DK1292187T3 - Transgen dyremodel for neurodegenerative lidelser - Google Patents

Transgen dyremodel for neurodegenerative lidelser

Info

Publication number
DK1292187T3
DK1292187T3 DK01949132T DK01949132T DK1292187T3 DK 1292187 T3 DK1292187 T3 DK 1292187T3 DK 01949132 T DK01949132 T DK 01949132T DK 01949132 T DK01949132 T DK 01949132T DK 1292187 T3 DK1292187 T3 DK 1292187T3
Authority
DK
Denmark
Prior art keywords
transgenic animal
animal model
neurodegenerative disorders
well
disease
Prior art date
Application number
DK01949132T
Other languages
Danish (da)
English (en)
Inventor
George-Hyslop Peter H St
Paul E Fraser
David Westaway
Original Assignee
Univ Toronto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Toronto filed Critical Univ Toronto
Application granted granted Critical
Publication of DK1292187T3 publication Critical patent/DK1292187T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0312—Animal model for Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0318—Animal model for neurodegenerative disease, e.g. non- Alzheimer's

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Environmental Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Animal Husbandry (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Eye Examination Apparatus (AREA)
DK01949132T 2000-06-20 2001-06-19 Transgen dyremodel for neurodegenerative lidelser DK1292187T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21253400P 2000-06-20 2000-06-20

Publications (1)

Publication Number Publication Date
DK1292187T3 true DK1292187T3 (da) 2006-08-21

Family

ID=22791418

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01949132T DK1292187T3 (da) 2000-06-20 2001-06-19 Transgen dyremodel for neurodegenerative lidelser

Country Status (13)

Country Link
EP (3) EP1292187B1 (enExample)
JP (3) JP4938956B2 (enExample)
AT (2) ATE323408T1 (enExample)
AU (1) AU2001270377A1 (enExample)
CA (1) CA2407847C (enExample)
CY (1) CY1105122T1 (enExample)
DE (2) DE60118913T2 (enExample)
DK (1) DK1292187T3 (enExample)
ES (1) ES2262662T3 (enExample)
MX (1) MXPA02011516A (enExample)
PT (1) PT1292187E (enExample)
SI (1) SI1292187T1 (enExample)
WO (1) WO2001097607A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ536064A (en) 2002-04-19 2008-06-30 Univ Toronto Immunological methods and compositions for the treatment of alzheimer's disease
US7544855B2 (en) * 2004-04-23 2009-06-09 Buck Institute Transgenic mouse whose genome comprises an APP having a mutation at amino acid 664
JP4590638B2 (ja) * 2006-03-20 2010-12-01 国立大学法人鳥取大学 家族性筋萎縮性側索硬化症（ｆａｌｓ）発症するトランスジェニックマウス
CL2007002908A1 (es) 2007-10-09 2008-05-30 Univ Concepcion Procedimiento electroquimico in vitro para evaluar capacidad neurotoxica de estructuras, principios activos y/o compuestos de interes en celulas vivas y que comprende medir y cuantificar los parametros electricos en membranas expuestas a dichos agreg
US20100306868A1 (en) * 2007-11-01 2010-12-02 Bernd Bohrmann Quadruple transgenic non-human animal
US20110214195A1 (en) * 2008-11-10 2011-09-01 The Regents Of The University Of Colorado, A Body Corporate Methods For Treating Clinical Conditions Associated With Lipoprotein Lipase Activity

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69426571T2 (de) 1993-10-27 2001-08-09 Elan Pharm Inc TRANSGENE TIERE, DIE APP Allele mit der schwedischen Mutation beherbergen
JPH07132033A (ja) 1993-11-12 1995-05-23 Hoechst Japan Ltd アルツハイマー病モデルトランスジェニック動物
US5877399A (en) 1994-01-27 1999-03-02 Johns Hopkins University Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
DE69533583T2 (de) * 1994-01-27 2005-10-06 Regents of the University of Minnesota, Southeast, Minneapolis Nicht humane, transgenische säugetiere mit sich entwickelnder neurologischer krankheit
WO1996040895A1 (en) * 1995-06-07 1996-12-19 Athena Neurosciences, Inc. Method for identifying alzheimer's disease therapeutics using transgenic animal models
US5894078A (en) 1996-02-26 1999-04-13 Advanced Bioconcept, Inc. Transgenic mouse expressing C-100 app
WO1999009150A1 (en) * 1996-08-15 1999-02-25 Bayer Corporation Method of introducing modifications into a gene
US5898094A (en) 1996-10-21 1999-04-27 University Of South Florida Transgenic mice expressing APPK670N,M671L and a mutant presenilin transgenes
TWI239847B (en) 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease

Also Published As

Publication number Publication date
DE60118913T2 (de) 2007-01-25
DE60118913D1 (de) 2006-05-24
PT1292187E (pt) 2006-07-31
JP2003535605A (ja) 2003-12-02
WO2001097607A3 (en) 2002-12-12
EP1728423A3 (en) 2007-02-28
ATE499832T1 (de) 2011-03-15
CA2407847C (en) 2013-08-27
EP2263453B1 (en) 2018-06-13
EP1292187A2 (en) 2003-03-19
ATE323408T1 (de) 2006-05-15
MXPA02011516A (es) 2005-07-01
DE60144164D1 (de) 2011-04-14
EP1728423A2 (en) 2006-12-06
WO2001097607A2 (en) 2001-12-27
ES2262662T3 (es) 2006-12-01
CY1105122T1 (el) 2010-03-03
CA2407847A1 (en) 2001-12-27
SI1292187T1 (sl) 2006-10-31
JP2009178162A (ja) 2009-08-13
JP5070236B2 (ja) 2012-11-07
JP2011172600A (ja) 2011-09-08
AU2001270377A1 (en) 2002-01-02
EP2263453A1 (en) 2010-12-22
JP4938956B2 (ja) 2012-05-23
EP1728423B1 (en) 2011-03-02
EP1292187B1 (en) 2006-04-19

Similar Documents

Publication Publication Date Title
DE60136272D1 (de) Diagnostika und therapeutika für makula degeneration erkrankungen
WO2002079440A8 (en) Transgenic mice containing gpcr5-1 gene disruptions
AU6264996A (en) Method for identifying alzheimer's disease therapeutics usin g transgenic animal models
ATE541923T1 (de) Transgener c. elegans als modellorganismus für untersuchungen zur alzheimer'schen krankheit
WO2002046390A3 (en) Transgenic mice containing rptpb tyrosine phosphatase gene disruptions
DK1292187T3 (da) Transgen dyremodel for neurodegenerative lidelser
AU6168396A (en) Method for identifying alzheimer's disease therapeutics usin g transgenic animal models
ATE522230T1 (de) Biphenyle als bilderzeugungsmittel bei der alzheimerschen krankheit
WO2003026395A3 (en) Mo54 gene disruptions, compositions and methods related thereto
CY1110788T1 (el) Διαγονιδιακα ζωα τα οποια παρουσιαζουν σημαντικες διαταραχες σχετικες με την νοσο alzheimer
DE60325519D1 (de) Doppel-transgenisches, nicht-humanes Säugertiermodell für die Alzheimer Krankheit
EP1414478A4 (en) INHIBITION OF NEURODEGENERATION
WO2002048342A3 (en) Knockout mice for trp6 gene
DE60121324D1 (de) Tiermodel für neurodegenerative erkrankungen
FR2878852B1 (fr) Procede de production d'immunoglobulines anti-thymocytes humains
WO2002003788A3 (en) Transgenic mice containing targeted phosphatase gene disruptions
WO2002101232A3 (en) Bace interacting proteins
WO2002079412A3 (en) Transgenic mice containing usp3-like deubiquitinating enzyme gene disruptions
BG106583A (en) Diagnosis of a person's risk of developing alcoholism
WO2002045497A3 (en) Transgenic mice containing dusp8 phosphatase gene disruptions
WO2002079446A3 (en) Transgenic mice containing gpr31 gene disruptions
WO2002045500A3 (en) Transgenic mice containing ptp36 tyrosine phosphatase disruptions
WO2002046391A3 (en) Transgenic mice containing nori gene disruptions
GB9808486D0 (en) A method for evaluating the risk of developing alzheimer's disease
WO2002045493A3 (en) Transgenic mice containing phosphatase target gene disruptions