CY1105122T1 - Διαγενες μοντελο με νευροεκφυλιστικες διαταραχες - Google Patents

Διαγενες μοντελο με νευροεκφυλιστικες διαταραχες

Info

Publication number
CY1105122T1
CY1105122T1 CY20061101003T CY061101003T CY1105122T1 CY 1105122 T1 CY1105122 T1 CY 1105122T1 CY 20061101003 T CY20061101003 T CY 20061101003T CY 061101003 T CY061101003 T CY 061101003T CY 1105122 T1 CY1105122 T1 CY 1105122T1
Authority
CY
Cyprus
Prior art keywords
neurodegeneral
intergenic
disorders
models
well
Prior art date
Application number
CY20061101003T
Other languages
Greek (el)
English (en)
Inventor
Peter H. St. George-Hyslop
Paul E. Fraser
David Westaway
Original Assignee
The Governing Council Of The University Of Toronto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Governing Council Of The University Of Toronto filed Critical The Governing Council Of The University Of Toronto
Publication of CY1105122T1 publication Critical patent/CY1105122T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0312—Animal model for Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0318—Animal model for neurodegenerative disease, e.g. non- Alzheimer's

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Environmental Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Animal Husbandry (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Eye Examination Apparatus (AREA)
CY20061101003T 2000-06-20 2006-07-19 Διαγενες μοντελο με νευροεκφυλιστικες διαταραχες CY1105122T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21253400P 2000-06-20 2000-06-20
PCT/CA2001/000900 WO2001097607A2 (en) 2000-06-20 2001-06-19 Transgenic animal model of neurodegenerative disorders

Publications (1)

Publication Number Publication Date
CY1105122T1 true CY1105122T1 (el) 2010-03-03

Family

ID=22791418

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061101003T CY1105122T1 (el) 2000-06-20 2006-07-19 Διαγενες μοντελο με νευροεκφυλιστικες διαταραχες

Country Status (13)

Country Link
EP (3) EP1292187B1 (enExample)
JP (3) JP4938956B2 (enExample)
AT (2) ATE323408T1 (enExample)
AU (1) AU2001270377A1 (enExample)
CA (1) CA2407847C (enExample)
CY (1) CY1105122T1 (enExample)
DE (2) DE60118913T2 (enExample)
DK (1) DK1292187T3 (enExample)
ES (1) ES2262662T3 (enExample)
MX (1) MXPA02011516A (enExample)
PT (1) PT1292187E (enExample)
SI (1) SI1292187T1 (enExample)
WO (1) WO2001097607A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ536064A (en) 2002-04-19 2008-06-30 Univ Toronto Immunological methods and compositions for the treatment of alzheimer's disease
US7544855B2 (en) * 2004-04-23 2009-06-09 Buck Institute Transgenic mouse whose genome comprises an APP having a mutation at amino acid 664
JP4590638B2 (ja) * 2006-03-20 2010-12-01 国立大学法人鳥取大学 家族性筋萎縮性側索硬化症（ｆａｌｓ）発症するトランスジェニックマウス
CL2007002908A1 (es) 2007-10-09 2008-05-30 Univ Concepcion Procedimiento electroquimico in vitro para evaluar capacidad neurotoxica de estructuras, principios activos y/o compuestos de interes en celulas vivas y que comprende medir y cuantificar los parametros electricos en membranas expuestas a dichos agreg
US20100306868A1 (en) * 2007-11-01 2010-12-02 Bernd Bohrmann Quadruple transgenic non-human animal
US20110214195A1 (en) * 2008-11-10 2011-09-01 The Regents Of The University Of Colorado, A Body Corporate Methods For Treating Clinical Conditions Associated With Lipoprotein Lipase Activity

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69426571T2 (de) 1993-10-27 2001-08-09 Elan Pharm Inc TRANSGENE TIERE, DIE APP Allele mit der schwedischen Mutation beherbergen
JPH07132033A (ja) 1993-11-12 1995-05-23 Hoechst Japan Ltd アルツハイマー病モデルトランスジェニック動物
US5877399A (en) 1994-01-27 1999-03-02 Johns Hopkins University Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
DE69533583T2 (de) * 1994-01-27 2005-10-06 Regents of the University of Minnesota, Southeast, Minneapolis Nicht humane, transgenische säugetiere mit sich entwickelnder neurologischer krankheit
WO1996040895A1 (en) * 1995-06-07 1996-12-19 Athena Neurosciences, Inc. Method for identifying alzheimer's disease therapeutics using transgenic animal models
US5894078A (en) 1996-02-26 1999-04-13 Advanced Bioconcept, Inc. Transgenic mouse expressing C-100 app
WO1999009150A1 (en) * 1996-08-15 1999-02-25 Bayer Corporation Method of introducing modifications into a gene
US5898094A (en) 1996-10-21 1999-04-27 University Of South Florida Transgenic mice expressing APPK670N,M671L and a mutant presenilin transgenes
TWI239847B (en) 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease

Also Published As

Publication number Publication date
DE60118913T2 (de) 2007-01-25
DE60118913D1 (de) 2006-05-24
PT1292187E (pt) 2006-07-31
JP2003535605A (ja) 2003-12-02
WO2001097607A3 (en) 2002-12-12
EP1728423A3 (en) 2007-02-28
ATE499832T1 (de) 2011-03-15
CA2407847C (en) 2013-08-27
DK1292187T3 (da) 2006-08-21
EP2263453B1 (en) 2018-06-13
EP1292187A2 (en) 2003-03-19
ATE323408T1 (de) 2006-05-15
MXPA02011516A (es) 2005-07-01
DE60144164D1 (de) 2011-04-14
EP1728423A2 (en) 2006-12-06
WO2001097607A2 (en) 2001-12-27
ES2262662T3 (es) 2006-12-01
CA2407847A1 (en) 2001-12-27
SI1292187T1 (sl) 2006-10-31
JP2009178162A (ja) 2009-08-13
JP5070236B2 (ja) 2012-11-07
JP2011172600A (ja) 2011-09-08
AU2001270377A1 (en) 2002-01-02
EP2263453A1 (en) 2010-12-22
JP4938956B2 (ja) 2012-05-23
EP1728423B1 (en) 2011-03-02
EP1292187B1 (en) 2006-04-19

Similar Documents

Publication Publication Date Title
EP1267616A4 (en) METHOD FOR MODULATING HAIR GROWTH
MX9708270A (es) Secuencias geneticas y proteinas relacionadas con la enfermedad de alzheimer, y uso de las mismas.
DE60139788D1 (de) Verfahren und zusammensetzungen für amyloidosis-verbundene krankheiten
DK0827611T3 (da) Hierarkisk biologisk modelleringssystem og fremgangsmåde
CY1109579T1 (el) Μιμητοσωματα του πυρηνα αρθρωσης μιμητικα της ανθρωπινης ερο, συνθεσεις, μεθοδοι και χρησεις
EP1601965A4 (en) SIMULATION OF NEUROLOGICAL DISEASES WITH ANIMAL MODEL
DE60211086D1 (de) Verfahren zur Bestimmung von Überschneidungen
FR2814873B1 (fr) Systeme d'imagerie par ultrasons, sonde a ultrasons et procede associe
CY1105122T1 (el) Διαγενες μοντελο με νευροεκφυλιστικες διαταραχες
DE69920409D1 (de) Verfahren zur herstellung von stilbenverbindungen
ATE134138T1 (de) Sonde für medizinische eingriffe in körperhöhlen
WO2001087055A3 (en) New screening tool for analyzing the behavior of laboratory animals
DE69907258D1 (de) Verfahren zur herstellung von dinatriumpamidronat
DE60316096D1 (de) Verfahren zur Herstellung von dreidimensionalen Polyimid-Wellenleitern.
NO20030937D0 (no) Kreatin-ester pronutrient forbindelser og utforminger
DK1297742T3 (da) Fremgangsmåde til indsamling af måledata under antomatisk malkning af et dyr
ATE329019T1 (de) Verfahren zur herstellung von klonierten vögeln
BR0210956A (pt) Método e aparelho para a medição e modelagem de um ambiente que é percebido subjetivamente por uma pessoa
DE60110485D1 (de) Verfahren zur Herstellung eines elektrophotographischen fotoempfindlichen Elementes, elektrophotographisches fotoempfindliches Element
ES2085852T3 (es) Derivados de piperazina ansioliticamente activos.
EP1414478A4 (en) INHIBITION OF NEURODEGENERATION
DE60235576D1 (de) Diagnostikum für die frühe phase von morbus alzheimer
ATE208368T1 (de) Verfahren zur herstellung von 3,4 disubstituirten dinitroanilinen
ATE332078T1 (de) Tiermodel für neurodegenerative erkrankungen
Fan Development and Application of Virtual Screening Protocols for Early Drug Discovery