PT1135513E - Terapia génica mediada por adenovírus - Google Patents
Terapia génica mediada por adenovírus Download PDFInfo
- Publication number
- PT1135513E PT1135513E PT99971860T PT99971860T PT1135513E PT 1135513 E PT1135513 E PT 1135513E PT 99971860 T PT99971860 T PT 99971860T PT 99971860 T PT99971860 T PT 99971860T PT 1135513 E PT1135513 E PT 1135513E
- Authority
- PT
- Portugal
- Prior art keywords
- adenovirus
- tumor
- patients
- gene
- resection
- Prior art date
Links
- 241000701161 unidentified adenovirus Species 0.000 title claims abstract description 32
- 238000001415 gene therapy Methods 0.000 title description 17
- 230000001404 mediated effect Effects 0.000 title description 8
- 108020004440 Thymidine kinase Proteins 0.000 claims abstract description 11
- 208000003174 Brain Neoplasms Diseases 0.000 claims abstract description 7
- 206010028980 Neoplasm Diseases 0.000 claims description 39
- 108090000623 proteins and genes Proteins 0.000 claims description 28
- 238000002271 resection Methods 0.000 claims description 20
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- 206010018338 Glioma Diseases 0.000 claims description 8
- 208000029824 high grade glioma Diseases 0.000 claims description 7
- 201000011614 malignant glioma Diseases 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 6
- 241000700584 Simplexvirus Species 0.000 claims description 3
- 239000003381 stabilizer Substances 0.000 claims description 3
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000011282 treatment Methods 0.000 abstract description 12
- 210000004027 cell Anatomy 0.000 description 27
- 241001430294 unidentified retrovirus Species 0.000 description 23
- 238000012546 transfer Methods 0.000 description 15
- 238000002595 magnetic resonance imaging Methods 0.000 description 14
- 241000700605 Viruses Species 0.000 description 13
- 238000004806 packaging method and process Methods 0.000 description 10
- 238000003556 assay Methods 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 description 8
- 101150066555 lacZ gene Proteins 0.000 description 6
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- 239000013598 vector Substances 0.000 description 5
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- 101710193519 Glial fibrillary acidic protein Proteins 0.000 description 4
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- 230000002441 reversible effect Effects 0.000 description 3
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 2
- 238000000729 Fisher's exact test Methods 0.000 description 2
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- 238000012313 Kruskal-Wallis test Methods 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
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- 239000000356 contaminant Substances 0.000 description 2
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- OPIFSICVWOWJMJ-AEOCFKNESA-N 5-bromo-4-chloro-3-indolyl beta-D-galactoside Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1OC1=CNC2=CC=C(Br)C(Cl)=C12 OPIFSICVWOWJMJ-AEOCFKNESA-N 0.000 description 1
- 102000007469 Actins Human genes 0.000 description 1
- 108010085238 Actins Proteins 0.000 description 1
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- 206010073128 Anaplastic oligodendroglioma Diseases 0.000 description 1
- 206010003571 Astrocytoma Diseases 0.000 description 1
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- 102000004190 Enzymes Human genes 0.000 description 1
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- 206010022998 Irritability Diseases 0.000 description 1
- 241000239218 Limulus Species 0.000 description 1
- 241000713862 Moloney murine sarcoma virus Species 0.000 description 1
- 241000204031 Mycoplasma Species 0.000 description 1
- 229930193140 Neomycin Natural products 0.000 description 1
- 108700019961 Neoplasm Genes Proteins 0.000 description 1
- 102000048850 Neoplasm Genes Human genes 0.000 description 1
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- 201000010133 Oligodendroglioma Diseases 0.000 description 1
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- 238000002105 Southern blotting Methods 0.000 description 1
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- 230000002411 adverse Effects 0.000 description 1
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- 206010002224 anaplastic astrocytoma Diseases 0.000 description 1
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- 230000003920 cognitive function Effects 0.000 description 1
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- 229960001334 corticosteroids Drugs 0.000 description 1
- 239000012228 culture supernatant Substances 0.000 description 1
- 230000000120 cytopathologic effect Effects 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- JXSJBGJIGXNWCI-UHFFFAOYSA-N diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate Chemical compound CCOC(=O)CC(SP(=S)(OC)OC)C(=O)OCC JXSJBGJIGXNWCI-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 238000001976 enzyme digestion Methods 0.000 description 1
- 230000001037 epileptic effect Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000003976 gap junction Anatomy 0.000 description 1
- 208000005017 glioblastoma Diseases 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 101150107092 had gene Proteins 0.000 description 1
- 206010019465 hemiparesis Diseases 0.000 description 1
- 238000011532 immunohistochemical staining Methods 0.000 description 1
- 238000012744 immunostaining Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000002608 intravascular ultrasound Methods 0.000 description 1
- 238000002075 inversion recovery Methods 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 238000011545 laboratory measurement Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 201000002364 leukopenia Diseases 0.000 description 1
- 229920006008 lipopolysaccharide Polymers 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
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- 230000036651 mood Effects 0.000 description 1
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- 229960004927 neomycin Drugs 0.000 description 1
- 230000003557 neuropsychological effect Effects 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
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- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 230000008488 polyadenylation Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 208000037821 progressive disease Diseases 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000001373 regressive effect Effects 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 201000005404 rubella Diseases 0.000 description 1
- 230000037152 sensory function Effects 0.000 description 1
- 230000006403 short-term memory Effects 0.000 description 1
- 230000000392 somatic effect Effects 0.000 description 1
- 210000001321 subclavian vein Anatomy 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 210000003478 temporal lobe Anatomy 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000003867 tiredness Effects 0.000 description 1
- 208000016255 tiredness Diseases 0.000 description 1
- 230000002463 transducing effect Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 238000011277 treatment modality Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 230000005751 tumor progression Effects 0.000 description 1
- 230000001173 tumoral effect Effects 0.000 description 1
- 238000005199 ultracentrifugation Methods 0.000 description 1
- 230000002861 ventricular Effects 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/861—Adenoviral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biochemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9824437.9A GB9824437D0 (en) | 1998-11-06 | 1998-11-06 | Gene therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1135513E true PT1135513E (pt) | 2006-12-29 |
Family
ID=10842035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT99971860T PT1135513E (pt) | 1998-11-06 | 1999-11-05 | Terapia génica mediada por adenovírus |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6579855B1 (https=) |
| EP (1) | EP1135513B2 (https=) |
| JP (1) | JP4733833B2 (https=) |
| KR (1) | KR20020013473A (https=) |
| CN (1) | CN1184321C (https=) |
| AT (1) | ATE341639T1 (https=) |
| AU (1) | AU749451B2 (https=) |
| CA (1) | CA2348624C (https=) |
| CY (1) | CY1106198T1 (https=) |
| DE (1) | DE69933468T3 (https=) |
| DK (1) | DK1135513T4 (https=) |
| ES (1) | ES2273521T5 (https=) |
| GB (1) | GB9824437D0 (https=) |
| HU (1) | HUP0104046A3 (https=) |
| NO (1) | NO330776B1 (https=) |
| PL (1) | PL193076B1 (https=) |
| PT (1) | PT1135513E (https=) |
| WO (1) | WO2000028059A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0910950D0 (en) | 2009-06-24 | 2009-08-05 | Ark Therapeutics Ltd | Filtration |
| GB0916997D0 (en) | 2009-09-28 | 2009-11-11 | Ark Therapeutics Ltd | Combination therapy |
| US20130296407A1 (en) * | 2011-01-18 | 2013-11-07 | Ark Therapeutics, Ltd. | Combination Therapy for Cancer |
| GB201100804D0 (en) * | 2011-01-18 | 2011-03-02 | Ark Therapeutics Ltd | Drug combination |
| CA2863964C (en) | 2012-02-07 | 2021-10-26 | Global Bio Therapeutics Usa, Inc. | Compartmentalized method of nucleic acid delivery and compositions and uses thereof |
| US20160058888A1 (en) * | 2013-05-08 | 2016-03-03 | Gliotherapy Limited | Treatment of Operable High-Grade Glioma With Sitimagene Ceradenovec Gene Therapy and Ganciclovir |
| WO2015021443A1 (en) | 2013-08-08 | 2015-02-12 | Global Bio Therapeutics Usa, Inc. | Clamp device for minimally invasive procedures and uses thereof |
| DE102019000490A1 (de) | 2019-01-23 | 2020-07-23 | HAEMES Verwaltungsgesellschaft mbH | Verwendung von Oligonukleotiden für die Behandlung von Tumoren |
| BR112022012112A2 (pt) | 2019-12-20 | 2022-09-06 | Regeneron Pharma | Agonistas de il2 e métodos de uso dos mesmos |
| MX2022014239A (es) | 2020-05-12 | 2023-02-09 | Regeneron Pharma | Nuevos agonistas de il10 y metodos para su uso. |
| CN117597365A (zh) | 2021-05-04 | 2024-02-23 | 再生元制药公司 | 多特异性fgf21受体激动剂及其应用 |
| TW202321282A (zh) | 2021-07-19 | 2023-06-01 | 美商再生元醫藥公司 | Il12受體促效劑及其使用方法 |
| TW202334223A (zh) | 2021-11-11 | 2023-09-01 | 美商再生元醫藥公司 | Ｃｄ２０－ｐｄ１結合分子及其使用方法 |
| EP4649088A1 (en) | 2023-01-13 | 2025-11-19 | Regeneron Pharmaceuticals, Inc. | Il12 receptor agonists and methods of use thereof |
| EP4649092A1 (en) | 2023-01-13 | 2025-11-19 | Regeneron Pharmaceuticals, Inc. | Fgfr3 binding molecules and methods of use thereof |
| IL322890A (en) | 2023-02-28 | 2025-10-01 | Regeneron Pharma | Multispecific molecules containing an MHC-peptide complex containing an MHC domain and an antigenic peptide and a partially targeted immune cell antigen |
| EP4709756A1 (en) | 2023-05-10 | 2026-03-18 | Regeneron Pharmaceuticals, Inc. | Cd20-pd1 binding molecules and methods of use thereof |
| WO2025106469A1 (en) | 2023-11-14 | 2025-05-22 | Regeneron Pharmaceuticals, Inc. | Engineered heavy chain variable domains and uses thereof |
| WO2025240335A1 (en) | 2024-05-13 | 2025-11-20 | Regeneron Pharmaceuticals, Inc. | Fgfr3 binding molecules and methods of use thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0662441B2 (ja) * | 1986-02-18 | 1994-08-17 | 花王株式会社 | 抗腫瘍物質徐放性製剤 |
| US5631236A (en) * | 1993-08-26 | 1997-05-20 | Baylor College Of Medicine | Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk |
-
1998
- 1998-11-06 GB GBGB9824437.9A patent/GB9824437D0/en not_active Ceased
-
1999
- 1999-11-05 WO PCT/EP1999/009017 patent/WO2000028059A1/en not_active Ceased
- 1999-11-05 KR KR1020017004945A patent/KR20020013473A/ko not_active Ceased
- 1999-11-05 AU AU13851/00A patent/AU749451B2/en not_active Ceased
- 1999-11-05 AT AT99971860T patent/ATE341639T1/de active
- 1999-11-05 PT PT99971860T patent/PT1135513E/pt unknown
- 1999-11-05 DK DK99971860.4T patent/DK1135513T4/da active
- 1999-11-05 PL PL349489A patent/PL193076B1/pl unknown
- 1999-11-05 HU HU0104046A patent/HUP0104046A3/hu not_active Application Discontinuation
- 1999-11-05 US US09/830,725 patent/US6579855B1/en not_active Expired - Lifetime
- 1999-11-05 JP JP2000581225A patent/JP4733833B2/ja not_active Expired - Fee Related
- 1999-11-05 DE DE69933468T patent/DE69933468T3/de not_active Expired - Lifetime
- 1999-11-05 ES ES99971860T patent/ES2273521T5/es not_active Expired - Lifetime
- 1999-11-05 CN CNB998129305A patent/CN1184321C/zh not_active Expired - Fee Related
- 1999-11-05 EP EP99971860A patent/EP1135513B2/en not_active Expired - Lifetime
- 1999-11-05 CA CA2348624A patent/CA2348624C/en not_active Expired - Fee Related
-
2001
- 2001-05-04 NO NO20012220A patent/NO330776B1/no not_active IP Right Cessation
-
2006
- 2006-10-13 CY CY20061101473T patent/CY1106198T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2273521T3 (es) | 2007-05-01 |
| GB9824437D0 (en) | 1999-01-06 |
| KR20020013473A (ko) | 2002-02-20 |
| DK1135513T4 (da) | 2011-11-21 |
| CA2348624A1 (en) | 2000-05-18 |
| EP1135513A1 (en) | 2001-09-26 |
| WO2000028059A1 (en) | 2000-05-18 |
| US6579855B1 (en) | 2003-06-17 |
| DE69933468T3 (de) | 2012-01-19 |
| CN1325450A (zh) | 2001-12-05 |
| ATE341639T1 (de) | 2006-10-15 |
| ES2273521T5 (es) | 2011-12-28 |
| DE69933468D1 (de) | 2006-11-16 |
| HUP0104046A3 (en) | 2003-09-29 |
| CN1184321C (zh) | 2005-01-12 |
| CY1106198T1 (el) | 2011-06-08 |
| DE69933468T2 (de) | 2007-01-11 |
| NO20012220L (no) | 2001-05-04 |
| NO20012220D0 (no) | 2001-05-04 |
| NO330776B1 (no) | 2011-07-11 |
| PL193076B1 (pl) | 2007-01-31 |
| HUP0104046A2 (hu) | 2002-01-28 |
| CA2348624C (en) | 2012-07-31 |
| JP4733833B2 (ja) | 2011-07-27 |
| EP1135513B1 (en) | 2006-10-04 |
| DK1135513T3 (da) | 2006-11-27 |
| JP2002529097A (ja) | 2002-09-10 |
| AU749451B2 (en) | 2002-06-27 |
| EP1135513B2 (en) | 2011-08-10 |
| AU1385100A (en) | 2000-05-29 |
| PL349489A1 (en) | 2002-07-29 |
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