DE60033062T2 - Antikörper spezifisch für dendritische zellen, zusammensetzungen und verfahren, die diese antikörper verwenden, das durch die antikörper detektierte antigen und die dadurch erhaltenen zellen - Google Patents
Antikörper spezifisch für dendritische zellen, zusammensetzungen und verfahren, die diese antikörper verwenden, das durch die antikörper detektierte antigen und die dadurch erhaltenen zellen Download PDFInfo
- Publication number
- DE60033062T2 DE60033062T2 DE60033062T DE60033062T DE60033062T2 DE 60033062 T2 DE60033062 T2 DE 60033062T2 DE 60033062 T DE60033062 T DE 60033062T DE 60033062 T DE60033062 T DE 60033062T DE 60033062 T2 DE60033062 T2 DE 60033062T2
- Authority
- DE
- Germany
- Prior art keywords
- bdca
- antigen
- cells
- cell
- mab
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- A—HUMAN NECESSITIES
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- A61P33/00—Antiparasitic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/7056—Lectin superfamily, e.g. CD23, CD72
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
- C12N5/064—Immunosuppressive dendritic cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5094—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for blood cell populations
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- General Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Physics & Mathematics (AREA)
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16555599P | 1999-11-15 | 1999-11-15 | |
| US165555P | 1999-11-15 | ||
| US16707699P | 1999-11-23 | 1999-11-23 | |
| US167076P | 1999-11-23 | ||
| US17900300P | 2000-01-28 | 2000-01-28 | |
| US179003P | 2000-01-28 | ||
| US18077500P | 2000-02-07 | 2000-02-07 | |
| US180775P | 2000-02-07 | ||
| US19682400P | 2000-04-11 | 2000-04-11 | |
| US196824P | 2000-04-11 | ||
| US19720500P | 2000-04-13 | 2000-04-13 | |
| US197205P | 2000-04-13 | ||
| PCT/IB2000/001832 WO2001036487A2 (en) | 1999-11-15 | 2000-11-15 | Antigen-binding fragments specific for dendritic cells, compositions and methods of use thereof antigens recognized thereby and cells obtained thereby |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60033062D1 DE60033062D1 (de) | 2007-03-08 |
| DE60033062T2 true DE60033062T2 (de) | 2007-08-23 |
Family
ID=27558547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60033062T Expired - Lifetime DE60033062T2 (de) | 1999-11-15 | 2000-11-15 | Antikörper spezifisch für dendritische zellen, zusammensetzungen und verfahren, die diese antikörper verwenden, das durch die antikörper detektierte antigen und die dadurch erhaltenen zellen |
Country Status (11)
| Country | Link |
|---|---|
| EP (3) | EP1783141A1 (enExample) |
| JP (4) | JP5007007B2 (enExample) |
| KR (1) | KR100868235B1 (enExample) |
| CN (1) | CN1454215B (enExample) |
| AU (1) | AU785198B2 (enExample) |
| CA (2) | CA2664137C (enExample) |
| DE (1) | DE60033062T2 (enExample) |
| DK (1) | DK1301539T3 (enExample) |
| ES (1) | ES2280264T3 (enExample) |
| PT (1) | PT1301539E (enExample) |
| WO (1) | WO2001036487A2 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1783141A1 (en) * | 1999-11-15 | 2007-05-09 | Miltenyi Biotec GmbH | Antigen-binding fragments specific for dendritic cells, compositions and methods of use thereof antigens recognized thereby and cells obtained thereby |
| EP1351985A2 (en) * | 2000-10-16 | 2003-10-15 | Bayer Aktiengesellschaft | Polynucleotide and polypeptide sequences of human dendritic cell immunoreceptors |
| US7252990B2 (en) | 2001-03-12 | 2007-08-07 | Lexicon Genetics Incorporated | Human dectin proteins and polynucleotides encoding the same |
| EP1395826A4 (en) * | 2001-05-17 | 2005-11-09 | Miltenyi Biotec Gmbh | ANTIGEN-BINDING FRAGMENTS FOR A SUB-GROUP OF DENDRITIC CELLS AND USE THEREOF |
| KR100522526B1 (ko) * | 2002-11-28 | 2005-10-19 | 주식회사 바이넥스 | 면역 치료용 수지상 세포의 제조방법 |
| CA2582471A1 (en) * | 2004-10-07 | 2006-04-13 | Universitaet Zuerich | Type i interferon blocking agents for prevention and treatment of psoriasis |
| KR101363120B1 (ko) | 2005-02-10 | 2014-02-13 | 베일러 리서치 인스티튜트 | 항-인터페론 알파 모노클로날 항체 및 사용 방법 |
| EP2279207B1 (en) | 2008-05-07 | 2015-09-09 | Argos Therapeutics, Inc. | Humanized antibodies against human interferon-alpha |
| NZ593240A (en) * | 2009-01-06 | 2013-01-25 | Functional Genetics Inc | Random homozygous gene perturbation (rhgp) with thermal assymetric interlaced (tail)-pcr |
| FR2968561B1 (fr) * | 2010-12-13 | 2013-08-09 | Lfb Biotechnologies | Utilisation d'un anticorps dirige contre une proteine membranaire |
| US20150238632A1 (en) * | 2012-09-18 | 2015-08-27 | University Of Washington Through Its Center For Commercialization | Compositions and Methods for Delivery of Antigens to Plasmacytoid Dendritic Cells |
| MX363407B (es) * | 2012-12-10 | 2019-03-22 | Biogen Ma Inc | Anticuerpos del antigeno 2 de celulas dendriticas anti-sangre y usos de los mismos. |
| AU2014365838B2 (en) | 2013-12-16 | 2021-01-14 | The University Of North Carolina At Chapel Hill | Depletion of plasmacytoid dendritic cells |
| CN109535254B (zh) | 2013-12-24 | 2022-06-24 | 安斯泰来制药株式会社 | 抗人bdca-2抗体、其生产方法、多核苷酸、表达载体、宿主细胞及医药组合物 |
| US10993990B2 (en) * | 2014-05-16 | 2021-05-04 | Baylor Research Institute | Methods and compositions for treating autoimmune and inflammatory conditions |
| WO2016038168A1 (en) * | 2014-09-10 | 2016-03-17 | Miltenyi Biotec Gmbh | A cell population for use in treting cancer |
| CA2969402C (en) | 2014-12-03 | 2019-06-11 | Samsung Life Public Welfare Foundation | Antibody binding to neuropilin 1 and use thereof |
| FR3034420A1 (fr) | 2015-03-31 | 2016-10-07 | Lab Francais Du Fractionnement | Anticorps monoclonaux anti-cd303 |
| FR3045386B1 (fr) * | 2015-12-16 | 2018-02-02 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Nouvelle utilisation d'un anticorps dirige contre une proteine membranaire |
| RS62463B1 (sr) * | 2016-10-21 | 2021-11-30 | Inst Nat Sante Rech Med | Postupci za unapređivanje odgovora t ćelija |
| FR3060394B1 (fr) * | 2016-12-16 | 2019-05-24 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Combinaison d'anticorps anti-cd303 et anti-amhrii |
| FR3060395B1 (fr) * | 2016-12-16 | 2019-05-24 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Combinaison d'anticorps anti-cd303 et anti-her2 |
| JP7158642B2 (ja) * | 2018-01-16 | 2022-10-24 | 国立大学法人山梨大学 | 質量分析装置及び質量分析システム |
| WO2020227595A1 (en) * | 2019-05-09 | 2020-11-12 | Atara Biotherapeutics, Inc. | Clec4-targeted car-t-cells |
| IL303279A (en) * | 2020-12-03 | 2023-07-01 | Biogen Ma Inc | Methods of treating cutaneous lupus erythematosus and systemic lupus erythematosus |
| CN114264825B (zh) * | 2021-12-22 | 2023-08-15 | 重庆医科大学附属儿童医院 | 一种b淋巴细胞发育亚群免疫分型的方法和试剂盒 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2190367A1 (en) * | 1995-03-15 | 1996-09-19 | Stefan Miltenyi | Isolation of hematopoietic dendritic cells by high gradient magnetic cell sorting |
| US5871728A (en) * | 1995-03-31 | 1999-02-16 | University Of Pittsburgh | Method of regulating dendritic cell maturation |
| US5788963A (en) * | 1995-07-31 | 1998-08-04 | Pacific Northwest Cancer Foundation | Isolation and/or preservation of dendritic cells for prostate cancer immunotherapy |
| US6046158A (en) * | 1996-12-20 | 2000-04-04 | Board Of Regents The University Of Texas Systems | Unique dendritic cell-associated C-type lectins, dectin-1 and dectin-2; compositions and uses thereof |
| HUP0002472A3 (en) * | 1997-07-09 | 2003-08-28 | Schering Corp | Isolated dendritic cell membrane protein genes |
| FI973762A0 (fi) * | 1997-09-23 | 1997-09-23 | Krohn Kai | Ny gen |
| CA2307014A1 (en) * | 1997-10-28 | 1999-05-06 | Immunex Corporation | Viral encoded semaphorin protein receptor dna and polypeptides |
| JP2002506645A (ja) * | 1998-03-17 | 2002-03-05 | シェーリング コーポレイション | 単離された哺乳動物膜タンパク質遺伝子および関連試薬 |
| EP1783141A1 (en) * | 1999-11-15 | 2007-05-09 | Miltenyi Biotec GmbH | Antigen-binding fragments specific for dendritic cells, compositions and methods of use thereof antigens recognized thereby and cells obtained thereby |
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2000
- 2000-11-15 EP EP07000097A patent/EP1783141A1/en not_active Ceased
- 2000-11-15 ES ES00979855T patent/ES2280264T3/es not_active Expired - Lifetime
- 2000-11-15 CA CA2664137A patent/CA2664137C/en not_active Expired - Lifetime
- 2000-11-15 JP JP2001538976A patent/JP5007007B2/ja not_active Expired - Lifetime
- 2000-11-15 PT PT00979855T patent/PT1301539E/pt unknown
- 2000-11-15 WO PCT/IB2000/001832 patent/WO2001036487A2/en not_active Ceased
- 2000-11-15 DE DE60033062T patent/DE60033062T2/de not_active Expired - Lifetime
- 2000-11-15 EP EP06023310.3A patent/EP1813626B1/en not_active Expired - Lifetime
- 2000-11-15 CA CA2396428A patent/CA2396428C/en not_active Expired - Lifetime
- 2000-11-15 EP EP00979855A patent/EP1301539B1/en not_active Expired - Lifetime
- 2000-11-15 KR KR1020027006247A patent/KR100868235B1/ko not_active Expired - Lifetime
- 2000-11-15 AU AU17233/01A patent/AU785198B2/en not_active Expired
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- 2000-11-15 DK DK00979855T patent/DK1301539T3/da active
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2007
- 2007-12-18 JP JP2007325800A patent/JP2008148700A/ja not_active Withdrawn
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2011
- 2011-01-27 JP JP2011015018A patent/JP5355602B2/ja not_active Expired - Lifetime
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2012
- 2012-03-01 JP JP2012045127A patent/JP5599834B2/ja not_active Expired - Fee Related
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| AU785198B2 (en) | 2006-11-02 |
| ES2280264T3 (es) | 2007-09-16 |
| CA2664137A1 (en) | 2009-07-16 |
| EP1783141A1 (en) | 2007-05-09 |
| AU1723301A (en) | 2001-05-30 |
| JP2008148700A (ja) | 2008-07-03 |
| DE60033062D1 (de) | 2007-03-08 |
| JP2011092210A (ja) | 2011-05-12 |
| JP5007007B2 (ja) | 2012-08-22 |
| WO2001036487A3 (en) | 2002-05-10 |
| JP2012152215A (ja) | 2012-08-16 |
| EP1813626B1 (en) | 2015-02-18 |
| EP1813626A1 (en) | 2007-08-01 |
| CN1454215B (zh) | 2013-01-02 |
| KR20030032904A (ko) | 2003-04-26 |
| EP1301539B1 (en) | 2007-01-17 |
| JP2004512006A (ja) | 2004-04-22 |
| JP5599834B2 (ja) | 2014-10-01 |
| WO2001036487A2 (en) | 2001-05-25 |
| DK1301539T3 (da) | 2007-05-21 |
| CA2396428C (en) | 2014-03-11 |
| CA2396428A1 (en) | 2001-05-25 |
| CA2664137C (en) | 2012-09-25 |
| PT1301539E (pt) | 2007-04-30 |
| EP1301539A2 (en) | 2003-04-16 |
| CN1454215A (zh) | 2003-11-05 |
| KR100868235B1 (ko) | 2008-11-12 |
| JP5355602B2 (ja) | 2013-11-27 |
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