방법
AU2005291741B2 (en) * 2004-10-07 2011-11-24 Universitat Zurich Type I interferon blocking agents for prevention and treatment of psoriasis
AU2006213800B2 (en) 2005-02-10 2012-02-09 Baylor Research Institute Anti-interferon alpha monoclonal antibodies and methods for use
JP5766598B2 (ja) 2008-05-07 2015-08-19 アーゴス セラピューティクス インコーポレイテッド ヒトインターフェロン−αに対するヒト化抗体
NZ593240A (en) * 2009-01-06 2013-01-25 Functional Genetics Inc Random homozygous gene perturbation (rhgp) with thermal assymetric interlaced (tail)-pcr
FR2968561B1 (fr) * 2010-12-13 2013-08-09 Lfb Biotechnologies Utilisation d'un anticorps dirige contre une proteine membranaire
WO2014047124A1 (en) * 2012-09-18 2014-03-27 University Of Washington Through Its Center For Commercialization Compositions and methods for delivery of antigens to plasmacytoid dendritic cells
WO2014093396A1 (en) * 2012-12-10 2014-06-19 Biogen Idec Ma Inc. Anti-blood dendritic cell antigen 2 antibodies and uses thereof
CN106029874B (zh) * 2013-12-16 2020-09-15 北卡罗来纳-查佩尔山大学 浆细胞样树突状细胞的耗竭
US10294301B2 (en) * 2013-12-24 2019-05-21 Astellas Pharma Inc. Anti-human BDCA-2 antibody
CA3185180A1 (en) * 2014-05-16 2015-11-19 Baylor Research Institute Methods and compositions for treating autoimmune and inflammatory conditions
ES2946697T3 (es) 2014-09-10 2023-07-24 Miltenyi Biotec Bv & Co Kg Una población celular para su uso en el tratamiento de cáncer
SG11201704500VA (en) 2014-12-03 2017-06-29 Samsung Life Public Welfare Foundation Antibody binding to neuropilin 1 and use thereof
FR3034420A1 (fr) 2015-03-31 2016-10-07 Lab Francais Du Fractionnement Anticorps monoclonaux anti-cd303
FR3045386B1 (fr) * 2015-12-16 2018-02-02 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Nouvelle utilisation d'un anticorps dirige contre une proteine membranaire
SI3529262T1 (sl) * 2016-10-21 2021-12-31 Inserm - Institut National De La Sante Et De La Recherche Medicale Postopki za spodbujanje odgovora T-celic
FR3060395B1 (fr) * 2016-12-16 2019-05-24 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Combinaison d'anticorps anti-cd303 et anti-her2
FR3060394B1 (fr) * 2016-12-16 2019-05-24 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Combinaison d'anticorps anti-cd303 et anti-amhrii
JP7158642B2 (ja) * 2018-01-16 2022-10-24 国立大学法人山梨大学 質量分析装置及び質量分析システム
WO2020227595A1 (en) * 2019-05-09 2020-11-12 Atara Biotherapeutics, Inc. Clec4-targeted car-t-cells
AR124247A1 (es) * 2020-12-03 2023-03-01 Biogen Ma Inc Métodos de tratamiento del lupus eritematoso cutáneo y lupus eritematoso sistémico
CN114264825B (zh) * 2021-12-22 2023-08-15 重庆医科大学附属儿童医院 一种b淋巴细胞发育亚群免疫分型的方法和试剂盒

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10500492A (ja) * 1995-03-15 1998-01-13 ミルテニー バイオテク インク 高勾配磁気細胞選別による造血樹状細胞の単離
US5871728A (en) * 1995-03-31 1999-02-16 University Of Pittsburgh Method of regulating dendritic cell maturation
US5788963A (en) * 1995-07-31 1998-08-04 Pacific Northwest Cancer Foundation Isolation and/or preservation of dendritic cells for prostate cancer immunotherapy
US6046158A (en) * 1996-12-20 2000-04-04 Board Of Regents The University Of Texas Systems Unique dendritic cell-associated C-type lectins, dectin-1 and dectin-2; compositions and uses thereof
AU755279C (en) * 1997-07-09 2004-02-19 Schering Corporation Isolated dendritic cell membrane protein genes
FI973762A0 (fi) * 1997-09-23 1997-09-23 Krohn Kai Ny gen
EP1027436A1 (en) * 1997-10-28 2000-08-16 Immunex Corporation Viral encoded semaphorin protein receptor dna and polypeptides
CA2323083A1 (en) * 1998-03-17 1999-09-23 Schering Corporation Isolated mammalian membrane protein genes and related reagents
CN1454215B (zh) * 1999-11-15 2013-01-02 米勒腾尼生物技术有限公司 树突状细胞特异的抗原结合片段、组合物及其使用方法、被其识别的抗原及由其获得的细胞

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