PT1284720E - L-fmau para o tratamento de infecção viral por hepatite delta - Google Patents
L-fmau para o tratamento de infecção viral por hepatite delta Download PDFInfo
- Publication number
- PT1284720E PT1284720E PT01922803T PT01922803T PT1284720E PT 1284720 E PT1284720 E PT 1284720E PT 01922803 T PT01922803 T PT 01922803T PT 01922803 T PT01922803 T PT 01922803T PT 1284720 E PT1284720 E PT 1284720E
- Authority
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- Prior art keywords
- compound
- hepatitis
- treatment
- hdv
- nucleoside
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- 208000037262 Hepatitis delta Diseases 0.000 title claims abstract description 98
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Classifications
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
- G01N33/5765—Hepatitis delta antigen
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/312—Phosphonates
- C12N2310/3125—Methylphosphonates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- Health & Medical Sciences (AREA)
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- Genetics & Genomics (AREA)
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19313500P | 2000-03-29 | 2000-03-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1284720E true PT1284720E (pt) | 2006-12-29 |
Family
ID=22712393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT01922803T PT1284720E (pt) | 2000-03-29 | 2001-03-29 | L-fmau para o tratamento de infecção viral por hepatite delta |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US6670342B2 (https=) |
| EP (1) | EP1284720B1 (https=) |
| JP (1) | JP2003528138A (https=) |
| KR (3) | KR100893549B1 (https=) |
| CN (1) | CN1268345C (https=) |
| AT (1) | ATE339211T1 (https=) |
| AU (1) | AU2001249564A1 (https=) |
| BR (1) | BR0109716A (https=) |
| CA (1) | CA2405502A1 (https=) |
| CY (1) | CY1105768T1 (https=) |
| DE (1) | DE60123042T2 (https=) |
| DK (1) | DK1284720T3 (https=) |
| ES (1) | ES2272460T3 (https=) |
| IL (1) | IL151981A0 (https=) |
| PT (1) | PT1284720E (https=) |
| WO (1) | WO2001072294A2 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL151981A0 (en) | 2000-03-29 | 2003-04-10 | Univ Georgetown | Method of treating hepatitis delta viral infection |
| US6787526B1 (en) | 2000-05-26 | 2004-09-07 | Idenix Pharmaceuticals, Inc. | Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides |
| DE10346721A1 (de) * | 2003-10-08 | 2005-05-04 | Holger Kalthoff | Oligonukleotide, diese enthaltende Mittel und deren Verwendung |
| US8642602B2 (en) * | 2009-02-04 | 2014-02-04 | University Of Georgia Research Foundation, Inc. | Method of inhibiting fibrogenesis and treating fibrotic disease |
| AU2010319999B2 (en) * | 2009-11-16 | 2014-01-16 | University Of Georgia Research Foundation, Inc. | 2'-Fluoro-6'-methylene carbocyclic nucleosides and methods of treating viral infections |
| US8816074B2 (en) | 2009-11-16 | 2014-08-26 | University of Georgia Foundation, Inc. | 2′-fluoro-6′-methylene carbocyclic nucleosides and methods of treating viral infections |
| AU2013308045B2 (en) | 2012-08-30 | 2018-10-04 | Replicor Inc. | Methods for the treatment of hepatitis B and hepatitis D infections |
| EA039949B1 (ru) * | 2012-09-21 | 2022-03-31 | Репликор Инк. | Способы лечения инфекций вирусом гепатита в и гепатита d |
| US10076512B2 (en) | 2014-05-01 | 2018-09-18 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| US11311519B2 (en) | 2014-05-01 | 2022-04-26 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| WO2016090107A2 (en) * | 2014-12-04 | 2016-06-09 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| CN104694544A (zh) * | 2015-03-24 | 2015-06-10 | 刘红卫 | 结合丁型肝炎病毒的核酸适配子及其应用 |
| KR20170132327A (ko) * | 2015-04-07 | 2017-12-01 | 스프링 뱅크 파마슈티칼스, 인크. | Hbv 감염의 치료를 위한 조성물 및 방법 |
| WO2016172342A1 (en) | 2015-04-21 | 2016-10-27 | Eiger Biopharmaceuticals, Inc. | Pharmaceutical compositions comprising lonafarnib and ritonavir |
| WO2017132332A1 (en) | 2016-01-28 | 2017-08-03 | Svenska Vaccinfabriken Produktion Ab | Chimeric hepatitis d virus antigen and hepatitis b virus pre s1 genes for use alone or in vaccines contaning hepatitis b virus genes |
| CN106333960A (zh) * | 2016-11-01 | 2017-01-18 | 侯建生 | 臭氧化油在肝病防治中的应用 |
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| US4211771A (en) | 1971-06-01 | 1980-07-08 | Robins Ronald K | Treatment of human viral diseases with 1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide |
| US4093714A (en) | 1974-03-15 | 1978-06-06 | Icn Pharmaceuticals, Inc. | 9β-D-Arabinofuranosylpurine nucleotides and method of use |
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| GB2060604B (en) | 1979-10-03 | 1983-11-23 | Univ Birmingham And Stichting | E15-(2-halogenovinyl)-2'-deoxycytidines |
| US4468384A (en) | 1982-01-05 | 1984-08-28 | The Research Foundation Of State University Of New York | Method for the inhibition of the replication of DNA viruses with 5-substituted 2-pyrimidinone nucleosides |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
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| US4666892A (en) | 1984-03-06 | 1987-05-19 | Sloan-Kettering Memorial Cancer Center | Method and composition for hepatitis treatment with pyrimidine nucleoside compounds |
| US5223263A (en) | 1988-07-07 | 1993-06-29 | Vical, Inc. | Liponucleotide-containing liposomes |
| ES2061500T5 (es) | 1986-06-17 | 2003-05-16 | Chiron Corp | Diagnosis y vacunas de la hepatitis delta, su preparacion y uso. |
| US5246924A (en) * | 1987-09-03 | 1993-09-21 | Sloan-Kettering Institute For Cancer Research | Method for treating hepatitis B virus infections using 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-ethyluracil |
| AU2526188A (en) | 1987-09-22 | 1989-04-18 | Regents Of The University Of California, The | Liposomal nucleoside analogues for treating aids |
| US5194654A (en) | 1989-11-22 | 1993-03-16 | Vical, Inc. | Lipid derivatives of phosphonoacids for liposomal incorporation and method of use |
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| AU7872491A (en) | 1990-05-07 | 1991-11-27 | Vical, Inc. | Lipid prodrugs of salicylate and nonsteroidal anti-inflammatory drugs |
| EP0531452A4 (en) | 1990-05-29 | 1993-06-09 | Vical, Inc. | Synthesis of glycerol di- and triphosphate derivatives |
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| US5543390A (en) | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Covalent microparticle-drug conjugates for biological targeting |
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| US5587362A (en) * | 1994-01-28 | 1996-12-24 | Univ. Of Ga Research Foundation | L-nucleosides |
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| IL151981A0 (en) * | 2000-03-29 | 2003-04-10 | Univ Georgetown | Method of treating hepatitis delta viral infection |
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2001
- 2001-03-29 IL IL15198101A patent/IL151981A0/xx unknown
- 2001-03-29 DE DE60123042T patent/DE60123042T2/de not_active Expired - Lifetime
- 2001-03-29 BR BR0109716-4A patent/BR0109716A/pt not_active Application Discontinuation
- 2001-03-29 JP JP2001570255A patent/JP2003528138A/ja not_active Withdrawn
- 2001-03-29 PT PT01922803T patent/PT1284720E/pt unknown
- 2001-03-29 AT AT01922803T patent/ATE339211T1/de not_active IP Right Cessation
- 2001-03-29 CA CA002405502A patent/CA2405502A1/en not_active Abandoned
- 2001-03-29 AU AU2001249564A patent/AU2001249564A1/en not_active Abandoned
- 2001-03-29 US US09/821,278 patent/US6670342B2/en not_active Expired - Lifetime
- 2001-03-29 KR KR1020027012957A patent/KR100893549B1/ko not_active Expired - Fee Related
- 2001-03-29 WO PCT/US2001/009987 patent/WO2001072294A2/en not_active Ceased
- 2001-03-29 DK DK01922803T patent/DK1284720T3/da active
- 2001-03-29 ES ES01922803T patent/ES2272460T3/es not_active Expired - Lifetime
- 2001-03-29 CN CNB018104134A patent/CN1268345C/zh not_active Expired - Fee Related
- 2001-03-29 EP EP01922803A patent/EP1284720B1/en not_active Expired - Lifetime
- 2001-03-29 KR KR1020087014186A patent/KR20080059679A/ko not_active Ceased
- 2001-03-29 KR KR1020087030736A patent/KR20090006230A/ko not_active Ceased
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2002
- 2002-11-22 US US10/302,814 patent/US7511027B2/en not_active Expired - Fee Related
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2006
- 2006-11-09 CY CY20061101613T patent/CY1105768T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE60123042T2 (de) | 2007-04-12 |
| DE60123042D1 (de) | 2006-10-26 |
| CN1431907A (zh) | 2003-07-23 |
| DK1284720T3 (da) | 2007-01-15 |
| ATE339211T1 (de) | 2006-10-15 |
| CY1105768T1 (el) | 2011-02-02 |
| US6670342B2 (en) | 2003-12-30 |
| AU2001249564A1 (en) | 2001-10-08 |
| IL151981A0 (en) | 2003-04-10 |
| JP2003528138A (ja) | 2003-09-24 |
| ES2272460T3 (es) | 2007-05-01 |
| EP1284720B1 (en) | 2006-09-13 |
| KR20030031472A (ko) | 2003-04-21 |
| BR0109716A (pt) | 2003-06-17 |
| KR20080059679A (ko) | 2008-06-30 |
| CN1268345C (zh) | 2006-08-09 |
| WO2001072294A3 (en) | 2002-05-23 |
| CA2405502A1 (en) | 2001-10-04 |
| KR100893549B1 (ko) | 2009-04-17 |
| KR20090006230A (ko) | 2009-01-14 |
| US20030158149A1 (en) | 2003-08-21 |
| EP1284720A2 (en) | 2003-02-26 |
| US20020160980A1 (en) | 2002-10-31 |
| US7511027B2 (en) | 2009-03-31 |
| WO2001072294A2 (en) | 2001-10-04 |
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