JP5007007B2 - 樹状細胞に特異的な抗原結合フラグメント、その組成物および使用方法、それによって認識される抗原およびそれによって得られる細胞 - Google Patents

樹状細胞に特異的な抗原結合フラグメント、その組成物および使用方法、それによって認識される抗原およびそれによって得られる細胞 Download PDF

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JP5007007B2
JP5007007B2 JP2001538976A JP2001538976A JP5007007B2 JP 5007007 B2 JP5007007 B2 JP 5007007B2 JP 2001538976 A JP2001538976 A JP 2001538976A JP 2001538976 A JP2001538976 A JP 2001538976A JP 5007007 B2 JP5007007 B2 JP 5007007B2
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ユルゲン シュミッツ，
アンドルゼフ ドゥジョネック，
デイビッド ウィリアム バック，
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ミルテニイ バイオテック ゲゼルシャフト ミット ベシュレンクテル ハフツング
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JP2001538976A 1999-11-15 2000-11-15 樹状細胞に特異的な抗原結合フラグメント、その組成物および使用方法、それによって認識される抗原およびそれによって得られる細胞 Expired - Lifetime JP5007007B2 (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US16555599P 1999-11-15 1999-11-15
US60/165,555 1999-11-15
US16707699P 1999-11-23 1999-11-23
US60/167,076 1999-11-23
US17900300P 2000-01-28 2000-01-28
US60/179,003 2000-01-28
US18077500P 2000-02-07 2000-02-07
US60/180,775 2000-02-07
US19682400P 2000-04-11 2000-04-11
US60/196,824 2000-04-11
US19720500P 2000-04-13 2000-04-13
US60/197,205 2000-04-13
PCT/IB2000/001832 WO2001036487A2 (en) 1999-11-15 2000-11-15 Antigen-binding fragments specific for dendritic cells, compositions and methods of use thereof antigens recognized thereby and cells obtained thereby

Related Child Applications (3)

Application Number Title Priority Date Filing Date
JP2007325800A Division JP2008148700A (ja) 1999-11-15 2007-12-18 樹状細胞に特異的な抗原結合フラグメント及びその使用
JP2011015018A Division JP5355602B2 (ja) 1999-11-15 2011-01-27 樹状細胞に特異的な抗原結合フラグメント、その組成物および使用方法、それによって認識される抗原およびそれによって得られる細胞
JP2012045127A Division JP5599834B2 (ja) 1999-11-15 2012-03-01 樹状細胞に特異的な抗原結合フラグメント、その組成物および使用方法、それによって認識される抗原およびそれによって得られる細胞

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JP2004512006A JP2004512006A (ja) 2004-04-22
JP2004512006A5 JP2004512006A5 (enExample) 2011-04-07
JP5007007B2 true JP5007007B2 (ja) 2012-08-22

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JP2001538976A Expired - Lifetime JP5007007B2 (ja) 1999-11-15 2000-11-15 樹状細胞に特異的な抗原結合フラグメント、その組成物および使用方法、それによって認識される抗原およびそれによって得られる細胞
JP2007325800A Withdrawn JP2008148700A (ja) 1999-11-15 2007-12-18 樹状細胞に特異的な抗原結合フラグメント及びその使用
JP2011015018A Expired - Lifetime JP5355602B2 (ja) 1999-11-15 2011-01-27 樹状細胞に特異的な抗原結合フラグメント、その組成物および使用方法、それによって認識される抗原およびそれによって得られる細胞
JP2012045127A Expired - Fee Related JP5599834B2 (ja) 1999-11-15 2012-03-01 樹状細胞に特異的な抗原結合フラグメント、その組成物および使用方法、それによって認識される抗原およびそれによって得られる細胞

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JP2007325800A Withdrawn JP2008148700A (ja) 1999-11-15 2007-12-18 樹状細胞に特異的な抗原結合フラグメント及びその使用
JP2011015018A Expired - Lifetime JP5355602B2 (ja) 1999-11-15 2011-01-27 樹状細胞に特異的な抗原結合フラグメント、その組成物および使用方法、それによって認識される抗原およびそれによって得られる細胞
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Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU785198B2 (en) * 1999-11-15 2006-11-02 Miltenyi Biotec B.V. & Co. KG Antigen-binding fragments specific for dendritic cells, compositions and methods of use thereof antigens recognised thereby and cells obtained thereby
JP2004511254A (ja) * 2000-10-16 2004-04-15 バイエル　アクチェンゲゼルシャフト ヒト樹状細胞免疫受容体の調節
US7252990B2 (en) 2001-03-12 2007-08-07 Lexicon Genetics Incorporated Human dectin proteins and polynucleotides encoding the same
WO2002093172A1 (en) * 2001-05-17 2002-11-21 Miltenyi Biotec Gmbh Antigen binding fragments for dendritic cell subset and use thereof
KR100522526B1 (ko) * 2002-11-28 2005-10-19 주식회사 바이넥스 면역 치료용 수지상 세포의 제조방법
EP2286835A1 (en) * 2004-10-07 2011-02-23 Universität Zürich Prorektorat Forschung Type I interferon blocking agents for prevention and treatment of psoriasis
MX2007009466A (es) 2005-02-10 2007-12-07 Baylor Res Inst Anticuerpos monoclonales de anti-interferon alfa y metodos para su uso.
JP5766598B2 (ja) 2008-05-07 2015-08-19 アーゴス セラピューティクス インコーポレイテッド ヒトインターフェロン−αに対するヒト化抗体
WO2010080782A2 (en) * 2009-01-06 2010-07-15 Functional Genetics, Inc. Random homozygous gene perburbation (rhgp) with thermal assymetric interlaced (tail)-pcr
FR2968561B1 (fr) * 2010-12-13 2013-08-09 Lfb Biotechnologies Utilisation d'un anticorps dirige contre une proteine membranaire
WO2014047124A1 (en) * 2012-09-18 2014-03-27 University Of Washington Through Its Center For Commercialization Compositions and methods for delivery of antigens to plasmacytoid dendritic cells
AU2013359419B2 (en) 2012-12-10 2018-03-15 Biogen Ma Inc. Anti-blood dendritic cell antigen 2 antibodies and uses thereof
EP3083946B1 (en) 2013-12-16 2024-08-07 The University of North Carolina at Chapel Hill Depletion of plasmacytoid dendritic cells
CN109535254B (zh) 2013-12-24 2022-06-24 安斯泰来制药株式会社 抗人bdca-2抗体、其生产方法、多核苷酸、表达载体、宿主细胞及医药组合物
CA3185180A1 (en) * 2014-05-16 2015-11-19 Baylor Research Institute Methods and compositions for treating autoimmune and inflammatory conditions
WO2016038168A1 (en) * 2014-09-10 2016-03-17 Miltenyi Biotec Gmbh A cell population for use in treting cancer
AU2015355731B2 (en) 2014-12-03 2018-07-26 Aimed Bio Inc. Antibody binding to neuropilin 1 and use thereof
FR3034420A1 (fr) * 2015-03-31 2016-10-07 Lab Francais Du Fractionnement Anticorps monoclonaux anti-cd303
FR3045386B1 (fr) * 2015-12-16 2018-02-02 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Nouvelle utilisation d'un anticorps dirige contre une proteine membranaire
KR102646708B1 (ko) * 2016-10-21 2024-03-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) T 세포 반응을 촉진하는 방법
FR3060395B1 (fr) * 2016-12-16 2019-05-24 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Combinaison d'anticorps anti-cd303 et anti-her2
FR3060394B1 (fr) * 2016-12-16 2019-05-24 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Combinaison d'anticorps anti-cd303 et anti-amhrii
JP7158642B2 (ja) * 2018-01-16 2022-10-24 国立大学法人山梨大学 質量分析装置及び質量分析システム
WO2020227595A1 (en) * 2019-05-09 2020-11-12 Atara Biotherapeutics, Inc. Clec4-targeted car-t-cells
MX2023006474A (es) * 2020-12-03 2023-08-16 Biogen Ma Inc Metodos de tratamiento del lupus eritematoso cutaneo y lupus eritematoso sistemico.
CN114264825B (zh) * 2021-12-22 2023-08-15 重庆医科大学附属儿童医院 一种b淋巴细胞发育亚群免疫分型的方法和试剂盒

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998028332A2 (en) * 1996-12-20 1998-07-02 Board Of Regents, The University Of Texas System Unique dendritic cell-associated c-type lectins, dectin-1 and dectin-2; compositions and uses thereof
WO1999002562A1 (en) * 1997-07-09 1999-01-21 Schering Corporation Isolated dendritic cell membrane protein genes
WO1999047673A2 (en) * 1998-03-17 1999-09-23 Schering Corporation Isolated mammalian membrane protein genes and related reagents
JP2008148700A (ja) * 1999-11-15 2008-07-03 Miltenyi Biotec Gmbh 樹状細胞に特異的な抗原結合フラグメント及びその使用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2190367A1 (en) * 1995-03-15 1996-09-19 Stefan Miltenyi Isolation of hematopoietic dendritic cells by high gradient magnetic cell sorting
US5871728A (en) * 1995-03-31 1999-02-16 University Of Pittsburgh Method of regulating dendritic cell maturation
US5788963A (en) * 1995-07-31 1998-08-04 Pacific Northwest Cancer Foundation Isolation and/or preservation of dendritic cells for prostate cancer immunotherapy
FI973762A0 (fi) * 1997-09-23 1997-09-23 Krohn Kai Ny gen
WO1999021997A1 (en) * 1997-10-28 1999-05-06 Immunex Corporation Viral encoded semaphorin protein receptor dna and polypeptides

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998028332A2 (en) * 1996-12-20 1998-07-02 Board Of Regents, The University Of Texas System Unique dendritic cell-associated c-type lectins, dectin-1 and dectin-2; compositions and uses thereof
WO1999002562A1 (en) * 1997-07-09 1999-01-21 Schering Corporation Isolated dendritic cell membrane protein genes
WO1999047673A2 (en) * 1998-03-17 1999-09-23 Schering Corporation Isolated mammalian membrane protein genes and related reagents
JP2008148700A (ja) * 1999-11-15 2008-07-03 Miltenyi Biotec Gmbh 樹状細胞に特異的な抗原結合フラグメント及びその使用

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