PT1292187E - Modelo animal transgenico de disturbios neurodegenerativos - Google Patents

Modelo animal transgenico de disturbios neurodegenerativos

Info

Publication number
PT1292187E
PT1292187E PT01949132T PT01949132T PT1292187E PT 1292187 E PT1292187 E PT 1292187E PT 01949132 T PT01949132 T PT 01949132T PT 01949132 T PT01949132 T PT 01949132T PT 1292187 E PT1292187 E PT 1292187E
Authority
PT
Portugal
Prior art keywords
transgenic animal
animal model
disturbles
neurodegenerative
well
Prior art date
Application number
PT01949132T
Other languages
English (en)
Portuguese (pt)
Inventor
Peter H St George-Hyslop
Paul E Fraser
Westaway David
Original Assignee
Univ Toronto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Toronto filed Critical Univ Toronto
Publication of PT1292187E publication Critical patent/PT1292187E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0312—Animal model for Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0318—Animal model for neurodegenerative disease, e.g. non- Alzheimer's

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Husbandry (AREA)
  • Wood Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Eye Examination Apparatus (AREA)
PT01949132T 2000-06-20 2001-06-19 Modelo animal transgenico de disturbios neurodegenerativos PT1292187E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21253400P 2000-06-20 2000-06-20

Publications (1)

Publication Number Publication Date
PT1292187E true PT1292187E (pt) 2006-07-31

Family

ID=22791418

Family Applications (1)

Application Number Title Priority Date Filing Date
PT01949132T PT1292187E (pt) 2000-06-20 2001-06-19 Modelo animal transgenico de disturbios neurodegenerativos

Country Status (13)

Country Link
EP (3) EP1292187B1 (enExample)
JP (3) JP4938956B2 (enExample)
AT (2) ATE499832T1 (enExample)
AU (1) AU2001270377A1 (enExample)
CA (1) CA2407847C (enExample)
CY (1) CY1105122T1 (enExample)
DE (2) DE60118913T2 (enExample)
DK (1) DK1292187T3 (enExample)
ES (1) ES2262662T3 (enExample)
MX (1) MXPA02011516A (enExample)
PT (1) PT1292187E (enExample)
SI (1) SI1292187T1 (enExample)
WO (1) WO2001097607A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100360555C (zh) 2002-04-19 2008-01-09 多伦多大学董事局 治疗阿尔茨海默氏病的免疫学方法及组合物
US7544855B2 (en) * 2004-04-23 2009-06-09 Buck Institute Transgenic mouse whose genome comprises an APP having a mutation at amino acid 664
JP4590638B2 (ja) * 2006-03-20 2010-12-01 国立大学法人鳥取大学 家族性筋萎縮性側索硬化症（ｆａｌｓ）発症するトランスジェニックマウス
CL2007002908A1 (es) 2007-10-09 2008-05-30 Univ Concepcion Procedimiento electroquimico in vitro para evaluar capacidad neurotoxica de estructuras, principios activos y/o compuestos de interes en celulas vivas y que comprende medir y cuantificar los parametros electricos en membranas expuestas a dichos agreg
CN101918564A (zh) * 2007-11-01 2010-12-15 弗·哈夫曼-拉罗切有限公司 非人类四元转基因动物
WO2010054324A2 (en) * 2008-11-10 2010-05-14 The Regents Of The University Of Colorado, A Body Corporate Methods for treating clinical conditions associated with lipoprotein lipase activity

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09507746A (ja) 1993-10-27 1997-08-12 アテナ ニューロサイエンシズ，インコーポレイティド Ｓｗｅｄｉｓｈ変異を有するＡＰＰ対立遺伝子を含有するトランスジェニック動物
JPH07132033A (ja) 1993-11-12 1995-05-23 Hoechst Japan Ltd アルツハイマー病モデルトランスジェニック動物
US5877399A (en) 1994-01-27 1999-03-02 Johns Hopkins University Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
EP0742831B1 (en) * 1994-01-27 2004-09-29 The Regents Of The University Of Minnesota Transgenic non-human mammals with progressive neurologic disease
JP2001517065A (ja) * 1995-06-07 2001-10-02 アセナ ニューロサイエンシーズ，インコーポレイテッド トランスジェニック動物モデルを用いてアルツハイマー病治療薬を同定する方法
US5894078A (en) 1996-02-26 1999-04-13 Advanced Bioconcept, Inc. Transgenic mouse expressing C-100 app
WO1999009150A1 (en) * 1996-08-15 1999-02-25 Bayer Corporation Method of introducing modifications into a gene
US5898094A (en) 1996-10-21 1999-04-27 University Of South Florida Transgenic mice expressing APPK670N,M671L and a mutant presenilin transgenes
TWI239847B (en) 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease

Also Published As

Publication number Publication date
DE60118913T2 (de) 2007-01-25
ATE499832T1 (de) 2011-03-15
EP1728423B1 (en) 2011-03-02
EP1728423A2 (en) 2006-12-06
EP1292187A2 (en) 2003-03-19
EP2263453B1 (en) 2018-06-13
EP2263453A1 (en) 2010-12-22
CA2407847C (en) 2013-08-27
JP2003535605A (ja) 2003-12-02
JP4938956B2 (ja) 2012-05-23
WO2001097607A3 (en) 2002-12-12
ES2262662T3 (es) 2006-12-01
SI1292187T1 (sl) 2006-10-31
AU2001270377A1 (en) 2002-01-02
MXPA02011516A (es) 2005-07-01
EP1292187B1 (en) 2006-04-19
WO2001097607A2 (en) 2001-12-27
DE60118913D1 (de) 2006-05-24
DK1292187T3 (da) 2006-08-21
ATE323408T1 (de) 2006-05-15
CA2407847A1 (en) 2001-12-27
CY1105122T1 (el) 2010-03-03
JP2011172600A (ja) 2011-09-08
EP1728423A3 (en) 2007-02-28
DE60144164D1 (de) 2011-04-14
JP5070236B2 (ja) 2012-11-07
JP2009178162A (ja) 2009-08-13

Similar Documents

Publication Publication Date Title
DE60016178D1 (de) Verfahren zur diagnose und zur charakterisierung von schlaganfall
NO20026199L (no) Forbindelser for behandling av Alzheimers sykdom
EP0653154A3 (en) Transgenic animal for Alzheimer's disease.
DE60218493D1 (de) Substituierte 7-aza-ä2.2.1übicycloheptane für die behandlung von krankheiten
PT841928E (pt) Formulacao de libertacao prolongada de d-trep-metilfenidato
ATE253812T1 (de) Kombinierte reinigungs und vormilkungs vorrichtung
ATE314354T1 (de) Radiopharmazeutika für die diagnose von alzheimer
AU6264996A (en) Method for identifying alzheimer's disease therapeutics usin g transgenic animal models
ATE541923T1 (de) Transgener c. elegans als modellorganismus für untersuchungen zur alzheimer'schen krankheit
DE60026150D1 (de) Diagnostika und therapeutika für osteoporose
FR2808596B1 (fr) Source sismique de fond de puits s'etendant axialement
DK1292187T3 (da) Transgen dyremodel for neurodegenerative lidelser
ATE259379T1 (de) Fluoresceinisothiocyanat-(fitc)-sinistrin, seine herstellung und verwendung
DE60122673D1 (de) Methoden zur diagnose und behandlung von herzkrankheiten
PT1267915E (pt) Metodos para tratar doencas com proteina c activada
DE60325519D1 (de) Doppel-transgenisches, nicht-humanes Säugertiermodell für die Alzheimer Krankheit
EP1414478A4 (en) INHIBITION OF NEURODEGENERATION
DK1670309T3 (da) Transgenetiske dyr med større lidelser i forbindelse med Alzheimers sygdom
FR2878852B1 (fr) Procede de production d'immunoglobulines anti-thymocytes humains
ATE371032T1 (de) Methoden und materialien fur genexpression
BR0107845A (pt) Diagnóstico do risco de uma pessoa desenvolver alcoolismo
DE69936502D1 (de) Zeitregistriersystem für den Pflegesektor
WO2002101232A3 (en) Bace interacting proteins
ATE336503T1 (de) Cyclophilin als allergen identifiziert
GB9808486D0 (en) A method for evaluating the risk of developing alzheimer's disease